Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein-Protein Interface

Journal of Molecular Biology

Volumn 361, Issue 1, 2006, Pages 195-208

  Joachimiak, Lukasz A ^a   Kortemme, Tanja ^b   Stoddard, Barry L ^c   Baker, David ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

computational design; DNAse; hydrogen bond network; immunity protein; protein protein interactions

Indexed keywords

DEOXYRIBONUCLEASE; PROTEIN; WATER;

ARTICLE; BINDING KINETICS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HYDROGEN BOND; IMMUNITY; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MOLECULE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ENGINEERING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REGULATORY MECHANISM; SAMPLING; STRUCTURE ANALYSIS; SURFACE PROPERTY; X RAY CRYSTALLOGRAPHY;

EID: 33745927413     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.05.022     Document Type: Article

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