Engineering an Mg2+ site to replace a structurally conserved arginine in the catalytic center of histidyl-tRNA synthetase by computer experiments

Proteins: Structure, Function and Genetics

Volumn 32, Issue 3, 1998, Pages 362-380

  Arnez, John G ^a   Flanagan, Karen ^a   Moras, Dino ^a   Simonson, Thomas ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Aminoacyl tRNA synthetase; ATP; Molecular dynamics simulations; Mutagenesis

Indexed keywords

AMINO ACID ANALYSIS; AMINO ACID METABOLISM; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; COMPUTER ANALYSIS; ENZYME ACTIVITY; ESCHERICHIA COLI; GENETIC ENGINEERING; GEOMETRY; MUTAGENESIS; PRIORITY JOURNAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN ENGINEERING; THERMUS THERMOPHILUS;

ADENOSINE TRIPHOSPHATE; ARGININE; HISTIDINE TRANSFER RNA LIGASE; MAGNESIUM;

ADENOSINE TRIPHOSPHATE; ARGININE; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; CONSERVED SEQUENCE; HISTIDINE-TRNA LIGASE; MAGNESIUM; MODELS, MOLECULAR; MUTATION; PROTEIN ENGINEERING; THERMUS THERMOPHILUS;

EID: 0032528684     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19980815)32:3<362::AID-PROT11>3.0.CO;2-7     Document Type: Article

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