Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism

Immunogenetics

Volumn 61, Issue 10, 2009, Pages 657-662

  Pappachan, John V ^a   Coulson, Tim G ^a,b   Child, Nicholas J A ^b,c   Markham, David J ^b,c   Nour, Sarah M ^b,c   Pulletz, Mark C K ^a   Rose Zerilli, Matthew J ^c   De Courcey Golder, Kim ^a   Barton, Sheila J ^b   Yang, Ian A ^b,c   Holloway, John W ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Macrophage migration inhibitory factor; Polymorphism (genetics); Severe sepsis; Systemic inflammatory response syndrome; Toll like receptor 4; Tumour necrosis factor alpha

Indexed keywords

DNA; LYMPHOTOXIN; MACROPHAGE MIGRATION INHIBITION FACTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA DETERMINATION; DNA POLYMORPHISM; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; INFLAMMATION; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MORTALITY; OUTCOME ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; SEPSIS; SURVIVAL RATE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; UNITED KINGDOM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; ENGLAND; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HOSPITAL MORTALITY; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INTENSIVE CARE UNITS; INTRAMOLECULAR OXIDOREDUCTASES; LYMPHOTOXIN-ALPHA; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 70350536773     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-009-0395-6     Document Type: Article

References (38)

1. NC Arbour E Lorenz BC Schutte J Zabner JN Kline M Jones K Frees JL Watt DA Schwartz 2000 TLR4 mutations are associated with endotoxin hyporesponsiveness in humans Nat Genet 25 187 191 10835634 10.1038/76048 1:CAS:528: DC%2BD3cXjvFOgtL8%3D (Pubitemid 30394990)
2. JP Bayley TH Ottenhoff CL Verweij 2004 Is there a future for TNF promoter polymorphisms? Genes Immun 5 315 329 14973548 10.1038/sj.gene.6364055 1:CAS:528:DC%2BD2cXlvVals7o%3D (Pubitemid 39139757)
3. RC Bone RA Balk FB Cerra RP Dellinger AM Fein WA Knaus RM Schein WJ Sibbald 1992 Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Chest 101 1644 1655 1303622 10.1378/chest.101.6.1644 1:STN:280:DyaK383ovFeiuw%3D%3D
4. H Bosshart M Heinzelmann 2007 Targeting bacterial endotoxin: two sides of a coin Ann NY Acad Sci 1096 1 17 17405910 10.1196/annals.1397.064 1:CAS:528:DC%2BD2sXkslequ7Y%3D (Pubitemid 47092492)
5. C Brun-Buisson 2000 The epidemiology of the systemic inflammatory response Intensive Care Med 26 Suppl 1 S64 S74 10786961 10.1007/s001340051121
6. NJ Child IA Yang MC Pulletz K de Courcy-Golder AL Andrews VJ Pappachan JW Holloway 2003 Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome Biochem Soc Trans 31 652 653 12773175 10.1042/BST0310652 1:CAS:528:DC%2BD3sXktF2iu70%3D (Pubitemid 36750749)
7. F De Benedetti C Meazza M Vivarelli F Rossi A Pistorio R Lamb M Lunt W Thomson A Ravelli R Donn A Martini 2003 Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis Arthritis Rheum 48 1398 1407 12746913 10.1002/art.10882 1:CAS:528:DC%2BD3sXkt1akt74%3D (Pubitemid 36554539)
8. JB de Kok ET Wiegerinck BA Giesendorf DW Swinkels 2002 Rapid genotyping of single nucleotide polymorphisms using novel minor groove binding DNA oligonucleotides (MGB probes) Hum Mutat 19 554 559 11968088 10.1002/humu.10076 (Pubitemid 34461629)
9. WD Docke F Randow U Syrbe D Krausch K Asadullah P Reinke HD Volk W Kox 1997 Monocyte deactivation in septic patients: restoration by IFN-gamma treatment Nat Med 3 678 681 9176497 10.1038/nm0697-678 1:CAS:528: DyaK2sXjsFOhsbs%3D (Pubitemid 27264980)
10. R Donn Z Alourfi F De Benedetti C Meazza E Zeggini M Lunt A Stevens E Shelley R Lamb WE Ollier W Thomson D Ray 2002 Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis Arthritis Rheum 46 2402 2409 12355488 10.1002/art.10492 1:CAS:528:DC%2BD38XosVGjuro%3D
11. RP Donn E Shelley WE Ollier W Thomson 2001 A novel 5′-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis Arthritis Rheum 44 1782 1785 11508429 10.1002/1529-0131(200108)44:8<1782::AID-ART314>3.0.CO;2-# 1:CAS:528:DC%2BD38XpvFY%3D (Pubitemid 32758224)
12. WD Dupont WD Plummer Jr 1990 Power and sample size calculations. A review and computer program Control Clin Trials 11 116 128 2161310 10.1016/0197-2456(90)90005-M 1:STN:280:DyaK3c3mvFSjsw%3D%3D (Pubitemid 20136185)
13. W Ertel JP Kremer J Kenney U Steckholzer D Jarrar O Trentz FW Schildberg 1995 Downregulation of proinflammatory cytokine release in whole blood from septic patients Blood 85 1341 1347 7858264 1:CAS:528:DyaK2MXjvFemsr8%3D
14. CW Fong AH Siddiqui DF Mark 1995 Characterization of protein complexes formed on the repressor elements of the human tumor necrosis factor alpha gene J Interferon Cytokine Res 15 887 895 8564711 10.1089/jir.1995.15.887 1:CAS:528:DyaK2MXovVehsbs%3D
15. AC Gordon AL Lagan E Aganna L Cheung CJ Peters MF McDermott JL Millo KI Welsh P Holloway GA Hitman RD Piper CS Garrard CJ Hinds 2004 TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study Genes Immun 5 631 640 15526005 10.1038/sj.gene.6364136 1:CAS:528: DC%2BD2cXhtVars7fF (Pubitemid 40045301)
16. DA Harrison CA Welch JM Eddleston 2006 The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database Crit Care 10 R42 16542492 10.1186/cc4854 (Pubitemid 47086800)
17. CL Holmes JA Russell KR Walley 2003 Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy Chest 124 1103 1115 12970043 10.1378/chest.124.3.1103 1:CAS:528:DC%2BD3sXnvF2ksb8%3D (Pubitemid 37123334)
18. RS Hotchkiss PE Swanson BD Freeman KW Tinsley JP Cobb GM Matuschak TG Buchman IE Karl 1999 Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction Crit Care Med 27 1230 1251 10446814 10.1097/00003246-199907000-00002 1:STN:280:DyaK1MznsVCrsg%3D%3D (Pubitemid 29379358)
19. W Kaluza E Reuss S Grossmann R Hug RE Schopf PR Galle E Maerker-Hermann T Hoehler 2000 Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism J Invest Dermatol 114 1180 1183 10844563 10.1046/j.1523-1747.2000. 00001.x 1:CAS:528:DC%2BD3cXktlyqt70%3D (Pubitemid 30415236)
20. WA Knaus EA Draper DP Wagner JE Zimmerman 1985 APACHE II: a severity of disease classification system Crit Care Med 13 818 829 3928249 10.1097/00003246-198510000-00009 1:STN:280:DyaL2M3otlyqtQ%3D%3D
21. JC Knight BJ Keating DP Kwiatkowski 2004 Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1 Nat Genet 36 394 399 15052269 10.1038/ng1331 1:CAS:528:DC%2BD2cXis1aht74%3D (Pubitemid 38437263)
22. SK Leaver SJ Finney A Burke-Gaffney TW Evans 2007 Sepsis since the discovery of Toll-like receptors: disease concepts and therapeutic opportunities Crit Care Med 35 1404 1410 17414083 10.1097/01.CCM.0000261883.16943.4B 1:CAS:528:DC%2BD2sXktlOhsb0%3D (Pubitemid 46642673)
23. JA Lederer ML Rodrick JA Mannick 1999 The effects of injury on the adaptive immune response Shock 11 153 159 10188766 10.1097/00024382-199903000- 00001 1:STN:280:DyaK1M3gt1Knuw%3D%3D
24. MM Levy MP Fink JC Marshall E Abraham D Angus D Cook J Cohen SM Opal JL Vincent G Ramsay 2003 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Intensive Care Med 29 530 538 12664219 (Pubitemid 36523666)
25. KJ Livak 1999 Allelic discrimination using fluorogenic probes and the 5′ nuclease assay Genet Anal 14 143 149 10084106 1:CAS:528: DyaK1MXhvVylsbo%3D
26. RM Locksley N Killeen MJ Lenardo 2001 The TNF and TNF receptor superfamilies: integrating mammalian biology Cell 104 487 501 11239407 10.1016/S0092-8674(01)00237-9 1:CAS:528:DC%2BD3MXis1KksrY%3D (Pubitemid 32201945)
27. SA Miller DD Dykes HF Polesky 1988 A simple salting out procedure for extracting DNA from human nucleated cells Nucleic Acids Res 16 1215 3344216 10.1093/nar/16.3.1215 1:CAS:528:DyaL1cXhsVKlsrs%3D
28. ST O'Sullivan JA Lederer AF Horgan DH Chin JA Mannick ML Rodrick 1995 Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection Ann Surg 222 482 490 7574928 discussion 490-2
29. MF Osuchowski K Welch J Siddiqui DG Remick 2006 Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality J Immunol 177 1967 1974 16849510 1:CAS:528:DC%2BD28XmvFClsL0%3D
30. P Rahman F Siannis C Butt V Farewell L Peddle F Pellett D Gladman 2006 TNFalpha polymorphisms and risk of psoriatic arthritis Ann Rheum Dis 65 919 923 16284098 10.1136/ard.2005.039164 1:CAS:528:DC%2BD28XntF2lsro%3D
31. MS Rangel-Frausto D Pittet M Costigan T Hwang CS Davis RP Wenzel 1995 The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study Jama 273 117 123 7799491 10.1001/jama.273.2.117 1:STN:280:DyaK2M%2FpslCntA%3D%3D
32. BM Reilly AT Evans JJ Schaider K Das JE Calvin LA Moran RR Roberts E Martinez 2002 Impact of a clinical decision rule on hospital triage of patients with suspected acute cardiac ischemia in the emergency department Jama 288 342 350 12117399 10.1001/jama.288.3.342
33. P Renner T Roger T Calandra 2005 Macrophage migration inhibitory factor: gene polymorphisms and susceptibility to inflammatory diseases Clin Infect Dis 41 Suppl 7 S513 S519 16237655 10.1086/432009 1:CAS:528:DC%2BD2MXht1emu7fE (Pubitemid 41598313)
34. T Roger J David MP Glauser T Calandra 2001 MIF regulates innate immune responses through modulation of Toll-like receptor 4 Nature 414 920 924 11780066 10.1038/414920a 1:CAS:528:DC%2BD38XhtlOlsw%3D%3D (Pubitemid 34024744)
35. AM Sutherland JA Russell 2005 Issues with polymorphism analysis in sepsis Clin Infect Dis 41 Suppl 7 S396 S402 16237637 10.1086/431989 1:CAS:528:DC%2BD2MXht1emtLbJ (Pubitemid 41598295)
36. JL Vincent R Moreno J Takala S Willatts A De Mendonca H Bruining CK Reinhart PM Suter LG Thijs 1996 The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis- Related Problems of the European Society of Intensive Care Medicine Intensive Care Med 22 707 710 8844239 10.1007/BF01709751 1:STN:280:DyaK2s%2FgtFantQ%3D%3D
37. CF Ware 2005 Network communications: lymphotoxins, LIGHT, and TNF Annu Rev Immunol 23 787 819 15771586 10.1146/annurev.immunol.23.021704.115719 1:CAS:528:DC%2BD2MXktFOju7o%3D (Pubitemid 40563185)
38. RG Westendorp JA Langermans TW Huizinga AH Elouali CL Verweij DI Boomsma JP Vandenbroucke 1997 Genetic influence on cytokine production and fatal meningococcal disease Lancet 349 170 173 9111542 10.1016/S0140-6736(96)06413-6 1:STN:280:DyaK2s3msFKgtA%3D%3D (Pubitemid 27039197)