SIRT1 regulates the ribosomal DNA locus: Epigenetic candles twinkle longevity in the Christmas tree

Biochemical and Biophysical Research Communications

Volumn 378, Issue 1, 2009, Pages 6-9

  Salminen, Antero ^a,b   Kaarniranta, Kai ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Aging; Epigenetics; Recombination; Ribosome; Sirtuins

Indexed keywords

HISTONE DEACETYLASE; METHYLTRANSFERASE; RIBOSOME DNA; SIRTUIN 1;

AGING; BIOGENESIS; BUDDING; CELL AGING; CELL METABOLISM; CHROMATIN STRUCTURE; DNA RECOMBINATION; DNA TRANSCRIPTION; ENERGY; ENERGY BALANCE; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE SILENCING; GENETIC RECOMBINATION; GENETIC REGULATION; GENETIC STABILITY; GENETIC TRANSCRIPTION; LIFESPAN; LONGEVITY; METABOLIC RATE; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; RNA GENE; SHORT SURVEY; YEAST;

AGING; CELL AGING; CELL NUCLEOLUS; DNA, RIBOSOMAL; EPIGENESIS, GENETIC; HISTONE DEACETYLASES; HUMANS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TRANSCRIPTION, GENETIC;

ABIES ALBA; MAMMALIA; SACCHAROMYCETALES;

EID: 56949101056     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.11.023     Document Type: Short Survey

References (46)

1. Fromont-Racine M., Senger B., Saveanu C., and Fasiolo F. Ribosome assembly in eukaryotes. Gene 313 (2003) 17-42
2. Raska I., Koberna K., Malinsky J., Fidlerova H., and Masata M. The nucleolus and transcription of ribosomal genes. Biol. Cell 96 (2004) 579-594
3. Mosgoeller W., Schöfer C., Steiner M., Sylvester J.E., and Hozak P. Arrangement of ribosomal genes in nucleolar domains revealed by detection of "Christmas tree" components. Histochem. Cell Biol. 116 (2001) 495-505
4. Koberna K., Malinsky J., Pliss A., Masata M., Vecerova J., Fialova M., Bednar J., and Raska I. Ribosomal genes in focus: new transcripts label the dense fibrillar components, form clusters indicative of "Christmas trees" in situ. J. Cell Biol. 157 (2002) 743-748
5. Raska I. Oldies but goldies: searching for Christmas trees within the nucleolar architecture. Trends Cell Biol. 13 (2003) 517-525
6. Grummt I., and Pikaard C.S. Epigenetic silencing of RNA polymerase I transcription. Nat. Rev. Mol. Cell Biol. 4 (2003) 641-649
7. Preuss S., and Pikaard C.S. RRNA gene silencing and nucleolar dominance: insights into a chromosome-scale epigenetic on/off switch. Biochim. Biophys. Acta 1769 (2007) 383-392
8. Grummt I. Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum. Mol. Genet. 16 (2007) R21-R27
9. McStay B., and Grummt I. The epigenetics of rRNA genes: from molecular to chromosome biology. Annu. Rev. Cell Dev. Biol. 24 (2008) 131-157
10. Berger S.L. The complex language of chromatin regulation during transcription. Nature 447 (2007) 407-412
11. Gasser S.M., and Cockell M.M. The molecular biology of the SIR proteins. Gene 279 (2001) 1-16
12. Imai S., Armstrong C.M., Kaeberlein M., and Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 (2000) 795-800
13. Guarente L. Diverse and dynamic functions of the Sir silencing complex. Nat. Genet. 23 (1999) 281-285
14. Blander G., and Guarente L. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73 (2004) 417-435
15. Michan S., and Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem. J. 404 (2007) 1-13
16. Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature 444 (2006) 868-874
17. Huang J., Brito I.L., Villen J., Gygi S.P., Amon A., and Moazed D. Inhibition of homologous recombination by cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev. 20 (2006) 2887-2901
18. Machin F., Paschos K., Jarmuz A., Torres-Rosell J., Pade C., and Aragon L. Condensin regulates rDNA silencing by modulating nucleolar Sir2p. Curr. Biol. 14 (2004) 125-130
19. Mellor J., and Morillon A. ISWI complexes in Saccharomyces cerevisiae. Biochim. Biophys. Acta 1677 (2004) 100-112
20. Dehe P.M., and Geli V. The multiple faces of Set1. Biochem. Cell Biol. 84 (2006) 536-548
21. Sinclair D.A., and Guarente L. Extrachromosomal rDNA circles-a cause of aging in yeast. Cell 91 (1997) 1033-1042
22. Kaeberlein M., McVey M., and Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 (1999) 2570-2580
23. Kobayashi T., Horiuchi T., Tongaonkar P., Vu L., and Nomura M. SIR2 regulates recombination between different rDNA repeats, But not recombination within individual rRNA genes in yeast. Cell 117 (2004) 441-453
24. Fabrizio P., Gattazzo C., Battistella L., Wei M., Cheng C., McGrew K., and Longo V.D. Sir2 blocks extreme life-span extension. Cell 123 (2005) 655-667
25. Longo V.D., and Kennedy B.K. Sirtuins in aging and age-related disease. Cell 126 (2006) 257-268
26. Murayama A., Ohmori K., Fujimura A., Minami H., Yasuzawa-Tanaka K., Kuroda T., Oie S., Daitoku H., Okuwaki M., Nagata K., Fukamizu A., kimura K., Shimizu T., and Yanagisawa J. Epigenetic control of rDNA loci in response to intracellular energy status. Cell 133 (2008) 627-639
27. Mayer C., Schmitz K.M., Li J., Grummt I., and Santoro R. Intergenic transcripts regulate the epigenetic state of rRNA genes. Mol. Cell 22 (2006) 351-361
28. Lebedev A., Scharffetter-Kochanek K., and Iben S. Truncated Cockayne syndrome B protein represses elongation by RNA polymerase I. J. Mol. Biol. 382 (2008) 266-274
29. Schumacher B., Garinis G.A., and Hoeijmakers J.H.J. Age to survive: DNA damage and aging. Trends Genet. 24 (2008) 77-85
30. Patil C.K., Mian I.S., and Campisi J. The thorny path linking cellular senescence to organismal aging. Mech. Ageing Dev. 126 (2005) 1040-1045
31. Jeyapalan J.C., and Sedivy J.M. Cellular senescence and organismal aging. Mech. Ageing Dev. 129 (2008) 467-474
32. Speakman J.R., Selman C., McLaren J.S., and Harper E.J. Living fast, dying when? The link between aging and energetics. J. Nutr. 132 (2002) 1583S-1597S
33. Hulbert A.J., Pamplona R., Buffenstein R., and Buttemer W.A. Life and death: metabolic rate, membrane composition, and life span of animals. Physiol. Rev. 87 (2007) 1175-1213
34. Bandyopadhyay D., and Medrano E.E. The emerging role of epigenetics in cellular and organismal aging. Exp. Gerontol. 38 (2003) 1299-1307
35. Sedivy J.M., Banumathy G., and Adams P.D. Aging by epigenetics-a consequence of chromatin damage?. Exp. Cell Res. 314 (2008) 1909-1917
36. Rattan S.I.S. Hormesis in aging. Ageing Res. Rev. 7 (2008) 63-78
37. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 (1956) 298-300
38. Dilova I., easlon E., and Lin S.J. Calorie restriction and the nutrient sensing signaling pathways. Cell. Mol. Life Sci. 64 (2007) 752-767
39. Mair W., and Dillin A. Aging and survival: the genetics of life span extension by dietary restriction. Annu. Rev. Biochem. 77 (2008) 727-754
40. Kaeberlein M., and Powers III R.W. Sir2 and calorie restriction in yeast: a skeptical perspective. Ageing Res. Rev. 6 (2007) 128-140
41. Mattson M.P. Hormesis defined. Ageing Res. Rev. 7 (2008) 1-7
42. Huffman D.M., Grizzle W.E., Bamman M.M., Kim J., Eltoum I.A., Elgavish A., and Nagy T.R. SIRT1 is significantly elevated in mouse and human cancer. Cancer Res. 67 (2007) 6612-6618
43. Sasaki T., Maier B., Bartke A., and Scrable H. Progressive loss pf SIRT1 with cell cycle withdrawal. Aging Cell 5 (2006) 413-422
44. Burhans W.C., and Weinberger M. DNA replication stress, genome instability and aging. Nucleic Acids Res. 35 (2007) 7545-7556
45. Hanada K., and Hickson I.D. Molecular genetics of RecQ helicase disorders. Cell. Mol. Life Sci. 64 (2007) 2306-2322
46. Machwe A., Orren D.K., and Bohr V.A. Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts. FASEB J. 14 (2000) 1715-1724