Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry

Human Genetics

Volumn 123, Issue 6, 2008, Pages 661-663

  Russell, James A ^a,b   Wellman, Hugh ^b   Walley, Keith R ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Sirius Genomics Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C;

ADULT; AGED; ALLELE; ARTICLE; ASIAN AMERICAN; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROGNOSIS; SEPSIS;

AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; FAR EAST; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; NORTH AMERICA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN C; SEPSIS;

EID: 45049085042     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-008-0509-5     Document Type: Article

References (3)

1. American College of Chest Physicians (ACCP)/Society of Critical Care Medicine Consensus Conference (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864-874
2. Chen QX, Wu SJ, Wang HH, Lv C, Cheng BL, Xie GH, Fang XM (2008) Protein C -1641A/-1654C haplotype is associated with organ dysfunction and the fatal outcome of severe sepsis in Chinese Han population. Hum Genet 123:281-287
3. Walley KR, Russell JA (2007) Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. Crit Care Med 35:12-17