Rational design of new binding specificity by simultaneous mutagenesis of calmodulin and a target peptide

Biochemistry

Volumn 45, Issue 41, 2006, Pages 12547-12559

  Green, David F ^a,b,f   Dennis, Andrew T ^c   Fam, Peter S ^c   Tidor, Bruce ^a,b,d   Jasanoff, Alan ^a,c,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d USA   (United States)

^e Massachusetts Institute of Technology Cambridge   (United States)

^f Stony Brook University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSENSORS; CALCIUM COMPOUNDS; CELLS; COMPLEXATION; MUTAGENESIS; PROTEINS;

CALCIUM BIOSENSORS; CALCIUM SATURATED CALMODULIN (CAM); PROMISCUITY; SIGNAL TRANSDUCTION PATHWAYS;

AMINO ACIDS;

CALMODULIN; CALMODULIN BINDING PROTEIN; MUTANT PROTEIN; PROTEIN KINASE; PROTEIN M13; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; QUALITATIVE ANALYSIS; SITE DIRECTED MUTAGENESIS; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM SIGNALING; CALMODULIN; CALMODULIN-BINDING PROTEINS; DRUG DESIGN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MYOSIN-LIGHT-CHAIN KINASE; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RABBITS; THERMODYNAMICS;

EID: 33750058234     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060857u     Document Type: Article

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