Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

Journal of Clinical Investigation

Volumn 100, Issue 11, 1997, Pages 2671-2679

  Pahan, Kalipada ^a   Sheikh, Faruk G ^a   Namboodiri, M S ^a   Singh, Inderjit ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Astrocytes; Cytokines; INOS; Lovastatin; Phenylacetate

Indexed keywords

ACETIC ACID; ARGINASE; CHOLESTEROL; COMPACTIN; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MEVALONIC ACID; MEVINOLIN; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENYLACETIC ACID; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UBIQUINONE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME INHIBITION; MACROPHAGE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031438501     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119812     Document Type: Article

References (44)

1. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB (Fed. Am. Soc. Exp. Biol.) J. 6:3051-3064.
2. Jaffrey, S.R., and S.H. Snyder. 1995. Nitric oxide: a neural messenger. Annu. Rev. Cell Dev. Biol. 11:417-440.
3. Hu, S.X., W.S. Sheng, P.K. Peterson, and C.C. Chao. 1995. Differential regulation by cytokines of human astrocyte nitric oxide production. Glia. 15: 491-494.
4. Galea, E., D.L. Feinstein, and D.J. Reis. 1992. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc. Natl. Acad. Sci. USA. 89:10945-10949.
5. Koprowski, H., Y.M. Zheng, E. Heber-Katz, N. Fraser, L. Rorke, Z.F. Fu, C. Hanlon, and B. Dietzshold. 1993. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proc. Natl. Acad. Sci. USA. 90:3024-3027.
6. Mitrovic, B., L.J. Ignarro, S. Montestruque, A. Smoll, and J.E. Merril. 1994. Nitric oxide as apotential pathological mechanism in demyelination: its effects on primary glial cells in vivo. Neuroscience. 61:575-585.
7. Bo, L., T.M. Dawson, S. Wesselingh, S. Mork, S. Choi, P.A. Kong, D. Hanley, and B.D. Trapp. 1994. Induction of nitric oxide synthase in demyelinatine regions of multiple sclerosis brains. Ann. Neurol. 36:778-786.
8. Merrill, J.E., L.J. Ignarro, M.P. Sherman, J. Melinek, and T.E. Lane. 1993. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151:2132-2141.
9. Pahan, K., F.G. Sheikh, A.M.S. Namboodiri, and I. Singh. 1997. N-Acetyl cysteine inhibits induction of NO production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes. Free Radical Biol. Med. 24:39-48.
10. Feinstein, D.L., E. Galea, J. Cermak, P. Chugh, L. Lyandvert, and D.J. Reis. 1994. Nitric oxide synthase expression in glial cells: suppression by tyrosine kinase inhibitors. J. Neurochem. 62:811-814.
11. Nishiya, T., T. Uehara, and Y. Nomura. 1995. Herbimycin A suppresses NF-kβ activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells. FEBS Lett. 371:333-336.
12. Reimann et al. 1994. J. Immunol. 153:5740-5749.
13. Li, S., and J.M. Sedivy. 1993. Raf-1 protein kinase activates the NF-kβ transcription factor by dissociating the cytoplasmic NF-kβ-Ikβ complex. Proc. Natl. Acad. Sci. USA. 90:9247-9251.
14. Xie, Q.-W., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NF-kβ/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705-4708.
15. Kwon, G., J.A. Corbett, C.P. Rodi, P. Sullivan, and M.L. McDaniel. 1995. Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of NF-kβ in the signaling mechanism. Endocrinology. 136:4790-4795.
16. Goldstein, J.L., and M.S. Brown. 1990. Regulation of the mevalonate pathway. Nature (Lond.). 343:425-430.
17. Casey, P.J., P.A. Solski, C.J. Der, and J.E. Buss. 1989. P21ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. USA. 86:8323-8327.
18. Kikuchi, A., and L.T. Williams. 1994. The post-translational modification of ras p21 is important for Raf-1 activation. J. Biol. Chem. 269:20054-20059.
19. Castillo, M., M. Martinez-Cayuela, M.F. Zafra, and E. Garcia-Peregrin. 1991. Effect of phenylalanine derivatives on the main regulatory enzymes of cholesterogenesis. Mol. Cell. Biochem. 105:21-25.
20. Samid, D., Z. Ram, W.R. Hudgins, S. Shack, L. Liu, S. Walbridge, E.H. Oldfield, and C.E. Meyers. 1994. Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria. Cancer Res. 54:891-895.
21. Samid, D., S. Shack, and L.T. Sherman. 1992. Phenylacetate: a novel nontoxic inducer of tumor cell differentiation. Cancer Res. 52:1988-1992.
22. McCarthy, K., and J. DeVellis. 1980. Preparation of separate astroglial and oligodendroglial cultures from rat cerebral tissue. J. Cell Biol. 85:890-902.
23. Giulian, D., and T.J. Baker. 1986. Characterization of amoebid microglia isolated from developing mammalian brain. J. Neurosci. 6:2163-2178.
24. Feinstein, D.L., E. Galea, S. Roberts, H. Berquist, H. Wang, and D.J. Reis. 1994. Induction of nitric oxide synthase in rat C6 glial cells. J. Neurochem. 62:315-321.
25. Pahan, K., A.M.S. Namboodiri, F.G. Sheikh, B.T. Smith, and I. Singh. 1997. Increasing cAMP attenuates induction of inducible nitric oxide synthase in rat primary astrocytes. J. Biol. Chem. 272:7786-7791.
26. Bradford, M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein-dye binding. Anal. Biochem. 72:248-254.
27. Geller, D.A., C.J. Lowenstein, R.A. Shapiro, A.K. Nussler, M. Di Silvio, S.C. Wang, D.K., Nakayama, R.L. Simmons, S.H. Snyder, and T.R. Billiar. 1993. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc. Natl. Acad. Sci. USA. 90:3491-3495.
28. Caira, F., C. Pacot, O. Bardot, M.C. Malki, and N. Latruffe. 1995. Transcriptional and post-transcriptional analysis of peroxisomal protein encoding genes from rat treated with an hypolipemic agent, ciprofibrate. Biochem. Pharmacol. 49:611-619.
29. Dignam, J.D., R.M. Lebovitz, and R.G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl. Acids Res. 11:1475-1489.
30. Repko, E.M., and W.A. Maltese. 1989. Post-translational isoprenylational of cellular proteins is altered in response to mevalonate availability. J. Biol. Chem. 264:9945-9952.
31. Sinenskv, M., L.A. Beck, S. Leonard, and R. Evans. 1991. Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis. J. Biol. Chem. 265:19937-19941.
32. Thibault, A., D. Samid, M.R. Cooper, W.D. Figg, A.C. Tompkins, N. Patronas, D.J. Headlee, D.R. Kohler, D.J. Venzon, and C.E. Myers. 1995. Phase I study of phenylacetate administration twice daily to patients with cancer. Cancer. 75:2932-2938.
33. Manne, V., C.S. Ricca, J.G. Brown, A.V. Tuomori, N. Yan, et al. 1995. Ras farnesylation as a target for novel antitumor agent: potent and selective farnesyl diphosphate analog inhibitors of farnesyl transferase. Drug Dev. Res. 34:121-137.
34. Sharif, S.F., R.J. Hariri, V.A. Chang, P.S. Barie, R.S. Wang, and J.B. Ghaiar. 1993. Human astrocyte production of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 following exposure to lipopolysaccharide endotoxin. Neurol. Res. 15:109-112.
35. Stefanova, I., M.L. Corcoran, E.M. Horak, L.M. Wahl, J.B. Bolen, and I.D. Horak. 1993. Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/561yn. J. Biol. Chem. 268:20725-20728.
36. Shin, H.S., B.E. Drysdale, M.L. Shin, P.W. Noble, S.N. Fisher, and W.A. Paznekas. 1994. Definition of a lipopolysaccharide-responsive element in the 5′-flanking regions of MuRantes and crg-2. Mol. Cell. Biol. 14:2914-2925.
37. Law, R.E., J.B. Stimmel, M.A. Damore, C. Carter, S. Clarke, and R. Wall. 1992. Lipopolysaccharide-induced NF-kB activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevilonin and 5′-methyladenosine: roles of protein isoprenylation and carboxylation reactions. Mol. Cell. Biol. 12:103-111.
38. k-ras(B). EMBO J. 10:641-646.
39. Kikuchi, A., and L.T. Williams. 1994. The post-translational modification of ras p21 is important for raf-1 activation. J. Biol. Chem. 269:20054-20059.
40. Jelinek, T., P. Dent, T.W. Sturgill, and M.J. Weber. 1996. Ras-induced activation of Raf-2 is dependent on tyrosine phosphorylation. Mol. Cell. Biol. 16:1027-1034.
41. Dawson, V.L., T.M. Dawson, E.D. London, D.T. Bredt, and S.H. Snyder. 1991. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA. 88:6368-6371.
42. Drapier, J.-C., and J.B. Hibbs. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophages effector cells. 1988. J. Immunol. 140:2829-2838.
43. Radi, R., J.S. Beckman, K.M. Bush, and B.A. Freeman. 1991. Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266:4244-4250.
44. Wink, D.A., K.S. Kasprazak, C.M. Maragos, R.K. Elespuru, M. Misra, T.M. Dunams, T.A. Cebula, W.H. Koch et al. 1991. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science (Wash. DC). 254: 1001-1003.