Integrated computational and experimental approach for lead optimization and design of compstatin variants with improved activity

Journal of the American Chemical Society

Volumn 125, Issue 28, 2003, Pages 8422-8423

  Klepeis, John L ^a   Floudas, Christodoulos A ^a   Morikis, Dimitrios ^b   Tsokos, C G ^c   Argyropoulos, E ^c   Spruce, L ^c   Lambris, John D ^c  

^a Princeton University   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT INHIBITOR; ISOLEUCYLCYSTEINYLVALYLVALYLGLUTAMINYLASPARTYLTRYPTOPHYLGLYCYLHISTIDYLHI STI DYLARGINYLCYSTEINYLTHREONINE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; COMPLEMENT INHIBITION; COMPUTER ANALYSIS; DRUG DESIGN; DRUG MECHANISM; DRUG SPECIFICITY; HYDROPHOBICITY; IMMUNOPROPHYLAXIS; PROTEIN FOLDING; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; DRUG DESIGN; PEPTIDES, CYCLIC; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037699589     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034846p     Document Type: Article

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