메뉴 건너뛰기




Volumn 26, Issue 1, 2012, Pages 1-10

Immunology meets neuroscience - Opportunities for immune intervention in neurodegenerative diseases

Author keywords

Alzheimer's disease; Immune therapy; Multiple sclerosis; Neurodegeneration; Neuroinflammation; T cells

Indexed keywords

ALEMTUZUMAB; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; BETA1A INTERFERON; FINGOLIMOD; GLATIRAMER; IBUPROFEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INTERFERON REGULATORY FACTOR; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN; NATALIZUMAB; RITUXIMAB; TOLL LIKE RECEPTOR;

EID: 81355138814     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2011.05.013     Document Type: Review
Times cited : (24)

References (114)
  • 1
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B., Bennett J.L., Krieger C., Tetzlaff W., Rossi F.M. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 2007, 10:1538-1543.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 5
    • 3142724732 scopus 로고    scopus 로고
    • Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    • Bettelli E., Sullivan B., Szabo S.J., Sobel R.A., Glimcher L.H., Kuchroo V.K. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 2004, 200:79-87.
    • (2004) J. Exp. Med. , vol.200 , pp. 79-87
    • Bettelli, E.1    Sullivan, B.2    Szabo, S.J.3    Sobel, R.A.4    Glimcher, L.H.5    Kuchroo, V.K.6
  • 7
    • 68149169760 scopus 로고    scopus 로고
    • Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease
    • Brereton C.F., Sutton C.E., Lalor S.J., Lavelle E.C., Mills K.H. Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease. J. Immunol. 2009, 183:1715-1723.
    • (2009) J. Immunol. , vol.183 , pp. 1715-1723
    • Brereton, C.F.1    Sutton, C.E.2    Lalor, S.J.3    Lavelle, E.C.4    Mills, K.H.5
  • 8
    • 7544246271 scopus 로고    scopus 로고
    • Analysis of microglial gene expression: identifying targets for CNS neurodegenerative and autoimmune disease
    • Carson M.J., Thrash J.C., Lo D. Analysis of microglial gene expression: identifying targets for CNS neurodegenerative and autoimmune disease. Am. J. Pharmacogenomics 2004, 4:321-330.
    • (2004) Am. J. Pharmacogenomics , vol.4 , pp. 321-330
    • Carson, M.J.1    Thrash, J.C.2    Lo, D.3
  • 9
    • 0031891953 scopus 로고    scopus 로고
    • Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice
    • Chen Y., Hancock W.W., Marks R., Gonnella P., Weiner H.L. Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice. J. Neuroimmunol. 1998, 82:149-159.
    • (1998) J. Neuroimmunol. , vol.82 , pp. 149-159
    • Chen, Y.1    Hancock, W.W.2    Marks, R.3    Gonnella, P.4    Weiner, H.L.5
  • 13
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos R.B., Bales K.R., Cummins D.J., Dodart J.C., Paul S.M., Holtzman D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2001, 98:8850-8855.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 14
    • 34250623663 scopus 로고    scopus 로고
    • Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy
    • Desai B.S., Monahan A.J., Carvey P.M., Hendey B. Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy. Cell Transplant. 2007, 16:285-299.
    • (2007) Cell Transplant. , vol.16 , pp. 285-299
    • Desai, B.S.1    Monahan, A.J.2    Carvey, P.M.3    Hendey, B.4
  • 16
    • 33947545098 scopus 로고    scopus 로고
    • Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid
    • Fan R., Xu F., Previti M.L., Davis J., Grande A.M., Robinson J.K., Van Nostrand W.E. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J. Neurosci. 2007, 27:3057-3063.
    • (2007) J. Neurosci. , vol.27 , pp. 3057-3063
    • Fan, R.1    Xu, F.2    Previti, M.L.3    Davis, J.4    Grande, A.M.5    Robinson, J.K.6    Van Nostrand, W.E.7
  • 17
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease
    • Ferrer I., Boada Rovira M., Sanchez Guerra M.L., Rey M.J., Costa-Jussa F. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Brain Pathol. 2004, 14:11-20.
    • (2004) Brain Pathol. , vol.14 , pp. 11-20
    • Ferrer, I.1    Boada Rovira, M.2    Sanchez Guerra, M.L.3    Rey, M.J.4    Costa-Jussa, F.5
  • 19
    • 77956507245 scopus 로고    scopus 로고
    • T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease
    • Fisher Y., Nemirovsky A., Baron R., Monsonego A. T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease. PLoS ONE 2010, 5:e10830.
    • (2010) PLoS ONE , vol.5
    • Fisher, Y.1    Nemirovsky, A.2    Baron, R.3    Monsonego, A.4
  • 21
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis - the plaque and its pathogenesis
    • Frohman E.M., Racke M.K., Raine C.S. Multiple sclerosis - the plaque and its pathogenesis. N. Engl. J. Med. 2006, 354:942-955.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 25
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., Weaver C.T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005, 6:1123-1132.
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 28
    • 73549089256 scopus 로고    scopus 로고
    • Multiple sclerosis: distribution of inflammatory cells in newly forming lesions
    • Henderson A.P., Barnett M.H., Parratt J.D., Prineas J.W. Multiple sclerosis: distribution of inflammatory cells in newly forming lesions. Ann. Neurol. 2009, 66:739-753.
    • (2009) Ann. Neurol. , vol.66 , pp. 739-753
    • Henderson, A.P.1    Barnett, M.H.2    Parratt, J.D.3    Prineas, J.W.4
  • 29
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman S.E., Allison E.K., El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J. Neurosci. 2008, 28:8354-8360.
    • (2008) J. Neurosci. , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 30
    • 77949890133 scopus 로고    scopus 로고
    • Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease
    • Hickman S.E., El Khoury J. Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease. CNS Neurol. Disord. Drug Targets 2010, 9:168-173.
    • (2010) CNS Neurol. Disord. Drug Targets , vol.9 , pp. 168-173
    • Hickman, S.E.1    El Khoury, J.2
  • 31
    • 79952016751 scopus 로고    scopus 로고
    • Future clinical challenges in multiple sclerosis: relevance to sphingosine 1-phosphate receptor modulator therapy
    • Hohlfeld R., Barkhof F., Polman C. Future clinical challenges in multiple sclerosis: relevance to sphingosine 1-phosphate receptor modulator therapy. Neurology 2011, 76:S28-37.
    • (2011) Neurology , vol.76
    • Hohlfeld, R.1    Barkhof, F.2    Polman, C.3
  • 33
    • 77953642555 scopus 로고    scopus 로고
    • Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis
    • Jain P., Coisne C., Enzmann G., Rottapel R., Engelhardt B. Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis. J. Immunol. 2010, 184:7196-7206.
    • (2010) J. Immunol. , vol.184 , pp. 7196-7206
    • Jain, P.1    Coisne, C.2    Enzmann, G.3    Rottapel, R.4    Engelhardt, B.5
  • 35
    • 73349115586 scopus 로고    scopus 로고
    • Spotlight on alemtuzumab
    • Jones J.L., Coles A.J. Spotlight on alemtuzumab. Int. MS J. 2009, 16:77-81.
    • (2009) Int. MS J. , vol.16 , pp. 77-81
    • Jones, J.L.1    Coles, A.J.2
  • 36
    • 68649089275 scopus 로고    scopus 로고
    • Gammadelta T cell receptors without a job
    • Kapsenberg M.L. Gammadelta T cell receptors without a job. Immunity 2009, 31:181-183.
    • (2009) Immunity , vol.31 , pp. 181-183
    • Kapsenberg, M.L.1
  • 38
    • 0028829010 scopus 로고
    • Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells
    • Khoruts A., Miller S.D., Jenkins M.K. Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells. J. Immunol. 1995, 155:5011-5017.
    • (1995) J. Immunol. , vol.155 , pp. 5011-5017
    • Khoruts, A.1    Miller, S.D.2    Jenkins, M.K.3
  • 39
    • 24744467358 scopus 로고    scopus 로고
    • Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines
    • Koenigsknecht-Talboo J., Landreth G.E. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J. Neurosci. 2005, 25:8240-8249.
    • (2005) J. Neurosci. , vol.25 , pp. 8240-8249
    • Koenigsknecht-Talboo, J.1    Landreth, G.E.2
  • 42
    • 0029957071 scopus 로고    scopus 로고
    • Interferon-gamma confers resistance to experimental allergic encephalomyelitis
    • Krakowski M., Owens T. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur. J. Immunol. 1996, 26:1641-1646.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1641-1646
    • Krakowski, M.1    Owens, T.2
  • 43
    • 46949104323 scopus 로고    scopus 로고
    • IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • Kroenke M.A., Carlson T.J., Andjelkovic A.V., Segal B.M. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 2008, 205:1535-1541.
    • (2008) J. Exp. Med. , vol.205 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 44
    • 79952213941 scopus 로고    scopus 로고
    • New interleukin-23 pathway inhibitors in dermatology: ustekinumab, briakinumab, and secukinumab
    • Kurzeja M., Rudnicka L., Olszewska M. New interleukin-23 pathway inhibitors in dermatology: ustekinumab, briakinumab, and secukinumab. Am. J. Clin. Dermatol. 2011, 12:113-125.
    • (2011) Am. J. Clin. Dermatol. , vol.12 , pp. 113-125
    • Kurzeja, M.1    Rudnicka, L.2    Olszewska, M.3
  • 45
    • 79956187649 scopus 로고    scopus 로고
    • in press. Caspase-1 processed cytokines IL-1β and IL-18 promote IL-17-production by γδ and CD4 T cells that mediate autoimmunity. J. Immunol.
    • Lalor, S.J., Dungan, L., Sutton, C.E., Basdeo, S.A., Fletcher, J.M., Mills, K.H.G., 2011. in press. Caspase-1 processed cytokines IL-1β and IL-18 promote IL-17-production by γδ and CD4 T cells that mediate autoimmunity. J. Immunol.
    • (2011)
    • Lalor, S.J.1    Dungan, L.2    Sutton, C.E.3    Basdeo, S.A.4    Fletcher, J.M.5    Mills, K.H.G.6
  • 48
    • 67849130968 scopus 로고    scopus 로고
    • Developing novel immunogens for a safe and effective Alzheimer's disease vaccine
    • Lemere C.A. Developing novel immunogens for a safe and effective Alzheimer's disease vaccine. Prog. Brain Res. 2009, 175:83-93.
    • (2009) Prog. Brain Res. , vol.175 , pp. 83-93
    • Lemere, C.A.1
  • 49
    • 66949169952 scopus 로고    scopus 로고
    • Amyloid beta interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier
    • Li M., Shang D.S., Zhao W.D., Tian L., Li B., Fang W.G., Zhu L., Man S.M., Chen Y.H. Amyloid beta interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier. J. Immunol. 2009, 182:5778-5788.
    • (2009) J. Immunol. , vol.182 , pp. 5778-5788
    • Li, M.1    Shang, D.S.2    Zhao, W.D.3    Tian, L.4    Li, B.5    Fang, W.G.6    Zhu, L.7    Man, S.M.8    Chen, Y.H.9
  • 50
    • 71349085295 scopus 로고    scopus 로고
    • Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-alpha-dependent
    • Liu Y.J., Guo D.W., Tian L., Shang D.S., Zhao W.D., Li B., Fang W.G., Zhu L., Chen Y.H. Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-alpha-dependent. Neurobiol. Aging 2010, 31:175-188.
    • (2010) Neurobiol. Aging , vol.31 , pp. 175-188
    • Liu, Y.J.1    Guo, D.W.2    Tian, L.3    Shang, D.S.4    Zhao, W.D.5    Li, B.6    Fang, W.G.7    Zhu, L.8    Chen, Y.H.9
  • 51
    • 77955842718 scopus 로고    scopus 로고
    • Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer's disease
    • Loewenbrueck K.F., Tigno-Aranjuez J.T., Boehm B.O., Lehmann P.V., Tary-Lehmann M. Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer's disease. Neurobiol. Aging 2010, 31:1732-1742.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1732-1742
    • Loewenbrueck, K.F.1    Tigno-Aranjuez, J.T.2    Boehm, B.O.3    Lehmann, P.V.4    Tary-Lehmann, M.5
  • 52
    • 77953483260 scopus 로고    scopus 로고
    • Age-related neuroinflammatory changes negatively impact on neuronal function
    • Lynch M.A. Age-related neuroinflammatory changes negatively impact on neuronal function. Front Aging Neurosci. 2010, 1:6.
    • (2010) Front Aging Neurosci. , vol.1 , pp. 6
    • Lynch, M.A.1
  • 53
    • 0031961832 scopus 로고    scopus 로고
    • Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy
    • Mackic J.B., Weiss M.H., Miao W., Kirkman E., Ghiso J., Calero M., Bading J., Frangione B., Zlokovic B.V. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J. Neurochem. 1998, 70:210-215.
    • (1998) J. Neurochem. , vol.70 , pp. 210-215
    • Mackic, J.B.1    Weiss, M.H.2    Miao, W.3    Kirkman, E.4    Ghiso, J.5    Calero, M.6    Bading, J.7    Frangione, B.8    Zlokovic, B.V.9
  • 54
    • 33847128514 scopus 로고    scopus 로고
    • Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease
    • Man S.M., Ma Y.R., Shang D.S., Zhao W.D., Li B., Guo D.W., Fang W.G., Zhu L., Chen Y.H. Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease. Neurobiol. Aging 2007, 28:485-496.
    • (2007) Neurobiol. Aging , vol.28 , pp. 485-496
    • Man, S.M.1    Ma, Y.R.2    Shang, D.S.3    Zhao, W.D.4    Li, B.5    Guo, D.W.6    Fang, W.G.7    Zhu, L.8    Chen, Y.H.9
  • 55
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius D., Kivisakk P., He B., Kostulas N., Ozenci V., Fredrikson S., Link H. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 1999, 5:101-104.
    • (1999) Mult. Scler. , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisakk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6    Link, H.7
  • 56
    • 0023782375 scopus 로고
    • Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
    • McGeer P.L., Itagaki S., McGeer E.G. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol. 1988, 76:550-557.
    • (1988) Acta Neuropathol. , vol.76 , pp. 550-557
    • McGeer, P.L.1    Itagaki, S.2    McGeer, E.G.3
  • 57
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies
    • McGeer P.L., Schulzer M., McGeer E.G. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 1996, 47:425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 58
    • 0141991072 scopus 로고    scopus 로고
    • Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy
    • McMenamin P.G., Wealthall R.J., Deverall M., Cooper S.J., Griffin B. Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy. Cell Tissue Res. 2003, 313:259-269.
    • (2003) Cell Tissue Res. , vol.313 , pp. 259-269
    • McMenamin, P.G.1    Wealthall, R.J.2    Deverall, M.3    Cooper, S.J.4    Griffin, B.5
  • 59
    • 77951880336 scopus 로고    scopus 로고
    • Activation of mixed glia by Abeta-specific Th1 and Th17 cells and its regulation by Th2 cells
    • McQuillan K., Lynch M.A., Mills K.H. Activation of mixed glia by Abeta-specific Th1 and Th17 cells and its regulation by Th2 cells. Brain Behav. Immun. 2010, 24:598-607.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 598-607
    • McQuillan, K.1    Lynch, M.A.2    Mills, K.H.3
  • 60
    • 33745946858 scopus 로고    scopus 로고
    • Progression of disease and a remedy: causative role of macrophages and microglia: remedial effect of immunomodulatory and immunosuppressive therapies "in combination"
    • Milder D.G. Progression of disease and a remedy: causative role of macrophages and microglia: remedial effect of immunomodulatory and immunosuppressive therapies "in combination" Med. Hypotheses 2006, 67:736-739.
    • (2006) Med. Hypotheses , vol.67 , pp. 736-739
    • Milder, D.G.1
  • 61
    • 58149268052 scopus 로고    scopus 로고
    • Induction, function and regulation of IL-17-producing T cells
    • Mills K.H. Induction, function and regulation of IL-17-producing T cells. Eur. J. Immunol. 2008, 38:2636-2649.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 2636-2649
    • Mills, K.H.1
  • 62
    • 0242268945 scopus 로고    scopus 로고
    • Immunotherapeutic approaches to Alzheimer's disease
    • Monsonego A., Weiner H.L. Immunotherapeutic approaches to Alzheimer's disease. Science 2003, 302:834-838.
    • (2003) Science , vol.302 , pp. 834-838
    • Monsonego, A.1    Weiner, H.L.2
  • 63
    • 84880189986 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • Morgan D. Immunotherapy for Alzheimer's disease. J. Alzheimers Dis. 2006, 9:425-432.
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 425-432
    • Morgan, D.1
  • 65
    • 77951879282 scopus 로고    scopus 로고
    • Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
    • Murphy A.C., Lalor S.J., Lynch M.A., Mills K.H. Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav. Immun. 2010, 24:641-651.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 641-651
    • Murphy, A.C.1    Lalor, S.J.2    Lynch, M.A.3    Mills, K.H.4
  • 66
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: an essential link between degeneration and regeneration
    • Neumann H., Kotter M.R., Franklin R.J. Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 2009, 132:288-295.
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.3
  • 67
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 72
    • 0038807049 scopus 로고    scopus 로고
    • Hematogenous macrophages express CD8 and distribute to regions of lesion cavitation after spinal cord injury
    • Popovich P.G., van Rooijen N., Hickey W.F., Preidis G., McGaughy V. Hematogenous macrophages express CD8 and distribute to regions of lesion cavitation after spinal cord injury. Exp. Neurol. 2003, 182:275-287.
    • (2003) Exp. Neurol. , vol.182 , pp. 275-287
    • Popovich, P.G.1    van Rooijen, N.2    Hickey, W.F.3    Preidis, G.4    McGaughy, V.5
  • 73
    • 79851496064 scopus 로고    scopus 로고
    • Antibody-based therapy in Alzheimer's disease
    • Pul R., Dodel R., Stangel M. Antibody-based therapy in Alzheimer's disease. Expert Opin. Biol. Ther. 2011, 11:343-357.
    • (2011) Expert Opin. Biol. Ther. , vol.11 , pp. 343-357
    • Pul, R.1    Dodel, R.2    Stangel, M.3
  • 74
    • 9144219644 scopus 로고    scopus 로고
    • Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity
    • Qin W., Ho L., Pompl P.N., Peng Y., Zhao Z., Xiang Z., Robakis N.K., Shioi J., Suh J., Pasinetti G.M. Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. J. Biol. Chem. 2003, 278:50970-50977.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50970-50977
    • Qin, W.1    Ho, L.2    Pompl, P.N.3    Peng, Y.4    Zhao, Z.5    Xiang, Z.6    Robakis, N.K.7    Shioi, J.8    Suh, J.9    Pasinetti, G.M.10
  • 75
    • 78449254879 scopus 로고    scopus 로고
    • Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu
    • Reed-Geaghan E.G., Reed Q.W., Cramer P.E., Landreth G.E. Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu. J. Neurosci. 2010, 30:15369-15373.
    • (2010) J. Neurosci. , vol.30 , pp. 15369-15373
    • Reed-Geaghan, E.G.1    Reed, Q.W.2    Cramer, P.E.3    Landreth, G.E.4
  • 76
    • 45949106077 scopus 로고    scopus 로고
    • Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease
    • Richard K.L., Filali M., Prefontaine P., Rivest S. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J. Neurosci. 2008, 28:5784-5793.
    • (2008) J. Neurosci. , vol.28 , pp. 5784-5793
    • Richard, K.L.1    Filali, M.2    Prefontaine, P.3    Rivest, S.4
  • 77
    • 66449130960 scopus 로고    scopus 로고
    • Regulation of innate immune responses in the brain
    • Rivest S. Regulation of innate immune responses in the brain. Nat. Rev. Immunol. 2009, 9:429-439.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 429-439
    • Rivest, S.1
  • 79
    • 70349854764 scopus 로고    scopus 로고
    • Gray-matter injury in multiple sclerosis
    • Rudick R.A., Trapp B.D. Gray-matter injury in multiple sclerosis. N. Engl. J. Med. 2009, 361:1505-1506.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1505-1506
    • Rudick, R.A.1    Trapp, B.D.2
  • 80
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning
    • Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat. Rev. Neurosci. 2002, 3:824-828.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 824-828
    • Schenk, D.1
  • 82
    • 38749120306 scopus 로고    scopus 로고
    • Increased T-cell reactivity and elevated levels of CD8+ memory T-cells in Alzheimer's disease-patients and T-cell hyporeactivity in an Alzheimer's disease-mouse model: implications for immunotherapy
    • Schindowski K., Eckert A., Peters J., Gorriz C., Schramm U., Weinandi T., Maurer K., Frolich L., Muller W.E. Increased T-cell reactivity and elevated levels of CD8+ memory T-cells in Alzheimer's disease-patients and T-cell hyporeactivity in an Alzheimer's disease-mouse model: implications for immunotherapy. Neuromolecular Med. 2007, 9:340-354.
    • (2007) Neuromolecular Med. , vol.9 , pp. 340-354
    • Schindowski, K.1    Eckert, A.2    Peters, J.3    Gorriz, C.4    Schramm, U.5    Weinandi, T.6    Maurer, K.7    Frolich, L.8    Muller, W.E.9
  • 83
    • 48849087125 scopus 로고    scopus 로고
    • Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
    • Segal B.M., Constantinescu C.S., Raychaudhuri A., Kim L., Fidelus-Gort R., Kasper L.H. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol. 2008, 7:796-804.
    • (2008) Lancet Neurol. , vol.7 , pp. 796-804
    • Segal, B.M.1    Constantinescu, C.S.2    Raychaudhuri, A.3    Kim, L.4    Fidelus-Gort, R.5    Kasper, L.H.6
  • 85
    • 34249899174 scopus 로고    scopus 로고
    • Sustained hippocampal IL-1beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    • Shaftel S.S., Kyrkanides S., Olschowka J.A., Miller J.N., Johnson R.E., O'Banion M.K. Sustained hippocampal IL-1beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J. Clin. Invest. 2007, 117:1595-1604.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1595-1604
    • Shaftel, S.S.1    Kyrkanides, S.2    Olschowka, J.A.3    Miller, J.N.4    Johnson, R.E.5    O'Banion, M.K.6
  • 86
    • 77950862182 scopus 로고    scopus 로고
    • Multiple sclerosis - candidate mechanisms underlying CNS atrophy
    • Siffrin V., Vogt J., Radbruch H., Nitsch R., Zipp F. Multiple sclerosis - candidate mechanisms underlying CNS atrophy. Trends Neurosci. 2010, 33:202-210.
    • (2010) Trends Neurosci. , vol.33 , pp. 202-210
    • Siffrin, V.1    Vogt, J.2    Radbruch, H.3    Nitsch, R.4    Zipp, F.5
  • 87
    • 6944234040 scopus 로고    scopus 로고
    • Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia
    • Simard A.R., Rivest S. Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. Faseb J. 2004, 18:998-1000.
    • (2004) Faseb J. , vol.18 , pp. 998-1000
    • Simard, A.R.1    Rivest, S.2
  • 88
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard A.R., Soulet D., Gowing G., Julien J.P., Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006, 49:489-502.
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 90
    • 53249138093 scopus 로고    scopus 로고
    • Brain endothelial cell-cell junctions: how to "open" the blood brain barrier
    • Stamatovic S.M., Keep R.F., Andjelkovic A.V. Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr. Neuropharmacol. 2008, 6:179-192.
    • (2008) Curr. Neuropharmacol. , vol.6 , pp. 179-192
    • Stamatovic, S.M.1    Keep, R.F.2    Andjelkovic, A.V.3
  • 91
    • 65449122461 scopus 로고    scopus 로고
    • Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg
    • Stephens L.A., Malpass K.H., Anderton S.M. Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg. Eur. J. Immunol. 2009, 39:1108-1117.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1108-1117
    • Stephens, L.A.1    Malpass, K.H.2    Anderton, S.M.3
  • 92
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart W.F., Kawas C., Corrada M., Metter E.J. Risk of Alzheimer's disease and duration of NSAID use. Neurology 1997, 48:626-632.
    • (1997) Neurology , vol.48 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 94
    • 69949118284 scopus 로고    scopus 로고
    • Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
    • Streit W.J., Braak H., Xue Q.S., Bechmann I. Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease. Acta Neuropathol. 2009, 118:475-485.
    • (2009) Acta Neuropathol. , vol.118 , pp. 475-485
    • Streit, W.J.1    Braak, H.2    Xue, Q.S.3    Bechmann, I.4
  • 95
    • 42649098547 scopus 로고    scopus 로고
    • Microglial degeneration in the aging brain - bad news for neurons?
    • Streit W.J., Miller K.R., Lopes K.O., Njie E. Microglial degeneration in the aging brain - bad news for neurons?. Front Biosci. 2008, 13:3423-3438.
    • (2008) Front Biosci. , vol.13 , pp. 3423-3438
    • Streit, W.J.1    Miller, K.R.2    Lopes, K.O.3    Njie, E.4
  • 96
    • 79952224560 scopus 로고    scopus 로고
    • Multiple sclerosis: autoimmune disease or autoimmune reaction?
    • Stys P.K. Multiple sclerosis: autoimmune disease or autoimmune reaction?. Can. J. Neurol. Sci. 2010, 37(Suppl. 2):S16-S23.
    • (2010) Can. J. Neurol. Sci. , vol.37 , Issue.SUPPL.2
    • Stys, P.K.1
  • 97
    • 9644275598 scopus 로고    scopus 로고
    • Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease
    • Sung S., Yang H., Uryu K., Lee E.B., Zhao L., Shineman D., Trojanowski J.Q., Lee V.M., Pratico D. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. Am. J. Pathol. 2004, 165:2197-2206.
    • (2004) Am. J. Pathol. , vol.165 , pp. 2197-2206
    • Sung, S.1    Yang, H.2    Uryu, K.3    Lee, E.B.4    Zhao, L.5    Shineman, D.6    Trojanowski, J.Q.7    Lee, V.M.8    Pratico, D.9
  • 98
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C., Brereton C., Keogh B., Mills K.H., Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 2006, 203:1685-1691.
    • (2006) J. Exp. Med. , vol.203 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5
  • 99
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T Cells, amplifying Th17 responses and autoimmunity
    • Sutton C.E., Lalor S.J., Sweeney C.M., Brereton C.F., Lavelle E.C., Mills K.H. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T Cells, amplifying Th17 responses and autoimmunity. Immunity 2009, 31:331-341.
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1    Lalor, S.J.2    Sweeney, C.M.3    Brereton, C.F.4    Lavelle, E.C.5    Mills, K.H.6
  • 101
    • 33750576993 scopus 로고    scopus 로고
    • Role of toll-like receptor signalling in Abeta uptake and clearance
    • Tahara K., Kim H.D., Jin J.J., Maxwell J.A., Li L., Fukuchi K. Role of toll-like receptor signalling in Abeta uptake and clearance. Brain 2006, 129:3006-3019.
    • (2006) Brain , vol.129 , pp. 3006-3019
    • Tahara, K.1    Kim, H.D.2    Jin, J.J.3    Maxwell, J.A.4    Li, L.5    Fukuchi, K.6
  • 102
    • 60349100558 scopus 로고    scopus 로고
    • Neuronal regulation of immune responses in the central nervous system
    • Tian L., Rauvala H., Gahmberg C.G. Neuronal regulation of immune responses in the central nervous system. Trends Immunol. 2009, 30:91-99.
    • (2009) Trends Immunol. , vol.30 , pp. 91-99
    • Tian, L.1    Rauvala, H.2    Gahmberg, C.G.3
  • 104
    • 0029830124 scopus 로고    scopus 로고
    • APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease
    • Trieb K., Ransmayr G., Sgonc R., Lassmann H., Grubeck-Loebenstein B. APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease. Neurobiol. Aging 1996, 17:541-547.
    • (1996) Neurobiol. Aging , vol.17 , pp. 541-547
    • Trieb, K.1    Ransmayr, G.2    Sgonc, R.3    Lassmann, H.4    Grubeck-Loebenstein, B.5
  • 105
    • 33744936550 scopus 로고    scopus 로고
    • IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production
    • Vaknin-Dembinsky A., Balashov K., Weiner H.L. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol. 2006, 176:7768-7774.
    • (2006) J. Immunol. , vol.176 , pp. 7768-7774
    • Vaknin-Dembinsky, A.1    Balashov, K.2    Weiner, H.L.3
  • 108
    • 37249008654 scopus 로고    scopus 로고
    • Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions
    • Walker D., Lue L.F. Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions. Curr. Neuropharmacol. 2007, 5:232-243.
    • (2007) Curr. Neuropharmacol. , vol.5 , pp. 232-243
    • Walker, D.1    Lue, L.F.2
  • 109
    • 33646384419 scopus 로고    scopus 로고
    • Immunology and immunotherapy of Alzheimer's disease
    • Weiner H.L., Frenkel D. Immunology and immunotherapy of Alzheimer's disease. Nat. Rev. Immunol. 2006, 6:404-416.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 404-416
    • Weiner, H.L.1    Frenkel, D.2
  • 112
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
    • Yan Q., Zhang J., Liu H., Babu-Khan S., Vassar R., Biere A.L., Citron M., Landreth G. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J. Neurosci. 2003, 23:7504-7509.
    • (2003) J. Neurosci. , vol.23 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3    Babu-Khan, S.4    Vassar, R.5    Biere, A.L.6    Citron, M.7    Landreth, G.8
  • 114
    • 33644910475 scopus 로고    scopus 로고
    • Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination
    • Zhao C., Li W.W., Franklin R.J. Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination. Neurobiol. Aging 2006, 27:1298-1307.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1298-1307
    • Zhao, C.1    Li, W.W.2    Franklin, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.