Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403

British Journal of Pharmacology

Volumn 132, Issue 4, 2001, Pages 815-827

  Salvemini, Daniela ^a   Mazzon, Emanuela ^b   Dugo, Laura ^c   Riley, Dennis P ^a   Serraino, Ivana ^c   Caputi, Achille P ^c   Cuzzocrea, Salvatore ^c  

^a MetaPhore Pharmaceuticals   (United States)

^b UNIVERSITY OF MESSINA   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

Adhesion molecules; Cytokines; Inflammation; Superoxide anions; Superoxide dismutase mimetic

Indexed keywords

3 NITROTYROSINE; CARRAGEENAN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPID; MANGANESE SUPEROXIDE DISMUTASE; MANGANESEDICHLORO(3,10,13,20,26 PENTAAZATETRACYCLO[20.3.1.0(4,9).0(14,19)] 1(26),22(23),24 HEXACOSATRIENE); NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRATE; NITRITE; OXIDE; PADGEM PROTEIN; PROSTAGLANDIN E2; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID PEROXIDATION; MALE; NEUTROPHIL; NONHUMAN; PLEURISY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

EID: 0035127194     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703841     Document Type: Article

References (76)

1. Superoxide: A two-edged sword
2. Function and activation of NF-kappa B in the immune system
3. Nuclear factor-kappa B: A pivotal transcription factor in chronic inflammatory diseases
4. Oxidative damage and tyrosine nitration from peroxynitrite
5. Pathological implications of nitric oxide, superoxide and peroxynitrite formation
6. Apparent hydroxyl radical production by peroxynitrite: Implication for endothelial injury from nitric oxide and superoxide
7. The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat
8. Measurement of cutaneous inflammation. Estimation of neutrophil content with an enzyme marker
9. Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia
10. DNA strand breaks, NAD metabolism, and programmed cell death
11. The role of peroxynitrite in nitric oxide-mediated toxicity
12. Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy
13. Role of IL-6 in the pleurisy and lung injury caused by carrageenan
14. Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in carrageenan-induced models of local inflammation
15. Nitric oxide and oxygen radicals: A question of balance
16. Hemorrhagic shock-induced bacterial translocation: The role of neutrophils and hydroxyl radicals
17. Mechanism of site-selective DNA nicking by the hydrodioxyl (perhydroxyl) radical
18. Superoxide dimutase (SOD) and the PAF-antagonist (BN 52021) reduce small intestinal damage induced by ischemia-reperfusion
19. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
20. Superoxide-mediated glomerulopathy in the endotoxin-treated pregnant rat
21. A review: Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions
22. Superoxide dismutase for therapeutic use: Clinical experience, dead ends and hopes
23. Superoxide radical and superoxide dismutases
24. Effects of antioxidants and PAF receptor antagonist in intestinal shock in the rat
25. Expression and function of cyclooxygenase-2 in mesothelial cells during late phase of rat carrageenin-induced pleurisy
26. Effects of catalase, peroxidase, superoxide dismutase and 10 scavengers of oxygen radicals in carrageenan edema and in adjuvant arthritis of rats
27. Bioavailability of superoxide dismutase: Implications for the anti-inflammatory action mechanism of orgotein
28. Mechanisms of oxidant-mediated cell injury: The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide
29. Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
30. Reactive species in ischemic rat lung injury: Contribution of peroxynitrite
31. Detection of recative nitrogen species using 2,7-dichlorodihydrofluorescein and dihydrorhodamine 123
32. Peroxynitrite formation from macrophage-derived nitric oxide
33. Peroxynitrite-mediated oxidation of dihydrorhodamine 123
34. Assessment of myeloperoxidase activity in renal tissue after ischemia/reperfusion
35. Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis
36. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide-deficient mice
37. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
38. Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite
39. Prospects for the use of antioxidant therapies
40. Superoxide dismutase: An enzymatic function for erythrocuprein
41. Free radicals and inflammation: Protection of synovial fluid by superoxide dismutase
42. Mitochondrial disease in superoxide dismutase 2 mutant mice
43. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts
44. Effect of liposomal-encapsulated superoxide dismutase on active oxygen-related human disorders. A preliminary study
45. Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: Roles of complement, bradykinin, and inducible cyclooxygenase-2
46. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction
47. Metalloporphyrin class of therapeutic catalyic antioxidants
48. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
49. Synthesis, characterization and stability of manganese (II) C-substituted 1,4,7,10,13-Pentaazacyclopentadecane complexes exhibiting superoxide dismutase activity
50. Toward the rational design of superoxide dismutase mimics: Mechanistic studies for the elucidation of substituent effects on the catalysis activity of macrocyclic manganese (II) complexes
51. DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes
52. Regulation of cyclooxygenase enzymes by nitric oxide
53. Therapeutic manipulations of peroxynitrite
54. Nitric oxide activates cyclooxygenase enzymes
55. Activation of the cyclooxygenase pathway by nitric oxide: New concepts of inflammation and therapy
56. Dual inhibition of nitric oxide and prostaglandin production contributes to the anti-inflammatory properties of nitric oxide synthase inhibitors
57. Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage
58. Peroxynitrite decomposition catalysts: Novel therapeutics for peroxynitrite-mediated pathology
59. Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation
60. Synzymes: Potent non-peptidic agents against superoxide-driven tissue injury
61. Oxidant injury of cells: DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide
62. Oxidant injury of cells
63. The formation of peroxynitrite in vivo from nitric oxide and superoxide
64. Peroxynitrite decomposition catalysts
65. Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment
66. Role of poly (ADP-ribose) synthetase in inflammation and ischaemia-reperfusion
67. Nitric oxide, peroxynitrite and poly (ADP-ribose) synthetase: Biochemistry and pathophysiological implications
68. Cyclo-oxygenase and nitric oxide isoforms in rat carrageenin-induced pleurisy
69. Pharmacokinetics and safety of intravenous recombinant human superoxide dismutase (NK341) in healthy subjects
70. 2+
71. - in neutrophil recruitment into sites of dermal and pulmonary vasculitis
72. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia
73. Superoxide dismutase and leupeptin prevent delayed reperfusion injury in the rat small intestine during burn shock
74. Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine
75. Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipolysaccharide