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Volumn 40, Issue 11, 2010, Pages 3210-3219

Lck regulates IL-10 expression in memory-like Th1 cells

Author keywords

IL 10; Memory; Signal transduction; Th1

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; PROTEIN KINASE LCK; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GATA3 PROTEIN, MOUSE; INTERLEUKIN 12; INTERLEUKIN 4; L SELECTIN; MAF PROTEIN, MOUSE; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR TBX21; T-BOX TRANSCRIPTION FACTOR TBX21; TRANSCRIPTION FACTOR C MAF;

EID: 79952114730     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040699     Document Type: Article
Times cited : (11)

References (53)
  • 1
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy, K. M. and Reiner, S. L., The lineage decisions of helper T cells. Nat. Rev. Immunol. 2002. 2: 933-944.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 2
    • 1242274405 scopus 로고    scopus 로고
    • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    • Pai, S. Y., Truitt, M. L. and Ho, I. C., GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl. Acad. Sci. USA 2004. 101: 1993-1998.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1993-1998
    • Pai, S.Y.1    Truitt, M.L.2    Ho, I.C.3
  • 3
    • 34249678457 scopus 로고    scopus 로고
    • T(H)1 cells control themselves by producing interleukin-10
    • O'Garra, A. and Vieira, P., T(H)1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 2007. 7: 425-428.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 425-428
    • O'Garra, A.1    Vieira, P.2
  • 4
    • 55149094739 scopus 로고    scopus 로고
    • Interleukin-10: new perspectives on an old cytokine
    • Mosser, D. M. and Zhang, X., Interleukin-10: new perspectives on an old cytokine. Immunol. Rev. 2008. 226: 205-218.
    • (2008) Immunol. Rev. , vol.226 , pp. 205-218
    • Mosser, D.M.1    Zhang, X.2
  • 5
    • 33847163271 scopus 로고    scopus 로고
    • CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    • Anderson, C. F., Oukka, M., Kuchroo, V. J. and Sacks, D., CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 2007. 204: 285-297.
    • (2007) J. Exp. Med. , vol.204 , pp. 285-297
    • Anderson, C.F.1    Oukka, M.2    Kuchroo, V.J.3    Sacks, D.4
  • 6
    • 33847144180 scopus 로고    scopus 로고
    • Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    • Jankovic, D., Kullberg, M. C., Feng, C. G., Goldszmid, R. S., Collazo, C. M., Wilson, M., Wynn, T. A. et al., Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med. 2007. 204: 273-283.
    • (2007) J. Exp. Med. , vol.204 , pp. 273-283
    • Jankovic, D.1    Kullberg, M.C.2    Feng, C.G.3    Goldszmid, R.S.4    Collazo, C.M.5    Wilson, M.6    Wynn, T.A.7
  • 7
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva, M., Christensen, J. R., Veldhoen, M., Murphy, T. L., Murphy, K. M. and O'Garra, A., Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 2009. 31: 209-219.
    • (2009) Immunity , vol.31 , pp. 209-219
    • Saraiva, M.1    Christensen, J.R.2    Veldhoen, M.3    Murphy, T.L.4    Murphy, K.M.5    O'Garra, A.6
  • 10
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski, R., Kim, H. P., Zhu, W., Levy, D. E. and Leonard, W. J., IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 2009. 182: 2859-2867.
    • (2009) J. Immunol. , vol.182 , pp. 2859-2867
    • Spolski, R.1    Kim, H.P.2    Zhu, W.3    Levy, D.E.4    Leonard, W.J.5
  • 12
    • 33646053861 scopus 로고    scopus 로고
    • Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function
    • Au-Yeung, B. B., Katzman, S. D. and Fowell, D. J., Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J. Immunol. 2006. 176: 3895-3899.
    • (2006) J. Immunol. , vol.176 , pp. 3895-3899
    • Au-Yeung, B.B.1    Katzman, S.D.2    Fowell, D.J.3
  • 13
    • 0035222187 scopus 로고    scopus 로고
    • A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation
    • Das, J., Chen, C. H., Yang, L., Cohn, L., Ray, P. and Ray, A., A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat. Immunol. 2001. 2: 45-50.
    • (2001) Nat. Immunol. , vol.2 , pp. 45-50
    • Das, J.1    Chen, C.H.2    Yang, L.3    Cohn, L.4    Ray, P.5    Ray, A.6
  • 14
    • 0036247432 scopus 로고    scopus 로고
    • T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J. Allergy Clin
    • Nel, A. E., T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. J. Allergy Clin. Immunol. 2002. 109: 758-770.
    • (2002) Immunol. , vol.109 , pp. 758-770
    • Nel, A.E.1
  • 15
    • 0036279840 scopus 로고    scopus 로고
    • T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy
    • Nel, A. E. and Slaughter, N., T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy. J. Allergy Clin. Immunol. 2002. 109: 901-915.
    • (2002) J. Allergy Clin. Immunol. , vol.109 , pp. 901-915
    • Nel, A.E.1    Slaughter, N.2
  • 16
    • 0032525233 scopus 로고    scopus 로고
    • Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
    • Rincon, M., Enslen, H., Raingeaud, J., Recht, M., Zapton, T., Su, M. S., Penix, L. A. et al., Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 1998. 17: 2817-2829.
    • (1998) EMBO J. , vol.17 , pp. 2817-2829
    • Rincon, M.1    Enslen, H.2    Raingeaud, J.3    Recht, M.4    Zapton, T.5    Su, M.S.6    Penix, L.A.7
  • 17
    • 0033514317 scopus 로고    scopus 로고
    • T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation
    • Yamashita, M., Kimura, M., Kubo, M., Shimizu, C., Tada, T., Perlmutter, R. M. and Nakayama, T., T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc. Natl. Acad. Sci. USA 1999. 96: 1024-1029.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1024-1029
    • Yamashita, M.1    Kimura, M.2    Kubo, M.3    Shimizu, C.4    Tada, T.5    Perlmutter, R.M.6    Nakayama, T.7
  • 18
    • 0031951071 scopus 로고    scopus 로고
    • The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production
    • Yoshida, H., Nishina, H., Takimoto, H., Marengere, L. E., Wakeham, A. C., Bouchard, D., Kong, Y. Y. et al., The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity 1998. 8: 115-124.
    • (1998) Immunity , vol.8 , pp. 115-124
    • Yoshida, H.1    Nishina, H.2    Takimoto, H.3    Marengere, L.E.4    Wakeham, A.C.5    Bouchard, D.6    Kong, Y.Y.7
  • 19
    • 0031895095 scopus 로고    scopus 로고
    • Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation
    • Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T. and Nakayama, T., Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation. Int. Immunol. 1998. 10: 577-591.
    • (1998) Int. Immunol. , vol.10 , pp. 577-591
    • Yamashita, M.1    Hashimoto, K.2    Kimura, M.3    Kubo, M.4    Tada, T.5    Nakayama, T.6
  • 20
    • 0035668540 scopus 로고    scopus 로고
    • Lck plays a critical role in Ca(2+) mobilization and CD28 costimulation in mature primary T cells
    • Trobridge, P. A. and Levin, S. D., Lck plays a critical role in Ca(2+) mobilization and CD28 costimulation in mature primary T cells. Eur. J. Immunol. 2001. 31: 3567-3579.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3567-3579
    • Trobridge, P.A.1    Levin, S.D.2
  • 21
    • 0034613251 scopus 로고    scopus 로고
    • Long-term survival but impaired homeostatic proliferation of Naive T cells in the absence of p56lck
    • Seddon, B., Legname, G., Tomlinson, P. and Zamoyska, R., Long-term survival but impaired homeostatic proliferation of Naive T cells in the absence of p56lck. Science 2000. 290: 127-131.
    • (2000) Science , vol.290 , pp. 127-131
    • Seddon, B.1    Legname, G.2    Tomlinson, P.3    Zamoyska, R.4
  • 22
    • 0037105615 scopus 로고    scopus 로고
    • TCR signals mediated by Src family kinases are essential for the survival of naive T cells
    • Seddon, B. and Zamoyska, R., TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J. Immunol. 2002. 169: 2997-3005.
    • (2002) J. Immunol. , vol.169 , pp. 2997-3005
    • Seddon, B.1    Zamoyska, R.2
  • 23
    • 0034845240 scopus 로고    scopus 로고
    • Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients
    • Tanchot, C., Le Campion, A., Leaument, S., Dautigny, N. and Lucas, B., Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients. Eur. J. Immunol. 2001. 31: 2256-2265.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2256-2265
    • Tanchot, C.1    Le Campion, A.2    Leaument, S.3    Dautigny, N.4    Lucas, B.5
  • 24
    • 0034698931 scopus 로고    scopus 로고
    • Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation
    • Goldrath, A. W., Bogatzki, L. Y. and Bevan, M. J., Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J. Exp. Med. 2000. 192: 557-564.
    • (2000) J. Exp. Med. , vol.192 , pp. 557-564
    • Goldrath, A.W.1    Bogatzki, L.Y.2    Bevan, M.J.3
  • 25
    • 0031897801 scopus 로고    scopus 로고
    • Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements
    • Barnden, M. J., Allison, J., Heath, W. R. and Carbone, F. R., Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 1998. 76: 34-40.
    • (1998) Immunol. Cell Biol. , vol.76 , pp. 34-40
    • Barnden, M.J.1    Allison, J.2    Heath, W.R.3    Carbone, F.R.4
  • 26
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G. and Glimcher, L. H., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000. 100: 655-669.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, C.G.5    Glimcher, L.H.6
  • 27
    • 33646012294 scopus 로고    scopus 로고
    • T helper cell differentiation: regulation by cis elements and epigenetics
    • Lee, G. R., Kim, S. T., Spilianakis, C. G., Fields, P. E. and Flavell, R. A., T helper cell differentiation: regulation by cis elements and epigenetics. Immunity 2006. 24: 369-379.
    • (2006) Immunity , vol.24 , pp. 369-379
    • Lee, G.R.1    Kim, S.T.2    Spilianakis, C.G.3    Fields, P.E.4    Flavell, R.A.5
  • 28
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and Il4 locus accessibility
    • Ansel, K. M., Djuretic, I., Tanasa, B. and Rao, A., Regulation of Th2 differentiation and Il4 locus accessibility. Annu. Rev. Immunol. 2006. 24: 607-656.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 29
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    • Barrat, F. J., Cua, D. J., Boonstra, A., Richards, D. F., Crain, C., Savelkoul, H. F., de Waal-Malefyt, R. et al., In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 2002. 195: 603-616.
    • (2002) J. Exp. Med. , vol.195 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3    Richards, D.F.4    Crain, C.5    Savelkoul, H.F.6    de Waal-Malefyt, R.7
  • 31
    • 2442450433 scopus 로고    scopus 로고
    • IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    • Vieira, P.L., Christensen, J.R., Minaee, S., O'Neill, E.J., Barrat, F.J., Boonstra, A., Barthlott, T. et al., IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J. Immunol. 2004. 172: 5986-5993.
    • (2004) J. Immunol. , vol.172 , pp. 5986-5993
    • Vieira, P.L.1    Christensen, J.R.2    Minaee, S.3    O'Neill, E.J.4    Barrat, F.J.5    Boonstra, A.6    Barthlott, T.7
  • 32
    • 35748951015 scopus 로고    scopus 로고
    • IL-10-producing type 1 regulatory T cells and allergy. Cell Mol
    • Wu, K., Bi, Y., Sun, K. and Wang, C. IL-10-producing type 1 regulatory T cells and allergy. Cell Mol. Immunol. 2007. 4: 269-275.
    • (2007) Immunol. , vol.4 , pp. 269-275
    • Wu, K.1    Bi, Y.2    Sun, K.3    Wang, C.4
  • 33
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot, C., Jin, H., Awasthi, A., Liu, S. M., Lai, C. Y., Madan, R., Sharpe, A. H. et al., Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J. Immunol. 2009. 183: 797-801.
    • (2009) J. Immunol. , vol.183 , pp. 797-801
    • Pot, C.1    Jin, H.2    Awasthi, A.3    Liu, S.M.4    Lai, C.Y.5    Madan, R.6    Sharpe, A.H.7
  • 34
    • 73249149628 scopus 로고    scopus 로고
    • c-Maf regulates IL-10 expression during Th17 polarization
    • Xu, J., Yang, Y., Qiu, G., Lal, G., Wu, Z., Levy, D. E., Ochando, J. C. et al., c-Maf regulates IL-10 expression during Th17 polarization. J. Immunol. 2009. 182: 6226-6236.
    • (2009) J. Immunol. , vol.182 , pp. 6226-6236
    • Xu, J.1    Yang, Y.2    Qiu, G.3    Lal, G.4    Wu, Z.5    Levy, D.E.6    Ochando, J.C.7
  • 35
    • 70449698534 scopus 로고    scopus 로고
    • c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells
    • Garcia, C. A., Wang, H., Benakanakere, M. R., Barrett, E., Kinane, D. F. and Martin, M., c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells. J. Immunol. 2009. 183: 4475-4482.
    • (2009) J. Immunol. , vol.183 , pp. 4475-4482
    • Garcia, C.A.1    Wang, H.2    Benakanakere, M.R.3    Barrett, E.4    Kinane, D.F.5    Martin, M.6
  • 36
    • 0036784641 scopus 로고    scopus 로고
    • IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway
    • Yoo, J. K., Cho, J. H., Lee, S. W. and Sung, Y. C., IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway. J. Immunol. 2002. 169: 3637-3643.
    • (2002) J. Immunol. , vol.169 , pp. 3637-3643
    • Yoo, J.K.1    Cho, J.H.2    Lee, S.W.3    Sung, Y.C.4
  • 37
    • 7944231534 scopus 로고    scopus 로고
    • Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
    • Palacios, E. H. and Weiss, A., Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 2004. 23: 7990-8000.
    • (2004) Oncogene , vol.23 , pp. 7990-8000
    • Palacios, E.H.1    Weiss, A.2
  • 39
    • 77952758927 scopus 로고    scopus 로고
    • Lck mediates Th2 differentiation through effects on T-bet and GATA-3
    • Kemp, K. L., Levin, S. D., Bryce, P. J. and Stein, P. L., Lck mediates Th2 differentiation through effects on T-bet and GATA-3. J Immunol. 2010. 184: 4178-4184.
    • (2010) J Immunol. , vol.184 , pp. 4178-4184
    • Kemp, K.L.1    Levin, S.D.2    Bryce, P.J.3    Stein, P.L.4
  • 40
    • 77952767221 scopus 로고    scopus 로고
    • Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development
    • Vang, K. B., Yang, J., Pagan, A. J., Li, L. X., Wang, J., Green, J. M., Beg, A. A. and Farrar, M. A., Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development. J. Immunol. 2010. 184: 4074-4077.
    • (2010) J. Immunol. , vol.184 , pp. 4074-4077
    • Vang, K.B.1    Yang, J.2    Pagan, A.J.3    Li, L.X.4    Wang, J.5    Green, J.M.6    Beg, A.A.7    Farrar, M.A.8
  • 41
    • 0029100831 scopus 로고
    • Functional dissection of the murine lck distal promoter
    • Wildin, R. S., Wang, H. U., Forbush, K. A. and Perlmutter, R. M., Functional dissection of the murine lck distal promoter. J. Immunol. 1995. 155: 1286-1295.
    • (1995) J. Immunol. , vol.155 , pp. 1286-1295
    • Wildin, R.S.1    Wang, H.U.2    Forbush, K.A.3    Perlmutter, R.M.4
  • 42
    • 0030798980 scopus 로고    scopus 로고
    • Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity
    • Heyeck, S. D., Wilcox, H. M., Bunnell, S. C. and Berg, L. J., Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J. Biol. Chem. 1997. 272: 25401-25408.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25401-25408
    • Heyeck, S.D.1    Wilcox, H.M.2    Bunnell, S.C.3    Berg, L.J.4
  • 44
    • 3142686560 scopus 로고    scopus 로고
    • Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet
    • Miller, A. T., Wilcox, H. M., Lai, Z. and Berg, L. J., Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. Immunity 2004. 21: 67-80.
    • (2004) Immunity , vol.21 , pp. 67-80
    • Miller, A.T.1    Wilcox, H.M.2    Lai, Z.3    Berg, L.J.4
  • 45
    • 45549105834 scopus 로고    scopus 로고
    • Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development
    • Hu, J. and August, A., Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development. J. Immunol. 2008. 180: 6544-6552.
    • (2008) J. Immunol. , vol.180 , pp. 6544-6552
    • Hu, J.1    August, A.2
  • 47
    • 34147163337 scopus 로고    scopus 로고
    • Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3
    • Chang, H. D., Helbig, C., Tykocinski, L., Kreher, S., Koeck, J., Niesner, U. and Radbruch, A., Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3. Eur. J. Immunol. 2007. 37: 807-817.
    • (2007) Eur. J. Immunol , vol.37 , pp. 807-817
    • Chang, H.D.1    Helbig, C.2    Tykocinski, L.3    Kreher, S.4    Koeck, J.5    Niesner, U.6    Radbruch, A.7
  • 48
    • 0033427612 scopus 로고    scopus 로고
    • Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells
    • Kurata, H., Lee, H. J., O'Garra, A. and Arai, N., Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity 1999. 11: 677-688.
    • (1999) Immunity , vol.11 , pp. 677-688
    • Kurata, H.1    Lee, H.J.2    O'Garra, A.3    Arai, N.4
  • 49
    • 0033973582 scopus 로고    scopus 로고
    • Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
    • Ouyang, W., Lohning, M., Gao, Z., Assenmacher, M., Ranganath, S., Radbruch, A. and Murphy, K. M., Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 2000. 12: 27-37.
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1    Lohning, M.2    Gao, Z.3    Assenmacher, M.4    Ranganath, S.5    Radbruch, A.6    Murphy, K.M.7
  • 50
    • 0033600848 scopus 로고    scopus 로고
    • SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
    • Cuevas, B., Lu, Y., Watt, S., Kumar, R., Zhang, J., Siminovitch, K. A. and Mills, G. B., SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J. Biol. Chem. 1999. 274: 27583-27589.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27583-27589
    • Cuevas, B.1    Lu, Y.2    Watt, S.3    Kumar, R.4    Zhang, J.5    Siminovitch, K.A.6    Mills, G.B.7
  • 51
    • 77953907465 scopus 로고    scopus 로고
    • Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways
    • Chen, X. G., Liu, F., Song, X. F., Wang, Z. H., Dong, Z. Q., Hu, Z. Q., Lan, R. Z. et al., Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways. Mol Carcinog. 2010. 49: 603-610.
    • (2010) Mol Carcinog , vol.49 , pp. 603-610
    • Chen, X.G.1    Liu, F.2    Song, X.F.3    Wang, Z.H.4    Dong, Z.Q.5    Hu, Z.Q.6    Lan, R.Z.7
  • 52
    • 4644250844 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
    • Zhuang, Z. Y., Xu, H., Clapham, D. E. and Ji, R. R., Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J. Neurosci. 2004. 24: 8300-8309.
    • (2004) J. Neurosci. , vol.24 , pp. 8300-8309
    • Zhuang, Z.Y.1    Xu, H.2    Clapham, D.E.3    Ji, R.R.4
  • 53
    • 0031005028 scopus 로고    scopus 로고
    • Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases
    • Grammer, T. C. and Blenis, J., Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases. Oncogene 1997. 14: 1635-1642.
    • (1997) Oncogene , vol.14 , pp. 1635-1642
    • Grammer, T.C.1    Blenis, J.2


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