Molecular dynamics simulations show that bound Mg2+ contributes to amino acid and aminoacyl adenylate binding specificity in aspartyl-tRNA synthetase through long range electrostatic interactions

Journal of Biological Chemistry

Volumn 281, Issue 33, 2006, Pages 23792-23803

  Thompson, Damien ^a,b   Simonson, Thomas ^a  

^a LABORATOIRE DE BIOCHIMIE   (France)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL BONDS; COMPUTER SIMULATION; ELECTROSTATICS; ENZYMES; GENES;

AMINOACYL ADENYLATE; ELECTROSTATIC INTERACTIONS; FREE ENERGY SIMULATIONS; MOLECULAR RECOGNITION;

MOLECULAR DYNAMICS;

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID; ASPARAGINE; ASPARTATE TRANSFER RNA LIGASE; ASPARTIC ACID; MAGNESIUM ION;

ADENYLATION; ARTICLE; BINDING KINETICS; BINDING SITE; CATALYSIS; COMPLEX FORMATION; ELECTRICITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; GENETIC CODE; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; RNA TRANSLATION; SIMULATION;

ADENOSINE MONOPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINOACYLATION; ARCHAEAL PROTEINS; ASPARAGINE; ASPARTATE-TRNA LIGASE; ASPARTIC ACID; BINDING SITES; CATALYSIS; CATIONS, DIVALENT; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENZYME STABILITY; MAGNESIUM; PYROCOCCUS; RNA, TRANSFER; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 33747671419     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602870200     Document Type: Article

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