IL-21 and IL-21 Receptor: A New Cytokine Pathway Modulates Innate and Adaptive Immunity

Immunologic Research

Volumn 28, Issue 2, 2003, Pages 131-140

  Collins, Mary ^a   Whitters, Matthew J ^a   Young, Deborah A ^a  

^a PFIZER INC   (United States)

Author keywords

Common; B cell; Cytokine; IL 21; IL 21R; IL 21R Deficient mice; NK cell; T cell

Indexed keywords

CYTOKINE; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN RECEPTOR; UNCLASSIFIED DRUG;

B LYMPHOCYTE; CELL DIFFERENTIATION; CHROMOSOME REARRANGEMENT; CYTOKINE PRODUCTION; DNA SEQUENCE; EXON; GENE STRUCTURE; IMMUNOMODULATION; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; HUMANS; INTERLEUKIN-15; INTERLEUKIN-21 RECEPTOR ALPHA SUBUNIT; INTERLEUKINS; KILLER CELLS, NATURAL; MICE; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-21; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 0344394529     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:28:2:131     Document Type: Review

References (21)

1. Bazan JF: Structural design and molecular evolution of a cytokine receptor superfamily. Proc Nat Acad Sci USA 1990;87:6934-6938.
2. Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, et al.: IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 2002;16:559-569.
3. Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, et al.: Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 2000;408:57-63.
4. Ozaki K, Kikly K, Michalovich D, Young PR, Leonard WJ: Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc Nat Acad Sci USA 2000;97:11439-11444.
5. Leonard WJ, O'Shea JJ: Jaks and STATs: biological implications. Ann Rev Immunol 1998;16:293-322.
6. Parrish-Novak J, Foster DC, Holly RD, Clegg CH: Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukocyte Biol 2002;72: 856-863.
7. Anderson DM, Johnson L, Glaccum MB, Copeland NG, Gilbert DJ, Jenkins NA, et al.: Chromosomal assignment and genomic structure of IL15. Genomics 1995;25: 701-706.
8. Wurster AL, Rodgers VL, Satoskar AR, Whitters MJ, Young DA, Collins M, Grusby MJ: Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med 2002;196: 969-977.
9. Tagaya Y, Bamford RN, DeFilippis AP, Waldmann TA: IL-15: a pleiotropic cytokine with diverse receptor/ signaling pathways whose expression is controlled at multiple levels. Immunity 1996;4:329-336.
10. Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K: Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 2001;167:1-5.
11. Habib T, Senadheera S, Weinberg K, Kaushansky K: The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry 2002;41:8725-8731.
12. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O: Signaling through the hematopoietic cytokine receptors. Ann Rev Immunol 1995;13:369-398.
13. Strengell M, Sareneva T, Foster D, Julkunen I, Matikainen S: IL-21 Up-regulates the expression of genes associated with innate immunity and Th1 response. J Immunol 2002;169:3600-3605.
14. Brenne AT, Baade Ro T, Waage A, Sundan A, Borset M, Hjorth-Hansen H: Interleukin-21 is a growth and survival factor for human myeloma cells. Blood 2002;99: 3756-3762.
15. Suto A, Nakajima H, Hirose K, Suzuki K, Kagami SI, Seto Y, et al. Interleukin-21 prevents antigen-induced IgE production by inhibiting germline Cε transcription of IL-4-stimulated B cells. Blood 2002;100:4565-4573.
16. Kennedy MK, Glaccum M, Brown SN, Butz EA, Viney JL, Embers M, et al.: Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 2000;191:771-780.
17. Ozaki K, Spolski R, Feng CG, Qi CF, Cheng J, Sher A, et al.: A critical role for IL-21 in regulating immunoglobulin production. Science 2002;298:1630-1634.
18. Van Leeuwen EM, Gamadia LE, Baars PA, Remmerswaal EB, Ten Berge IJ, Van Lier RA: Proliferation requirements of cytomegalovirus-specific, effector-type human CD8(+) T cells. J Immunol 2002;169: 5838-5843.
19. Kuhn R, Rajewsky K, Muller W: Generation and analysis of interleukin-4 deficient mice. Science 1991;254: 707-710.
20. Ueda C, Akasaka T, Kurata M, Maesako Y, Nishikori M, Ichinohasama R, et al.: The gene for interleukin-21 receptor is the partner of BCL6 in t(3;16)(q27;p11), which is recurrently observed in diffuse large B-cell lymphoma. Oncogene 2002;21:368-376.
21. Bennett F, Luxenberg D, Ling V, Wang I-M, Marquette K, Lowe D, et al.: PD-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4 and IL-21, but not CD28, IL-7 and IL-15 responses. J Immunol 2003; 170:711-718.