Free-energy simulations and experiments reveal long-range electrostatic interactions and substrate-assisted specificity in an aminoacyl-tRNA synthetase

ChemBioChem

Volumn 7, Issue 2, 2006, Pages 337-344

  Thompson, Damien ^a,b   Plateau, Pierre ^a   Simonson, Thomas ^a  

^a CNRS   (France)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Enzyme catalysis; Free energy; Genetic code; Molecular dynamics; Molecular recognition

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; ASPARAGINE; ASPARTATE TRANSFER RNA LIGASE; ASPARTIC ACID; GLUTAMIC ACID; HISTIDINE; MAGNESIUM ION; TRANSFER RNA;

ARTICLE; COMPARATIVE STUDY; ENERGY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; SIMULATION;

ADENOSINE TRIPHOSPHATE; AMINO ACIDS; AMINO ACYL-TRNA SYNTHETASES; BINDING SITES; ELECTROSTATICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 32344451863     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200500364     Document Type: Article

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