Interaction between α-synuclein and other proteins in neurodegenerative disorders

TheScientificWorldJournal

Volumn 11, Issue , 2011, Pages 1893-1907

  Jellinger, Kurt A ^a  

^a INSTITUTE OF CLINICAL NEUROBIOLOGY   (Austria)

Author keywords

alzheimer disease; coformer seeding; neurodegeneration; parkinson disease; pathogenesis; protein interaction

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; EXTRACELLULAR SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CEREBELLAR ATAXIA; DEGENERATIVE DISEASE; DEMENTIA; FAMILIAL DISEASE; GENE FREQUENCY; GENETIC PREDISPOSITION; HUMAN; HUNTINGTON CHOREA; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRION DISEASE; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; TRISOMY 21;

ALPHA-SYNUCLEIN; AMYLOID BETA-PEPTIDES; HUMANS; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION; PROTEIN BINDING; TAU PROTEINS;

EID: 81455139926     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2011/371893     Document Type: Article

References (162)

1. Jucker M., Walker L. C., Pathogenic protein seeding in Alzheimer's disease and other neurodegenerative disorders. Annals of Neurology. In press
2. Golde T. E., Miller V. M., Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases Alzheimer's Research Therapy 2009 1 2, article 5
3. Gadad B. S., Britton G. B., Rao K. S., Targeting oligomers in neurodegenerative disorders: lessons from -synuclein, tau, and amyloid- peptide Journal of Alzheimer's Disease 2011 24 supplement 2 223 232
4. Patterson K. R., Remmers C., Fu Y., Brooker S., Kanaan N. M., Vana L., Ward S., Reyes J. F., Philibert K., Glucksman M. J., Binder L. I., Characterization of prefibrillar tau oligomers in vitro and in Alzheimer disease The Journal of Biological Chemistry 2011 286 26 23063 23076
5. Olivares D., Huang X., Branden L., Greig N. H., Rogers J. T., Physiological and pathological role of alpha-synuclein in parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element International Journal of Molecular Sciences 2009 10 3 1226 1260
6. Winner B., Jappelli R., Maji S. K., Desplats P. A., Boyer L., Aigner S., Hetzer C., Loher T., Vilar M., Campioni S., Tzitzilonis C., Soragni A., Jessberger S., Mira H., Consiglio A., Pham E., Masliah E., Gage F. H., Riek R., In vivo demonstration that -synuclein oligomers are toxic Proceedings of the National Academy of Sciences of the United States of America 2011 108 10 4194 4199
7. Danzer K. M., Krebs S. K., Wolff M., Birk G., Hengerer B., Seeding induced by -synuclein oligomers provides evidence for spreading of -synuclein pathology Journal of Neurochemistry 2009 111 1 192 203
8. Lee S. J., Desplats P., Sigurdson C., Tsigelny I., Masliah E., Cell-to-cell transmission of non-prion protein aggregates Nature Reviews Neurology 2010 6 12 702 706
9. Wu H. Y., Hudry E., Hashimoto T., Kuchibhotla K., Rozkalne A., Fan Z., Spires-Jones T., Xie H., Arbel-Ornath M., Grosskreutz C. L., Bacskai B. J., Hyman B. T., Amyloid induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation Journal of Neuroscience 2010 30 7 2636 2649
10. Fox L. M., William C. M., Adamowicz D. H., Pitstick R., Carlson G. A., Spires-Jones T. L., Hyman B. T., Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model Journal of Neuropathology and Experimental Neurology 2011 70 7 588 595
11. Noble W., Planel E., Zehr C., Olm V., Meyerson J., Suleman F., Gaynor K., Wang L., LaFrancois J., Feinstein B., Burns M., Krishnamurthy P., Wen Y., Bhat R., Lewis J., Dickson D., Duff K., Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo Proceedings of the National Academy of Sciences of the United States of America 2005 102 19 6990 6995 (Pubitemid 40675429)
12. Engel T., Goi-Oliver P., Lucas J. J., Avila J., Hernndez F., Chronic lithium administration to FTDP-17 tau and GSK-3 overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert Journal of Neurochemistry 2006 99 6 1445 1455 (Pubitemid 44924224)
13. Lucas J. J., Hernndez F., Gmez-Ramos P., Morn M. A., Hen R., Avila J., Decreased nuclear -catenin, tau hyperphosphorylation and neurodegeneration in GSK-3 conditional transgenic mice The EMBO Journal 2001 20 1-2 27 39 (Pubitemid 32099099)
14. de Calignon A., Fox L. M., Pitstick R., Carlson G. A., Bacskai B. J., Spires-Jones T. L., Hyman B. T., Caspase activation precedes and leads to tangles Nature 2010 464 7292 1201 1204
15. Guo J. L., Lee V. M.-Y., Seeding of normal tau by pathological tau conformers drives pathogenesis of Alzheimer-like tangles The Journal of Biological Chemistry 2011 286 17 15317 15331
16. Irvine G. B., El-Agnaf O. M., Shankar G. M., Walsh D. M., Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases Molecular Medicine 2008 14 7-8 451 464
17. Higashi S., Iseki E., Yamamoto R., Minegishi M., Hino H., Fujisawa K., Togo T., Katsuse O., Uchikado H., Furukawa Y., Kosaka K., Arai H., Concurrence of TDP-43, tau and -synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies Brain Research 2007 1184 1 284 294 (Pubitemid 350160566)
18. Iseki E., Togo T., Suzuki K., Katsuse O., Marui W., de Silva R., Lees A., Yamamoto T., Kosaka K., Dementia with Lewy bodies from the perspective of tauopathy Acta Neuropathologica 2003 105 3 265 270 (Pubitemid 36798819)
19. Miklossy J., Steele J. C., Yu S., McCall S., Sandberg G., McGeer E. G., McGeer P. L., Enduring involvement of tau, -amyloid, -synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC) Acta Neuropathologica 2008 116 6 625 637
20. Galpern W. R., Lang A. E., Interface between tauopathies and synucleinopathies: a tale of two proteins Annals of Neurology 2006 59 3 449 458 (Pubitemid 43358065)
21. Arai Y., Yamazaki M., Mori O., Muramatsu H., Asano G., Katayama Y., -Synuclein-positive structures in cases with sporadic Alzheimer's disease: morphology and its relationship to tau aggregation Brain Research 2001 888 2 287 296 (Pubitemid 32058794)
22. Duda J. E., Giasson B. I., Mabon M. E., Miller D. C., Golbe L. I., Lee V. M. Y., Trojanowski J. Q., Concurrence of -synuclein and tau brain pathology in the Contursi kindred Acta Neuropathologica 2002 104 1 7 11 (Pubitemid 36075353)
23. Maries E., Dass B., Collier T. J., Kordower J. H., Steece-Collier K., The role of -synuclein in Parkinson's disease: insights from animal models Nature Reviews Neuroscience 2003 4 9 727 738 (Pubitemid 37280152)
24. Waxman E. A., Giasson B. I., Induction of intracellular tau aggregation is promoted by -synuclein seeds and provides novel insights into the hyperphosphorylation of tau Journal of Neuroscience 2011 31 21 7604 7618
25. Nonaka T., Watanabe S. T., Iwatsubo T., Hasegawa M., Seeded aggregation and toxicity of -synuclein and tau: cellular models of neurodegenerative diseases The Journal of Biological Chemistry 2010 285 45 34885 34898
26. Duka T., Duka V., Joyce J. N., Sidhu A., -Synuclein contributes to GSK-3 -catalyzed Tau phosphorylation in Parkinson's disease models The FASEB Journal 2009 23 9 2820 2830
27. Wills J., Credle J., Haggerty T., Lee J.-H., Oaks A. W., Sidhu A., Tauopathic changes in the striatum of A53T -synuclein mutant mouse model of Parkinson's disease PLoS One 2011 6 3
28. Kaul T., Credle J., Haggerty T., Oaks A. W., Masliah E., Sidhu A., Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease BMC Neuroscience 2011 12, article 79
29. Haggerty T., Credle J., Rodriguez O., Wills J., Oaks A. W., Masliah E., Sidhu A., Hyperphosphorylated Tau in an -synuclein-overexpressing transgenic model of Parkinson's disease European Journal of Neuroscience 2011 33 9 1598 1610
30. Qureshi H. Y., Paudel H. K., Parkinsonian neurotoxin 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) and -synuclein mutations promote tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in Vitro The Journal of Biological Chemistry 2011 286 7 5055 5068
31. Riedel M., Goldbaum O., Richter-Landsberg C., -Synuclein promotes the recruitment of tau to protein inclusions in oligodendroglial cells: effects of oxidative and proteolytic stress Journal of Molecular Neuroscience 2009 39 1-2 226 234
32. Chaves R. S., Melo T. Q., Martins S. A., Ferrari M. F. R., Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure BMC Neuroscience 2010 11, article 144
33. Lei P., Ayton S., Finkelstein D. I., Adlard P. A., Masters C. L., Bush A. I., Tau protein: relevance to Parkinson's disease International Journal of Biochemistry and Cell Biology 2010 42 11 1775 1778
34. Emmer K. L., Waxman E. A., Covy J. P., Giasson B. I., E46K human -synuclein transgenic mice develop lewy-like and tau pathology associated with age-dependent, detrimental motor impairment The Journal of Biological Chemistry 2011 286 40 35104 35118
35. Wills J., Jones J., Haggerty T., Duka V., Joyce J. N., Sidhu A., Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia Experimental Neurology 2010 225 1 210 218
36. Baum L., Seger R., Woodgett J. R., Kawabata S., Maruyama K., Koyama M., Silver J., Saitoh T., Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement Molecular Brain Research 1995 34 1 1 17
37. Hernndez F., Gmez de Barreda E., Fuster-Matanzo A., Lucas J. J., Avila J., GSK3: a possible link between beta amyloid peptide and tau protein Experimental Neurology 2010 223 2 322 325
38. Hooper C., Killick R., Lovestone S., The GSK3 hypothesis of Alzheimer's disease Journal of Neurochemistry 2008 104 6 1433 1439 (Pubitemid 351316776)
39. Lebel M., Patenaude C., Allyson J., Massicotte G., Cyr M., Dopamine D1 receptor activation induces tau phosphorylation via cdk5 and GSK3 signaling pathways Neuropharmacology 2009 57 4 392 402
40. McNaught K. S. P., Belizaire R., Jenner P., Olanow C. W., Isacson O., Selective loss of 20S proteasome -subunits in the substantia nigra pars compacta in Parkinson's disease Neuroscience Letters 2002 326 3 155 158 (Pubitemid 34722448)
41. Duka T., Rusnak M., Drolet R. E., Duka V., Wersinger C., Goudreau J. L., Sidhu A., Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of Parkinsonism The FASEB Journal 2006 20 13 2302 2312 (Pubitemid 44953860)
42. Duka T., Sidhu A., The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of -Synuclein, in SH-SY5Y neuroblastoma cells Neurotoxicity Research 2006 10 1 1 10
43. Kozikowski A. P., Gaisina I. N., Petukhov P. A., Sridhar J., King L. T., Blond S. Y., Duka T., Rusnak M., Sidhu A., Highly potent and specific GSK-3 inhibitors that block tau phosphorylation and decrease -synuclein protein expression in a cellular model of Parkinson's disease ChemMedChem 2006 1 2 256 266 (Pubitemid 43700306)
44. van Eersel J., Bi M., Ke Y. D., Hodges J. R., Xuereb J. H., Gregory G. C., Halliday G. M., Gtz J., Kril J. J., Ittner L. M., Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains Journal of Neural Transmission 2009 116 10 1243 1251
45. Giasson B. I., Forman M. S., Higuchi M., Golbe L. I., Graves C. L., Kotzbauer P. T., Trojanowski J. Q., Lee V. M. Y., Initiation and synergistic fibrillization of tau and alpha-synuctein Science 2003 300 5619 636 640 (Pubitemid 36520587)
46. Uversky V. N., Neuropathology, biochemistry, and biophysics of -synuclein aggregation Journal of Neurochemistry 2007 103 1 17 37 (Pubitemid 47407730)
47. Tsigelny I. F., Crews L., Desplats P., Shaked G. M., Sharikov Y., Mizuno H., Spencer B., Rockenstein E., Trejo M., Platoshyn O., Yuan J. X. J., Masliah E., Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases PLoS One 2008 3 9
48. Kotzbauer P. T., Giasson B. I., Kravitz A. V., Golbe L. I., Mark M. H., Trojanowski J. Q., Lee V. M. Y., Fibrillization of -synuclein and tau in familial Parkinson's disease caused by the A53T -synuclein mutation Experimental Neurology 2004 187 2 279 288 (Pubitemid 38610274)
49. Morales R., Estrada L. D., Diaz-Espinoza R., Morales-Scheihing D., Jara M. C., Castilla J., Soto C., Molecular cross talk between misfolded proteins in animal models of alzheimer's and prion diseases Journal of Neuroscience 2010 30 13 4528 4535
50. Williams-Gray C. H., Evans J. R., Goris A., Foltynie T., Ban M., Robbins T. W., Brayne C., Kolachana B. S., Weinberger D. R., Sawcer S. J., Barker R. A., The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort Brain 2009 132 11 2958 2969
51. Wray S., Lewis P. A., A tangled webtau and sporadic Parkinson's disease Front Psychiatry 2010 1, article 150
52. Clarimn J., Molina-Porcel L., Gmez-Isla T., Blesa R., Guardia-Laguarta C., Gonzlez-Neira A., Estorch M., Ma Grau J., Barraquer L., Roig C., Ferrer I., Lle A., Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study Journal of Neuropathology and Experimental Neurology 2009 68 1 73 82
53. Reiniger L., Lukic A., Linehan J., Rudge P., Collinge J., Mead S., Brandner S., Tau, prions and A : the triad of neurodegeneration Acta Neuropathologica 2011 121 1 5 20
54. Peuralinna T., Oinas M., Polvikoski T., Paetau A., Sulkava R., Niinist L., Kalimo H., Hernandez D., Hardy J., Singleton A., Tienari P. J., Myllykangas L., Neurofibrillary tau pathology modulated by genetic variation of -synuclein Annals of Neurology 2008 64 3 348 352
55. Muntané G., Dalf E., Martinez A., Ferrer I., Phosphorylation of tau and -synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related -synucleinopathies Neuroscience 2008 152 4 913 923
56. Frasier M., Walzer M., McCarthy L., Magnuson D., Lee J. M., Haas C., Kahle P., Wolozin B., Tau phosphorylation increases in symptomatic mice overexpressing A30P -synuclein Experimental Neurology 2005 192 2 274 287 (Pubitemid 40347257)
57. Fujishiro H., Tsuboi Y., Lin W. L., Uchikado H., Dickson D. W., Co-localization of tau and -synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies Acta Neuropathologica 2008 116 1 17 24
58. Shao C. Y., Crary J. F., Rao C., Sacktor T. C., Mirra S. S., Atypical protein kinase C in neurodegenerative disease II: PKC / in tauopathies and -synucleinopathies Journal of Neuropathology and Experimental Neurology 2006 65 4 327 335 (Pubitemid 44264830)
59. Ishizawa T., Mattila P., Davies P., Wang D., Dickson D. W., Colocalization of tau and alpha-synuclein epitopes in Lewy bodies Journal of Neuropathology and Experimental Neurology 2003 62 4 389 397 (Pubitemid 36403039)
60. Piao Y. S., Hayashi S., Hasegawa M., Wakabayashi K., Yamada M., Yoshimoto M., Ishikawa A., Iwatsubo T., Takahashi H., Co-localization of -synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration Acta Neuropathologica 2001 101 3 285 293 (Pubitemid 32219764)
61. Nagaishi M., Yokoo H., Nakazato Y., Tau-positive glial cytoplasmic granules in multiple system atrophy Neuropathology 2011 31 3 299 305
62. Dickson D. W., -Synuclein and the lewy body disorders Current Opinion in Neurology 2001 14 4 423 432
63. Trembath Y., Rosenberg C., Ervin J. F., Schmechel D. E., Gaskell P., Pericak-Vance M., Vance J., Hulette C. M., Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease Acta Neuropathologica 2003 105 5 484 488 (Pubitemid 36798845)
64. Uchikado H., Lin W.-L., Delucia M. W., Dickson D. W., Alzheimer disease with amygdala lewy bodies: a distinct form of -synucleinopathy Journal of Neuropathology and Experimental Neurology 2006 65 7 685 697 (Pubitemid 44297259)
65. Attems J., Quass M., Jellinger K. A., Tau and -synuclein brainstem pathology in Alzheimer disease: relation with extrapyramidal signs Acta Neuropathologica 2007 113 1 53 62 (Pubitemid 44782929)
66. Burns J. M., Galvin J. E., Roe C. M., Morris J. C., McKeel D. W., The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs Neurology 2005 64 8 1397 1403 (Pubitemid 40570508)
67. Liu Y., Stern Y., Chun M. R., Jacobs D. M., Yau P., Goldman J. E., Pathological correlates of extrapyramidal signs in Alzheimer's disease Annals of Neurology 1997 41 3 368 374 (Pubitemid 27114048)
68. Saito Y., Ruberu N. N., Sawabe M., Arai T., Kazama H., Hosoi T., Yamanouchi H., Murayama S., Lewy body-related -synucleinopathy in aging Journal of Neuropathology and Experimental Neurology 2004 63 7 742 749
69. Jellinger K., Unusual tau in MSA. Neuropathology. In press
70. Jellinger K. A., Interaction between alpha-synuclein and tau in Parkinson's disease Comment on Wills et al.: elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia Experimental Neurology 2011 225 1 210 218
71. Jellinger K. A., Interaction between alpha-synuclein and tau in Parkinson's disease Comment on Wills et al.: elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia Experimental Neurology 2011 227 1 13 18
72. Lee V. M. Y., Giasson B. I., Trojanowski J. Q., More than just two peas in a pod: common amyloidogenic properties of tau and -synuclein in neurodegenerative diseases Trends in Neurosciences 2004 27 3 129 134 (Pubitemid 38251512)
73. Mandal P. K., Pettegrew J. W., Masliah E., Hamilton R. L., Mandal R., Interaction between A peptide and synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease Neurochemical Research 2006 31 9 1153 1162 (Pubitemid 44379676)
74. Obi K., Akiyama H., Kondo H., Shimomura Y., Hasegawa M., Iwatsubo T., Mizuno Y., Mochizuki H., Relationship of phosphorylated -synuclein and tau accumulation to A deposition in the cerebral cortex of dementia with Lewy bodies Experimental Neurology 2008 210 2 409 420
75. Lee S.-J., Lim H.-S., Masliah E., Lee H.-J., Protein aggregate spreading in neurodegenerative diseases: problems and perspectives Neuroscience Research 2011 70 4 339 348
76. Mollenhauer B., Locascio J. J., Schulz-Schaeffer W., Sixel-Dring F., Trenkwalder C., -Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study The Lancet Neurology 2011 10 3 230 240
77. Parnetti L., Chiasserini D., Bellomo G., Giannandrea D., de Carlo C., Qureshi M. M., Ardah M. T., Varghese S., Bonanni L., Borroni B., Tambasco N., Eusebi P., Rossi A., Onofrj M., Padovani A., Calabresi P., El-Agnaf O., Cerebrospinal fluid Tau/ -synuclein ratio in Parkinson's disease and degenerative dementias Movement Disorders 2011 26 8 1428 1435
78. Pletnikova O., West N., Lee M. K., Rudow G. L., Skolasky R. L., Dawson T. M., Marsh L., Troncoso J. C., A deposition is associated with enhanced cortical -synuclein lesions in Lewy body diseases Neurobiology of Aging 2005 26 8 1183 1192 (Pubitemid 40726011)
79. Huang H. C., Jiang Z. F., Accumulated amyloid- peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease Journal of Alzheimer's Disease 2009 16 1 15 27
80. Lashley T., Holton J. L., Gray E., Kirkham K., O'Sullivan S. S., Hilbig A., Wood N. W., Lees A. J., Revesz T., Cortical -synuclein load is associated with amyloid- plaque burden in a subset of Parkinson's disease patients Acta Neuropathologica 2008 115 4 417 425
81. Masliah E., Rockenstein E., Veinbergs I., Sagara Y., Mallory M., Hashimoto M., Mucke L., -Amyloid peptides enhance -synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 2001 98 21 12245 12250 (Pubitemid 32959858)
82. Bate C., Gentleman S., Williams A., alpha-synuclein induced synapse damage is enhanced by amyloid-beta1-42 Molecular Neurodegeneration 2010 5, article 55
83. Small S. A., Duff K., Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis Neuron 2008 60 4 534 542
84. Olh J., Vincze O., Virk D., Simon D., Bozs Z., Tokési N., Horvth I., Hlavanda E., Kovcs J., Magyar A., Szucs M., Orosz F., Penke B., Ovdi J., Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, -amyloid, and -synuclein The Journal of Biological Chemistry 2011 286 39 34088 34100
85. Jellinger K. A., Basic mechanisms of neurodegeneration: a critical update Journal of Cellular and Molecular Medicine 2010 14 3 457 487
86. Querfurth H. W., LaFerla F. M., Alzheimer's disease The New England Journal of Medicine 2010 362 4 329 344
87. Braak H., Braak E., Staging of Alzheimer's disease-related neurofibrillary changes Neurobiology of Aging 1995 16 3 271 278
88. Selkoe D. J., Alzheimer's disease is a synaptic failure Science 2002 298 5594 789 791 (Pubitemid 35231524)
89. Hardy J., The relationship between amyloid and tau Journal of Molecular Neuroscience 2003 20 2 203 206 (Pubitemid 36693824)
90. Gtz J., Lim Y. A., Ke Y. D., Eckert A., Ittner L. M., Dissecting toxicity of tau and -amyloid Neurodegenerative Diseases 2010 7 13 10 12
91. Ittner L. M., Gtz J., Amyloid- and taua toxic pas de deux in Alzheimer's disease Nature Reviews Neuroscience 2010 12 65 72
92. Hardy J., Selkoe D. J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 2002 297 5580 353 356 (Pubitemid 34790756)
93. Bertram L., Tanzi R. E., The genetic epidemiology of neurodegenerative disease The Journal of Clinical Investigation 2005 115 6 1449 1457 (Pubitemid 40814649)
94. Small D. H., Mok S. S., Bornstein J. C., Alzheimer's disease and A toxicity: from top to bottom Nature Reviews Neuroscience 2001 2 8 595 598 (Pubitemid 33679833)
95. Gtz J., Streffer J. R., David D., Schild A., Hoerndli F., Pennanen L., Kurosinski P., Chen F., Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy Molecular Psychiatry 2004 9 7 664 683 (Pubitemid 38932172)
96. De Felice F. G., Wu D., Lambert M. P., Fernandez S. J., Velasco P. T., Lacor P. N., Bigio E. H., Jerecic J., Acton P. J., Shughrue P. J., Chen-Dodson E., Kinney G. G., Klein W. L., Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A oligomers Neurobiology of Aging 2008 29 9 1334 1347 (Pubitemid 351970596)
97. Jin M., Shepardson N., Yang T., Chen G., Walsh D., Selkoe D. J., Soluble amyloid -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration Proceedings of the National Academy of Sciences of the United States of America 2011 108 14 5819 5824
98. Bolmont T., Clavaguera F., Meyer-Luehmann M., Herzig M. C., Radde R., Staufenbiel M., Lewis J., Hutton M., Tolnay M., Jucker M., Induction of tau pathology by intracerebral infusion of amyloid- -containing brain extract and by amyloid- deposition in APP x tau transgenic mice American Journal of Pathology 2007 171 6 2012 2020
99. Gtz J., Chen F., Van Dorpe J., Nitsch R. M., Formation of neurofibrillary tangles in P301L tau transgenic mice induced by A 42 fibrils Science 2001 293 5534 1491 1495 (Pubitemid 32807681)
100. Billings L. M., Oddo S., Green K. N., McGaugh J. L., LaFerla F. M., Intraneuronal A causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice Neuron 2005 45 5 675 688 (Pubitemid 40320703)
101. Gong E. J., Park H. R., Kim M. E., Piao S., Lee E., Jo D.-G., Chung H. Y., Ha N.-C., Mattson M. P., Lee J., Morin attenuates tau hyperphosphorylation by inhibiting GSK3 Neurobiology of Disease 2011 44 2 223 230
102. Coomaraswamy J., Kilger E., Wlfing H., Schfer C., Kaeser S. A., Wegenast-Braun B. M., Hefendehl J. K., Wolburg H., Mazzella M., Ghiso J., Goedert M., Akiyama H., Garcia-Sierra F., Wolfer D. P., Mathews P. M., Jucker M., Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2010 107 17 7969 7974
103. Winton M. J., Lee E. B., Sun E., Wong M. M., Leight S., Zhang B., Trojanowski J. Q., Lee V. M.-Y., Intraneuronal APP, not free A peptides in 3xtg-AD mice: implications for tau versus A -mediated Alzheimer neurodegeneration Journal of Neuroscience 2011 31 21 7691 7699
104. Wirths O., Dins A., Bayer T. A., AbetaPP accumulation and/or intraneuronal Abeta accumulation? The 3xtg-AD mouse model revisited. Journal of Alzheimer's Disease. In press
105. Rhein V., Song X., Wiesner A., Ittner L. M., Baysang G., Meier F., Ozmen L., Bluethmann H., Drse S., Brandt U., Savaskan E., Czech C., Gtz J., Eckert A., Amyloid- and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice Proceedings of the National Academy of Sciences of the United States of America 2009 106 47 20057 20062
106. Eckert A., Schmitt K., Mitochondrial dysfunctionthe beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-beta toxicity Alzheimer's Research Therapy 2011 3, article 15
107. Eckert A., Schulz K. L., Rhein V., Gtz J., Convergence of amyloid- and tau pathologies on mitochondria in vivo Molecular Neurobiology 2010 41 2-3 107 114
108. Rajendran L., Honsho M., Zahn T. R., Keller P., Geiger K. D., Verkade P., Simons K., Alzheimer's disease -amyloid peptides are released in association with exosomes Proceedings of the National Academy of Sciences of the United States of America 2006 103 30 11172 11177 (Pubitemid 44156491)
109. Roberson E. D., Scearce-Levie K., Palop J. J., Yan F., Cheng I. H., Wu T., Gerstein H., Yu G. Q., Mucke L., Reducing endogenous tau ameliorates amyloid -induced deficits in an Alzheimer's disease mouse model Science 2007 316 5825 750 754 (Pubitemid 46717684)
110. Ittner L. M., Ke Y. D., Delerue F., Bi M., Gladbach A., van Eersel J., Wlfing H., Chieng B. C., Christie M. J., Napier I. A., Eckert A., Staufenbiel M., Hardeman E., Gtz J., Dendritic function of tau mediates amyloid- toxicity in alzheimer's disease mouse models Cell 2010 142 3 387 397
111. Vossel K. A., Zhang K., Brodbeck J., Daub A. C., Sharma P., Finkbeiner S., Cui B., Mucke L., Tau reduction prevents A -induced defects in axonal transport Science 2010 330 6001 198 198
112. Saper C. B., Wainer B. H., German D. C., Axonal and transneuronal transport in the transmission of neurological disease: potential role in system degenerations, including Alzheimer's disease Neuroscience 1987 23 2 389 398 (Pubitemid 18004218)
113. Stamer K., Vogel R., Thies E., Mandelkow E., Mandelkow E. M., Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress Journal of Cell Biology 2002 156 6 1051 1063 (Pubitemid 34839854)
114. Pappolla M. A., Omar R. A., Kim K. S., Robakis N. K., Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease American Journal of Pathology 1992 140 621 628
115. Novak P., Prcina M., Kontsekova E., Tauons and prions: infamous cousins? Journal of Alzheimer's Disease 2011 26 3 413 430
116. Guo J. P., Arai T., Miklossy J., McGeer P. L., Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2006 103 1953 1958 (Pubitemid 43228799)
117. Miller Y., Ma B., Nussinov R., Synergistic interactions between repeats in tau protein and A amyloids may be responsible for accelerated aggregation via polymorphic States Biochemistry 2011 50 23 5172 5181
118. Yoshiyama Y., Higuchi M., Zhang B., Huang S. M., Iwata N., Saido T., Maeda J., Suhara T., Trojanowski J. Q., Lee V. M. Y., Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model Neuron 2007 53 3 337 351 (Pubitemid 46161268)
119. Avila J., Alzheimer disease: caspases first Nature Reviews Neurology 2010 6 11 587 588
120. Braak H., Del Tredici K., Rb U., De Vos R. A. I., Jansen Steur E. N. H., Braak E., Staging of brain pathology related to sporadic Parkinson's disease Neurobiology of Aging 2003 24 2 197 211 (Pubitemid 36007810)
121. Braak H., Del Tredici K., Neuroanatomy and pathology of sporadic Parkinson's disease Advances in Anatomy, Embryology, and Cell Biology 2009 201 1 119
122. Braak H., Del Tredici K., Pathophysiology of sporadic Parkinson's disease Fortschritte der Neurologie-Psychiatrie 2010 78 supplement 1 S2 S4
123. Parkkinen L., Pirttil T., Alafuzoff I., Applicability of current staging/categorization of -synuclein pathology and their clinical relevance Acta Neuropathologica 2008 115 4 399 407
124. Kalaitzakis M. E., Graeber M. B., Gentleman S. M., Pearce R. K. B., Controversies over the staging of -synuclein pathology in Parkinson's disease Acta Neuropathologica 2008 116 1 125 128
125. Jellinger K. A., A critical evaluation of current staging of -synuclein pathology in Lewy body disorders Biochimica et Biophysica Acta 2009 1792 7 730 740
126. Dickson D. W., Uchikado H., Fujishiro H., Tsuboi Y., Evidence in favor of Braak staging of Parkinson's disease Movement Disorders 2010 25 supplement 1 S78 S82
127. Kordower J. H., Chu Y., Hauser R. A., Olanow C. W., Freeman T. B., Transplanted dopaminergic neurons develop PD pathologic changes: a second case report Movement Disorders 2008 23 16 2303 2306
128. Li J. Y., Englund E., Holton J. L., Soulet D., Hagell P., Lees A. J., Lashley T., Quinn N. P., Rehncrona S., Bjrklund A., Widner H., Revesz T., Lindvall O., Brundin P., Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation Nature Medicine 2008 14 5 501 503 (Pubitemid 351655211)
129. Brundin P., Li J. Y., Holton J. L., Lindvall O., Revesz T., Research in motion: the enigma of Parkinson's disease pathology spread Nature Reviews Neuroscience 2008 9 10 741 745
130. Li J. Y., Englund E., Widner H., Rehncrona S., Bjrklund A., Lindvall O., Brundin P., Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease Movement Disorders 2010 25 8 1091 1096
131. Hansen C., Angot E., Bergstrm A.-L., Steiner J. A., Pieri L., Paul G., Outeiro T. F., Melki R., Kallunki P., Fog K., Li J.-Y., Brundin P., -Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells The Journal of Clinical Investigation 2011 121 2 715 725
132. Lee H.-J., Suk J.-E., Bae E.-J., Lee J.-H., Paik S. R., Lee S.-J., Assembly-dependent endocytosis and clearance of extracellular -synuclein International Journal of Biochemistry and Cell Biology 2008 40 9 1835 1849
133. Desplats P., Lee H. J., Bae E. J., Patrick C., Rockenstein E., Crews L., Spencer B., Masliah E., Lee S. J., Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein Proceedings of the National Academy of Sciences of the United States of America 2009 106 31 13010 13015
134. Kordower J. H., Dodiya H. B., Kordower A. M., Terpstra B., Paumier K., Madhavan L., Sortwell C., Steece-Collier K., Collier T. J., Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat Neurobiology of Disease 2011 43 3 552 557
135. Aguzzi A., Rajendran L., The transcellular spread of cytosolic amyloids, prions, and prionoids Neuron 2009 64 6 783 790
136. Angot E., Steiner J. A., Hansen C., Li J. Y., Brundin P., Are synucleinopathies prion-like disorders? The Lancet Neurology 2010 9 11 1128 1138
137. Brundin P., Melki R., Kopito R., Prion-like transmission of protein aggregates in neurodegenerative diseases Nature Reviews Molecular Cell Biology 2010 11 4 301 307
138. Goedert M., Clavaguera F., Tolnay M., The propagation of prion-like protein inclusions in neurodegenerative diseases Trends in Neurosciences 2010 33 7 317 325
139. Chia R., Tattum M. H., Jones S., Collinge J., Fisher E. M. C., Jackson G. S., Superoxide dismutase 1 and tgSOD1G93A mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis PLoS One 2010 5 5
140. Mnch C., O'Brien J., Bertolotti A., Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells Proceedings of the National Academy of Sciences of the United States of America 2011 108 9 3548 3553
141. Ren P. H., Lauckner J. E., Kachirskaia I., Heuser J. E., Melki R., Kopito R. R., Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates Nature Cell Biology 2009 11 2 219 225
142. Furukawa Y., Kaneko K., Watanabe S., Yamanaka K., Nukina N., A seeding
143. Novk M., Truncated tau protein as a new marker for Alzheimer's disease Acta Virologica 1994 38 3 173 189
144. Clavaguera F., Bolmont T., Crowther R. A., Abramowski D., Frank S., Probst A., Fraser G., Stalder A. K., Beibel M., Staufenbiel M., Jucker M., Goedert M., Tolnay M., Transmission and spreading of tauopathy in transgenic mouse brain Nature Cell Biology 2009 11 7 909 913
145. Frost B., Jacks R. L., Diamond M. I., Propagation of Tau misfolding from the outside to the inside of a cell The Journal of Biological Chemistry 2009 284 19 12845 12852
146. Frost B., Ollesch J., Wille H., Diamond M. I., Conformational diversity of wild-type tau fibrils specified by templated conformation change The Journal of Biological Chemistry 2009 284 6 3546 3551
147. Braak H., Del Tredici K., The pathological process underlying Alzheimer's disease in individuals under thirty Acta Neuropathologica 2011 121 2 171 181
148. Braak H., Del Tredici K., Alzheimer's pathogenesis: is there neuron-to-neuron propagation? Acta Neuropathologica 2011 121 5 589 595
149. Braak H., Braak E., Neuropathological stageing of Alzheimer-related changes Acta Neuropathologica 1991 82 4 239 259
150. Braak H., Alafuzoff I., Arzberger T., Kretzschmar H., Tredici K., Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry Acta Neuropathologica 2006 112 4 389 404 (Pubitemid 44469160)
151. Alafuzoff I., Arzberger T., Al-Sarraj S., Bodi I., Bogdanovic N., Braak H., Bugiani O., Del-Tredici K., Ferrer I., Gelpi E., Giaccone G., Graeber M. B., Ince P., Kamphorst W., King A., Korkolopoulou P., Kovcs G. G., Larionov S., Meyronet D., Monoranu C., Parchi P., Patsouris E., Roggendorf W., Seilhean D., Tagliavini F., Stadelmann C., Streichenberger N., Thal D. R., Wharton S. B., Kretzschmar H., Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe consortium Brain Pathology 2008 18 4 484 496
152. Balch W. E., Morimoto R. I., Dillin A., Kelly J. W., Adapting proteostasis for disease intervention Science 2008 319 5865 916 919 (Pubitemid 351263754)
153. Urushitani M., Sik A., Sakurai T., Nukina N., Takahashi R., Julien J. P., Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis Nature Neuroscience 2006 9 1 108 118 (Pubitemid 43011916)
154. Hu W. T., Chen-Plotkin A., Arnold S. E., Grossman M., Clark C. M., Shaw L. M., McCluskey L., Elman L., Karlawish J., Hurtig H. I., Siderowf A., Lee V. M. Y., Soares H., Trojanowski J. Q., Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease Acta Neuropathologica 2010 120 3 385 399
155. Mollenhauer B., Bibl M., Esselmann H., Steinacker P., Trenkwalder C., Wiltfang J., Otto M., Tauopathies and synucleinopathies: do cerebrospinal fluid -amyloid peptides reflect disease-specific pathogenesis? Journal of Neural Transmission 2007 114 7 919 927 (Pubitemid 47013596)
156. Hu X., Crick S. L., Bu G., Frieden C., Pappu R. V., Lee J. M., Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide Proceedings of the National Academy of Sciences of the United States of America 2009 106 48 20324 20329
157. Bibl M., Mollenhauer B., Esselmann H., Lewczuk P., Klafki H. W., Sparbier K., Smirnov A., Cepek L., Trenkwalder C., Rther E., Kornhuber J., Otto M., Wiltfang J., CSF amyloid- -peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia Brain 2006 129 5 1177 1187
158. Tomiyama T., Matsuyama S., Iso H., Umeda T., Takuma H., Ohnishi K., Ishibashi K., Teraoka R., Sakama N., Yamashita T., Nishitsuji K., Ito K., Shimada H., Lambert M. P., Klein W. L., Mori H., A mouse model of amyloid oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo Journal of Neuroscience 2010 30 14 4845 4856
159. Clinton L. K., Blurton-Jones M., Myczek K., Trojanowski J. Q., LaFerla F. M., Synergistic interactions between A, tau, and -synuclein: acceleration of neuropathology and cognitive decline Journal of Neuroscience 2010 30 21 7281 7289
160. Mrak R. E., Griffin W. S. T., Common inflammatory mechanisms in Lewy body disease and Alzheimer disease Journal of Neuropathology and Experimental Neurology 2007 66 8 683 686 (Pubitemid 47344247)
161. Fein J. A., Sokolow S., Miller C. A., Vinters H. V., Yang F., Cole G. M., Gylys K. H., Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes American Journal of Pathology 2008 172 6 1683 1692 (Pubitemid 351793359)
162. Takahashi R. H., Capetillo-Zarate E., Lin M. T., Milner T. A., Gouras G. K., Co-occurrence of Alzheimer's disease -amyloid and tau pathologies at synapses Neurobiology of Aging 2010 31 7 1145 1152