메뉴 건너뛰기




Volumn 125, Issue 1, 2004, Pages 12-23

Plasminogen activator inhibitor 1 (PAI-1): In vitro activities and clinical relevance

Author keywords

Anticoagulation; Fibrinolysis; PAI 1; Plasminogen activator; Thrombin

Indexed keywords

ACTIVATED PROTEIN C; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBIN; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

EID: 1842610168     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2004.04844.x     Document Type: Review
Times cited : (50)

References (119)
  • 1
    • 0037418247 scopus 로고    scopus 로고
    • No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age
    • Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group (2003) No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age. Circulation, 107, 1117-1122.
    • (2003) Circulation , vol.107 , pp. 1117-1122
  • 3
    • 0029022692 scopus 로고
    • Molecular evolution of plasminogen activator inhibitor-1 functional stability
    • Berkenpas, M.B., Lawrence, D.A. & Ginsburg, D. (1995) Molecular evolution of plasminogen activator inhibitor-1 functional stability. EMBO Journal, 14, 2969-2977.
    • (1995) EMBO Journal , vol.14 , pp. 2969-2977
    • Berkenpas, M.B.1    Lawrence, D.A.2    Ginsburg, D.3
  • 4
    • 0028909718 scopus 로고
    • Thrombolysis and reocclusion in experimental jugular vein and coronary artery thrombosis. Effects of a plasminogen activator inhibitor type 1-neutralizing monoclonal antibody
    • Biemond, B.J., Levi, M., Coronel, R., Janse, M.J., ten Cate, J.W. & Pannekoek, H. (1995a) Thrombolysis and reocclusion in experimental jugular vein and coronary artery thrombosis. Effects of a plasminogen activator inhibitor type 1-neutralizing monoclonal antibody. Circulation, 91, 1175-1181.
    • (1995) Circulation , vol.91 , pp. 1175-1181
    • Biemond, B.J.1    Levi, M.2    Coronel, R.3    Janse, M.J.4    Ten Cate, J.W.5    Pannekoek, H.6
  • 5
    • 0029041753 scopus 로고
    • Plasminogen activator and plasminogen activator inhibitor I release during experimental endotoxaemia in chimpanzees: Effect of interventions in the cytokine and coagulation cascades
    • Biemond, B.J., Levi, M., Ten Cate, H., Van der Poll, T., Buller, H.R., Hack, C.E. & Ten Cate, J.W. (1995b) Plasminogen activator and plasminogen activator inhibitor I release during experimental endotoxaemia in chimpanzees: effect of interventions in the cytokine and coagulation cascades. Clinical Science (London), 88, 587-594.
    • (1995) Clinical Science (London) , vol.88 , pp. 587-594
    • Biemond, B.J.1    Levi, M.2    Ten Cate, H.3    Van Der Poll, T.4    Buller, H.R.5    Hack, C.E.6    Ten Cate, J.W.7
  • 6
    • 0035909969 scopus 로고    scopus 로고
    • Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: A systematic review
    • Boekholdt, S.M., Bijsterveld, N.R., Moons, A.H., Levi, M., Buller, H.R. & Peters, R.J. (2001) Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: a systematic review. Circulation, 104, 3063-3068.
    • (2001) Circulation , vol.104 , pp. 3063-3068
    • Boekholdt, S.M.1    Bijsterveld, N.R.2    Moons, A.H.3    Levi, M.4    Buller, H.R.5    Peters, R.J.6
  • 7
    • 0037369233 scopus 로고    scopus 로고
    • The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1
    • van der Bom, J.G., Bots, M.L., Haverkate, F., Kluft, C. & Grobbee, D.E. (2003) The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1. Blood, 101, 1841-1844.
    • (2003) Blood , vol.101 , pp. 1841-1844
    • Van Der Bom, J.G.1    Bots, M.L.2    Haverkate, F.3    Kluft, C.4    Grobbee, D.E.5
  • 9
    • 0030685740 scopus 로고    scopus 로고
    • Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: A gene targeting and gene transfer study in mice
    • Carmeliet, P., Moons, L., Lijnen, R., Janssens, S., Lupu, F., Collen, D. & Gerard, R.D. (1997) Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice. Circulation 96, 3180-3191.
    • (1997) Circulation , vol.96 , pp. 3180-3191
    • Carmeliet, P.1    Moons, L.2    Lijnen, R.3    Janssens, S.4    Lupu, F.5    Collen, D.6    Gerard, R.D.7
  • 12
    • 0037416209 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins
    • Czekay, R.P., Aertgeerts, K., Curriden, S.A. & Loskutoff, D.J. (2003) Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins. Journal of Cell Biology, 160, 781-791.
    • (2003) Journal of Cell Biology , vol.160 , pp. 781-791
    • Czekay, R.P.1    Aertgeerts, K.2    Curriden, S.A.3    Loskutoff, D.J.4
  • 13
    • 0032739834 scopus 로고    scopus 로고
    • The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: Release of a kinetic block by a heterologous protein surface loop
    • Dekker, R.J., Eichinger, A., Stoop, A.A., Bode, W., Pannekoek, H. & Horrevoets, A.J. (1999) The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. Journal of Molecular Biology, 293, 613-627.
    • (1999) Journal of Molecular Biology , vol.293 , pp. 613-627
    • Dekker, R.J.1    Eichinger, A.2    Stoop, A.A.3    Bode, W.4    Pannekoek, H.5    Horrevoets, A.J.6
  • 14
    • 0038706557 scopus 로고    scopus 로고
    • A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin
    • Dekker, R.J., Pannekoek, H. & Horrevoets, A.J. (2003) A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin. European Journal of Biochemistry, 270, 1942-1951.
    • (2003) European Journal of Biochemistry , vol.270 , pp. 1942-1951
    • Dekker, R.J.1    Pannekoek, H.2    Horrevoets, A.J.3
  • 15
    • 0034830757 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin
    • Deng, G., Curriden, S.A., Hu, G., Czekay, R.P. & Loskutoff, D.J. (2001) Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin. Journal of Cell Physiology, 189, 23-33.
    • (2001) Journal of Cell Physiology , vol.189 , pp. 23-33
    • Deng, G.1    Curriden, S.A.2    Hu, G.3    Czekay, R.P.4    Loskutoff, D.J.5
  • 16
    • 0036329424 scopus 로고    scopus 로고
    • Urokinase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: From pilot to level 1 evidence studies
    • Duffy, M.J. (2002) Urokinase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: from pilot to level 1 evidence studies. Clinical Chemistry, 48, 1194-1197.
    • (2002) Clinical Chemistry , vol.48 , pp. 1194-1197
    • Duffy, M.J.1
  • 17
    • 0035920257 scopus 로고    scopus 로고
    • Regulation of vascular bed-specific prothrombotic potential
    • Edelberg, J.M., Christie, P.D. & Rosenberg, R.D. (2001) Regulation of vascular bed-specific prothrombotic potential. Circulation Research, 89, 117-124.
    • (2001) Circulation Research , vol.89 , pp. 117-124
    • Edelberg, J.M.1    Christie, P.D.2    Rosenberg, R.D.3
  • 18
    • 0025347305 scopus 로고
    • Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties
    • Ehrlich, H.J., Gebbink, R.K., Keijer, J., Linders, M., Preissner, K.T. & Pannekoek, H. (1990) Alteration of serpin specificity by a protein cofactor. Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties. Journal of Biological Chemdistry, 265, 13029-13035.
    • (1990) Journal of Biological Chemdistry , vol.265 , pp. 13029-13035
    • Ehrlich, H.J.1    Gebbink, R.K.2    Keijer, J.3    Linders, M.4    Preissner, K.T.5    Pannekoek, H.6
  • 19
    • 0026355181 scopus 로고
    • Thrombin neutralizes plasminogen activator inhibitor 1 (PAI-1) that is complexed with vitronectin in the endothelial cell matrix
    • Ehrlich, H.J., Gebbink, R.K., Preissner, K.T., Keijer, J., Esmon, N.L., Mertens, K. & Pannekoek, H. (1991) Thrombin neutralizes plasminogen activator inhibitor 1 (PAI-1) that is complexed with vitronectin in the endothelial cell matrix. Journal of Cell Biology, 115, 1773-1781.
    • (1991) Journal of Cell Biology , vol.115 , pp. 1773-1781
    • Ehrlich, H.J.1    Gebbink, R.K.2    Preissner, K.T.3    Keijer, J.4    Esmon, N.L.5    Mertens, K.6    Pannekoek, H.7
  • 20
    • 0030054203 scopus 로고    scopus 로고
    • Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
    • Eitzman, D.T., McCoy, R.D., Zheng, X., Fay, W.P., Shen, T., Ginsburg, D. & Simon, R.H. (1996) Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. Journal of Clinical Investigation, 97, 232-237.
    • (1996) Journal of Clinical Investigation , vol.97 , pp. 232-237
    • Eitzman, D.T.1    McCoy, R.D.2    Zheng, X.3    Fay, W.P.4    Shen, T.5    Ginsburg, D.6    Simon, R.H.7
  • 21
    • 0034650976 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice
    • Eitzman, D.T., Westrick, R.J., Nabel, E.G. & Ginsburg, D. (2000a) Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Blood, 95, 577-580.
    • (2000) Blood , vol.95 , pp. 577-580
    • Eitzman, D.T.1    Westrick, R.J.2    Nabel, E.G.3    Ginsburg, D.4
  • 22
    • 0034672348 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery
    • Eitzman, D.T., Westrick, R.J., Xu, Z., Tyson, J. & Ginsburg, D. (2000b) Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood, 96, 4212-4215.
    • (2000) Blood , vol.96 , pp. 4212-4215
    • Eitzman, D.T.1    Westrick, R.J.2    Xu, Z.3    Tyson, J.4    Ginsburg, D.5
  • 23
    • 0034615559 scopus 로고    scopus 로고
    • Regulation of blood coagulation
    • Esmon, C.T. (2000) Regulation of blood coagulation. Biochimica et Biophysica Acta, 1477, 349-360.
    • (2000) Biochimica et Biophysica Acta , vol.1477 , pp. 349-360
    • Esmon, C.T.1
  • 24
    • 0345725987 scopus 로고    scopus 로고
    • Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice
    • Farrehi, P.M., Ozaki, C.K., Carmeliet, P. & Fay, W.P. (1998) Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice. Circulation, 97, 1002-1008.
    • (1998) Circulation , vol.97 , pp. 1002-1008
    • Farrehi, P.M.1    Ozaki, C.K.2    Carmeliet, P.3    Fay, W.P.4
  • 25
    • 0024401071 scopus 로고
    • Platelet plasminogen activator inhibitor: Purification and characterization of interaction with plasminogen activators and activated protein C
    • Fay, W.P. & Owen, W.G. (1989) Platelet plasminogen activator inhibitor: purification and characterization of interaction with plasminogen activators and activated protein C. Biochemistry, 28, 5773-5778.
    • (1989) Biochemistry , vol.28 , pp. 5773-5778
    • Fay, W.P.1    Owen, W.G.2
  • 26
    • 0026448949 scopus 로고
    • Brief report: Complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation
    • Fay, W.P., Shapiro, A.D., Shih, J.L., Schleef, R.R. & Ginsburg, D. (1992) Brief report: complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation. New England Journal of Medicine, 327, 1729-1733.
    • (1992) New England Journal of Medicine , vol.327 , pp. 1729-1733
    • Fay, W.P.1    Shapiro, A.D.2    Shih, J.L.3    Schleef, R.R.4    Ginsburg, D.5
  • 27
    • 0028006095 scopus 로고
    • Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms
    • Fay, W.P., Eitzman, D.T., Shapiro, A.D., Madison, E.L. & Ginsburg, D. (1994) Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms. Blood, 83, 351-356.
    • (1994) Blood , vol.83 , pp. 351-356
    • Fay, W.P.1    Eitzman, D.T.2    Shapiro, A.D.3    Madison, E.L.4    Ginsburg, D.5
  • 28
    • 0030997665 scopus 로고    scopus 로고
    • Human plasminogen activator inhibitor-1 (PAI-1) deficiency: Characterization of a large kindred with a null mutation in the PAI-1 gene
    • Fay, W.P., Parker, A.C., Condrey, L.R. & Shapiro, A.D. (1997) Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. Blood, 90, 204-208.
    • (1997) Blood , vol.90 , pp. 204-208
    • Fay, W.P.1    Parker, A.C.2    Condrey, L.R.3    Shapiro, A.D.4
  • 29
    • 0033559292 scopus 로고    scopus 로고
    • Vitronectin inhibits the thrombotic response to arterial injury in mice
    • Fay, W.P., Parker, A.C., Ansari, M.N., Zheng, X. & Ginsburg, D. (1999) Vitronectin inhibits the thrombotic response to arterial injury in mice. Blood, 93, 1825-1830.
    • (1999) Blood , vol.93 , pp. 1825-1830
    • Fay, W.P.1    Parker, A.C.2    Ansari, M.N.3    Zheng, X.4    Ginsburg, D.5
  • 30
    • 0038518463 scopus 로고    scopus 로고
    • Promoter (4G/5G) Plasminogen Activator Inhibitor-1 Genotype and Plasminogen Activator Inhibitor-1 Levels in Blacks, Hispanics, and Non-Hispanic Whites: The Insulin Resistance Atherosclerosis Study
    • Festa, A., D'Agostino, Jr, R., Rich, S.S., Jenny, N.S., Tracy, R.P. & Haffner, S.M. (2003) Promoter (4G/5G) Plasminogen Activator Inhibitor-1 Genotype and Plasminogen Activator Inhibitor-1 Levels in Blacks, Hispanics, and Non-Hispanic Whites: The Insulin Resistance Atherosclerosis Study. Circulation, 107, 2422-2427.
    • (2003) Circulation , vol.107 , pp. 2422-2427
    • Festa, A.1    D'Agostino Jr., R.2    Rich, S.S.3    Jenny, N.S.4    Tracy, R.P.5    Haffner, S.M.6
  • 31
    • 0034911310 scopus 로고    scopus 로고
    • Hemostatic risk factors for atherothrombotic disease: An epidemiologic view
    • Folsom, A.R. (2001) Hemostatic risk factors for atherothrombotic disease: an epidemiologic view. Thrombosis and Haemostasis, 86, 366-373.
    • (2001) Thrombosis and Haemostasis , vol.86 , pp. 366-373
    • Folsom, A.R.1
  • 32
    • 0023733487 scopus 로고
    • Activated protein C increases fibrin clot lysis by neutralization of plasminogen activator inhibitor - No evidence for a cofactor role of protein S
    • de Fouw, N.J., de Jong, Y.F., Haverkate, F. & Bertina, R.M. (1988) Activated protein C increases fibrin clot lysis by neutralization of plasminogen activator inhibitor - no evidence for a cofactor role of protein S. Thrombosis and Haemostasis, 60, 328-333.
    • (1988) Thrombosis and Haemostasis , vol.60 , pp. 328-333
    • Fouw, N.J.1    De Jong, Y.F.2    Haverkate, F.3    Bertina, R.M.4
  • 33
    • 0036881059 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 levels and polymorphisms: Association with venous thromboembolism
    • Francis, C.W. (2002) Plasminogen activator inhibitor-1 levels and polymorphisms: association with venous thromboembolism. Archives of Pathology and Laboratory Medicine, 126, 1401-1404.
    • (2002) Archives of Pathology and Laboratory Medicine , vol.126 , pp. 1401-1404
    • Francis, C.W.1
  • 34
  • 35
    • 0027405990 scopus 로고
    • Specific glycosaminoglycans support the inhibition of thrombin by plasminogen activator inhibitor 1
    • Gebbink, R.K., Reynolds, C.H., Tollefsen, D.M., Mertens, K. & Pannekoek, H. (1993) Specific glycosaminoglycans support the inhibition of thrombin by plasminogen activator inhibitor 1. Biochemistry, 32, 1675-1680.
    • (1993) Biochemistry , vol.32 , pp. 1675-1680
    • Gebbink, R.K.1    Reynolds, C.H.2    Tollefsen, D.M.3    Mertens, K.4    Pannekoek, H.5
  • 38
    • 0031743824 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor 1 contains a cryptic high affinity receptor binding site that is exposed upon complex formation with tissue-type plasminogen activator
    • Horn, I.R., van den Berg, B.M., Moestrup, S.K., Pannekoek, H. & van Zonneveld, A.J. (1998) Plasminogen activator inhibitor 1 contains a cryptic high affinity receptor binding site that is exposed upon complex formation with tissue-type plasminogen activator. Thrombosis and Haemostasis, 80, 822-828.
    • (1998) Thrombosis and Haemostasis , vol.80 , pp. 822-828
    • Horn, I.R.1    Van Den Berg, B.M.2    Moestrup, S.K.3    Pannekoek, H.4    Van Zonneveld, A.J.5
  • 39
    • 0027388955 scopus 로고
    • Thrombin-variable region 1 (VR1). Evidence for the dominant contribution of VR1 of serine proteases to their interaction with plasminogen activator inhibitor 1
    • Horrevoets, A.J., Tans, G., Smilde, A.E., van Zonneveld, A.J. & Pannekoek, H. (1993) Thrombin-variable region 1 (VR1). Evidence for the dominant contribution of VR1 of serine proteases to their interaction with plasminogen activator inhibitor 1. Journal of Biological Chemistry, 268, 779-782.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 779-782
    • Horrevoets, A.J.1    Tans, G.2    Smilde, A.E.3    Van Zonneveld, A.J.4    Pannekoek, H.5
  • 40
    • 0031035376 scopus 로고    scopus 로고
    • A steady-state template model that describes the kinetics of fibrin-stimulated [Glu1]- and [Lys78]plasminogen activation by native tissue-type plasminogen activator and variants that lack either the finger or kringle-2 domain
    • Horrevoets, A.J., Pannekoek, H. & Nesheim, M.E. (1997) A steady-state template model that describes the kinetics of fibrin-stimulated [Glu1]-and [Lys78]plasminogen activation by native tissue-type plasminogen activator and variants that lack either the finger or kringle-2 domain. Journal of Biological Chemistry, 272, 2183-2191.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 2183-2191
    • Horrevoets, A.J.1    Pannekoek, H.2    Nesheim, M.E.3
  • 41
    • 0020472522 scopus 로고
    • Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin
    • Hoylaerts, M., Rijken, D.C., Lijnen, H.R. & Collen, D. (1982) Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. Journal of Biological Chemistry, 257, 2912-2919.
    • (1982) Journal of Biological Chemistry , vol.257 , pp. 2912-2919
    • Hoylaerts, M.1    Rijken, D.C.2    Lijnen, H.R.3    Collen, D.4
  • 42
    • 0024392512 scopus 로고
    • Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage
    • Idell, S., Peters, J., James, K.K., Fair, D.S. & Coalson, J.J. (1989) Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage. Journal of Clinical Investigation, 84, 181-193.
    • (1989) Journal of Clinical Investigation , vol.84 , pp. 181-193
    • Idell, S.1    Peters, J.2    James, K.K.3    Fair, D.S.4    Coalson, J.J.5
  • 43
    • 0035344647 scopus 로고    scopus 로고
    • Induction of plasminogen activator inhibitor 1 gene expression in adipocytes by thiazolidinediones
    • Ihara, H., Urano, T., Takada, A. & Loskutoff, D.J. (2001) Induction of plasminogen activator inhibitor 1 gene expression in adipocytes by thiazolidinediones. FASEB Journal, 15, 1233-1235.
    • (2001) FASEB Journal , vol.15 , pp. 1233-1235
    • Ihara, H.1    Urano, T.2    Takada, A.3    Loskutoff, D.J.4
  • 45
    • 0031853098 scopus 로고    scopus 로고
    • The 4G/5G polymorphism of the plasminogen activator inhibitor gene is associated with the time course of progression to acute coronary syndromes
    • Iwai, N., Shimoike, H., Nakamura, Y., Tamaki, S. & Kinoshita, M. (1998) The 4G/5G polymorphism of the plasminogen activator inhibitor gene is associated with the time course of progression to acute coronary syndromes. Atherosclerosis, 136, 109-114.
    • (1998) Atherosclerosis , vol.136 , pp. 109-114
    • Iwai, N.1    Shimoike, H.2    Nakamura, Y.3    Tamaki, S.4    Kinoshita, M.5
  • 46
    • 0141832847 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
    • Juhan-Vague, I., Alessi, M.C., Mavri, A. & Morange, P.E. (2003) Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk. Journal of Thrombosis and Haemostasis, 1, 1575-1579.
    • (2003) Journal of Thrombosis and Haemostasis , vol.1 , pp. 1575-1579
    • Juhan-Vague, I.1    Alessi, M.C.2    Mavri, A.3    Morange, P.E.4
  • 47
    • 0025990175 scopus 로고
    • On the target specificity of plasminogen activator inhibitor 1: The role of heparin, vitronectin, and the reactive site
    • Keijer, J., Linders, M., Wegman, J.J., Ehrlich, H.J., Mertens, K. & Pannekoek, H. (1991a) On the target specificity of plasminogen activator inhibitor 1: the role of heparin, vitronectin, and the reactive site. Blood, 78, 1254-1261.
    • (1991) Blood , vol.78 , pp. 1254-1261
    • Keijer, J.1    Linders, M.2    Wegman, J.J.3    Ehrlich, H.J.4    Mertens, K.5    Pannekoek, H.6
  • 48
    • 0025895787 scopus 로고
    • Vitronectin governs the interaction between plasminogen activator inhibitor 1 and tissue-type plasminogen activator
    • Keijer, J., Ehrlich, H.J., Linders, M., Preissner, K.T. & Pannekoek, H. (1991b) Vitronectin governs the interaction between plasminogen activator inhibitor 1 and tissue-type plasminogen activator. Journal of Biological Chemistry, 266, 10700-10707.
    • (1991) Journal of Biological Chemistry , vol.266 , pp. 10700-10707
    • Keijer, J.1    Ehrlich, H.J.2    Linders, M.3    Preissner, K.T.4    Pannekoek, H.5
  • 49
    • 0035970097 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice
    • Konstantinides, S., Schäfer, K., Thinnes, T. & Loskutoff, D.J. (2001) Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice. Circulation, 103, 576-583.
    • (2001) Circulation , vol.103 , pp. 576-583
    • Konstantinides, S.1    Schäfer, K.2    Thinnes, T.3    Loskutoff, D.J.4
  • 50
    • 0036924418 scopus 로고    scopus 로고
    • Do PAI-1 and vitronectin promote or inhibit neoinn'ma formation? the exact role of the fibrinolytic system in vascular remodeling remains uncertain
    • Konstantinides, S., Schäfer, K. & Loskutoff, D.J. (2002) Do PAI-1 and vitronectin promote or inhibit neoinn'ma formation? The exact role of the fibrinolytic system in vascular remodeling remains uncertain. Arteriosclerosis, Thrombosis and Vascular Biology, 22, 1943-1945.
    • (2002) Arteriosclerosis, Thrombosis and Vascular Biology , vol.22 , pp. 1943-1945
    • Konstantinides, S.1    Schäfer, K.2    Loskutoff, D.J.3
  • 51
    • 0022501332 scopus 로고
    • Studies on the release of a plasminogen activator inhibitor by human platelets
    • Kruithof, E.K., Tran-Thang, C. & Bachmann, F. (1986) Studies on the release of a plasminogen activator inhibitor by human platelets. Thrombosis and Haemostasis, 55, 201-205.
    • (1986) Thrombosis and Haemostasis , vol.55 , pp. 201-205
    • Kruithof, E.K.1    Tran-Thang, C.2    Bachmann, F.3
  • 52
    • 0037093228 scopus 로고    scopus 로고
    • Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function
    • Kunz, G., Ohlin, A.K., Adami, A., Zoller, B., Svensson, P. & Lane, D.A. (2002) Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function. Blood, 99, 3646-3653.
    • (2002) Blood , vol.99 , pp. 3646-3653
    • Kunz, G.1    Ohlin, A.K.2    Adami, A.3    Zoller, B.4    Svensson, P.5    Lane, D.A.6
  • 53
    • 0034161456 scopus 로고    scopus 로고
    • Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease
    • Lane, D.A. & Grant, P.J. (2000) Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood, 95, 1517-1532.
    • (2000) Blood , vol.95 , pp. 1517-1532
    • Lane, D.A.1    Grant, P.J.2
  • 55
    • 0030898213 scopus 로고    scopus 로고
    • Characterization of the binding of different conformational forms of plasminogen activator inhibitor-1 to vitronectin. Implications for the regulation of pericellular proteolysis
    • Lawrence, D.A., Palaniappan, S., Stefansson, S., Olson, S.T., Francis-Chmura, A.M., Shore, J.D. & Ginsburg, D. (1997) Characterization of the binding of different conformational forms of plasminogen activator inhibitor-1 to vitronectin. Implications for the regulation of pericellular proteolysis. Journal of Biological Chemistry, 272, 7676-7680.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 7676-7680
    • Lawrence, D.A.1    Palaniappan, S.2    Stefansson, S.3    Olson, S.T.4    Francis-Chmura, A.M.5    Shore, J.D.6    Ginsburg, D.7
  • 56
    • 0026597817 scopus 로고
    • Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis
    • Levi, M., Biemond, B.J., van Zonneveld, A.J., ten Cate, J.W. & Pannekoek, H. (1992) Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis. Circulation, 85, 305-312.
    • (1992) Circulation , vol.85 , pp. 305-312
    • Levi, M.1    Biemond, B.J.2    Van Zonneveld, A.J.3    Ten Cate, J.W.4    Pannekoek, H.5
  • 58
    • 0023181782 scopus 로고
    • Structure of the human plasminogen activator inhibitor 1 gene: Nonrandom distribution of introns
    • Loskutoff, D.J., Linders, M., Keijer, J., Veerman, H., van Heerikhuizen, H. & Pannekoek, H. (1987) Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns. Biochemistry, 26, 3763-3768.
    • (1987) Biochemistry , vol.26 , pp. 3763-3768
    • Loskutoff, D.J.1    Linders, M.2    Keijer, J.3    Veerman, H.4    Van Heerikhuizen, H.5    Pannekoek, H.6
  • 59
    • 0034043503 scopus 로고    scopus 로고
    • The fat mouse. A powerful genetic model to study hemostatic gene expression in obesity/NIDDM
    • Loskutoff, D.J., Fujisawa, K. & Samad, F. (2000) The fat mouse. A powerful genetic model to study hemostatic gene expression in obesity/NIDDM. Annals of the New York Acadamy of Sciences, 902, 272-282.
    • (2000) Annals of the New York Acadamy of Sciences , vol.902 , pp. 272-282
    • Loskutoff, D.J.1    Fujisawa, K.2    Samad, F.3
  • 63
    • 0028786263 scopus 로고
    • Structure of PAI-1 and its function in fibrinolysis: An update
    • van Meijer, M. & Pannekoek, H. (1995) Structure of PAI-1 and its function in fibrinolysis: an update. Fibrinolysis, 9, 263-276.
    • (1995) Fibrinolysis , vol.9 , pp. 263-276
    • Van Meijer, M.1    Pannekoek, H.2
  • 64
    • 0029986456 scopus 로고    scopus 로고
    • Selective screening of a large phage display library of plasminogen activator inhibitor 1 mutants to localize interaction sites with either thrombin or the variable region 1 of tissue-type plasminogen activator
    • van Meijer, M., Roelofs, Y., Neels, J., Horrevoets, A.J., van Zonneveld, A.J. & Pannekoek, H. (1996) Selective screening of a large phage display library of plasminogen activator inhibitor 1 mutants to localize interaction sites with either thrombin or the variable region 1 of tissue-type plasminogen activator. Journal of Biological Chemistry, 271, 7423-7428.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 7423-7428
    • Van Meijer, M.1    Roelofs, Y.2    Neels, J.3    Horrevoets, A.J.4    Van Zonneveld, A.J.5    Pannekoek, H.6
  • 65
    • 0030942190 scopus 로고    scopus 로고
    • The composition of complexes between plasminogen activator inhibitor 1, vitronectin and either thrombin or tissue-type plasminogen activator
    • van Meijer, M., Stoop, A., Smilde, A., Preissner, K.T., van Zonneveld, A.J. & Pannekoek, H. (1997a) The composition of complexes between plasminogen activator inhibitor 1, vitronectin and either thrombin or tissue-type plasminogen activator. Thrombosis and Haemostasis, 77, 516-521.
    • (1997) Thrombosis and Haemostasis , vol.77 , pp. 516-521
    • Van Meijer, M.1    Stoop, A.2    Smilde, A.3    Preissner, K.T.4    Van Zonneveld, A.J.5    Pannekoek, H.6
  • 66
    • 0030954682 scopus 로고    scopus 로고
    • The suicide substrate reaction between plasminogen activator inhibitor 1 and thrombin is regulated by the cofactors vitronectin and heparin
    • van Meijer, M., Smilde, A., Tans, G., Nesheim, M.E., Pannekoek, H. & Horrevoets, A.J. (1997b) The suicide substrate reaction between plasminogen activator inhibitor 1 and thrombin is regulated by the cofactors vitronectin and heparin. Blood, 90, 1874-1882.
    • (1997) Blood , vol.90 , pp. 1874-1882
    • Van Meijer, M.1    Smilde, A.2    Tans, G.3    Nesheim, M.E.4    Pannekoek, H.5    Horrevoets, A.J.6
  • 67
    • 0029855166 scopus 로고    scopus 로고
    • Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis
    • Mesters, R.M., Florke, N., Ostermann, H. & Kienast, J. (1996) Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis. Thrombosis and Haemostasis, 75, 902-907.
    • (1996) Thrombosis and Haemostasis , vol.75 , pp. 902-907
    • Mesters, R.M.1    Florke, N.2    Ostermann, H.3    Kienast, J.4
  • 70
    • 0021687079 scopus 로고
    • Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells
    • van Mourik, J.A., Lawrence, D.A. & Loskutoff, D.J. (1984) Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells. Journal of Biological Chemistry, 259, 14914-14921.
    • (1984) Journal of Biological Chemistry , vol.259 , pp. 14914-14921
    • Van Mourik, J.A.1    Lawrence, D.A.2    Loskutoff, D.J.3
  • 71
    • 0027272044 scopus 로고
    • Kinetics of inactivation of alpha-thrombin by plasminogen activator inhibitor-1. Comparison of the effects of native and urea-treated forms of vitronectin
    • Naski, M.C., Lawrence, D.A., Mosher, D.F., Podor, T.J. & Ginsburg, D. (1993) Kinetics of inactivation of alpha-thrombin by plasminogen activator inhibitor-1. Comparison of the effects of native and urea-treated forms of vitronectin. Journal of Biological Chemistry, 268, 12367-71232.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 12367-71232
    • Naski, M.C.1    Lawrence, D.A.2    Mosher, D.F.3    Podor, T.J.4    Ginsburg, D.5
  • 72
    • 0021050803 scopus 로고
    • A simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombin
    • Nesheim, M.E. (1983) A simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombin. Journal of Biological Chemistry, 258, 1 4708-1 4717.
    • (1983) Journal of Biological Chemistry , vol.258 , pp. 14708-14717
    • Nesheim, M.E.1
  • 73
    • 0037962014 scopus 로고    scopus 로고
    • Independence of growth factor induced plasminogen activator inhibitor type-1 (PAI-1) expression from the 4G/5G polymorphism of the PAI-1 gene
    • Nordt, T.K., Eschenfelder, E., Peter, K., Sobel, B.E. & Bode, C. (2003) Independence of growth factor induced plasminogen activator inhibitor type-1 (PAI-1) expression from the 4G/5G polymorphism of the PAI-1 gene. Thrombosis and Haemostasis, 90, 36-42.
    • (2003) Thrombosis and Haemostasis , vol.90 , pp. 36-42
    • Nordt, T.K.1    Eschenfelder, E.2    Peter, K.3    Sobel, B.E.4    Bode, C.5
  • 77
    • 0036077426 scopus 로고    scopus 로고
    • Endogenous vitronectin and plasminogen activator inhibitor-1 promote neointima formation in murine carotid arteries
    • Peng, L., Bhatia, N., Parker, A.C., Zhu, Y. & Fay, W.P. (2002) Endogenous vitronectin and plasminogen activator inhibitor-1 promote neointima formation in murine carotid arteries. Arteriosclerosis, Thrombosis and Vascular Biology, 22, 934-939.
    • (2002) Arteriosclerosis, Thrombosis and Vascular Biology , vol.22 , pp. 934-939
    • Peng, L.1    Bhatia, N.2    Parker, A.C.3    Zhu, Y.4    Fay, W.P.5
  • 82
    • 0033517789 scopus 로고    scopus 로고
    • Role of exosites 1 and 2 in thrombin reaction with plasminogen activator inhibitor-1 in the absence and presence of cofactors
    • Rezaie, A.R. (1999) Role of exosites 1 and 2 in thrombin reaction with plasminogen activator inhibitor-1 in the absence and presence of cofactors. Biochemistry, 38, 1 4592-1 4599.
    • (1999) Biochemistry , vol.38 , pp. 14592-14599
    • Rezaie, A.R.1
  • 83
    • 0035844272 scopus 로고    scopus 로고
    • Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C
    • Rezaie, A.R. (2001) Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C. Journal of Biological Chemistry, 276, 1 5567-1 5570.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 15567-15570
    • Rezaie, A.R.1
  • 84
    • 0028845757 scopus 로고
    • Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex
    • Rezaie, A.R., Cooper, S.T., Church, F.C. & Esmon, C.T. (1995) Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex. Journal of Biological Chemistry, 270, 2 5336-2 5339.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 25336-25339
    • Rezaie, A.R.1    Cooper, S.T.2    Church, F.C.3    Esmon, C.T.4
  • 85
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald, M., Petrovan, R.J., Donner, A., Mueller, B.M. & Ruf, W. (2002) Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science, 296, 1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 87
    • 0030942189 scopus 로고    scopus 로고
    • Thrombi formed in a Chandler loop mimic human arterial thrombi in structure and RAI-1 content and distribution
    • Robbie, L.A., Young, S.P., Bennett, B. & Booth, N.A. (1997) Thrombi formed in a Chandler loop mimic human arterial thrombi in structure and RAI-1 content and distribution. Thrombosis and Haemostasis, 77, 510-515.
    • (1997) Thrombosis and Haemostasis , vol.77 , pp. 510-515
    • Robbie, L.A.1    Young, S.P.2    Bennett, B.3    Booth, N.A.4
  • 90
    • 0034252457 scopus 로고    scopus 로고
    • Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes
    • Samad, F., Pandey, M., Bell, P.A. & Loskutoff, D.J. (2000) Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes. Molecular Medicine, 6, 680-692.
    • (2000) Molecular Medicine , vol.6 , pp. 680-692
    • Samad, F.1    Pandey, M.2    Bell, P.A.3    Loskutoff, D.J.4
  • 91
    • 0035432902 scopus 로고    scopus 로고
    • Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice
    • Schäfer, K., Fujisawa, K., Konstantinides, S. & Loskutoff, D.J. (2001) Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice. FASEB Journal, 15, 1840-1842.
    • (2001) FASEB Journal , vol.15 , pp. 1840-1842
    • Schäfer, K.1    Fujisawa, K.2    Konstantinides, S.3    Loskutoff, D.J.4
  • 94
    • 0028918245 scopus 로고
    • Identification of tissue-type plasminogenactivator-specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity
    • Sherman, P.M., Lawrence, D.A., Verhamme, I.M., Paielli, D., Shore, J.D. & Ginsburg, D. (1995) Identification of tissue-type plasminogenactivator- specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity. Journal of Biological Chemistry, 270, 9301-9306.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 9301-9306
    • Sherman, P.M.1    Lawrence, D.A.2    Verhamme, I.M.3    Paielli, D.4    Shore, J.D.5    Ginsburg, D.6
  • 95
    • 0342545947 scopus 로고    scopus 로고
    • Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1
    • Sjoland, H., Eitzman, D.T., Gordon, D., Westrick, R., Nabel, E.G. & Ginsburg, D. (2000) Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arteriosclerosis, Thrombosis and Vascular Biology, 20, 846-852.
    • (2000) Arteriosclerosis, Thrombosis and Vascular Biology , vol.20 , pp. 846-852
    • Sjoland, H.1    Eitzman, D.T.2    Gordon, D.3    Westrick, R.4    Nabel, E.G.5    Ginsburg, D.6
  • 97
    • 0029745109 scopus 로고    scopus 로고
    • The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin
    • Stefansson, S. & Lawrence, D.A. (1996) The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin. Nature, 383, 441-443.
    • (1996) Nature , vol.383 , pp. 441-443
    • Stefansson, S.1    Lawrence, D.A.2
  • 98
    • 0029873479 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2
    • Stefansson, S., Lawrence, D.A. & Argraves, W.S. (1996) Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. Journal of Biological Chemistry, 271, 8215-8220.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 8215-8220
    • Stefansson, S.1    Lawrence, D.A.2    Argraves, W.S.3
  • 99
    • 0032513248 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein
    • Stefansson, S., Muhammad, S., Cheng, X.F., Battey, F.D., Strickland, D.K. & Lawrence, D.A. (1998) Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein. Journal of Biological Chemistry, 273, 6358-6366.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 6358-6366
    • Stefansson, S.1    Muhammad, S.2    Cheng, X.F.3    Battey, F.D.4    Strickland, D.K.5    Lawrence, D.A.6
  • 101
    • 0034074308 scopus 로고    scopus 로고
    • Colocalization of thrombin, PAI-1, and vitronectin in the atherosclerotic vessel wall: A potential regulatory mechanism of thrombin activity by PAI-1/ vitronectin complexes
    • Stoop, A.A., Lupu, F. & Pannekoek, H. (2000) Colocalization of thrombin, PAI-1, and vitronectin in the atherosclerotic vessel wall: a potential regulatory mechanism of thrombin activity by PAI-1/ vitronectin complexes. Arteriosclerosis, Thrombosis and Vascular Biology, 20, 1143-1149.
    • (2000) Arteriosclerosis, Thrombosis and Vascular Biology , vol.20 , pp. 1143-1149
    • Stoop, A.A.1    Lupu, F.2    Pannekoek, H.3
  • 102
    • 0035951303 scopus 로고    scopus 로고
    • Different structural requirements for plasminogen activator inhibitor 1 (PAI-1) during latency transition and proteinase inhibition as evidenced by phage-displayed hypermutated PAI-1 libraries
    • Stoop, A.A., Eldering, E., Dafforn, T.R., Read, R.J. & Pannekoek, H. (2001) Different structural requirements for plasminogen activator inhibitor 1 (PAI-1) during latency transition and proteinase inhibition as evidenced by phage-displayed hypermutated PAI-1 libraries. Journal of Molecular Biology, 305, 773-783.
    • (2001) Journal of Molecular Biology , vol.305 , pp. 773-783
    • Stoop, A.A.1    Eldering, E.2    Dafforn, T.R.3    Read, R.J.4    Pannekoek, H.5
  • 103
    • 0028630732 scopus 로고
    • The role of the finger domain of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in initiation and progression of thrombolysis
    • Stringer, H.A., van Swieten, P., Horrevoets, A.J., Smilde, A. & Pannekoek, H. (1994a) The role of the finger domain of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in initiation and progression of thrombolysis. Thrombosis and Haemostasis, 72, 900-905.
    • (1994) Thrombosis and Haemostasis , vol.72 , pp. 900-905
    • Stringer, H.A.1    Van Swieten, P.2    Horrevoets, A.J.3    Smilde, A.4    Pannekoek, H.5
  • 104
    • 0027933421 scopus 로고
    • Plasminogen activator inhibitor-1 released from activated platelets plays a key role in thrombolysis resistance. Studies with thrombi generated in the Chandler loop
    • Stringer, H.A., van Swieten, P., Heijnen, H.F., Sixma, J.J. & Pannekoek, H. (1994b) Plasminogen activator inhibitor-1 released from activated platelets plays a key role in thrombolysis resistance. Studies with thrombi generated in the Chandler loop. Arteriosclerosis and Thrombosis, 14, 1452-1458.
    • (1994) Arteriosclerosis and Thrombosis , vol.14 , pp. 1452-1458
    • Stringer, H.A.1    Van Swieten, P.2    Heijnen, H.F.3    Sixma, J.J.4    Pannekoek, H.5
  • 105
    • 0030915443 scopus 로고    scopus 로고
    • Variants of tissue-type plasminogen activator that display extraordinary resistance to inhibition by the serpin plasminogen activator inhibitor type 1
    • Tachias, K. & Madison, E.L. (1997) Variants of tissue-type plasminogen activator that display extraordinary resistance to inhibition by the serpin plasminogen activator inhibitor type 1. Journal of Biological Chemistry, 272, 14580-14585.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 14580-14585
    • Tachias, K.1    Madison, E.L.2
  • 109
    • 0033871724 scopus 로고    scopus 로고
    • Influence of the -675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden
    • Visanji, J.M., Seargent, J., Tahri, D., Croft, S.A., Makris, M., Preston, F.E., Peake, I.R. & Daly, M.E. (2000) Influence of the -675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden. British Journal of Haematology, 110, 135-138.
    • (2000) British Journal of Haematology , vol.110 , pp. 135-138
    • Visanji, J.M.1    Seargent, J.2    Tahri, D.3    Croft, S.A.4    Makris, M.5    Preston, F.E.6    Peake, I.R.7    Daly, M.E.8
  • 111
    • 0024311846 scopus 로고
    • Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA
    • Wagner, O.F., de Vries, C., Hohmann, C., Veerman, H. & Pannekoek, H. (1989) Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA. Journal of Clinical Investigation, 84, 647-655.
    • (1989) Journal of Clinical Investigation , vol.84 , pp. 647-655
    • Wagner, O.F.1    De Vries, C.2    Hohmann, C.3    Veerman, H.4    Pannekoek, H.5
  • 113
    • 0034508887 scopus 로고    scopus 로고
    • Thrombomodulin: A linker of coagulation and fibrinolysis and predictor of risk of arterial thrombosis
    • Wu, K.K. & Matijevic-Aleksic, N. (2000) Thrombomodulin: a linker of coagulation and fibrinolysis and predictor of risk of arterial thrombosis. Annals of Medicine, 32, (Suppl. 1), 73-77.
    • (2000) Annals of Medicine , vol.32 , Issue.1 SUPPL. , pp. 73-77
    • Wu, K.K.1    Matijevic-Aleksic, N.2
  • 114
    • 0036841486 scopus 로고    scopus 로고
    • Aging accelerates endotoxin-induced thrombosis: Increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging
    • Yamamoto, K., Shimokawa, T., Yi, H., Isobe, K., Kojima, T., Loskutoff, D.J. & Saito, H. (2002a) Aging accelerates endotoxin-induced thrombosis: increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging. American Journal of Pathology, 161, 1805-1814.
    • (2002) American Journal of Pathology , vol.161 , pp. 1805-1814
    • Yamamoto, K.1    Shimokawa, T.2    Yi, H.3    Isobe, K.4    Kojima, T.5    Loskutoff, D.J.6    Saito, H.7
  • 116
    • 0141509969 scopus 로고    scopus 로고
    • Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin
    • Yang, L., Manithody, C., Walston, T.D., Cooper, S.T. & Rezaie, A.R. (2003) Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin. Journal of Biological Chemistry, 278, 37465-37470.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 37465-37470
    • Yang, L.1    Manithody, C.2    Walston, T.D.3    Cooper, S.T.4    Rezaie, A.R.5
  • 118
    • 0033564748 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance
    • Zhu, Y., Carmeliet, P. & Fay, W.P. (1999) Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance. Circulation, 99, 3050-3055.
    • (1999) Circulation , vol.99 , pp. 3050-3055
    • Zhu, Y.1    Carmeliet, P.2    Fay, W.P.3
  • 119
    • 0035954247 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type 1 enhances neointima formation after oxidative vascular injury in atherosclerosis-prone mice
    • Zhu, Y., Farrehi, P.M. & Fay, W.P. (2001) Plasminogen activator inhibitor type 1 enhances neointima formation after oxidative vascular injury in atherosclerosis-prone mice. Circulation, 103, 3105-3110.
    • (2001) Circulation , vol.103 , pp. 3105-3110
    • Zhu, Y.1    Farrehi, P.M.2    Fay, W.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.