메뉴 건너뛰기




Volumn 206, Issue 8, 2009, Pages 1755-1767

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; MYELIN BASIC PROTEIN; TRANSCRIPTION FACTOR T BET;

EID: 68149100383     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20082118     Document Type: Article
Times cited : (135)

References (64)
  • 1
    • 34248374256 scopus 로고    scopus 로고
    • Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cells
    • Adler, H.S., S. Kubsch, E. Graulich, S. Ludwig, J. Knop, and K. Steinbrink. 2007. Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cells. Blood. 109:4351-4359.
    • (2007) Blood , vol.109 , pp. 4351-4359
    • Adler, H.S.1    Kubsch, S.2    Graulich, E.3    Ludwig, S.4    Knop, J.5    Steinbrink, K.6
  • 2
    • 33847163271 scopus 로고    scopus 로고
    • CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    • Anderson, C.F., M. Oukka, V.J. Kuchroo, and D. Sacks. 2007. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204:285-297.
    • (2007) J. Exp. Med , vol.204 , pp. 285-297
    • Anderson, C.F.1    Oukka, M.2    Kuchroo, V.J.3    Sacks, D.4
  • 5
    • 4344610090 scopus 로고    scopus 로고
    • Naive T cells are resistant to anergy induction by anti-CD3 antibodies
    • Andris, F., S. Denanglaire, F. de Mattia, J. Urbain, and O. Leo. 2004. Naive T cells are resistant to anergy induction by anti-CD3 antibodies. J. Immunol. 173:3201-3208.
    • (2004) J. Immunol , vol.173 , pp. 3201-3208
    • Andris, F.1    Denanglaire, S.2    de Mattia, F.3    Urbain, J.4    Leo, O.5
  • 6
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman, C., S. Mauze, M.W. Leach, R.L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995-1004.
    • (1999) J. Exp. Med , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 7
  • 8
    • 0026047598 scopus 로고
    • Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor β-chain transgenic mice
    • Blackman, M.A., T.H. Finkel, J. Kappler, J. Cambier, and P. Marrack. 1991. Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor β-chain transgenic mice. Proc. Natl. Acad. Sci. USA. 88:6682-6686.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6682-6686
    • Blackman, M.A.1    Finkel, T.H.2    Kappler, J.3    Cambier, J.4    Marrack, P.5
  • 9
    • 0032821774 scopus 로고    scopus 로고
    • Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
    • Burkhart, C., G.Y. Liu, S.M. Anderton, B. Metzler, and D.C. Wraith. 1999. Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int. Immunol. 11:1625-1634.
    • (1999) Int. Immunol , vol.11 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Anderton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 10
    • 0029031681 scopus 로고
    • Peripheral deletion of antigen-reactive T cells in oral tolerance
    • Chen, Y., J. Inobe, R. Marks, P. Gonnella, V.K. Kuchroo, and H.L. Weiner. 1995. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 376:177-180.
    • (1995) Nature , vol.376 , pp. 177-180
    • Chen, Y.1    Inobe, J.2    Marks, R.3    Gonnella, P.4    Kuchroo, V.K.5    Weiner, H.L.6
  • 13
    • 0026000892 scopus 로고
    • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
    • de Waal Malefyt, R., J. Haanen, H. Spits, M.G. Roncarolo, A. te Velde, C. Figdor, K. Johnson, R. Kastelein, H. Yssel, and J.E. de Vries. 1991. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174:915-924.
    • (1991) J. Exp. Med , vol.174 , pp. 915-924
    • de Waal1    Malefyt, R.2    Haanen, J.3    Spits, H.4    Roncarolo, M.G.5    te Velde, A.6    Figdor, C.7    Johnson, K.8    Kastelein, R.9    Yssel, H.10    de Vries, J.E.11
  • 14
    • 0037099733 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells
    • Dieckmann, D., C.H. Bruett, H. Ploettner, M.B. Lutz, and G. Schuler. 2002. Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med. 196:247-253.
    • (2002) J. Exp. Med , vol.196 , pp. 247-253
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, G.5
  • 17
    • 0030058433 scopus 로고    scopus 로고
    • Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells
    • Groux, H., M. Bigler, J.E. de Vries, and M.-G. Roncarolo. 1996. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J. Exp. Med. 184:19-29.
    • (1996) J. Exp. Med , vol.184 , pp. 19-29
    • Groux, H.1    Bigler, M.2    de Vries, J.E.3    Roncarolo, M.-G.4
  • 18
    • 0030062937 scopus 로고    scopus 로고
    • Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice
    • Guery, J.C., F. Galbiati, S. Smiroldo, and L. Adorini. 1996. Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485-497.
    • (1996) J. Exp. Med , vol.183 , pp. 485-497
    • Guery, J.C.1    Galbiati, F.2    Smiroldo, S.3    Adorini, L.4
  • 19
    • 66049149509 scopus 로고    scopus 로고
    • Identification and characterization of IL-10/IFN-γ-producing effector-like T cells with regulatory function in human blood
    • Haringer, B., L. Lozza, B. Steckel, and J. Geginat. 2009. Identification and characterization of IL-10/IFN-γ-producing effector-like T cells with regulatory function in human blood. J. Exp. Med. 206:1009-1017.
    • (2009) J. Exp. Med , vol.206 , pp. 1009-1017
    • Haringer, B.1    Lozza, L.2    Steckel, B.3    Geginat, J.4
  • 20
    • 10344239897 scopus 로고    scopus 로고
    • Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells
    • Harris, J.E., K.D. Bishop, N.E. Phillips, J.P. Mordes, D.L. Greiner, A.A. Rossini, and M.P. Czech. 2004. Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells. J. Immunol. 173:7331-7338.
    • (2004) J. Immunol , vol.173 , pp. 7331-7338
    • Harris, J.E.1    Bishop, K.D.2    Phillips, N.E.3    Mordes, J.P.4    Greiner, D.L.5    Rossini, A.A.6    Czech, M.P.7
  • 21
    • 0031882452 scopus 로고    scopus 로고
    • Differences between responses of naive and activated T cells to anergy induction
    • Hayashi, R.J., D.Y. Loh, O. Kanagawa, and F. Wang. 1998. Differences between responses of naive and activated T cells to anergy induction. J. Immunol. 160:33-38.
    • (1998) J. Immunol , vol.160 , pp. 33-38
    • Hayashi, R.J.1    Loh, D.Y.2    Kanagawa, O.3    Wang, F.4
  • 22
    • 13344259977 scopus 로고    scopus 로고
    • Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells
    • Heufler, C., F. Koch, U. Stanzl, G. Topar, M. Wysocka, G. Trinchieri, A. Enk, R.M. Steinman, N. Romani, and G. Schuler. 1996. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur. J. Immunol. 26:659-668.
    • (1996) Eur. J. Immunol , vol.26 , pp. 659-668
    • Heufler, C.1    Koch, F.2    Stanzl, U.3    Topar, G.4    Wysocka, M.5    Trinchieri, G.6    Enk, A.7    Steinman, R.M.8    Romani, N.9    Schuler, G.10
  • 23
    • 0029962451 scopus 로고    scopus 로고
    • Negative feedback mechanism suppresses interleukin-12 production by antigen-presenting cells interacting with T helper 2 cells
    • Hino, A., and H. Nariuchi. 1996. Negative feedback mechanism suppresses interleukin-12 production by antigen-presenting cells interacting with T helper 2 cells. Eur. J. Immunol. 26:623-628.
    • (1996) Eur. J. Immunol , vol.26 , pp. 623-628
    • Hino, A.1    Nariuchi, H.2
  • 24
    • 0027451437 scopus 로고
    • Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice
    • Hoyne, G.F., R.E. O'Hehir, D.C. Wraith, W.R. Thomas, and J.R. Lamb. 1993. Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J. Exp. Med. 178:1783-1788.
    • (1993) J. Exp. Med , vol.178 , pp. 1783-1788
    • Hoyne, G.F.1    O'Hehir, R.E.2    Wraith, D.C.3    Thomas, W.R.4    Lamb, J.R.5
  • 27
    • 0030002449 scopus 로고    scopus 로고
    • IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells
    • Jeannin, P., Y. Delneste, M. Seveso, P. Life, and J.Y. Bonnefoy. 1996. IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J. Immunol. 156:3159-3165.
    • (1996) J. Immunol , vol.156 , pp. 3159-3165
    • Jeannin, P.1    Delneste, Y.2    Seveso, M.3    Life, P.4    Bonnefoy, J.Y.5
  • 28
    • 0031452406 scopus 로고    scopus 로고
    • Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences
    • Karachunski, P.I., N.S. Ostlie, D.K. Okita, and B.M. Conti-Fine. 1997. Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences. J. Clin. Invest. 100:3027-3035.
    • (1997) J. Clin. Invest , vol.100 , pp. 3027-3035
    • Karachunski, P.I.1    Ostlie, N.S.2    Okita, D.K.3    Conti-Fine, B.M.4
  • 29
    • 0028466130 scopus 로고
    • Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
    • Kearney, E.R., K.A. Pape, D.Y. Loh, and M.K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:327-339.
    • (1994) Immunity , vol.1 , pp. 327-339
    • Kearney, E.R.1    Pape, K.A.2    Loh, D.Y.3    Jenkins, M.K.4
  • 30
    • 0029831666 scopus 로고    scopus 로고
    • High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
    • Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kampgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741-746.
    • (1996) J. Exp. Med , vol.184 , pp. 741-746
    • Koch, F.1    Stanzl, U.2    Jennewein, P.3    Janke, K.4    Heufler, C.5    Kampgen, E.6    Romani, N.7    Schuler, G.8
  • 31
    • 1642529495 scopus 로고    scopus 로고
    • Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen
    • Kohyama, M., D. Sugahara, S. Sugiyama, H. Yagita, K. Okumura, and N. Hozumi. 2004. Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen. Proc. Natl. Acad. Sci. USA. 101:4192-4197.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4192-4197
    • Kohyama, M.1    Sugahara, D.2    Sugiyama, S.3    Yagita, H.4    Okumura, K.5    Hozumi, N.6
  • 32
    • 12844274909 scopus 로고    scopus 로고
    • Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
    • Levings, M.K., S. Gregori, E. Tresoldi, S. Cazzaniga, C. Bonini, and M.G. Roncarolo. 2005. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. Blood. 105:1162-1169.
    • (2005) Blood , vol.105 , pp. 1162-1169
    • Levings, M.K.1    Gregori, S.2    Tresoldi, E.3    Cazzaniga, S.4    Bonini, C.5    Roncarolo, M.G.6
  • 34
    • 0028824098 scopus 로고
    • Low avidity recognition of self-antigen by T cells permits escape from central tolerance
    • Liu, G.Y., P.J. Fairchild, R.M. Smith, J.R. Prowle, D. Kioussis, and D.C. Wraith. 1995. Low avidity recognition of self-antigen by T cells permits escape from central tolerance. Immunity. 3:407-415.
    • (1995) Immunity , vol.3 , pp. 407-415
    • Liu, G.Y.1    Fairchild, P.J.2    Smith, R.M.3    Prowle, J.R.4    Kioussis, D.5    Wraith, D.C.6
  • 35
    • 0037455003 scopus 로고    scopus 로고
    • Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10
    • Lohning, M., A. Hutloff, T. Kallinich, H.W. Mages, K. Bonhagen, A. Radbruch, E. Hamelmann, and R.A. Kroczek. 2003. Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J. Exp. Med. 197:181-193.
    • (2003) J. Exp. Med , vol.197 , pp. 181-193
    • Lohning, M.1    Hutloff, A.2    Kallinich, T.3    Mages, H.W.4    Bonhagen, K.5    Radbruch, A.6    Hamelmann, E.7    Kroczek, R.A.8
  • 38
    • 0037450740 scopus 로고    scopus 로고
    • Prevention of arthritis by interleukin 10-producing B cells
    • Mauri, C., D. Gray, N. Mushtaq, and M. Londei. 2003. Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med. 197:489-501.
    • (2003) J. Exp. Med , vol.197 , pp. 489-501
    • Mauri, C.1    Gray, D.2    Mushtaq, N.3    Londei, M.4
  • 39
    • 0027380361 scopus 로고
    • Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: Influence of MHC binding affinity
    • Metzler, B., and D.C. Wraith. 1993. Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity. Int. Immunol. 5:1159-1165.
    • (1993) Int. Immunol , vol.5 , pp. 1159-1165
    • Metzler, B.1    Wraith, D.C.2
  • 41
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering
    • Miller, A., O. Lider, A.B. Roberts, M.B. Sporn, and H.L. Weiner. 1992. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc. Natl. Acad. Sci. USA. 89:421-425.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 421-425
    • Miller, A.1    Lider, O.2    Roberts, A.B.3    Sporn, M.B.4    Weiner, H.L.5
  • 44
    • 33646015692 scopus 로고    scopus 로고
    • Antigen-induced IL-10+ regulatory T cells are independent of CD25+ regulatory cells for their growth, differentiation, and function
    • Nicolson, K.S., E.J. O'Neill, A. Sundstedt, H.B. Streeter, S. Minaee, and D.C. Wraith. 2006. Antigen-induced IL-10+ regulatory T cells are independent of CD25+ regulatory cells for their growth, differentiation, and function. J. Immunol. 176:5329-5337.
    • (2006) J. Immunol , vol.176 , pp. 5329-5337
    • Nicolson, K.S.1    O'Neill, E.J.2    Sundstedt, A.3    Streeter, H.B.4    Minaee, S.5    Wraith, D.C.6
  • 45
    • 34249678457 scopus 로고    scopus 로고
    • T(H)1 cells control themselves by producing interleukin-10
    • O'Garra, A., and P. Vieira. 2007. T(H)1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 7:425-428.
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 425-428
    • O'Garra, A.1    Vieira, P.2
  • 46
    • 85047692430 scopus 로고    scopus 로고
    • IL-10-producing and naturally occurring CD4+ Tregs: Limiting collateral damage
    • O'Garra, A., P.L. Vieira, P. Vieira, and A.E. Goldfeld. 2004. IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage. J. Clin. Invest. 114:1372-1378.
    • (2004) J. Clin. Invest , vol.114 , pp. 1372-1378
    • O'Garra, A.1    Vieira, P.L.2    Vieira, P.3    Goldfeld, A.E.4
  • 47
    • 3543002218 scopus 로고    scopus 로고
    • Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation
    • Ohkusu-Tsukada, K., N. Tominaga, H. Udono, and K. Yui. 2004. Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation. Mol. Cell. Biol. 24:6957-6966.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 6957-6966
    • Ohkusu-Tsukada, K.1    Tominaga, N.2    Udono, H.3    Yui, K.4
  • 48
    • 33748104738 scopus 로고    scopus 로고
    • IL-10 is essential for disease protection following intranasal peptide administration in the C57BL/6 model of EAE
    • O'Neill, E.J., M.J. Day, and D.C. Wraith. 2006. IL-10 is essential for disease protection following intranasal peptide administration in the C57BL/6 model of EAE. J. Neuroimmunol. 178:1-8.
    • (2006) J. Neuroimmunol , vol.178 , pp. 1-8
    • O'Neill, E.J.1    Day, M.J.2    Wraith, D.C.3
  • 51
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
    • (1995) J. Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 53
    • 33744907022 scopus 로고    scopus 로고
    • Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation
    • Shaw, M.H., G.J. Freeman, M.F. Scott, B.A. Fox, D.J. Bzik, Y. Belkaid, and G.S. Yap. 2006. Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J. Immunol. 176:7263-7271.
    • (2006) J. Immunol , vol.176 , pp. 7263-7271
    • Shaw, M.H.1    Freeman, G.J.2    Scott, M.F.3    Fox, B.A.4    Bzik, D.J.5    Belkaid, Y.6    Yap, G.S.7
  • 54
    • 0029962104 scopus 로고    scopus 로고
    • Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope
    • Staines, N.A., N. Harper, F.J. Ward, V. Malmstrom, R. Holmdahl, and S. Bansal. 1996. Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope. Clin. Exp. Immunol. 103:368-375.
    • (1996) Clin. Exp. Immunol , vol.103 , pp. 368-375
    • Staines, N.A.1    Harper, N.2    Ward, F.J.3    Malmstrom, V.4    Holmdahl, R.5    Bansal, S.6
  • 55
    • 0030636560 scopus 로고    scopus 로고
    • Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo
    • Sundstedt, A., I. Hoiden, A. Rosendahl, T. Kalland, N. van Rooijen, and M. Dohlsten. 1997. Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo. J. Immunol. 158:180-186.
    • (1997) J. Immunol , vol.158 , pp. 180-186
    • Sundstedt, A.1    Hoiden, I.2    Rosendahl, A.3    Kalland, T.4    van Rooijen, N.5    Dohlsten, M.6
  • 56
    • 0037310355 scopus 로고    scopus 로고
    • Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo
    • Sundstedt, A., E.J. O'Neill, K.S. Nicolson, and D.C. Wraith. 2003. Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J. Immunol. 170:1240-1248.
    • (2003) J. Immunol , vol.170 , pp. 1240-1248
    • Sundstedt, A.1    O'Neill, E.J.2    Nicolson, K.S.3    Wraith, D.C.4
  • 57
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
    • Tian, J., M.A. Atkinson, M. Clare-Salzler, A. Herschenfeld, T. Forsthuber, P.V. Lehmann, and D.L. Kaufman. 1996. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. 183:1561-1567.
    • (1996) J. Exp. Med , vol.183 , pp. 1561-1567
    • Tian, J.1    Atkinson, M.A.2    Clare-Salzler, M.3    Herschenfeld, A.4    Forsthuber, T.5    Lehmann, P.V.6    Kaufman, D.L.7
  • 58
    • 0035914926 scopus 로고    scopus 로고
    • Regulatory role of T cells producing both interferon gamma and interleukin 10 in persistent infection
    • Trinchieri, G. 2001. Regulatory role of T cells producing both interferon gamma and interleukin 10 in persistent infection. J. Exp. Med. 194:F53-F57.
    • (2001) J. Exp. Med , vol.194
    • Trinchieri, G.1
  • 59
    • 33847165817 scopus 로고    scopus 로고
    • Interleukin-10 production by effector T cells: Th1 cells show self control
    • Trinchieri, G. 2007. Interleukin-10 production by effector T cells: Th1 cells show self control. J. Exp. Med. 204:239-243.
    • (2007) J. Exp. Med , vol.204 , pp. 239-243
    • Trinchieri, G.1
  • 64
    • 53349145748 scopus 로고    scopus 로고
    • Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease
    • Zhu, B., A.L. Symonds, J.E. Martin, D. Kioussis, D.C. Wraith, S. Li, and P. Wang. 2008. Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J. Exp. Med. 205:2295-2307.
    • (2008) J. Exp. Med , vol.205 , pp. 2295-2307
    • Zhu, B.1    Symonds, A.L.2    Martin, J.E.3    Kioussis, D.4    Wraith, D.C.5    Li, S.6    Wang, P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.