Gene-environment interaction between MBL2 genotype and smoking, and the risk of Gram-positive bacteraemia

Scandinavian Journal of Immunology

Volumn 68, Issue 4, 2008, Pages 438-444

  Huttunen, R ^a,b   Aittoniemi, J ^c   Laine, J ^a   Vuento, R ^c   Karjalainen, J ^b   Rovio, A T ^d   Eklund, C ^b   Hurme, M ^b,c   Huhtala, H ^e   Syrjanen J ^a,b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c PIRKANMAA HOSPITAL DISTRICT   (Finland)

^d UNIVERSITY OF TAMPERE   (Finland)

^e UNIVERSITY OF TAMPERE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

MANNOSE BINDING LECTIN 2;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BACTEREMIA; BETA HEMOLYTIC STREPTOCOCCUS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; ESCHERICHIA COLI; FEMALE; GENE; GENETIC POLYMORPHISM; GENOTYPE ENVIRONMENT INTERACTION; GRAM POSITIVE BACTERIUM; HUMAN; MAJOR CLINICAL STUDY; MALE; MBL2 GENE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR; SMOKING; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ADULT; AGED; AGED, 80 AND OVER; BACTEREMIA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MALE; MANNOSE-BINDING LECTIN; MIDDLE AGED; PROMOTER REGIONS (GENETICS); RISK FACTORS; SMOKING;

EID: 51349113033     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2008.02149.x     Document Type: Article

References (30)

1. Turner MW, Hamvas RM. Mannose-binding lectin: structure, function, genetics and disease associations. Rev Immunogenet 2000 2 : 305 22.
2. Turner MW. The role of mannose-binding lectin in health and disease. Mol Immunol 2003 40 : 423 9.
3. Koch A, Melbye M, Sorensen P et al. Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. JAMA 2001 285 : 1316 21.
4. Summerfield JA, Sumiya M, Levin M, Turner MW. Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series. BMJ 1997 314 : 1229 32.
5. Vekemans M, Robinson J, Georgala A et al. Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy. Clin Infect Dis 2007 44 : 1593 601.
6. Garred P, Madsen HO, Halberg P et al. Mannose-binding lectin polymorphisms and susceptibility to infection in systemic lupus erythematosus. Arthritis Rheum 1999 42 : 2145 52.
7. Tacx AN, Groeneveld AB, Hart MH, Aarden LA, Hack CE. Mannan-binding lectin in febrile adults: no correlation with microbial infection and complement activation. J Clin Pathol 2003 56 : 956 9.
8. Kronborg G, Weis N, Madsen HO et al. Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. J Infect Dis 2002 185 : 1517 20.
9. Lausen B, Schmiegelow K, Andreassen B, Madsen HO, Garred P. Infections during induction therapy of childhood acute lymphoblastic leukemia - no association to mannose-binding lectin deficiency. Eur J Haematol 2006 76 : 481 7.
10. Sutherland AM, Walley KR, Russell JA. Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit Care Med 2005 33 : 638 44.
11. Fidler KJ, Wilson P, Davies JC, Turner MW, Peters MJ, Klein NJ. Increased incidence and severity of the systemic inflammatory response syndrome in patients deficient in mannose-binding lectin. Intensive Care Med 2004 30 : 1438 45.
12. Garred P, Strom J, Quist L, Taaning E, Madsen HO. Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis 2003 188 : 1394 403.
13. Gordon AC, Waheed U, Hansen TK et al. Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock 2006 25 : 88 93.
14. Eisen DP, Dean MM, Thomas P et al. Low mannose-binding lectin function is associated with sepsis in adult patients. FEMS Immunol Med Microbiol 2006 48 : 274 82.
15. Smithson A, Munoz A, Suarez B et al. Association between mannose-binding lectin deficiency and septic shock following acute pyelonephritis due to Escherichia coli. Clin Vaccine Immunol 2007 14 : 256 61.
16. Karjalainen J, Hulkkonen J, Pessi T et al. The IL1A genotype associates with atopy in non-asthmatic adults. J Allergy Clin Immunol 2002 110 : 429 34.
17. Huttunen R, Laine J, Lumio J, Vuento R, Syrjanen J. Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia. BMC Infect Dis 2007 7 : 13.
18. Vincent JL, Moreno R, Takala J et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. Intensive Care Med 1996 22 : 707 10.
19. Madsen HO, Garred P, Kurtzhals JA et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 1994 40 : 37 44.
20. Hibberd ML, Sumiya M, Summerfield JA, Booy R, Levin M. Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Meningococcal Research Group. Lancet 1999 353 : 1049 53.
21. Roy S, Knox K, Segal S et al. MBL genotype and risk of invasive pneumococcal disease: a case-control study. Lancet 2002 359 : 1569 73.
22. Mullighan CG, Heatley S, Doherty K et al. Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation. Blood 2002 99 : 3524 9.
23. Hickling TP, Clark H, Malhotra R, Sim RB. Collectins and their role in lung immunity. J Leukoc Biol 2004 75 : 27 33.
24. Sopori M. Effects of cigarette smoke on the immune system. Nat Rev Immunol 2002 2 : 372 7.
25. Nuorti JP, Butler JC, Farley MM et al. Cigarette smoking and invasive pneumococcal disease. N Engl J Med 2000 342 : 681 9.
26. Super M, Thiel S, Lu J, Levinsky RJ, Turner MW. Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet 1989 2 : 1236 9.
27. Neth O, Jack DL, Dodds AW, Holzel H, Klein NJ, Turner MW. Mannose-binding lectin binds to a range of clinically relevant micro-organisms and promotes complement deposition. Infect Immun 2000 68 : 688 93.
28. Dommett RM, Klein N, Turner MW. Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens 2006 68 : 193 209.
29. van Emmerik LC, Kuijper EJ, Fijen CA, Dankert J, Thiel S. Binding of mannan-binding protein to various bacterial pathogens of meningitis. Clin Exp Immunol 1994 97 : 411 6.
30. Hellemann D, Larsson A, Madsen HO et al. Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients. Hum Mol Genet 2007 16 : 3071 80.