Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis

Clinical and Experimental Immunology

Volumn 127, Issue 2, 2002, Pages 331-336

  Arnalich, F ^a,b   Lopez Maderuelo D ^a   Codoceo, R ^a   Lopez, J ^a   Solis Garrido, L M ^a   Capiscol, C ^a   Fernandez Capitan C ^a   Madero, R ^a   Montiel, C ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL INFANTIL LA PAZ   (Spain)

Author keywords

Cytokine production; Gene polymorphism; Interleukin 1Ra; Mononuclear cells; Outcome; Peripheral blood; Sepsis

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ADULT; AGED; ALLELE; ARTICLE; BLOOD DONOR; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENOTYPE; HOMOZYGOTE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; MORTALITY; PNEUMONIA; PRIORITY JOURNAL; RISK FACTOR; SEPSIS; SURVIVAL;

EID: 0036130257     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01743.x     Document Type: Article

References (22)

1. The immunogenetics of human infectious diseases
2. Gene polymorphisms of interleukin 1 and 10 in infectious and autoimmune diseases
3. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock
4. A genomic polymorphism within the tumour necrosis factor locus influences plasma tumour necrosis factor-α concentrations and outcome of patients with severe sepsis
5. Association of TNF2, a TNF promoter polymorphism, with septic shock susceptibility and mortality: A multi-center study
6. Cytokine and cytokine receptor polymorphisms in infectious diseases
7. Comparison of two polymorphisms of the interleukin-1 gene family: Interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis
8. Predictive value of nuclear factor κ-B activity and plasma cytokine levels in patients with sepsis
9. Polymorphism in the human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat
10. IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1β genes
11. Cytokine production by normal human monocytes: Inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism
12. Definitions for sepsis and organ failure and guidelines for the use of innovative therapy in sepsis
13. APACHE II: A severity of disease classification system
14. Prediction of outcome from intensive care: A prospective cohort study comparing Acute Physiologic and Chronic Health Evaluation II and III prognostic systems in a United Kingdom intensive care unit
15. 2+ channels, derived from mRNA identification studies
16. Cell-mediated immune response and cytokine production in idiopathic senile anorexia
17. Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus
18. Lack of association between an interleukin-1 receptor antagonist gene polymorphism and systemic lupus erythematosus
19. Association of the interleukin-1 receptor antagonist gene with ulcerative colitis in Northern European Caucasians
20. Lack of association between an interleukin-1 receptor antagonist gene polymorphism and ulcerative colitis
21. Imbalance of the interleukin-1 system in the colonic mucosa - Association with intestinal inflammation and interleukin-1 receptor antagonist genotype 2
22. Novel interleukin-1 receptor antagonist exon polymorphisms and their use in allele-specific mRNA assessment