Computational protein design with a generalized born solvent model: Application to asparaginyl-tRNA synthetase

Proteins: Structure, Function and Bioinformatics

Volumn 79, Issue 12, 2011, Pages 3448-3468

  Polydorides, Savvas ^a   Amara, Najette ^b   Aubard, Caroline ^b   Plateau, Pierre ^b   Simonson, Thomas ^b   Archontis, Georgios ^a  

^a UNIVERSITY OF CYPRUS   (Cyprus)

^b LABORATOIRE DE BIOCHIMIE   (France)

Author keywords

Aminoacyl tRNA synthetases; Asparaginyl tRNA synthetase; Computational protein design; Generalized Born model; Genetic code; Implicit solvent models; Molecular dynamics simulations; Poisson Boltzmann calculations; Protein ligand interactions

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID;

ADENYLATION; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; COMPUTATIONAL PROTEIN DESIGN; ENERGY YIELD; HUMAN; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; AMINO ACIDS; ASPARTATE-TRNA LIGASE; BINDING SITES; COMPUTATIONAL BIOLOGY; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RNA, TRANSFER, AMINO ACYL; SUBSTRATE SPECIFICITY; TYROSINE-TRNA LIGASE;

EID: 81055158020     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.23042     Document Type: Article

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