Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy

Immunology

Volumn 93, Issue 1, 1998, Pages 96-101

  Cuzzocrea, S ^a,c   Caputi, A P ^a   Zingarelli, B ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXYNITRITE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; CELL DAMAGE; CYTOTOXICITY; DNA STRAND BREAKAGE; ENDOTHELIUM CELL; LIPID PEROXIDATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; PLEURISY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; BLOTTING, WESTERN; CARRAGEENAN; CELL CULTURE TECHNIQUES; DNA DAMAGE; ENERGY METABOLISM; MACROPHAGES; MALE; NITRATES; PLEURA; PLEURISY; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031891671     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00409.x     Document Type: Article

References (35)

1. BECKMAN J.S., BECKMAN T.W., CHEN J., MARSHALL P.A. & FREEMAN B.A. (1990) Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Ssi USA 87, 1620.
2. CROW J.P. & BECKMAN S. (1995) The role of peroxynitrite in nitric oxide-mediated toxicity. Curr Top Microbiol Immunol 196, 57.
3. ZINGARELLI B., DAY B.J., CRAPO J., SALZMAN A.L. & SZABÓ C. (1997) The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. Br J Pharmacol 120, 259.
4. SALVEMINI D., WANG Z.Q., WYATT P., BOURDON D.M., MARINO M.H., MANNING P.T. & CURRIE M.G. (1996) Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol 118, 829.
5. SALVEMINI D., WANG Z.Q., BOURDON D.M., STERN M.K., CURRIE M.G. & MANNING P.T. (1996) Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema. Eur J Pharmacol 303, 217.
6. ZINGARELLI B., O'CONNOR M., WONG H., SALZMAN A.L. & SZABÓ C. (1996) Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 156, 350.
7. SZABÓ C. (1996) DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radical Biol Med 21, 855.
8. SZABÓ C., ZINGARELLI B., O'CONNOR M. & SALZMAN A.L. (1996) DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA 93, 1753.
9. DARLEY-USMAR V., WISEMAN H. & HALLIWELL B. (1995) Nitric oxide and oxygen radicals: a question of balance. FEBS Lett 369, 131.
10. DARLEY-USMAR V. & HALLIWELL B. (1996) Blood radicals. Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharmaceut Res 13, 649.
11. COCHRANE C. (1991) Mechanisms of oxidant injury of cells. Molec Aspects Med 12, 137.
12. IALENTI A., IANARO A., MONCADA S. & DI ROSA M. (1995) Modulation of acute inflammation by endogenous nitric oxide. Eur J Pharmacol 211, 177.
13. CUZZOCREA S., ZINGARELLI B., CALAPAI G., NAVA F. & CAPUTI A.P. (1997) Zymosan-activated plasma induces paw oedema by nitric oxide and prostaglandin production. Life Sci 60, 215.
14. G-monomethylarginine, reduces carrageenan-induced pleurisy in the rat. J Pharmacol Exp Ther 273, 1295.
15. BANASIK M., KOMURA H., SHIMOYAMA M. & UEDA K. (1992) Specific inhibitors of poly (ADP-ribose) synthetase and mono (ADP-ribosyl) transferase. J Biol Chem 267, 1569.
16. SZABÓ C., CUZZOCREA S., ZINGARELLI B., O'CONNOR M. & SALZMAN A.L. (1997) Endothelial dysfunction in endotoxic shock: importance of the activation of poly (ADP ribose synthetase (PARS) by peroxynitrite. J Clin Invest 100, 723.
17. SCHRAUFSTATTER I.U., HINSHAW D.B., HYSLOP P.A., SPRAGG R.G. & COCHRANE C.G. (1986) Oxidant injury of cells: DNA strandbreaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest 77, 1312.
18. SZABÓ C., MITCHELL J.A., THIEMERMANN C. & VANE J.R. (1993) Nitric oxide-mediated hyporectivity to norepinephrine precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 108, 786.
19. HELLER B., WANG Z.Q., WAGNER E.F. et al. (1995) Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J Biol Chem 270, 11 176.
20. OH-ISHI S., HAYASHI I., HAVASHI M., YAMAKI K. & UTSUNOMIVA I. (1989) Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: rat pleurisy induced by carrageenin and phorbol myristate acetate. Dermatologica 179 (Suppl 1), 68.
21. PESKAR B.M., TRAUTMANN M., NOWAK P. & PESKAR B.A. (1991) Release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenin-induced inflammation: effect of non-steroidal anti-inflammatory drugs. Agents Actions 33, 240.
22. CUZZOCREA S., FILIPPELLI A., ZINGARELLI B., FALCIANI M., CAPUTI A.P. & ROSSI F. (1997) Role of nitric oxide in a non-septic shock model induced by zymosan in the rat. Shock-7, 351.
23. DA MOTTA J.I., CUNHA F.Q., VARGAFTIG B.B. & FERREIRA S.H. (1994) Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletion. Br J Pharmacol, 112, 111.
24. DAWSON J., SEDGWICK A.D., EDWARDS J.C. & LEES P. (1991) A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse. Int J Tissue React 13, 171.
25. WISEMAN H. & HALLIWELL B. (1996) Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 313, 17-29.
26. WANG Z.Q., AUER B., STINGL L., BERGHAMMER H., HAIDACHER D., SCHWEIGER M. & WAGNER E.F. (1995) Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Develop 9, 510.
27. BAUER P.I., KIRSTEN E., YOUNG L.J.T. et al. (1996) Modification of growth related enzymatic pathways and apparent loss of tumorigenicity of a ras-transformed bovine endothelial cell line by treatment with 5-iodo-6-amino-1,2-benzopyrone. Int J Oncol 8, 239.
28. KIRKLAND J.B. (1991) Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase. Biochim Biophys Acta 1092, 319.
29. SPRAGG R.G. (1991) DNA strand break formation following exposure of bovine pulmonary artery and aortic endothelial cells to reactive oxygen products. Am J Respir Cell Mol Biol 4, 4.
30. JUNOD A.F., JORNOT L. & PETERSEN H. (1989) Differential effects of hyperoxia and hydrogen peroxide on DNA damage, polyadenosine diphosphate-ribose polymerase activity, and nicotinamide adenine dinucleotide and adenosine triphosphate contents in cultured endothelial cells and fibroblasts. J Cell Physiol 140, 177.
31. THIES R.L. & AUTOR A.P. (1991) Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by polyADP-ribose polymerase activation causing NAD depletion and altered energy balance. Arch Biochem Biophys 286, 353.
32. ANDREOLI S.P. (1989) Mechanisms of endothelial cell ATP depletion after oxidant injury. Pediatr Res 25, 97.
33. + depletion. Biochem Biophys Res Comm 199, 1270.
34. ZHANG J., DAWSON V.L., DAWSON T.M. & SNYDER S.H. (1994) Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science 263, 687.
35. SALGO M.G., BERMUDEZ E., SQUADRITO G. & PRYOR W. (1995) DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes. Arch Biochem Biophys 322, 500.