Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis

Journal of Experimental Medicine

Volumn 189, Issue 2, 1999, Pages 341-346

  Bozza, Marcelo ^a,c   Satoskar, Abhay R ^a   Lin, Guosheng ^a   Lu, Bao ^b   Humbles, Alison A ^b   Gerard, Craig ^b   David, John R ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Gene deficient mice; Lipopolysaccharide; Migration inhibitory factor; Pseudomonas aeruginosa; Sepsis

Indexed keywords

GALACTOSAMINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MIGRATION INHIBITION FACTOR; NITRIC OXIDE; STAPHYLOCOCCUS ENTEROTOXIN B; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE DISRUPTION; IMMUNITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SEPSIS;

ANIMALS; ENTEROTOXINS; INTERFERON TYPE II; INTERLEUKINS; LIPOPOLYSACCHARIDES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MACROPHAGES; MICE; MICE, KNOCKOUT; NEUTROPHILS; NITRIC OXIDE; PSEUDOMONAS AERUGINOSA; SEPSIS; THIOGLYCOLATES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033579884     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.2.341     Document Type: Article

References (31)

1. David, J.R., M. Bozza, and C. Carini. 1996. Macrophage migration inhibitory factor. In Human Cytokines. Handbook for Basic and Clinical Research, Vol. 2. B.B. Aggarwal and J.U. Gutterman, editors. Blackwell Science, Cambridge, MA. 222-256.
2. Bucala, R. 1996. MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response. FASEB J. 10:1607-1613.
3. Bernhagen, J., T. Calandra, R.A. Mitchell, S.B. Martin, K.J. Tracey, W. Voelter, K.R. Manogue, A. Cerami, and R. Bucala. 1993. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia. Nature. 365:756-759. (See published erratum 378:419.)
4. Calandra, T., J. Bernhagen, C.N. Metz, L.A. Spiegel, M. Bacher, T. Donnelly, A. Cerami, and R. Bucala. 1995. MIF as a glucocorticoid-induced modulator of cytokine production. Nature. 377:68-71.
5. Mikulowska, A., C.N. Metz, R. Bucala, and R. Holmdahl. 1997. Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice. J. Immunol. 158:5514-5517.
6. Lan, H.Y., M. Bacher, N. Yang, W. Mu, D.J. Nikolic-Paterson, C. Metz, A. Meinhardt, R. Bucala, and R.C. Atkins. 1997. The pathogenic role of macrophage migration inhibitory factor in immunologically induced kidney disease in the rat J. Exp. Med. 185:1455-1465.
7. Xu, D., S.J. McSorley, L. Tetley, S. Chatfield, G. Dougan, W.L. Chan, A. Satoskar, J.R. David, and F.Y. Liew. 1998. Protective effect on Leishmania major infection of migration inhibitory factor, TNF-alpha, and IFN-gamma administered orally via attenuated Salmonella typhimurium. J. Immunol. 160:1285-1289.
8. Juttner, S., J. Bernhagen, C.N. Metz, M. Rollinghoff, R. Bucala, and A. Gessner. 1998. Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha. J. Immunol. 161:2383-2390.
9. Lanahan, A., J.B. Williams, L.K. Sanders, and D. Nathans. 1992. Growth factor-induced delayed early response genes. Mol. Cell. Biol. 12:3919-3929.
10. Wistow, G.J., M.P. Shaughnessy, D.C. Lee, J. Hodin, and P.S. Zelenka. 1993. A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens. Proc. Natl. Acad. Sci. USA. 90:1272-1275.
11. Suzuki, H., H. Kanagawa, and J. Nishihira. 1996. Evidence for the presence of macrophage migration inhibitory factor in murine reproductive organs and early embryos. Immunol. Lett. 51:141-147.
12. Morrison, D.C., and J.L. Ryan. 1987. Endotoxins and disease mechanisms. Annu. Rev. Med. 38:417-432.
13. Calandra, T., J. Bernhagen, R.A. Mitchell, and R. Bucala. 1994. The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J. Exp. Med. 179:1895-1902.
14. Bozza, M., L.F. Kolakowski, Jr., N.A. Jenkins, D.J. Gilbert, N.G. Copeland, J.R. David, and C. Gerard. 1995. Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudo-genes. Genomics. 27:412-419.
15. 15N]nitrate in biological fluids. Anal. Biochem. 126:131-138.
16. Hopken, U.E., B. Lu, N.P. Gerard, and C. Gerard. 1996. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature. 383:86-89.
17. Buckley, T.L., and F.P. Nijkamp. 1994. Mucosal exudation associated with a pulmonary delayed-type hypersensitivity reaction in the mouse. Role for the tachykinins. J. Immunol. 153:4169-4178.
18. Hewett, J.A., and R.A. Roth. 1993. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides. Pharmacol. Rev. 45:382-411.
19. Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10:411-452.
20. Freudenberg, M.A., D. Keppler, and C. Galanos. 1986. Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin. Infect. Immun. 51:891-895.
21. Bernhagen, J., R.A. Mitchell, T. Calandra, W. Voelter, A. Cerami, and R. Bucala. 1994. Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF). Biochemistry. 33: 14144-14155.
22. Lehmann, V., M.A. Freudenberg, and C. Galanos. 1987. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. J. Exp. Med. 165:657-663.
23. Leist, M., F. Gantner, I. Bohlinger, P.G. Germann, G. Tiegs, and A. Wendel. 1994. Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest. J. Immunol. 153:1778-1788.
24. Gutierrez-Ramos, J.C., and H. Bluethmann. 1997. Molecules and mechanisms operating in septic shock: lessons from knockout mice. Immunol. Today. 18:329-334.
25. Kotzin, B.L., D.Y. Leung, J. Kappler, and P. Marrack. 1993. Superantigens and their potential role in human disease. Adv. Immunol. 54:99-166.
26. Xu, H., J.A. Gonzalo, Y. St Pierre, I.R. Williams, T.S. Kupper, R.S. Cotran, T.A. Springer, and J.C. Gutierrez-Ramos. 1994. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J. Exp. Med. 180: 95-109.
27. Makita, H., M. Nishimura, K. Miyamoto, T. Nakano, Y. Tanino, J. Hirokawa, J. Nishihira, and Y. Kawakami. 1998. Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation. Am. J. Respir. Crit. Care Med. 158:573-579.
28. Haziot, A., E. Ferrero, F. Kontgen, N. Hijiya, S. Yamamoto, J. Silver, C.L. Stewart, and S.M. Goyert. 1996. Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity. 4:407-414.
29. Porat, R., B.D. Clark, S.M. Wolff, and C.A. Dinarello. 1991. Enhancement of growth of virulent strains of Escherichia coli by interleukin-1. Science. 254:430-432.
30. Luo, G., D.W. Niesel, R.A. Shaban, E.A. Grimm, and G.R. Klimpel. 1993. Tumor necrosis factor alpha binding to bacteria: evidence for a high-affinity receptor and alteration of bacterial virulence properties. Infect. Immun. 61:830-835.
31. Donnelly, S.C., C. Haslett, P.T. Reid, I.S. Grant, W.A. Wallace, C.N. Metz, L.J. Bruce, and R. Bucala. 1997. Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat. Med. 3:320-323.