Testing the coulomb/accessible surface area solvent model for protein stability, ligand binding, and protein design

BMC Bioinformatics

Volumn 9, Issue , 2008, Pages

  am Busch, Marcel Schmidt ^a   Lopes, Anne ^a   Amara, Najette ^a   Bathelt, Christine ^a   Simonson, Thomas ^a  

^a LABORATOIRE DE BIOCHIMIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACCESSIBLE SURFACE AREAS; COMPUTATIONAL ENGINEERING; COMPUTATIONAL PROTEIN DESIGN; GENERALIZED BORN/SURFACE AREA; IMPLICIT SOLVENT MODEL; OPTIMIZATION PROCEDURES; PROTEIN STRUCTURE PREDICTION; PROTEIN-LIGAND BINDING AFFINITIES;

AMINO ACIDS; BINDING ENERGY; BIOCHEMICAL ENGINEERING; ITERATIVE METHODS; LIGANDS; OPTIMIZATION; PROTEINS; SOLVATION; SOLVENTS; STABILITY;

STRUCTURAL DESIGN;

ABELSON KINASE; ASPARTATE TRANSFER RNA LIGASE; ASPARTIC ACID DERIVATIVE; CD4 ANTIGEN; CHYMOTRYPSIN; GLYCOPROTEIN GP 120; IMATINIB; LYSOZYME; PROTEIN SH3; SOLVENT; TRYPSIN; TYROSINE DERIVATIVE; TYROSINE TRANSFER RNA LIGASE; LIGAND; PROTEIN;

ANALYTICAL ERROR; ARTICLE; BINDING AFFINITY; COMPUTER AIDED DESIGN; DRUG BINDING; INTERMETHOD COMPARISON; LIGAND BINDING; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PERFORMANCE MEASUREMENT SYSTEM; PROCESS MODEL; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SEQUENCE ANALYSIS; SOLVATION; SOLVENT EFFECT; STRUCTURAL BIOINFORMATICS; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG STABILITY; METHODOLOGY; MOLECULAR GENETICS; PROTEIN BINDING; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER SIMULATION; DRUG STABILITY; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEINS; SEQUENCE ANALYSIS, PROTEIN; SOLVENTS;

EID: 42149195952     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-9-148     Document Type: Article

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