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Volumn 20, Issue 13, 2006, Pages 2302-2312

Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of Parkinsonism

Author keywords

synuclein knock out mice; Alzheimer's disease; Mesencephalic neurons; Neurodegeneration; PD

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; SERINE; TAU PROTEIN;

EID: 33845643466     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6092com     Document Type: Article
Times cited : (96)

References (62)
  • 1
    • 17844365594 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease
    • Morris, H. R. (2005) Genetics of Parkinson's disease. Ann Med. 37, 86-96
    • (2005) Ann Med. , vol.37 , pp. 86-96
    • Morris, H.R.1
  • 3
    • 30444457574 scopus 로고    scopus 로고
    • The alpha-synuclein mutation E46K promotes aggregation in cultured cells
    • Pandey, N., Schmidt, R. E., and Galvin, J. E. (2006) The alpha-synuclein mutation E46K promotes aggregation in cultured cells. Exp. Neurol. 197, 515-520
    • (2006) Exp. Neurol. , vol.197 , pp. 515-520
    • Pandey, N.1    Schmidt, R.E.2    Galvin, J.E.3
  • 6
    • 0033215063 scopus 로고    scopus 로고
    • Synucleins in synaptic plasticity and neurodegenerative disorders
    • Clayton, D. F., and George, J. M. (1999) Synucleins in synaptic plasticity and neurodegenerative disorders. J. Neurosci. Res. 58, 120-129
    • (1999) J. Neurosci. Res. , vol.58 , pp. 120-129
    • Clayton, D.F.1    George, J.M.2
  • 7
    • 0036884733 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein
    • Lotharius, J., and Brundin, P. (2002) Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein. Nat. Rev. Neurosci. 12, 932-942
    • (2002) Nat. Rev. Neurosci. , vol.12 , pp. 932-942
    • Lotharius, J.1    Brundin, P.2
  • 8
    • 3042655068 scopus 로고    scopus 로고
    • Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
    • Perez, R.G., and Hastings, T. G. (2004) Could a loss of alpha-synuclein function put dopaminergic neurons at risk? J. Neurochem. 89, 1318-1324
    • (2004) J. Neurochem. , vol.89 , pp. 1318-1324
    • Perez, R.G.1    Hastings, T.G.2
  • 9
    • 1842454976 scopus 로고    scopus 로고
    • Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse?
    • Sidhu, A., Wersinger, C., and Vernier, P. (2004a) Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB J. 18, 637-647
    • (2004) FASEB J. , vol.18 , pp. 637-647
    • Sidhu, A.1    Wersinger, C.2    Vernier, P.3
  • 10
    • 2342496196 scopus 로고    scopus 로고
    • Alpha-synuclein regulation of the dopaminergic transporter: A possible role in the pathogenesis of Parkinson's disease
    • Sidhu, A., Wersinger, C., and Vernier, P. (2004b) Alpha-synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. FEBS Lett. 565, 1-5
    • (2004) FEBS Lett. , vol.565 , pp. 1-5
    • Sidhu, A.1    Wersinger, C.2    Vernier, P.3
  • 11
    • 0031789960 scopus 로고    scopus 로고
    • Lewy body diseases and multi-system atrophy as alpha-synucleopathies
    • Goedert, M., and Spillantini, M. G. (1998) Lewy body diseases and multi-system atrophy as alpha-synucleopathies. Mol. Psychiatry 3, 462-465
    • (1998) Mol. Psychiatry , vol.3 , pp. 462-465
    • Goedert, M.1    Spillantini, M.G.2
  • 12
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer, W., and Przedborski, S. (2003) Parkinson's disease: mechanisms and models. Neuron 39, 889-909
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 16
    • 0032990543 scopus 로고    scopus 로고
    • Antibodies to α-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease
    • Lippa, C. F., Schmidt, M. L., Lee, V. M.-Y., and Trojanowski, J. Q. (1999) Antibodies to α-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann. Neurol. 45, 353-357
    • (1999) Ann. Neurol. , vol.45 , pp. 353-357
    • Lippa, C.F.1    Schmidt, M.L.2    Lee, V.M.-Y.3    Trojanowski, J.Q.4
  • 17
    • 0032849237 scopus 로고    scopus 로고
    • Cellular co-localization of phosphorylated tau- and NACP/α- synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies
    • Arima, K., Hirai, S., Sunohara, N., Aoto, K., Izumiyama, Y., Uéda, K., Ikeda, K., and Kawai, M. (1999) Cellular co-localization of phosphorylated tau- and NACP/α-synuclein-epitopes in Lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies. Brain Res. 843, 53-61
    • (1999) Brain Res. , vol.843 , pp. 53-61
    • Arima, K.1    Hirai, S.2    Sunohara, N.3    Aoto, K.4    Izumiyama, Y.5    Uéda, K.6    Ikeda, K.7    Kawai, M.8
  • 18
    • 0033537922 scopus 로고    scopus 로고
    • Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disese
    • Iseki, E., Marui, W., Kosaka, K., and Uéda, K. (1999) Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disese. Neurosci. Lett. 265, 9-12
    • (1999) Neurosci. Lett. , vol.265 , pp. 9-12
    • Iseki, E.1    Marui, W.2    Kosaka, K.3    Uéda, K.4
  • 20
    • 0034712918 scopus 로고    scopus 로고
    • Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation
    • Serpell, L. C., Berriman, J., Jakes, R., Goedert, M.,and Crowther, R. A. (2000) Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proc. Natl. Acad. Sci. U. S. A. 97, 4897-4902
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 4897-4902
    • Serpell, L.C.1    Berriman, J.2    Jakes, R.3    Goedert, M.4    Crowther, R.A.5
  • 22
    • 2342556414 scopus 로고    scopus 로고
    • Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation
    • Kotzbauer, P. T., Giasson, B. I., Kravitz, A. V., Golbe, L. I., Mark, M. H., Trojanowski, J. Q., and Lee, V. M. (2004) Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation. Exp. Neurol. 187, 279-288
    • (2004) Exp. Neurol. , vol.187 , pp. 279-288
    • Kotzbauer, P.T.1    Giasson, B.I.2    Kravitz, A.V.3    Golbe, L.I.4    Mark, M.H.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 23
    • 0027058857 scopus 로고
    • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
    • Drechsel, D. N., Hyman, A. A., Cobb, M. H., and Kirschner, M. W. (1992) Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol. Cell Bio. 3, 1141-1154
    • (1992) Mol. Cell Bio. , vol.3 , pp. 1141-1154
    • Drechsel, D.N.1    Hyman, A.A.2    Cobb, M.H.3    Kirschner, M.W.4
  • 24
    • 0027338266 scopus 로고
    • Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
    • Biernat, J., Gustke, N., Drewes, G., Mandelkow, E. M., and Mandelkow, F. (1993) Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron 11, 153-163
    • (1993) Neuron , vol.11 , pp. 153-163
    • Biernat, J.1    Gustke, N.2    Drewes, G.3    Mandelkow, E.M.4    Mandelkow, F.5
  • 25
    • 0036931159 scopus 로고    scopus 로고
    • Tau neurofibrillary pathology and microtubule stability
    • Michaelis, M. L., Dobrowsky, R. T., and Li, G. (2002) Tau neurofibrillary pathology and microtubule stability. J. Mol. Neurosci. 19, 289-293
    • (2002) J. Mol. Neurosci. , vol.19 , pp. 289-293
    • Michaelis, M.L.1    Dobrowsky, R.T.2    Li, G.3
  • 26
  • 27
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • Lucas, J. J., Hernandez, F., Gomez-Ramos, P., Moran, M. A., Hen, R., and Avila, J. (2001) Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 20, 27-39
    • (2001) EMBO J. , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 28
    • 4844219627 scopus 로고    scopus 로고
    • Promotion of hyperphosphorylation by frontotemporal dementia tau mutations
    • Alonso, A.C., Mederlyova, A., Novak, M., Grundke-Iqbal, I., and Iqbal, K. (2004) Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. J. Biol. Chem. 279, 34873-34881
    • (2004) J. Biol. Chem. , vol.279 , pp. 34873-34881
    • Alonso, A.C.1    Mederlyova, A.2    Novak, M.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 29
    • 0037010285 scopus 로고    scopus 로고
    • Alzheimer's disease: Beta-Amyloid protein and tau
    • Morishima-Kawashima, M., and Ihara, Y. (2002) Alzheimer's disease: beta-Amyloid protein and tau. J. Neurosci. Res. 70, 392-401
    • (2002) J. Neurosci. Res. , vol.70 , pp. 392-401
    • Morishima-Kawashima, M.1    Ihara, Y.2
  • 30
    • 12344323961 scopus 로고    scopus 로고
    • Tau phosphorylation in neuronal cell function and dysfunction
    • Johnson, G. V., and Stoothoff, W. H. (2004) Tau phosphorylation in neuronal cell function and dysfunction. J. Cell Sci. 17, 5721-57219
    • (2004) J. Cell Sci. , vol.17 , pp. 5721-57219
    • Johnson, G.V.1    Stoothoff, W.H.2
  • 32
    • 0027308924 scopus 로고
    • Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
    • Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., and Lee, V. M. (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10, 1089-1099
    • (1993) Neuron , vol.10 , pp. 1089-1099
    • Bramblett, G.T.1    Goedert, M.2    Jakes, R.3    Merrick, S.E.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 34
    • 0028593606 scopus 로고
    • Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404
    • Otvos, L. Jr., Feiner, L., Lang, E., Szendrei, G. L., Goedert, M., and Lee, V. M. (1994) Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404. J. Neurosci. Res. 39, 669-673
    • (1994) J. Neurosci. Res. , vol.39 , pp. 669-673
    • Otvos Jr., L.1    Feiner, L.2    Lang, E.3    Szendrei, G.L.4    Goedert, M.5    Lee, V.M.6
  • 36
    • 3542993306 scopus 로고    scopus 로고
    • Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration
    • Drolet, R.E., Behrouz, B., Lookingland, K. J., and Goudreau, J. L. (2004) Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration. Neurotoxicology 25, 761-769
    • (2004) Neurotoxicology , vol.25 , pp. 761-769
    • Drolet, R.E.1    Behrouz, B.2    Lookingland, K.J.3    Goudreau, J.L.4
  • 37
    • 0642364992 scopus 로고    scopus 로고
    • Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress
    • Wersinger, C., Prou, D., Vernier, P., and Sidhu, A. (2003) Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress. FASEB J. 17, 2151-2153
    • (2003) FASEB J. , vol.17 , pp. 2151-2153
    • Wersinger, C.1    Prou, D.2    Vernier, P.3    Sidhu, A.4
  • 38
    • 0015697938 scopus 로고
    • Isolated removal of hypothalamic or other brain nuclei of the rat
    • Palkovits, M. (1973) Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res. 59, 449-450
    • (1973) Brain Res. , vol.59 , pp. 449-450
    • Palkovits, M.1
  • 39
    • 0025312551 scopus 로고
    • Dopaminergic and beta-adrenergic receptor control of alpha-melanocyte- stimulating hormone secretion during stress
    • Lindley, S. E., Lookingland, K. J., and Moore, K. E. (1990) Dopaminergic and beta-adrenergic receptor control of alpha-melanocyte-stimulating hormone secretion during stress. Neuroendocrinology 52, 46-51
    • (1990) Neuroendocrinology , vol.52 , pp. 46-51
    • Lindley, S.E.1    Lookingland, K.J.2    Moore, K.E.3
  • 40
    • 0031610371 scopus 로고    scopus 로고
    • Measurement of Cell Death
    • Loo, D. T., and Rillema, J. R. (1998) Measurement of cell death. Methods Cell Biol. 57, 251-264
    • (1998) Methods Cell Biol. , vol.57 , pp. 251-264
    • Loo, D.T.1    Rillema, J.R.2
  • 41
    • 0036904519 scopus 로고    scopus 로고
    • Assembly of tau in transgenic animals expressing P301L tau: Alteration of phosphorylation and solubility
    • Sahara, N., Lewis, J., DeTure, M., McGowan, E., Dickson, D. W., Hutton, M., and Yen, S. H. (2002) Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility. J. Neurochem. 83, 1498-1508
    • (2002) J. Neurochem. , vol.83 , pp. 1498-1508
    • Sahara, N.1    Lewis, J.2    DeTure, M.3    McGowan, E.4    Dickson, D.W.5    Hutton, M.6    Yen, S.H.7
  • 43
    • 0037052633 scopus 로고    scopus 로고
    • MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells
    • Gomez-Santos, C., Ferrer, I., Reiriz, J., Vinals, F., Barrachina, M., and Ammbrosio, S. (2002) MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. Brain Res. 935, 32-39
    • (2002) Brain Res. , vol.935 , pp. 32-39
    • Gomez-Santos, C.1    Ferrer, I.2    Reiriz, J.3    Vinals, F.4    Barrachina, M.5    Ammbrosio, S.6
  • 45
    • 0031741247 scopus 로고    scopus 로고
    • J. New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
    • Hanger, D. P., Betts, J. C., Loviny, T. L., Blackstock, W. P., and Anderton, B. H. (1998) J. New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J. Neurochem. 71, 2465-2476
    • (1998) J. Neurochem. , vol.71 , pp. 2465-2476
    • Hanger, D.P.1    Betts, J.C.2    Loviny, T.L.3    Blackstock, W.P.4    Anderton, B.H.5
  • 46
    • 0035500991 scopus 로고    scopus 로고
    • Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells
    • Payton, J. E., Perrin, R. J., Clayton, D. F., and George, J. M. (2001) Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells. Brain Res. Mol. Brain Res. 95, 138-145
    • (2001) Brain Res. Mol. Brain Res. , vol.95 , pp. 138-145
    • Payton, J.E.1    Perrin, R.J.2    Clayton, D.F.3    George, J.M.4
  • 48
    • 26644462144 scopus 로고    scopus 로고
    • Disruption of the interaction of α-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter
    • Wersinger, C., and Sidhu, A. (2005) Disruption of the interaction of α-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter. Biochemistry 44, 13612-13624
    • (2005) Biochemistry , vol.44 , pp. 13612-13624
    • Wersinger, C.1    Sidhu, A.2
  • 49
    • 0033520474 scopus 로고    scopus 로고
    • Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356
    • Jensen, P. H., Hager, H., Nielsen, M. S., Hojrup, P., Gliemann, J., and Jakes, R. (1999) alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. J. Biol. Chem. 274, 25481-25489
    • (1999) J. Biol. Chem. , vol.274 , pp. 25481-25489
    • Jensen, P.H.1    Hager, H.2    Nielsen, M.S.3    Hojrup, P.4    Gliemann, J.5    Jakes, R.6
  • 52
    • 0038404962 scopus 로고    scopus 로고
    • Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- induced parkinsonism in mice
    • Schlüter, O.M., Fornai, F., Alessandri, M.G., Takamori, S., Geppert, M., Jahn R., and Sudhof, T. C. (2003) Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuroscience 118, 985-1002
    • (2003) Neuroscience , vol.118 , pp. 985-1002
    • Schlüter, O.M.1    Fornai, F.2    Alessandri, M.G.3    Takamori, S.4    Geppert, M.5    Jahn, R.6    Sudhof, T.C.7
  • 53
    • 27744450270 scopus 로고    scopus 로고
    • Synuclein expression in the substantia nigra of MPTP-lesioned non-human primates
    • Purisai, M. G., McCormack, A. L., Langston, W. J., Johnston, L. C., and DiMonte, D. A. (2005) alpha-Synuclein expression in the substantia nigra of MPTP-lesioned non-human primates. Neurobiol. Dis. 20, 898-906
    • (2005) Neurobiol. Dis. , vol.20 , pp. 898-906
    • Purisai, M.G.1    McCormack, A.L.2    Langston, W.J.3    Johnston, L.C.4    DiMonte, D.A.5
  • 54
    • 1842621154 scopus 로고    scopus 로고
    • Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: Effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-pigallo-catechin-3-gallate
    • Mandel, S., Maor, G., and Youdim, M. B. (2004) Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-pigallo-catechin-3-gallate. J. Mol. Neurosci. 24, 401-416
    • (2004) J. Mol. Neurosci. , vol.24 , pp. 401-416
    • Mandel, S.1    Maor, G.2    Youdim, M.B.3
  • 56
    • 0026595846 scopus 로고
    • Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
    • Goedert, M., Spillantini, M. G., Cairns, N. J., and Crowther, R. A. (1992) Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 8, 159-168
    • (1992) Neuron , vol.8 , pp. 159-168
    • Goedert, M.1    Spillantini, M.G.2    Cairns, N.J.3    Crowther, R.A.4
  • 57
    • 0033966487 scopus 로고    scopus 로고
    • Synuclein upregulation in substantia nigra dopaminergic neurons following administration of the Parkinsonian toxin MPTP
    • Vila, M., Vukosavic, S., Jackson-Lewis, V., Neystat, M., Jakowec, M., and Przedborski, S. (2000) alpha-Synuclein upregulation in substantia nigra dopaminergic neurons following administration of the Parkinsonian toxin MPTP. J. Neurochem. 74, 721-729
    • (2000) J. Neurochem. , vol.74 , pp. 721-729
    • Vila, M.1    Vukosavic, S.2    Jackson-Lewis, V.3    Neystat, M.4    Jakowec, M.5    Przedborski, S.6
  • 59
    • 0037159608 scopus 로고    scopus 로고
    • Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
    • Meredith, G. E., Totterdell, S., Petroske, E., Santa Cruz, K., Callison, R. C., and Lau Y.-S. (2002) Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res. 956, 156-165
    • (2002) Brain Res. , vol.956 , pp. 156-165
    • Meredith, G.E.1    Totterdell, S.2    Petroske, E.3    Santa Cruz, K.4    Callison, R.C.5    Lau, Y.-S.6
  • 60
    • 9644259136 scopus 로고    scopus 로고
    • Selective alterations of gene expression in mice induced by MPTP
    • Xu, Z., Cawthon, D., McCastlain, K. A., Slikker, W., Jr., and Ali, S. F. (2005) Selective alterations of gene expression in mice induced by MPTP. Synapse 55, 45-51
    • (2005) Synapse , vol.55 , pp. 45-51
    • Xu, Z.1    Cawthon, D.2    McCastlain, K.A.3    Slikker Jr., W.4    Ali, S.F.5
  • 61
    • 0042848693 scopus 로고    scopus 로고
    • A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein
    • Du, H., Tang, L., Luo, X., Li, H.., Hu, J., Zhou, J., and Hu, H. Y. (2003) A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein. Biochemistry 29, 8870-8878
    • (2003) Biochemistry , vol.29 , pp. 8870-8878
    • Du, H.1    Tang, L.2    Luo, X.3    Li, H.4    Hu, J.5    Zhou, J.6    Hu, H.Y.7
  • 62
    • 14244253319 scopus 로고    scopus 로고
    • Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies
    • Iqbal, K., and Grundke-Iqbal, I. (2005) Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies. Acta Neuropathol. (Berl.) 109, 25-31
    • (2005) Acta Neuropathol. (Berl.) , vol.109 , pp. 25-31
    • Iqbal, K.1    Grundke-Iqbal, I.2


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