Computational design of protein-ligand binding: modifying the specificity of asparaginyl-trna synthetase

Journal of Computational Chemistry

Volumn 31, Issue 6, 2010, Pages 1273-1286

  Anne, Lopes ^a   Schmidt Am Busch, M ^a   Thomas, Simonson ^a  

^a LABORATOIRE DE BIOCHIMIE   (France)

Author keywords

Aminoacyl trna synthetase; Computer simulations; Continuum electrostatics; Directed evolution; Enzyme; Genetic code; Molecular dynamics

Indexed keywords

AMINOACYL; CONTINUUM ELECTROSTATICS; DIRECTED EVOLUTION; GENETIC CODE; SYNTHETASES;

AMINO ACIDS; CATALYSTS; COMPLEXATION; COMPUTATIONAL METHODS; COMPUTER SIMULATION; DISSOCIATION; ELECTROSTATICS; ENZYMES; FREE ENERGY; LIGANDS; MOLECULAR DYNAMICS; ORGANIC ACIDS; STRUCTURAL DESIGN;

BINDING ENERGY;

AMINOACYL TRANSFER RNA; ASPARAGINYL TRANSFER RIBONUCLEIC ACID SYNTHETASE; ASPARAGINYL-TRNA SYNTHETASE; ASPARTATE TRANSFER RNA LIGASE; LIGAND;

ARTICLE; BINDING SITE; BIOLOGY; CHEMISTRY; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENETICS; METABOLISM; METHODOLOGY; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

ASPARTATE-TRNA LIGASE; BINDING SITES; COMPUTATIONAL BIOLOGY; ENZYME ACTIVATION; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING; RNA, TRANSFER, AMINO ACYL; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 77950578546     PISSN: 01928651     EISSN: 1096987X     Source Type: Journal    
DOI: 10.1002/jcc.21414     Document Type: Article

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