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Volumn 33, Issue 11, 2005, Pages 2521-2526

APOE polymorphism is associated with risk of severe sepsis in surgical patients

Author keywords

Apolipoprotein E; Association study; Genetic; Human; Inflammation; Polymorphism; Postoperative; Sepsis

Indexed keywords

APOLIPOPROTEIN E;

EID: 27944465278     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000186368.96146.FB     Document Type: Article
Times cited : (60)

References (59)
  • 1
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • Cohen J: The immunopathogenesis of sepsis. Nature 2002; 420:885-891
    • (2002) Nature , vol.420 , pp. 885-891
    • Cohen, J.1
  • 2
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 3
    • 0026874127 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
    • (1992) Crit Care Med , vol.20 , pp. 864-874
  • 4
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3
  • 5
    • 0038582331 scopus 로고    scopus 로고
    • Lipoprotein metabolism in patients with severe sepsis
    • van Leeuwen HJ, Heezius EC, Dallinga GM, et al: Lipoprotein metabolism in patients with severe sepsis. Crit Care Med 2003; 31:1359-1366
    • (2003) Crit Care Med , vol.31 , pp. 1359-1366
    • Van Leeuwen, H.J.1    Heezius, E.C.2    Dallinga, G.M.3
  • 6
    • 0032200584 scopus 로고    scopus 로고
    • Association of serum tumor necrosis factor levels with decrease of cholesterol during septic shock
    • Fraunberger P, Pilz G, Cremer P, et al: Association of serum tumor necrosis factor levels with decrease of cholesterol during septic shock. Shock 1998; 10:359-363
    • (1998) Shock , vol.10 , pp. 359-363
    • Fraunberger, P.1    Pilz, G.2    Cremer, P.3
  • 7
    • 0034883374 scopus 로고    scopus 로고
    • Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients
    • Gordon BR, Parker TS, Levine DM, et al: Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients. Crit Care Med 2001; 29:1563-1568
    • (2001) Crit Care Med , vol.29 , pp. 1563-1568
    • Gordon, B.R.1    Parker, T.S.2    Levine, D.M.3
  • 8
    • 4644226092 scopus 로고    scopus 로고
    • When good cholesterol goes bad
    • Fogelman AM: When good cholesterol goes bad. Nat Med 2004; 10:902-903
    • (2004) Nat Med , vol.10 , pp. 902-903
    • Fogelman, A.M.1
  • 9
    • 1542719622 scopus 로고    scopus 로고
    • Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation
    • Chenaud C, Merlani PG, Roux-Lombard P, et al: Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation. Crit Care Med 2004; 32:632-637
    • (2004) Crit Care Med , vol.32 , pp. 632-637
    • Chenaud, C.1    Merlani, P.G.2    Roux-Lombard, P.3
  • 10
    • 0038468462 scopus 로고    scopus 로고
    • Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure
    • Levels JH, Lemaire LC, van den Ende AE, et al: Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure. Crit Care Med 2003; 31:1647-1653
    • (2003) Crit Care Med , vol.31 , pp. 1647-1653
    • Levels, J.H.1    Lemaire, L.C.2    Van Den Ende, A.E.3
  • 11
    • 0034575124 scopus 로고    scopus 로고
    • Apolipoprotein E: Far more than a lipid transport protein
    • Mahley RW, Rail SC Jr: Apolipoprotein E: Far more than a lipid transport protein. Annu Rev Genomics Hum Genet 2000; 1:507-537
    • (2000) Annu Rev Genomics Hum Genet , vol.1 , pp. 507-537
    • Mahley, R.W.1    Rail Jr., S.C.2
  • 12
    • 0034001020 scopus 로고    scopus 로고
    • Altered immune responses in apolipoprotein E-deficient mice
    • Laskowitz DT, Lee DM, Schmechel D, et al: Altered immune responses in apolipoprotein E-deficient mice. J Lipid Res 2000; 41:613-620
    • (2000) J Lipid Res , vol.41 , pp. 613-620
    • Laskowitz, D.T.1    Lee, D.M.2    Schmechel, D.3
  • 13
    • 4143061183 scopus 로고    scopus 로고
    • A dual role for apolipoprotein e in neuroinflammation: Anti- and pro-inflammatory activity
    • Guo L, LaDu MJ, Van Eldik LJ: A dual role for apolipoprotein e in neuroinflammation: Anti- and pro-inflammatory activity. J Mol Neurosci 2004; 23:205-212
    • (2004) J Mol Neurosci , vol.23 , pp. 205-212
    • Guo, L.1    LaDu, M.J.2    Van Eldik, L.J.3
  • 14
    • 0031687891 scopus 로고    scopus 로고
    • Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo
    • Roselaar SE, Daugherty A: Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo. J Lipid Res 1998; 39:1740-1743
    • (1998) J Lipid Res , vol.39 , pp. 1740-1743
    • Roselaar, S.E.1    Daugherty, A.2
  • 15
    • 0032941090 scopus 로고    scopus 로고
    • Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection
    • de Bont N, Netea MG, Demacker PN, et al: Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection. J Lipid Res 1999; 40:680-685
    • (1999) J Lipid Res , vol.40 , pp. 680-685
    • De Bont, N.1    Netea, M.G.2    Demacker, P.N.3
  • 16
    • 4444372754 scopus 로고    scopus 로고
    • Apolipoprotein-E-deficient mice exhibit an increased susceptibility to disseminated candidiasis
    • Alieke GV, De Bont N, Netea MG, et al: Apolipoprotein-E-deficient mice exhibit an increased susceptibility to disseminated candidiasis. Med Mycol 2004; 42:341-348
    • (2004) Med Mycol , vol.42 , pp. 341-348
    • Alieke, G.V.1    De Bont, N.2    Netea, M.G.3
  • 17
    • 0035283401 scopus 로고    scopus 로고
    • Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response
    • Lynch JR, Morgan D, Mance J, et al: Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol 2001; 114:107-113
    • (2001) J Neuroimmunol , vol.114 , pp. 107-113
    • Lynch, J.R.1    Morgan, D.2    Mance, J.3
  • 18
    • 1542467336 scopus 로고    scopus 로고
    • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
    • Lynch JR, Tang W, Wang H, et al: APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. J Biol Chem 2003; 278:48529-48533
    • (2003) J Biol Chem , vol.278 , pp. 48529-48533
    • Lynch, J.R.1    Tang, W.2    Wang, H.3
  • 19
    • 0035937812 scopus 로고    scopus 로고
    • Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis
    • Van Oosten M, Rensen PC, Van Amersfoort ES, et al: Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis. J Biol Chem 2001; 276:8820-8824
    • (2001) J Biol Chem , vol.276 , pp. 8820-8824
    • Van Oosten, M.1    Rensen, P.C.2    Van Amersfoort, E.S.3
  • 20
    • 0029048261 scopus 로고
    • ApoE as a prognostic factor for post-traumatic coma
    • Sorbi S, Nacmias B, Piacentini S, et al: ApoE as a prognostic factor for post-traumatic coma. Nat Med 1995; 1:852
    • (1995) Nat Med , vol.1 , pp. 852
    • Sorbi, S.1    Nacmias, B.2    Piacentini, S.3
  • 21
    • 0033554880 scopus 로고    scopus 로고
    • Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury
    • Friedman G, Froom P, Sazbon L, et al: Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury. Neurology 1999; 52:244-248
    • (1999) Neurology , vol.52 , pp. 244-248
    • Friedman, G.1    Froom, P.2    Sazbon, L.3
  • 22
    • 0034844043 scopus 로고    scopus 로고
    • Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass
    • Grocott HP, Newman MF, El-Moalem H, et al: Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass. J Thorac Cardiovasc Surg 2001; 122:622-623
    • (2001) J Thorac Cardiovasc Surg , vol.122 , pp. 622-623
    • Grocott, H.P.1    Newman, M.F.2    El-Moalem, H.3
  • 23
    • 0022256529 scopus 로고
    • APACHE II: A severity of disease classification system
    • Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
    • (1985) Crit Care Med , vol.13 , pp. 818-829
    • Knaus, W.A.1    Draper, E.A.2    Wagner, D.P.3
  • 24
    • 0025257612 scopus 로고
    • Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI
    • Hixson JE, Vernier DT: Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 1990; 31:545-548
    • (1990) J Lipid Res , vol.31 , pp. 545-548
    • Hixson, J.E.1    Vernier, D.T.2
  • 25
    • 0026689178 scopus 로고
    • Performing the exact test of Hardy-Weinberg proportion for multiple alleles
    • Guo SW, Thompson EA: Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 1992; 48:361-372
    • (1992) Biometrics , vol.48 , pp. 361-372
    • Guo, S.W.1    Thompson, E.A.2
  • 27
    • 0036843337 scopus 로고    scopus 로고
    • Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients
    • Majetschak M, Obertacke U, Schade FU, et al: Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients. Clin Diagn Lab Immunol 2002; 9:1205-1211
    • (2002) Clin Diagn Lab Immunol , vol.9 , pp. 1205-1211
    • Majetschak, M.1    Obertacke, U.2    Schade, F.U.3
  • 28
    • 0033546610 scopus 로고    scopus 로고
    • Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: A multicenter study
    • Mira JP, Cariou A, Grall F, et al: Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: A multicenter study. JAMA 1999; 282:561-568
    • (1999) JAMA , vol.282 , pp. 561-568
    • Mira, J.P.1    Cariou, A.2    Grall, F.3
  • 29
    • 0012382804 scopus 로고    scopus 로고
    • Comparison of two polymorphisms of the interleukin-1 gene family: Interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis
    • Fang XM, Schroder S, Hoeft A, et al: Comparison of two polymorphisms of the interleukin-1 gene family: Interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med 1999; 27:1330-1334
    • (1999) Crit Care Med , vol.27 , pp. 1330-1334
    • Fang, X.M.1    Schroder, S.2    Hoeft, A.3
  • 30
    • 14944375926 scopus 로고    scopus 로고
    • Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
    • Sutherland AM, Walley KR, Russell JA: Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005; 33:638-644
    • (2005) Crit Care Med , vol.33 , pp. 638-644
    • Sutherland, A.M.1    Walley, K.R.2    Russell, J.A.3
  • 31
    • 0036162008 scopus 로고    scopus 로고
    • Functional genomics of critical illness and injury
    • Chung TP, Laramie JM, Province M, et al: Functional genomics of critical illness and injury. Crit Care Med 2002; 30(1 Suppl):S51-S57
    • (2002) Crit Care Med , vol.30 , Issue.1 SUPPL.
    • Chung, T.P.1    Laramie, J.M.2    Province, M.3
  • 32
    • 0037253163 scopus 로고    scopus 로고
    • Influence of interleukin-10 polymorphisms on interleukin-10 expression and survival in critically ill patients
    • Lowe PR, Galley HF, Abdel-Fattah A, et al: Influence of interleukin-10 polymorphisms on interleukin-10 expression and survival in critically ill patients. Crit Care Med 2003; 31:34-38
    • (2003) Crit Care Med , vol.31 , pp. 34-38
    • Lowe, P.R.1    Galley, H.F.2    Abdel-Fattah, A.3
  • 33
    • 0038047591 scopus 로고    scopus 로고
    • Methodologic quality and genotyping reproducibility in studies of tumor necrosis factor-308 G→A single nucleotide polymorphism and bacterial sepsis: Implications for studies of complex traits
    • Peters DL, Barber RC, Flood EM, et al: Methodologic quality and genotyping reproducibility in studies of tumor necrosis factor-308 G→A single nucleotide polymorphism and bacterial sepsis: implications for studies of complex traits. Crit Care Med 2003; 31:1691-1696
    • (2003) Crit Care Med , vol.31 , pp. 1691-1696
    • Peters, D.L.1    Barber, R.C.2    Flood, E.M.3
  • 34
    • 2942726193 scopus 로고    scopus 로고
    • Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis
    • Texereau J, Pene, F, Chiche JD et al: Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis. Crit Care Med 2004; 32(5 Suppl):S313-S319
    • (2004) Crit Care Med , vol.32 , Issue.5 SUPPL.
    • Texereau, J.1    Pene, F.2    Chiche, J.D.3
  • 35
    • 14944367038 scopus 로고    scopus 로고
    • Can single nucleotide polymorphisms in innate immune receptors predict development of septic complications in intensive care unit patients?
    • Wang JE: Can single nucleotide polymorphisms in innate immune receptors predict development of septic complications in intensive care unit patients? Crit Care Med 2005; 33:695-696
    • (2005) Crit Care Med , vol.33 , pp. 695-696
    • Wang, J.E.1
  • 36
    • 0036255629 scopus 로고    scopus 로고
    • Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate
    • Gibot SA, Cariou A, Drouet L, et al: Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate. Crit Care Med 2002; 30:969-973
    • (2002) Crit Care Med , vol.30 , pp. 969-973
    • Gibot, S.A.1    Cariou, A.2    Drouet, L.3
  • 37
    • 0020313079 scopus 로고
    • Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells
    • Avila EM, Holdsworth G, Sasaki N, et al: Apoprotein E suppresses phytohemagglutinin-activated phospholipid turnover in peripheral blood mononuclear cells. J Biol Chem 1982; 257:5900-5909
    • (1982) J Biol Chem , vol.257 , pp. 5900-5909
    • Avila, E.M.1    Holdsworth, G.2    Sasaki, N.3
  • 38
    • 0022608931 scopus 로고
    • Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein, LDL-In
    • Pepe MG, Curtiss LK: Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein, LDL-In. J Immunol 1986; 136:3716-3723
    • (1986) J Immunol , vol.136 , pp. 3716-3723
    • Pepe, M.G.1    Curtiss, L.K.2
  • 39
    • 0021249765 scopus 로고
    • Immunoregulation by low density lipoproteins in man. Inhibition of mitogen-induced T lymphocyte proliferation by interference with transferrin metabolism
    • Cuthbert JA, Lipsky PE: Immunoregulation by low density lipoproteins in man. Inhibition of mitogen-induced T lymphocyte proliferation by interference with transferrin metabolism. J Clin Invest 1984; 73:992-1003
    • (1984) J Clin Invest , vol.73 , pp. 992-1003
    • Cuthbert, J.A.1    Lipsky, P.E.2
  • 40
    • 0026033247 scopus 로고
    • Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo
    • Terkeltaub RA, Dyer CA, Martin J, et al: Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo. J Clin Invest 1991; 87:20-26
    • (1991) J Clin Invest , vol.87 , pp. 20-26
    • Terkeltaub, R.A.1    Dyer, C.A.2    Martin, J.3
  • 41
    • 8444242086 scopus 로고    scopus 로고
    • Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice
    • Grainger DJ, Reckless J, McKilligin E: Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice. J Immunol 2004; 173:6366-6375
    • (2004) J Immunol , vol.173 , pp. 6366-6375
    • Grainger, D.J.1    Reckless, J.2    McKilligin, E.3
  • 42
    • 0036135127 scopus 로고    scopus 로고
    • Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema
    • Lynch JR, Pineda JA, Morgan D, et al: Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol 2002; 51:113-117
    • (2002) Ann Neurol , vol.51 , pp. 113-117
    • Lynch, J.R.1    Pineda, J.A.2    Morgan, D.3
  • 43
    • 0035152093 scopus 로고    scopus 로고
    • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides
    • Laskowitz DT, Thekdi AD, Thekdi SD, et al: Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. Exp Neurol 2001; 167:74-85
    • (2001) Exp Neurol , vol.167 , pp. 74-85
    • Laskowitz, D.T.1    Thekdi, A.D.2    Thekdi, S.D.3
  • 44
    • 0035095238 scopus 로고    scopus 로고
    • ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response
    • Barlage S, Frohlich D, Bottcher A, et al: ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response. J Lipid Res 2001; 42:281-290
    • (2001) J Lipid Res , vol.42 , pp. 281-290
    • Barlage, S.1    Frohlich, D.2    Bottcher, A.3
  • 45
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • Sullivan PM, Mezdour H, Aratani Y, et al: Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 1997; 272:17972-17980
    • (1997) J Biol Chem , vol.272 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3
  • 46
    • 0034898960 scopus 로고    scopus 로고
    • Genetic predisposition in patients undergoing cardiopulmonary bypass surgery is associated with an increase of inflammatory cytokines
    • Drabe N, Zund G, Grunenfelder J, et al: Genetic predisposition in patients undergoing cardiopulmonary bypass surgery is associated with an increase of inflammatory cytokines. Eur J Cardiothorac Surg 2001; 20:609-613
    • (2001) Eur J Cardiothorac Surg , vol.20 , pp. 609-613
    • Drabe, N.1    Zund, G.2    Grunenfelder, J.3
  • 47
    • 0035208088 scopus 로고    scopus 로고
    • Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery
    • Newman MF, Grocott HP, Mathew JP, et al: Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery. Stroke 2001; 32:2874-2881
    • (2001) Stroke , vol.32 , pp. 2874-2881
    • Newman, M.F.1    Grocott, H.P.2    Mathew, J.P.3
  • 48
    • 0034603415 scopus 로고    scopus 로고
    • The role of apolipoprotein e in Alzheimer's disease, acute brain injury and cerebrovascular disease: Evidence of common mechanisms and utility of animal models
    • Horsburgh K, McCarron MO, White F, et al: The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: Evidence of common mechanisms and utility of animal models. Neurobiol Aging 2000; 21:245-255
    • (2000) Neurobiol Aging , vol.21 , pp. 245-255
    • Horsburgh, K.1    McCarron, M.O.2    White, F.3
  • 50
    • 0031831690 scopus 로고    scopus 로고
    • Microglial activation in Alzheimer disease: Association with APOE genotype
    • Egensperger R, Kosel S, von Eitzen U, et al: Microglial activation in Alzheimer disease: Association with APOE genotype. Brain Pathol 1998; 8:439-447
    • (1998) Brain Pathol , vol.8 , pp. 439-447
    • Egensperger, R.1    Kosel, S.2    Von Eitzen, U.3
  • 51
    • 0038238372 scopus 로고    scopus 로고
    • Does apolipoprotein E polymorphism influence susceptibility to malaria?
    • Wozniak MA, Faragher EB, Todd JA, et al: Does apolipoprotein E polymorphism influence susceptibility to malaria? J Med Genet 2003; 40:348-351
    • (2003) J Med Genet , vol.40 , pp. 348-351
    • Wozniak, M.A.1    Faragher, E.B.2    Todd, J.A.3
  • 52
    • 0035135076 scopus 로고    scopus 로고
    • Herpes simplex encephalitis: Involvement of apolipoprotein E genotype
    • Lin WR, Wozniak MA, Esiri MM, et al: Herpes simplex encephalitis: Involvement of apolipoprotein E genotype. J Neurol Neurosurg Psychiatry 2001; 70:117-119
    • (2001) J Neurol Neurosurg Psychiatry , vol.70 , pp. 117-119
    • Lin, W.R.1    Wozniak, M.A.2    Esiri, M.M.3
  • 53
    • 0345020546 scopus 로고    scopus 로고
    • HSV-1 and risk of Alzheimer's disease
    • Itzhaki RF, Lin WR, Wilcock GK, et al: HSV-1 and risk of Alzheimer's disease. Lancet 1998; 352:238
    • (1998) Lancet , vol.352 , pp. 238
    • Itzhaki, R.F.1    Lin, W.R.2    Wilcock, G.K.3
  • 54
    • 0035984436 scopus 로고    scopus 로고
    • Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus
    • Wozniak MA, Itzhaki RF, Faragher EB, et al: Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. Hepatology 2002; 36:456-463
    • (2002) Hepatology , vol.36 , pp. 456-463
    • Wozniak, M.A.1    Itzhaki, R.F.2    Faragher, E.B.3
  • 55
    • 0032948510 scopus 로고    scopus 로고
    • Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes
    • Mamotte CD, Sturm M, Foo JI, et al: Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes. Am J Physiol 1999; 276:E553-E557
    • (1999) Am J Physiol , vol.276
    • Mamotte, C.D.1    Sturm, M.2    Foo, J.I.3
  • 56
    • 0029896263 scopus 로고    scopus 로고
    • Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors
    • Bohnet K, Pillot T, Visvikis S, et al: Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors. J Lipid Res 1996; 37:1316-1324
    • (1996) J Lipid Res , vol.37 , pp. 1316-1324
    • Bohnet, K.1    Pillot, T.2    Visvikis, S.3
  • 57
    • 0034112161 scopus 로고    scopus 로고
    • Incidence and mortality of severe sepsis in surgical intensive care patients: The influence of patient gender on disease process and outcome
    • Wichmann MW, Inthorn D, Andress HJ, et al: Incidence and mortality of severe sepsis in surgical intensive care patients: The influence of patient gender on disease process and outcome. Intensive Care Med 2000; 26:167-172
    • (2000) Intensive Care Med , vol.26 , pp. 167-172
    • Wichmann, M.W.1    Inthorn, D.2    Andress, H.J.3
  • 58
    • 0037442092 scopus 로고    scopus 로고
    • Population stratification and spurious allelic association
    • Cardon LR, Palmer LJ: Population stratification and spurious allelic association. Lancet 2003; 361:598-604
    • (2003) Lancet , vol.361 , pp. 598-604
    • Cardon, L.R.1    Palmer, L.J.2
  • 59
    • 19944432946 scopus 로고    scopus 로고
    • Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    • Tang H, Quertermous T, Rodriguez B, et al: Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet 2005; 76:268-275
    • (2005) Am J Hum Genet , vol.76 , pp. 268-275
    • Tang, H.1    Quertermous, T.2    Rodriguez, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.