Dendritic cells at the interface of innate and acquired immunity: The role for epigenetic changes

Journal of Leukocyte Biology

Volumn 83, Issue 3, 2008, Pages 439-446

  Wen, Haitao ^a   Schaller, Matthew A ^a   Dou, Yali ^a   Hogaboam, Cory M ^a   Kunkel, Steven L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cell memory; Cytokine; Host defense; Long term; Sepsis; Toll like receptors

Indexed keywords

HISTONE;

CELL FUNCTION; CONFERENCE PAPER; DENDRITIC CELL; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPIGENETICS; EUKARYOTE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REPERFUSION INJURY; SEPSIS; UBIQUITINATION; ACTIVE IMMUNIZATION; GENE EXPRESSION REGULATION; IMMUNOLOGY; INFECTION; INFLAMMATION; NEOPLASM; REVIEW;

DENDRITIC CELLS; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, ACTIVE; IMMUNITY, NATURAL; INFECTION; INFLAMMATION; NEOPLASMS; SEPSIS;

EID: 43349088279     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0607357     Document Type: Conference Paper

References (87)

1. Steinman, R. M., Cohn, Z. A. (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137, 1142-1162.
2. Steinman, R. M., Cohn, Z. A. (1974) Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J. Exp. Med. 139, 380-397.
3. Steinman, R. M., Adams, J. C., Cohn, Z. A. (1975) Identification of a novel cell type in peripheral lymphoid organs of mice. IV. Identification and distribution in mouse spleen. J. Exp. Med. 141, 804-820.
4. Banchereau, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
5. Trombetta, E. S., Mellman, I. (2005) Cell biology of antigen processing in vitro and in vivo. Annu. Rev. Immunol. 23, 975-1028.
6. Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B., Palucka, K. (2000) Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767-811.
7. Grosjean, I., Caux, C., Bella, C., Berger, I., Wild, F., Banchereau, J., Kaiserlian, D. (1997) Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells. J. Exp. Med. 186, 801-812.
8. Wilson, N. S., Behrens, G. M., Lundie, R. J., Smith, C. M., Waithman, J., Young, L., Forehan, S. P., Mount, A., Steptoe, R. J., Shortman, K. D., de Koning-Ward, T. F., Belz, G. T., Carbone, F. R., Crabb, B. S., Heath, W. R., Volladangos, J. A. (2006) Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat. Immunol. 7, 165-172.
9. Chaux, P., Moutet, M., Faivre, J., Martin, F., Martin, M. (1996) Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 costimulatory molecules of the T-cell activation. Lab. Invest. 74, 975-983.
10. Ghiringhelli, F., Puig, P. E., Roux, S., Parcellier, A., Schmitt, E., Solary, E., Kroemer, G., Martin, F., Chauffert, B., Zitvogel, L. (2005) Tumor cells convert immature myeloid dendritic cells into TGF-β-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J. Exp. Med. 202, 919-929.
11. Aspord, C., Pedroza-Gonzalez, A., Gallegos, M., Tindle, S., Burton, E. C., Su, D., Marches, F., Banchereau, J., Palucka, A. K. (2007) Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development. J. Exp. Med. 204, 1037-1047.
12. Reddy, R. C., Chen, G. H., Tekchandani, P. K., Standiford, T. J. (2001) Sepsis-induced immunosuppression: from bad to worse. Immunol. Res. 24, 273-287.
13. Angele, M. K., Faist, E. (2002) Clinical review: immunodepression in the surgical patient and increased susceptibility to infection. Crit. Care 6, 298-305.
14. Maier, S., Traeger, T., Entleutner, M., Westerholt, A., Kleist, B., Huser, N., Holzmann, B., Stier, A., Pfeffer, K., Heidecke, C. D. (2004) Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock 21, 505-511.
15. Hubbard, W. J., Choudhry, M., Schwacha, M. G., Kerby, J. D., Rue III, L. W., Bland, K. I., Chaudry, I. H. (2005) Cecal ligation and puncture. Shock 24 (Suppl. 1), 52-57.
16. Walley, K. R., Lukacs, N. W., Standiford, T. J., Strieter, R. M., Kunkel, S. L. (1996) Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect. Immun. 64, 4733-4738.
17. Benjamim, C. F., Hogaboam, C. M., Lukacs, N. W., Kunkel, S. L. (2003) Septic mice are susceptible to pulmonary aspergillosis. Am. J. Pathol. 163, 2605-2617.
18. Benjamim, C. F., Lundy, S. K., Lukacs, N. W., Hogaboam, C. M., Kunkel, S. L. (2005) Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood 105, 3588-3595.
19. Wen, H., Hogaboam, C. M., Gauldie, J., Kunkel, S. L. (2006) Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am. J. Pathol. 168, 1940-1950.
20. Hotchkiss, R. S., Nicholson, D. W. (2006) Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 6, 813-822.
21. Flohe, S. B., Agrawal, H., Schmitz, D., Gertz, M., Flohe, S., Schade, F. U. (2006) Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. J. Leukoc. Biol. 79, 473-481.
22. Reik, W. (2007) Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447, 425-432.
23. Jones, P. A., Baylin, S. B. (2007) The epigenomics of cancer. Cell 128, 683-692.
24. Ballestar, E., Esteller, M., Richardson, B. C. (2006) The epigenetic face of systemic lupus erythematosus. J. Immunol. 176, 7143-7147.
25. Kouzarides, T. (2007) Chromatin modifications and their function. Cell 128, 693-705.
26. Martin, C., Zhang, Y. (2007) Mechanisms of epigenetic inheritance. Curr. Opin. Cell Biol. 19, 266-272.
27. Hotchkiss, R. S., Tinsley, K. W., Swanson, P. E., Grayson, M. H., Osborne, D. F., Wagner, T. H., Cobb, J. P., Coopersmith, C., Karl, I. E. (2002) Depletion of dendritic cells, but not macrophages, in patients with sepsis. J. Immunol. 168, 2493-2500.
28. Hiramatsu, M., Hotchkiss, R. S., Karl, I. E., Buchman, T. G. (1997) Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway. Shock 7, 247-253.
29. Hotchkiss, R. S., Swanson, P. E., Cobb, J. P., Jacobson, A., Buchman, T. G., Karl, I. E. (1997) Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit. Care Med. 25, 1298-1307.
30. Efron, P. A., Martins, A., Minnich, D., Tinsley, K., Ungaro, R., Bahjat, F. R., Hotchkiss, R., Clare-Salzler, M., Moldawer, L. L. (2004) Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J. Immunol. 173, 3035-3043.
31. Ding, Y., Chung, C. S., Newton, S., Chen, Y., Carlton, S., Albina, J. E., Ayala, A. (2004) Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice. Shock 22, 137-144.
32. Serbina, N. V., Pamer, E. G. (2006) Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7, 311-317.
33. Walkley, C. R., Olsen, G. H., Dworkin, S., Fabb, S. A., Swann, J., McArthur, G. A., Westmoreland, S. V., Chambon, P., Scadden, D. T., Purton, L. E. (2007) A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor γ deficiency. Cell 129, 1097-1110.
34. Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E., Orkin, S. H. (2007) Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129, 1081-1095.
35. Quartin, A. A., Schein, R. M., Kett, D. H., Peduzzi, P. N. (1997) Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA 277, 1058-1063.
36. Griffith, T. S., Yu, X., Herndon, J. M., Green, D. R., Ferguson, T. A. (1996) CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 5, 7-16.
37. Voll, R. E., Herrmann, M., Roth, E. A., Stach, C., Kalden, J. R., Girkontaite, I. (1997) Immunosuppressive effects of apoptotic cells. Nature 390, 350-351.
38. Albert, M. L. (2004) Death-defying immunity: do apoptotic cells influence antigen processing and presentation? Nat. Rev. Immunol. 4, 223-231.
39. Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., Henson, P. M. (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J. Clin. Invest. 101, 890-898.
40. Kim, S., Elkon, K. B., Ma, X. (2004) Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Immunity 21, 643-653.
41. Benjamim, C. F., Hogaboam, C. M., Kunkel, S. L. (2004) The chronic consequences of severe sepsis. J. Leukoc. Biol. 75, 408-412.
42. Abraham, E., Nick, J. A., Azam, T., Kim, S. H., Mira, J. P., Svetkauskaite, D., He, Q., Zamora, M., Murphy, J., Park, J. S., Overdier, K., Dinarello, C. A. (2006) Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans. J. Immunol. 176, 7753-7760.
43. Ramirez-Carrozzi, V. R., Nazarian, A. A., Li, C. C., Gore, S. L., Sridharan, R., Imbalzano, A. N., Smale, S. T. (2006) Selective and antagonistic functions of SWI/SNF and Mi-2β nucleosome remodeling complexes during an inflammatory response. Genes Dev. 20, 282-296.
44. Garcia-Ramallo, E., Marques, T., Prats, N., Beleta, J., Kunkel, S. L., Godessart, N. (2002) Resident cell chemokine expression serves as the major mechanism for leukocyte recruitment during local inflammation. J. Immunol. 169, 6467-6473.
45. Cohen, J. (2002) The immunopathogenesis of sepsis. Nature 420, 885-891.
46. Venet, F., Tissot, S., Debard, A. L., Faudot, C., Crampe, C., Pachot, A., Ayala, A., Monneret, G. (2007) Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: correlation with severity and secondary septic shock. Crit. Care Med. 35, 1910-1917.
47. Perl, T. M., Dvorak, L., Hwang, T., Wenzel, R. P. (1995) Long-term survival and function after suspected gram-negative sepsis. JAMA 274, 338-345.
48. Martin, G. S., Mannino, D. M., Eaton, S., Moss, M. (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 348, 1546-1554.
49. Ertel, W., Kremer, J. P., Kenney, J., Steckholzer, U., Jarrar, D., Trentz, O., Schildberg, F. W. (1995) Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 85, 1341-1347.
50. Docke, W. D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K., Reinke, P., Volk, H. D., Kox, W. (1997) Monocyte deactivation in septic patients: restoration by IFN-γ treatment. Nat. Med. 3, 678-681.
51. Oberholzer, A., Oberholzer, C., Moldawer, L. L. (2001) Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16, 83-96.
52. Nagano, H., Tilney, N. L. (1997) Chronic allograft failure: the clinical problem. Am. J. Med. Sci. 313, 305-309.
53. Lemanske Jr., R. F. (2002) The childhood origins of asthma (COAST) study. Pediatr. Allergy Immunol. 13 (Suppl. 15), 38-43.
54. Openshaw, P. J., Dean, G. S., Culley, F. J. (2003) Links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approaches. Pediatr. Infect. Dis. J. 22, S58-S64.
55. Rodgers, G. L., Mortensen, J., Fisher, M. C., Lo, A., Cresswell, A., Long, S. S. (2000) Predictors of infectious complications after burn injuries in children. Pediatr. Infect. Dis. J. 19, 990-995.
56. Kobayashi, M., Takahashi, H., Sanford, A. P., Herndon, D. N., Pollard, R. B., Suzuki, F. (2002) An increase in the susceptibility of burned patients to infectious complications due to impaired production of macrophage inflammatory protein 1 α. J. Immunol. 169, 4460-4466.
57. Berger, S. L. (2007) The complex language of chromatin regulation during transcription. Nature 447, 407-412.
58. Feinberg, A. P. (2007) Phenotypic plasticity and the epigenetics of human disease. Nature 447, 433-440.
59. Kornberg, R. D., Lorch, Y. (1999) Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98, 285-294.
60. Olins, D. E., Olins, A. L. (2003) Chromatin history: our view from the bridge. Nat. Rev. Mol. Cell Biol. 4, 809-814.
61. Margueron, R., Trojer, P., Reinberg, D. (2005) The key to development: interpreting the histone code? Curr. Opin. Genet. Dev. 15, 163-176.
62. Zhang, K., Dent, S. Y. (2005) Histone modifying enzymes and cancer: going beyond histones. J. Cell. Biochem. 96, 1137-1148.
63. Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z. W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., Jenuwein, T. (2000) Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-599.
64. Martin, C., Zhang, Y. (2005) The diverse functions of histone lysine methylation. Nat. Rev. Mol. Cell Biol. 6, 838-849.
65. Tschiersch, B., Hofmann, A., Krauss, V., Dorn, R., Korge, G., Reuter, G. (1994) The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J. 13, 3822-3831.
66. Jones, R. S., Gelbart, W. M. (1993) The Drosophila Polycomb-group gene enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13, 6357-6366.
67. Stassen, M. J., Bailey, D., Nelson, S., Chinwalla, V., Harte, P. J. (1995) The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Mech. Dev. 52, 209-223.
68. Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C., Schreiber, S. L., Mellor, J., Kouzarides, T. (2002) Active genes are tri-methylated at K4 of histone H3. Nature 419, 407-411.
69. Milne, T. A., Briggs, S. D., Brock, H. W., Martin, M. E., Gibbs, D., Allis, C. D., Hess, J. L. (2002) MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol. Cell 10, 1107-1117.
70. Gu, Y., Nakamura, T., Alder, H., Prasad, R., Canaani, O., Cimino, G., Croce, C. M., Canaani, E. (1992) The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71, 701-708.
71. Wysocka, J., Swigut, T., Milne, T. A., Dou, Y., Zhang, X., Burlingame, A. L., Roeder, R. G., Brivanlou, A. H., Allis, C. D. (2005) WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell 121, 859-872.
72. Dou, Y., Milne, T. A., Ruthenburg, A. J., Lee, S., Lee, J. W., Verdine, G. L., Allis, C. D., Roeder, R. G. (2006) Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat. Struct. Mol. Biol. 13, 713-719.
73. Kouzarides, T. (2002) Histone methylation in transcriptional control. Curr. Opin. Genet. Dev. 12, 198-209.
74. Cao, R., Zhang, Y. (2004) The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14, 155-164.
75. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., Jenuwein, T. (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120.
76. Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., Kouzarides, T. (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124.
77. Ansel, K. M., Djuretic, I., Tanasa, B., Rao, A. (2006) Regulation of Th2 differentiation and IL4 locus accessibility. Annu. Rev. Immunol. 24, 607-656.
78. Murphy, K. M., Reiner, S. L. (2002) The lineage decisions of helper T cells. Nat. Rev. Immunol. 2, 933-944.
79. Mowen, K. A., Glimcher, L. H. (2004) Signaling pathways in Th2 development. Immunol. Rev. 202, 203-222.
80. Zhu, J., Min, B., Hu-Li, J., Watson, C. J., Grinberg, A., Wang, Q., Killeen, N., Urban Jr., J. F., Guo, L., Paul, W. E. (2004) Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat. Immunol. 5, 1157-1165.
81. Akimzhanov, A. M., Yang, X. O., Dong, C. (2007) Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J. Biol. Chem. 282, 5969-5972.
82. Foster, S. L., Hargreaves, D. C., Medzhitov, R. (2007) Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 447, 972-978.
83. Gantner, B. N., Singh, H. (2007) Immunology: short-term memory. Nature 447, 916-917.
84. Sica, A., Bronte, V. (2007) Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 117, 1155-1166.
85. Hotchkiss, R. S., Swanson, P. E., Freeman, B. D., Tinsley, K. W., Cobb, J. P., Matuschak, G. M., Buchman, T. G., Karl, I. E. (1999) Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit. Care Med. 27, 1230-1251.
86. Hsieh, C. S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., Murphy, K. M. (1993) Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547-549.
87. Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F., Lanzavecchia, A. (2005) Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6, 769-776.