Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum

Critical Care Medicine

Volumn 37, Issue 5, 2009, Pages 1558-1566

  Wong, Hector R ^a   Cvijanovich, Natalie ^b   Allen, Geoffrey L ^c   Lin, Richard ^d   Anas, Nick ^e   Meyer, Keith ^f   Freishtat, Robert J ^g   Monaco, Marie ^a   Odoms, Kelli ^a   Sakthivel, Bhuvaneswari ^a   Shanley, Thomas P ^h  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OAKLAND   (United States)

^c CHILDREN S MERCY HOSPITAL   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^f MIAMI CHILDREN'S HOSPITAL   (United States)

^g CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^h UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Antigen presentation; Children; Inflammation; Microarray; T cell; Zinc

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; ZINC;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; ARTICLE; CHILD; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DATA BASE; DNA MICROARRAY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REPRESSION; HUMAN; INNATE IMMUNITY; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEPSIS; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; UPREGULATION;

CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CRITICAL CARE; CRITICAL ILLNESS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENE REGULATORY NETWORKS; GENOME; HUMANS; INTENSIVE CARE UNITS, PEDIATRIC; LONGITUDINAL STUDIES; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSPECTIVE STUDIES; REFERENCE VALUES; RNA; SENSITIVITY AND SPECIFICITY; SEPSIS; SHOCK, SEPTIC; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 67650470273     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819fcc08     Document Type: Article

References (46)

1. Proulx F, Fayon M, Farrell CA, et al: Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest 1996; 109:1033-1037
2. Shanley TP, Hallstrom C, Wong HR: Sepsis. In: Pediatric Critical Care Medicine. Third Edition. Fuhrman BP, Zimmerman JJ (Eds). St. Louis, Mosby, 2006, pp 1474-1493
3. Goldstein B, Giroir B, Randolph A: International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6:2-8
4. Baue AE: MOF, MODS, and SIRS: What is in a name or an acronym? Shock 2006; 26: 438-449
5. Baue AE: A debate on the subject "Are SIRS and MODS important entities in the clinical evaluation of patients?" The con position. Shock 2000; 14:590-593
6. Carcillo JA, Fields AI: Clinical practice parameters for hemodynamic support of pedi-atric and neonatal patients in septic shock. Crit Care Med 2002; 30:1365-1378
7. Wong HR, Shanley TP, Sakthivel B, et al: Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics 2007; 30:146-155
8. Shanley TP, Cvijanovich N, Lin R, et al: Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med 2007; 13:495-508
9. Wong HR: Pediatric septic shock treatment: New clues from genomic profiling. Pharmacogenomics 2007; 8:1287-1290
10. Cvijanovich N, Shanley TP, Lin R, et al: Validating the genomic signature of pediatric septic shock. Physiol Genomics 2008; 34: 127-134
11. Pollack MM, Patel KM, Ruttimann UE: The Pediatric Risk of Mortality III - Acute Physiology Score (PRISM III-APS): A method of assessing physiologic instability for pediatric intensive care unit patients. J Pediatr 1997; 131:575-581
12. Wilkinson JD, Pollack MM, Ruttimann UE, et al: Outcome of pediatric patients with multiple organ system failure. Crit Care Med 1986; 14:271-274
13. Irizarry RA, Hobbs B, Collin F, et al: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4:249-264
14. Calvano SE, Xiao W, Richards DR, et al: A network-based analysis of systemic inflammation in humans. Nature 2005; 437: 1032-1037
15. Dennis G Jr, Sherman BT, Hosack DA, et al: DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003; 4:P3
16. Mi H, Guo N, Kejariwal A, et al: PANTHER version 6: Protein sequence and function evolution data with expanded representation of biological pathways. Nucleic Acids Res 2007; 35:D247-D252
17. Thomas PD, Campbell MJ, Kejariwal A, et al: PANTHER: A library of protein families and subfamilies indexed by function. Genome Res 2003; 13:2129-2141
18. Chen J, Xu H, Aronow BJ, et al: Improved human disease candidate gene prioritization using mouse phenotype. BMC Bioinformatics 2007; 8:392
19. Golub TR, Slonim DK, Tamayo P, et al: Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring. Science 1999; 286:531-537
20. Alizadeh AA, Staudt LM: Genomic-scale gene expression profiling of normal and malignant immune cells. Curr Opin Immunol 2000; 12: 219-225
21. Dave SS, Wright G, Tan B, et al: Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 2004; 351: 2159-2169
22. Ebert BL, Golub TR: Genomic approaches to hematologic malignancies. Blood 2004; 104: 923-932
23. Ramaswamy S, Tamayo P, Rifkin R, et al: Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci USA 2001; 98:15149-15154
24. Sorlie T, Perou CM, Tibshirani R, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001; 98:10869-10874
25. van de Vijver MJ, He YD, van't Veer LJ, et al: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347:1999-2009
26. Watson RS, Carcillo JA, Linde-Zwirble WT, et al: The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med 2003; 167:695-701
27. Watson RS, Carcillo JA: Scope and epidemiology of pediatric sepsis. Pediatr Crit Care Med 005; 6:S3-S5
28. Abraham E: Why immunomodulatory therapies have not worked in sepsis. Intensive Care Med 1999; 25:556-566
29. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150
30. Rink L, Haase H: Zinc homeostasis and immunity. Trends Immunol 2007; 28:1-4
31. Fraker PJ, King LE: Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr 2004; 24:277-298
32. Ibs KH, Rink L: Zinc-altered immune function. J Nutr 2003; 133:1452S-1456S
33. Moore KW, de Waal Malefyt R, Coffman RL, et al: Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683-765
34. de Waal Malefyt R, Abrams J, Bennett B, et al: Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregula-tory role of IL-10 produced by monocytes. J Exp Med 1991; 174:1209-1220
35. Taga K, Mostowski H, Tosato G: Human interleukin-10 can directly inhibit T-cell growth. Blood 1993; 81:2964-2971
36. Li MO, Wan YY, Sanjabi S, et al: Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 2006; 24: 99-146
37. Dong Y, Tang L, Letterio JJ, et al: The smad3 protein is involved in TGF-beta inhibition of class II transactivator and class II MHC expression. J Immunol 2001; 167:311-319
38. Fontes JD, Kanazawa S, Nekrep N, et al: The class II transactivator CIITA is a transcriptional integrator. Microbes Infect 1999; 1:863-869
39. Masternak K, Muhlethaler-Mottet A, Villard J, et al: Molecular genetics of the Bare lymphocyte syndrome. Rev Immunogenet 2000; 2:267-282
40. Nelms K, Keegan AD, Zamorano J, et al: The IL-4 receptor: Signaling mechanisms and biologic functions. Annu Rev Immunol 1999; 17:701-738
41. Aroeira LS, Martinez AC: The role of IL-4 in the staphylococcal enterotoxin B-triggered immune response: Increased susceptibility to shock and deletion of CD8Vbeta8+ T cells in IL-4 knockout mice. Eur J Immunol 1999; 29:1397-1405
42. Wong HR, Cvijanovich N, Wheeler DS, et al: Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med 2008; 178:276-282
43. Ayala A, Chaudry IH: Immune dysfunction in murine polymicrobial sepsis: Mediators, macrophages, lymphocytes and apoptosis. Shock 1996; 6:S27-S38
44. Hotchkiss RS, Swanson PE, Freeman BD, et al: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27:1230-1251
45. Hotchkiss RS, Tinsley KW, Karl IE: Role of apoptotic cell death in sepsis. Scand J Infect Dis 2003; 35:585-592
46. Felmet KA, Hall MW, Clark RS, et al: Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol 2005; 174:3765-3772