Why (-)deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects

Mechanisms of Ageing and Development

Volumn 123, Issue 8, 2002, Pages 1087-1100

  Kitani, Kenichi ^a   Minami, Chiyoko ^a   Isobe, Ken ichi ^a   Maehara, Kayoko ^a   Kanai, Setsuko ^b   Ivy, Gwen O ^c   Carrillo, Maria Christina ^d  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Catalase; Cytokines; Life span prolongation; Superoxide dismutase

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MANGANESE SUPEROXIDE DISMUTASE; MONOAMINE OXIDASE INHIBITOR; SELEGILINE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

AGING; ANTIOXIDANT ACTIVITY; BRAIN REGION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; LONGEVITY; NATURAL KILLER CELL; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL; REVIEW; SURVIVAL RATE;

AGING; ANIMALS; ANTIOXIDANTS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATALASE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; MONOAMINE OXIDASE INHIBITORS; NERVE GROWTH FACTORS; NEUROPROTECTIVE AGENTS; SELEGILINE; SUPEROXIDE DISMUTASE;

ANIMALIA; CANIS FAMILIARIS; CRICETINAE; FELIS CATUS; GYMNOMYZA SAMOENSIS;

EID: 0037198066     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00392-X     Document Type: Review

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