메뉴 건너뛰기




Volumn 176, Issue 1-2, 2006, Pages 63-75

Exogenous IL-12 suppresses experimental autoimmune encephalomyelitis (EAE) by tuning IL-10 and IL-5 levels in an IFN-γ-dependent way

Author keywords

Autoimmune disease; Cytokines; Experimental autoimmune encephalomyelitis; Interferon ; Interleukin 12

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 5; NEUTRALIZING ANTIBODY;

EID: 33746039702     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.04.009     Document Type: Article
Times cited : (12)

References (88)
  • 2
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher B., Durell B.G., and Noelle R.J. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110 (2002) 493-497
    • (2002) J. Clin. Invest. , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 3
    • 0032193696 scopus 로고    scopus 로고
    • IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice
    • Bettelli E., Das M.P., Howard E.D., Weiner H.L., Sobel R.A., and Kuchroo V.K. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J. Immunol. 161 (1998) 3299-3306
    • (1998) J. Immunol. , vol.161 , pp. 3299-3306
    • Bettelli, E.1    Das, M.P.2    Howard, E.D.3    Weiner, H.L.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 4
    • 0029994319 scopus 로고    scopus 로고
    • Interferon-γ: biology and role in pathogenesis
    • Billiau A. Interferon-γ: biology and role in pathogenesis. Adv. Immunol. 62 (1996) 61-130
    • (1996) Adv. Immunol. , vol.62 , pp. 61-130
    • Billiau, A.1
  • 6
  • 7
    • 0032005162 scopus 로고    scopus 로고
    • Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis
    • Bright J.J., Musuro B.F., Du C., and Sriram S. Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis. J. Neuroimmunol. 82 (1998) 22-30
    • (1998) J. Neuroimmunol. , vol.82 , pp. 22-30
    • Bright, J.J.1    Musuro, B.F.2    Du, C.3    Sriram, S.4
  • 8
    • 0019359228 scopus 로고
    • Relapsing experimental allergic encephalomyelitis in the SJL/J mouse
    • Brown A.M., and McFarlin D.E. Relapsing experimental allergic encephalomyelitis in the SJL/J mouse. Lab. Invest. 45 (1981) 278-284
    • (1981) Lab. Invest. , vol.45 , pp. 278-284
    • Brown, A.M.1    McFarlin, D.E.2
  • 9
    • 0034601012 scopus 로고    scopus 로고
    • Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
    • Chu C.-Q., Wittmer S., and Dalton D.K. Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J. Exp. Med. 192 (2000) 123-128
    • (2000) J. Exp. Med. , vol.192 , pp. 123-128
    • Chu, C.-Q.1    Wittmer, S.2    Dalton, D.K.3
  • 10
    • 0029148025 scopus 로고
    • Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo
    • Collins P.D., Marleau S., Griffiths-Johnson D.A., Jose P.J., and Williams T.J. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J. Exp. Med. 182 (1995) 1169-1174
    • (1995) J. Exp. Med. , vol.182 , pp. 1169-1174
    • Collins, P.D.1    Marleau, S.2    Griffiths-Johnson, D.A.3    Jose, P.J.4    Williams, T.J.5
  • 11
    • 0032211092 scopus 로고    scopus 로고
    • Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis
    • Constantinescu C.S., Wysocka M., Hilliard B., Ventura E.S., Lavi E., Trinchieri G., and Rostami A. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J. Immunol. 161 (1998) 5097-5104
    • (1998) J. Immunol. , vol.161 , pp. 5097-5104
    • Constantinescu, C.S.1    Wysocka, M.2    Hilliard, B.3    Ventura, E.S.4    Lavi, E.5    Trinchieri, G.6    Rostami, A.7
  • 12
    • 0035177433 scopus 로고    scopus 로고
    • Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively
    • Constantinescu C.S., Hilliard B., Ventura E., Wysocka M., Showe L., Lavi E., Fujioka T., Scott P., Trinchieri G., and Rostami A. Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively. Clin. Immunol. 98 (2001) 23-30
    • (2001) Clin. Immunol. , vol.98 , pp. 23-30
    • Constantinescu, C.S.1    Hilliard, B.2    Ventura, E.3    Wysocka, M.4    Showe, L.5    Lavi, E.6    Fujioka, T.7    Scott, P.8    Trinchieri, G.9    Rostami, A.10
  • 13
    • 0033559981 scopus 로고    scopus 로고
    • Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis
    • Cua D.J., Groux H., Hinton D.R., Stohlman S.A., and Coffman R.L. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 189 (1999) 1005-1010
    • (1999) J. Exp. Med. , vol.189 , pp. 1005-1010
    • Cua, D.J.1    Groux, H.2    Hinton, D.R.3    Stohlman, S.A.4    Coffman, R.L.5
  • 15
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    • Dalton D.K., Pitts-Meek S., Keshav S., Figari I.S., Bradley A., and Stewart T.A. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259 (1993) 1739-1742
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1    Pitts-Meek, S.2    Keshav, S.3    Figari, I.S.4    Bradley, A.5    Stewart, T.A.6
  • 16
    • 0031769693 scopus 로고    scopus 로고
    • Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis
    • Di Rosa F., Francesconi A., Di Virgilio A., Finocchi L., Santilio I., and Barnaba V. Lack of Th2 cytokine increase during spontaneous remission of experimental allergic encephalomyelitis. Eur. J. Immunol. 28 (1998) 3893-3903
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3893-3903
    • Di Rosa, F.1    Francesconi, A.2    Di Virgilio, A.3    Finocchi, L.4    Santilio, I.5    Barnaba, V.6
  • 17
    • 0026131154 scopus 로고
    • Murine interferon-γ/interleukin-1 fusion protein used as antigens for the generation of hybridomas producing monoclonal anti-interleukin-1 antibodies
    • Dijkmans R., Martens E., Beuken E., Cornette F., Dillen C., Heremans H., Boraschi D., and Billiau A. Murine interferon-γ/interleukin-1 fusion protein used as antigens for the generation of hybridomas producing monoclonal anti-interleukin-1 antibodies. Cytokine 3 (1991) 134-140
    • (1991) Cytokine , vol.3 , pp. 134-140
    • Dijkmans, R.1    Martens, E.2    Beuken, E.3    Cornette, F.4    Dillen, C.5    Heremans, H.6    Boraschi, D.7    Billiau, A.8
  • 18
    • 0026619266 scopus 로고
    • Effect of interferon-gamma on myelin basic protein-specific T cell line proliferation in response to antigen-pulsed accessory cells
    • Duong T.T., Finkelman F.D., and Strejan G.H. Effect of interferon-gamma on myelin basic protein-specific T cell line proliferation in response to antigen-pulsed accessory cells. Cell. Immunol. 145 (1992) 311-323
    • (1992) Cell. Immunol. , vol.145 , pp. 311-323
    • Duong, T.T.1    Finkelman, F.D.2    Strejan, G.H.3
  • 19
    • 0026558531 scopus 로고
    • Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse
    • Duong T.T., St. Louis J., Gilbert J.J., Finkelman F.D., and Strejan G.H. Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse. J. Neuroimmunol. 36 (1992) 105-115
    • (1992) J. Neuroimmunol. , vol.36 , pp. 105-115
    • Duong, T.T.1    St. Louis, J.2    Gilbert, J.J.3    Finkelman, F.D.4    Strejan, G.H.5
  • 20
    • 0028170342 scopus 로고
    • Effect of anti-interferon-γ monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains
    • Duong T.T., Finkelman F.D., Singh B., and Strejan G.H. Effect of anti-interferon-γ monoclonal antibody treatment on the development of experimental allergic encephalomyelitis in resistant mouse strains. J. Neuroimmunol. 53 (1994) 101-107
    • (1994) J. Neuroimmunol. , vol.53 , pp. 101-107
    • Duong, T.T.1    Finkelman, F.D.2    Singh, B.3    Strejan, G.H.4
  • 24
    • 0029984051 scopus 로고    scopus 로고
    • Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10
    • Gerosa F., Paganin C., Peritt D., Paiola F., Scupoli M.T., Aste-Amezaga M., Frank I., and Trinchieri G. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med. 183 (1996) 2559-2569
    • (1996) J. Exp. Med. , vol.183 , pp. 2559-2569
    • Gerosa, F.1    Paganin, C.2    Peritt, D.3    Paiola, F.4    Scupoli, M.T.5    Aste-Amezaga, M.6    Frank, I.7    Trinchieri, G.8
  • 26
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran B., Zhang G.X., Yu S., Li J., Chen X.H., Ventura E.S., Kamoun M., and Rostami A. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169 (2002) 7104-7110
    • (2002) J. Immunol. , vol.169 , pp. 7104-7110
    • Gran, B.1    Zhang, G.X.2    Yu, S.3    Li, J.4    Chen, X.H.5    Ventura, E.S.6    Kamoun, M.7    Rostami, A.8
  • 27
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., and Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6 (2005) 1123-1132
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 28
    • 0023188860 scopus 로고
    • Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide
    • Heremans H., Dijkmans R., Sobis H., Vandekerckhove F., and Billiau A. Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide. J. Immunol. 138 (1987) 4175-4179
    • (1987) J. Immunol. , vol.138 , pp. 4175-4179
    • Heremans, H.1    Dijkmans, R.2    Sobis, H.3    Vandekerckhove, F.4    Billiau, A.5
  • 29
    • 0029829385 scopus 로고    scopus 로고
    • Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against IFN-γ
    • Heremans H., Dillen C., Groenen M., Martens E., and Billiau A. Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against IFN-γ. Eur. J. Immunol. 26 (1996) 2393-2398
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2393-2398
    • Heremans, H.1    Dillen, C.2    Groenen, M.3    Martens, E.4    Billiau, A.5
  • 30
    • 0032775094 scopus 로고    scopus 로고
    • Role of endogenous interleukin-12 (IL-12) in induced and spontaneous relapses of experimental autoimmune encephalomyelitis in mice
    • Heremans H., Dillen C., Groenen M., Matthys P., and Billiau A. Role of endogenous interleukin-12 (IL-12) in induced and spontaneous relapses of experimental autoimmune encephalomyelitis in mice. Eur. Cytokine Netw. 10 (1999) 171-179
    • (1999) Eur. Cytokine Netw. , vol.10 , pp. 171-179
    • Heremans, H.1    Dillen, C.2    Groenen, M.3    Matthys, P.4    Billiau, A.5
  • 31
    • 0030069075 scopus 로고    scopus 로고
    • High doses of interleukin-12 inhibit the development of joint disease in DBA/1mice immunized with type II collagen in complete Freund's adjuvant
    • Hess H., Gately M.K., Rüde E., Schmitt E., Szeliga J., and Germann T. High doses of interleukin-12 inhibit the development of joint disease in DBA/1mice immunized with type II collagen in complete Freund's adjuvant. Eur. J. Immunol. 26 (1996) 187-191
    • (1996) Eur. J. Immunol. , vol.26 , pp. 187-191
    • Hess, H.1    Gately, M.K.2    Rüde, E.3    Schmitt, E.4    Szeliga, J.5    Germann, T.6
  • 32
    • 18144387626 scopus 로고    scopus 로고
    • Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3
    • Hong J., Li N., Zhang X., Zheng B., and Zhang J.Z. Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6449-6454
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 6449-6454
    • Hong, J.1    Li, N.2    Zhang, X.3    Zheng, B.4    Zhang, J.Z.5
  • 33
    • 0033992422 scopus 로고    scopus 로고
    • Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing-remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide
    • Ichikawa M., Koh C.S., Inoue A., Tsuyusaki J., Yamazaki M., Inaba Y., Sekiguchi Y., Itoh M., Yagita H., and Komiyama A. Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing-remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide. J. Neuroimmunol. 102 (2000) 56-66
    • (2000) J. Neuroimmunol. , vol.102 , pp. 56-66
    • Ichikawa, M.1    Koh, C.S.2    Inoue, A.3    Tsuyusaki, J.4    Yamazaki, M.5    Inaba, Y.6    Sekiguchi, Y.7    Itoh, M.8    Yagita, H.9    Komiyama, A.10
  • 34
    • 0028806468 scopus 로고
    • Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β
    • Issazadeh S., Ljungdahl A., Hojeberg B., Mustafa M., and Olsson T. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β. J. Neuroimmunol. 61 (1995) 205-212
    • (1995) J. Neuroimmunol. , vol.61 , pp. 205-212
    • Issazadeh, S.1    Ljungdahl, A.2    Hojeberg, B.3    Mustafa, M.4    Olsson, T.5
  • 35
    • 0030248470 scopus 로고    scopus 로고
    • Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β
    • Issazadeh S., Lorentzen J.C., Mustafa M.I., Hojeberg B., Mussener A., and Olsson T. Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β. J. Neuroimmunol. 69 (1996) 103-115
    • (1996) J. Neuroimmunol. , vol.69 , pp. 103-115
    • Issazadeh, S.1    Lorentzen, J.C.2    Mustafa, M.I.3    Hojeberg, B.4    Mussener, A.5    Olsson, T.6
  • 37
    • 30144433577 scopus 로고    scopus 로고
    • Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma
    • Kelchtermans H., De Klerck B., Mitera T., Van Balen M., Bullens D., Billiau A., Leclercq G., and Matthys P. Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma. Arthritis Res. Ther. 7 (2005) R402-R415
    • (2005) Arthritis Res. Ther. , vol.7
    • Kelchtermans, H.1    De Klerck, B.2    Mitera, T.3    Van Balen, M.4    Bullens, D.5    Billiau, A.6    Leclercq, G.7    Matthys, P.8
  • 38
    • 0036838536 scopus 로고    scopus 로고
    • Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • Kohm A.P., Carpentier P.A., Anger H.A., and Miller S.D. Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169 (2002) 4712-4716
    • (2002) J. Immunol. , vol.169 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 39
    • 0023236981 scopus 로고
    • Induction of synchronized relapses in SJL/J mice with chronic relapsing experimental allergic encephalomyelitis
    • Kozlowski P.B., Schuller-Lewis G.B., and Wisniewski H.M. Induction of synchronized relapses in SJL/J mice with chronic relapsing experimental allergic encephalomyelitis. Acta Neuropathol. 74 (1987) 163-168
    • (1987) Acta Neuropathol. , vol.74 , pp. 163-168
    • Kozlowski, P.B.1    Schuller-Lewis, G.B.2    Wisniewski, H.M.3
  • 40
    • 0029957071 scopus 로고    scopus 로고
    • Interferon-γ confers resistance to experimental allergic encephalomyelitis
    • Krakowski M., and Owens T. Interferon-γ confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 26 (1996) 1641-1646
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1641-1646
    • Krakowski, M.1    Owens, T.2
  • 41
    • 0025999081 scopus 로고
    • Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats
    • Kuroda Y., and Shimamoto Y. Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats. J. Neuroimmunol. 34 (1991) 159-164
    • (1991) J. Neuroimmunol. , vol.34 , pp. 159-164
    • Kuroda, Y.1    Shimamoto, Y.2
  • 42
    • 0030739650 scopus 로고    scopus 로고
    • Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
    • Lafaille J.J., Keere F.V., Hsu A.L., Baron J.L., Haas W., Raine C.S., and Tonegawa S. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186 (1997) 307-312
    • (1997) J. Exp. Med. , vol.186 , pp. 307-312
    • Lafaille, J.J.1    Keere, F.V.2    Hsu, A.L.3    Baron, J.L.4    Haas, W.5    Raine, C.S.6    Tonegawa, S.7
  • 43
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
    • Lenardo M.J. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature 353 (1991) 858-861
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 44
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard J.P., Waldburger K.E., and Goldman S.J. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181 (1995) 381-386
    • (1995) J. Exp. Med. , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 45
    • 0030475608 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis by interleukin-12
    • Leonard J.P., Waldburger K.E., and Goldman S.J. Regulation of experimental autoimmune encephalomyelitis by interleukin-12. Ann. N.Y. Acad. Sci. 795 (1996) 216-226
    • (1996) Ann. N.Y. Acad. Sci. , vol.795 , pp. 216-226
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 48
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells
    • Manetti R., Parronchi P., Guidizi M.G., Piccinni M.-P., Maggi E., Trinchieri G., and Romagnani S. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells. J. Exp. Med. 177 (1993) 1199-1204
    • (1993) J. Exp. Med. , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Guidizi, M.G.3    Piccinni, M.-P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 50
    • 0028969526 scopus 로고
    • Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of Lewis rats with myelin basic protein
    • Martin D., Near S.L., Bendele A., and Russell D.A. Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of Lewis rats with myelin basic protein. Exp. Neurol. 131 (1995) 221-228
    • (1995) Exp. Neurol. , vol.131 , pp. 221-228
    • Martin, D.1    Near, S.L.2    Bendele, A.3    Russell, D.A.4
  • 51
    • 23844478869 scopus 로고    scopus 로고
    • Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system
    • McGeachy M.J., Stephens L.A., and Anderton S.M. Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system. J. Immunol. 175 (2005) 3025-3032
    • (2005) J. Immunol. , vol.175 , pp. 3025-3032
    • McGeachy, M.J.1    Stephens, L.A.2    Anderton, S.M.3
  • 52
    • 0028329177 scopus 로고
    • Effects of IL-12 on helper T cell-dependent immune responses in vivo
    • McKnight A.J., Zimmer G.J., Fogelman I., Wolf S.F., and Abbas A.K. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152 (1994) 2172-2179
    • (1994) J. Immunol. , vol.152 , pp. 2172-2179
    • McKnight, A.J.1    Zimmer, G.J.2    Fogelman, I.3    Wolf, S.F.4    Abbas, A.K.5
  • 53
    • 0029038922 scopus 로고
    • A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells
    • Mendel I., Kerlero de Rosbo N., and Ben-Nun A. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells. Eur. J. Immunol. 25 (1995) 1951-1959
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1951-1959
    • Mendel, I.1    Kerlero de Rosbo, N.2    Ben-Nun, A.3
  • 54
    • 0021328623 scopus 로고
    • Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice
    • Mokhtarian M.F., McFarlin D.E., and Raine C.S. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309 (1984) 356-358
    • (1984) Nature , vol.309 , pp. 356-358
    • Mokhtarian, M.F.1    McFarlin, D.E.2    Raine, C.S.3
  • 55
    • 3242740010 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies
    • Montero E., Nussbaum G., Kaye J.F., Perez R., Lage A., Ben-Nun A., and Cohen I.R. Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodies. J. Autoimmun. 23 (2004) 1-7
    • (2004) J. Autoimmun. , vol.23 , pp. 1-7
    • Montero, E.1    Nussbaum, G.2    Kaye, J.F.3    Perez, R.4    Lage, A.5    Ben-Nun, A.6    Cohen, I.R.7
  • 57
    • 0030465405 scopus 로고    scopus 로고
    • Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice
    • O'Hara Jr. R.M., Henderson S.L., and Nagelin A. Prevention of a Th1 disease by a Th1 cytokine: IL-12 and diabetes in NOD mice. Ann. N.Y. Acad. Sci. 795 (1996) 241-249
    • (1996) Ann. N.Y. Acad. Sci. , vol.795 , pp. 241-249
    • O'Hara Jr., R.M.1    Henderson, S.L.2    Nagelin, A.3
  • 58
    • 0028990468 scopus 로고
    • Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Olsson T. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 144 (1995) 245-268
    • (1995) Immunol. Rev. , vol.144 , pp. 245-268
    • Olsson, T.1
  • 60
    • 0028959239 scopus 로고
    • The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis
    • Owens T., and Sriram S. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis. Neurol. Clin. 13 (1995) 51-73
    • (1995) Neurol. Clin. , vol.13 , pp. 51-73
    • Owens, T.1    Sriram, S.2
  • 62
    • 0034607616 scopus 로고    scopus 로고
    • Interleukin-2 gene deletion produces a robust reduction in susceptibility to experimental autoimmune encephalomyelitis in C57BL/6 mice
    • Petitto J.M., Streit W.J., Huang Z., Butfiloski E., and Schiffenbauer J. Interleukin-2 gene deletion produces a robust reduction in susceptibility to experimental autoimmune encephalomyelitis in C57BL/6 mice. Neurosci. Lett. 285 (2000) 66-70
    • (2000) Neurosci. Lett. , vol.285 , pp. 66-70
    • Petitto, J.M.1    Streit, W.J.2    Huang, Z.3    Butfiloski, E.4    Schiffenbauer, J.5
  • 63
    • 17544398702 scopus 로고    scopus 로고
    • Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
    • Refaeli Y., Van Parijs L., London C.A., Tschopp J., and Abbas A.K. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8 (1998) 615-623
    • (1998) Immunity , vol.8 , pp. 615-623
    • Refaeli, Y.1    Van Parijs, L.2    London, C.A.3    Tschopp, J.4    Abbas, A.K.5
  • 64
    • 0025000863 scopus 로고
    • An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis
    • Ruddle N.H., Bergman C.M., McGrath K.M., Lingenheld E.G., Grunnet M.L., Padula S.J., and Clark R.B. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 172 (1990) 1193-1200
    • (1990) J. Exp. Med. , vol.172 , pp. 1193-1200
    • Ruddle, N.H.1    Bergman, C.M.2    McGrath, K.M.3    Lingenheld, E.G.4    Grunnet, M.L.5    Padula, S.J.6    Clark, R.B.7
  • 65
    • 0029788704 scopus 로고    scopus 로고
    • IL-12 unmasks latent autoimmune disease in resistant mice
    • Segal B.M., and Shevach E.M. IL-12 unmasks latent autoimmune disease in resistant mice. J. Exp. Med. 184 (1996) 771-775
    • (1996) J. Exp. Med. , vol.184 , pp. 771-775
    • Segal, B.M.1    Shevach, E.M.2
  • 66
    • 0031156982 scopus 로고    scopus 로고
    • Microbial products induce autoimmune disease by an IL-12-dependent pathway
    • Segal B.M., Klinman D.M., and Shevach E.M. Microbial products induce autoimmune disease by an IL-12-dependent pathway. J. Immunol. 158 (1997) 5087-5090
    • (1997) J. Immunol. , vol.158 , pp. 5087-5090
    • Segal, B.M.1    Klinman, D.M.2    Shevach, E.M.3
  • 67
    • 0032536447 scopus 로고    scopus 로고
    • An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
    • Segal B.M., Dwyer B.K., and Shevach E.M. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187 (1998) 537-546
    • (1998) J. Exp. Med. , vol.187 , pp. 537-546
    • Segal, B.M.1    Dwyer, B.K.2    Shevach, E.M.3
  • 68
    • 0026094706 scopus 로고
    • Anti-tumor necrosis factor therapy abrogates autoimmune demyelination
    • Selmaj K., Raine C.S., and Cross A.H. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol. 30 (1991) 694-700
    • (1991) Ann. Neurol. , vol.30 , pp. 694-700
    • Selmaj, K.1    Raine, C.S.2    Cross, A.H.3
  • 69
    • 0030944709 scopus 로고    scopus 로고
    • IL-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat
    • Smith T., Hewson A.K., Kingsley C.I., Leonard J.P., and Cuzner M.L. IL-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat. Am. J. Pathol. 150 (1997) 1909-1917
    • (1997) Am. J. Pathol. , vol.150 , pp. 1909-1917
    • Smith, T.1    Hewson, A.K.2    Kingsley, C.I.3    Leonard, J.P.4    Cuzner, M.L.5
  • 70
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain S.L., Weinberg A.D., English M., and Huston G. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145 (1990) 3796-3806
    • (1990) J. Immunol. , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 71
    • 0031043631 scopus 로고    scopus 로고
    • Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis
    • Tanuma N., Kojima T., Shin T., Aikawa Y., Kohji T., Ishihara Y., and Matsumoto Y. Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis. J. Neuroimmunol. 73 (1997) 197-206
    • (1997) J. Neuroimmunol. , vol.73 , pp. 197-206
    • Tanuma, N.1    Kojima, T.2    Shin, T.3    Aikawa, Y.4    Kohji, T.5    Ishihara, Y.6    Matsumoto, Y.7
  • 72
    • 0031803057 scopus 로고    scopus 로고
    • Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis
    • Tarrant T.K., Silver P.B., Chan C.-C., Wiggert B., and Caspi R.R. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J. Immunol. 161 (1998) 122-127
    • (1998) J. Immunol. , vol.161 , pp. 122-127
    • Tarrant, T.K.1    Silver, P.B.2    Chan, C.-C.3    Wiggert, B.4    Caspi, R.R.5
  • 73
    • 0033579881 scopus 로고    scopus 로고
    • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis
    • Tarrant T.K., Silver P.B., Wahlsten J.L., Rizzo L.V., Chan C.C., Wiggert B., and Caspi R.R. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J. Exp. Med. 189 (1999) 219-230
    • (1999) J. Exp. Med. , vol.189 , pp. 219-230
    • Tarrant, T.K.1    Silver, P.B.2    Wahlsten, J.L.3    Rizzo, L.V.4    Chan, C.C.5    Wiggert, B.6    Caspi, R.R.7
  • 74
    • 0028970060 scopus 로고
    • Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13 (1995) 251-276
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 75
    • 0027141832 scopus 로고
    • Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: relative roles of interleukin (IL)-4 and IL-10
    • van der Veen R.C., and Stohlman S.A. Encephalitogenic Th1 cells are inhibited by Th2 cells with related peptide specificity: relative roles of interleukin (IL)-4 and IL-10. J. Neuroimmunol. 48 (1993) 213-220
    • (1993) J. Neuroimmunol. , vol.48 , pp. 213-220
    • van der Veen, R.C.1    Stohlman, S.A.2
  • 77
    • 0030039962 scopus 로고    scopus 로고
    • Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12-preferential expansion of interferon-γ-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms
    • Waldburger K.E., Hastings R.C., Schaub R.G., Goldman S.J., and Leonard J.P. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12-preferential expansion of interferon-γ-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms. Am. J. Pathol. 148 (1996) 375-382
    • (1996) Am. J. Pathol. , vol.148 , pp. 375-382
    • Waldburger, K.E.1    Hastings, R.C.2    Schaub, R.G.3    Goldman, S.J.4    Leonard, J.P.5
  • 78
    • 0242468114 scopus 로고    scopus 로고
    • IL-5-deficient mice are susceptible to experimental autoimmune encephalomyelitis
    • Weir C., Bernard C.C., and Backstrom B.T. IL-5-deficient mice are susceptible to experimental autoimmune encephalomyelitis. Int. Immunol. 15 (2003) 1283-1289
    • (2003) Int. Immunol. , vol.15 , pp. 1283-1289
    • Weir, C.1    Bernard, C.C.2    Backstrom, B.T.3
  • 79
    • 0035884845 scopus 로고    scopus 로고
    • The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunity
    • Wensky A., Marcondes M.C., and Lafaille J.J. The role of IFN-gamma in the production of Th2 subpopulations: implications for variable Th2-mediated pathologies in autoimmunity. J. Immunol. 167 (2001) 3074-3081
    • (2001) J. Immunol. , vol.167 , pp. 3074-3081
    • Wensky, A.1    Marcondes, M.C.2    Lafaille, J.J.3
  • 80
    • 0030587910 scopus 로고    scopus 로고
    • IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Willenborg D.O., Fordham S., Bernard C.C.A., Cowden W.B., and Ramshaw I.A. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157 (1996) 3223-3227
    • (1996) J. Immunol. , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.A.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 83
    • 0031586024 scopus 로고    scopus 로고
    • Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis
    • Xu H., Rizzo L.V., Silver P.B., and Caspi R.R. Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of early and committed effector T cells in experimental autoimmune uveitis. Cell. Immunol. 178 (1997) 69-78
    • (1997) Cell. Immunol. , vol.178 , pp. 69-78
    • Xu, H.1    Rizzo, L.V.2    Silver, P.B.3    Caspi, R.R.4
  • 84
    • 0036036384 scopus 로고    scopus 로고
    • Differential expression of cytokines (IL-2, IFN-gamma, IL-10) and adhesion molecules (VCAM-1, LFA-1, CD44) between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis
    • Yang J., Lindsberg P.J., Hukkanen V., Seljelid R., Gahmberg C.G., and Meri S. Differential expression of cytokines (IL-2, IFN-gamma, IL-10) and adhesion molecules (VCAM-1, LFA-1, CD44) between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis. Scand. J. Immunol. 56 (2002) 286-293
    • (2002) Scand. J. Immunol. , vol.56 , pp. 286-293
    • Yang, J.1    Lindsberg, P.J.2    Hukkanen, V.3    Seljelid, R.4    Gahmberg, C.G.5    Meri, S.6
  • 85
    • 0033065120 scopus 로고    scopus 로고
    • The involvement of IL-12 in murine experimentally induced autoimmune thyroid disease
    • Zaccone P., Hutchings P., Nicoletti F., Penna G., Adorini L., and Cooke A. The involvement of IL-12 in murine experimentally induced autoimmune thyroid disease. Eur. J. Immunol. 29 (1999) 1933-1942
    • (1999) Eur. J. Immunol. , vol.29 , pp. 1933-1942
    • Zaccone, P.1    Hutchings, P.2    Nicoletti, F.3    Penna, G.4    Adorini, L.5    Cooke, A.6
  • 86
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • Zamvil S.S., and Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8 (1990) 579-621
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 579-621
    • Zamvil, S.S.1    Steinman, L.2
  • 87
    • 0037442020 scopus 로고    scopus 로고
    • Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
    • Zhang G.X., Gran B., Yu S., Li J., Siglienti I., Chen X., Kamoun M., and Rostami A. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J. Immunol. 170 (2003) 2153-2160
    • (2003) J. Immunol. , vol.170 , pp. 2153-2160
    • Zhang, G.X.1    Gran, B.2    Yu, S.3    Li, J.4    Siglienti, I.5    Chen, X.6    Kamoun, M.7    Rostami, A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.