Computational redesign of endonuclease DNA binding and cleavage specificity

Nature

Volumn 441, Issue 7093, 2006, Pages 656-659

  Ashworth, Justin ^a   Havranek, James J ^a   Duarte, Carlos M ^a   Sussman, Django ^c   Monnat Jr , Raymond J ^b   Stoddard, Barry L ^c   Baker, David ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOTECHNOLOGY; COMPUTATION THEORY; CONFORMATIONS; DRUG PRODUCTS; PROTEINS; SUBSTITUTION REACTIONS;

BASE-PAIR SUBSTITUTIONS; COMPUTATIONAL PROTEIN DESIGN; DNA-BINDING; REPROGRAMMING;

DNA;

ENDONUCLEASE; ENDONUCLEASE I MSOI; UNCLASSIFIED DRUG;

AMINO ACID; BIOTECHNOLOGY; CLEAVAGE; CRYSTALLOGRAPHY; DNA; ENZYME ACTIVITY; GENE EXPRESSION; MEDICINE; MONTE CARLO ANALYSIS; PROTEIN; RECOGNITION; X-RAY SPECTROSCOPY;

ACCREDITATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; DNA BINDING; DNA CLEAVAGE; ENZYME CONFORMATION; ENZYME SPECIFICITY; INTRON; MOLECULAR RECOGNITION; MONTE CARLO METHOD; PREDICTION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN ENGINEERING; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 33745278855     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04818     Document Type: Article

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