-
1
-
-
79955782066
-
Optogenetic deconstruction of sleep-wake circuitry in the brain
-
Adamantidis, A., Carter, M. C., and de Lecea, L. (2010). Optogenetic deconstruction of sleep-wake circuitry in the brain. Front Mol Neurosci 2, 31.
-
(2010)
Front Mol Neurosci
, vol.2
, pp. 31
-
-
Adamantidis, A.1
Carter, M.C.2
de Lecea, L.3
-
2
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., and Flier, J. S. (1996). Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252.
-
(1996)
Nature
, vol.382
, pp. 250-252
-
-
Ahima, R.S.1
Prabakaran, D.2
Mantzoros, C.3
Qu, D.4
Lowell, B.5
Maratos-Flier, E.6
Flier, J.S.7
-
3
-
-
68349103200
-
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors
-
Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J. A., Nonneman, R. J., Hartmann, J., Moy, S. S., Nicolelis, M. A., et al. (2009). Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63, 27-39.
-
(2009)
Neuron
, vol.63
, pp. 27-39
-
-
Alexander, G.M.1
Rogan, S.C.2
Abbas, A.I.3
Armbruster, B.N.4
Pei, Y.5
Allen, J.A.6
Nonneman, R.J.7
Hartmann, J.8
Moy, S.S.9
Nicolelis, M.A.10
-
4
-
-
79951992387
-
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
-
Aponte, Y., Atasoy, D., and Sternson, S. M. (2011). AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nat Neurosci 14, 351-355.
-
(2011)
Nat Neurosci
, vol.14
, pp. 351-355
-
-
Aponte, Y.1
Atasoy, D.2
Sternson, S.M.3
-
5
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C. Jr, Elmquist, J. K., et al. (2004). Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42, 983-991.
-
(2004)
Neuron
, vol.42
, pp. 983-991
-
-
Balthasar, N.1
Coppari, R.2
McMinn, J.3
Liu, S.M.4
Lee, C.E.5
Tang, V.6
Kenny, C.D.7
McGovern, R.A.8
Chua Jr., S.C.9
Elmquist, J.K.10
-
6
-
-
0345168238
-
The role of leptin receptor signaling in feeding and neuroendocrine function
-
Bates, S. H., and Myers, M. G. Jr. (2003). The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab 14, 447-452.
-
(2003)
Trends Endocrinol Metab
, vol.14
, pp. 447-452
-
-
Bates, S.H.1
Myers Jr., M.G.2
-
7
-
-
41549136121
-
The brain, appetite, and obesity
-
Berthoud, H. R., and Morrison, C. (2008). The brain, appetite, and obesity. Annu Rev Psychol 59, 55-92.
-
(2008)
Annu Rev Psychol
, vol.59
, pp. 55-92
-
-
Berthoud, H.R.1
Morrison, C.2
-
8
-
-
2342439732
-
Leptin signaling in the central nervous system and the periphery
-
Bjørbaek, C., and Kahn, B. B. (2004). Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 59, 305-331.
-
(2004)
Recent Prog Horm Res
, vol.59
, pp. 305-331
-
-
Bjørbaek, C.1
Kahn, B.B.2
-
9
-
-
3042819531
-
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
-
Blevins, J. E., Schwartz, M. W., and Baskin, D. G. (2004). Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am J Physiol Regul Integr Comp Physiol 287, R87-R96.
-
(2004)
Am J Physiol Regul Integr Comp Physiol
, vol.287
, pp. 87-96
-
-
Blevins, J.E.1
Schwartz, M.W.2
Baskin, D.G.3
-
10
-
-
77249131674
-
Hypothalamic nutrient sensing in the control of energy homeostasis
-
Blouet, C., and Schwartz, G. J. (2010). Hypothalamic nutrient sensing in the control of energy homeostasis. Behav Brain Res 209, 1-12.
-
(2010)
Behav Brain Res
, vol.209
, pp. 1-12
-
-
Blouet, C.1
Schwartz, G.J.2
-
11
-
-
77956173468
-
Neurodevelopmental actions of leptin
-
Bouret, S. G. (2010). Neurodevelopmental actions of leptin. Brain Res 1350, 2-9.
-
(2010)
Brain Res
, vol.1350
, pp. 2-9
-
-
Bouret, S.G.1
-
12
-
-
1642349297
-
Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice
-
Bouret, S. G., Draper, S. J., and Simerly, R. B. (2004a). Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci 24, 2797-2805.
-
(2004)
J Neurosci
, vol.24
, pp. 2797-2805
-
-
Bouret, S.G.1
Draper, S.J.2
Simerly, R.B.3
-
13
-
-
1842536210
-
Trophic action of leptin on hypothalamic neurons that regulate feeding
-
Bouret, S. G., Draper, S. J., and Simerly, R. B. (2004b). Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304, 108-110.
-
(2004)
Science
, vol.304
, pp. 108-110
-
-
Bouret, S.G.1
Draper, S.J.2
Simerly, R.B.3
-
14
-
-
12844278828
-
Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus
-
Breen, T. L., Conwell, I. M., and Wardlaw, S. L. (2005). Effects of fasting, leptin, and insulin on AGRP and POMC peptide release in the hypothalamus. Brain Res 1032, 141-148.
-
(2005)
Brain Res
, vol.1032
, pp. 141-148
-
-
Breen, T.L.1
Conwell, I.M.2
Wardlaw, S.L.3
-
15
-
-
0000833791
-
Mechanism of the development of obesity in animals with hypothalamic lesions
-
Brobeck, J. R. (1946). Mechanism of the development of obesity in animals with hypothalamic lesions. Physiol Rev 26, 541-559.
-
(1946)
Physiol Rev
, vol.26
, pp. 541-559
-
-
Brobeck, J.R.1
-
16
-
-
0032443807
-
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
-
Broberger, C., Johansen, J., Johansson, C., Schalling, M., and Hökfelt, T. (1998). The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci U S A 95, 15043-15048.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 15043-15048
-
-
Broberger, C.1
Johansen, J.2
Johansson, C.3
Schalling, M.4
Hökfelt, T.5
-
17
-
-
18244395309
-
Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice
-
Buettner, C., Patel, R., Muse, E. D., Bhanot, S., Monia, B. P., McKay, R., Obici, S., and Rossetti, L. (2005). Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice. J Clin Invest 115, 1306-1313.
-
(2005)
J Clin Invest
, vol.115
, pp. 1306-1313
-
-
Buettner, C.1
Patel, R.2
Muse, E.D.3
Bhanot, S.4
Monia, B.P.5
McKay, R.6
Obici, S.7
Rossetti, L.8
-
18
-
-
79955635264
-
Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents dietinduced obesity
-
Chao, P. T., Yang, L., Aja, S., Moran, T. H., and Bi, S. (2011). Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents dietinduced obesity. Cell Metab 13, 573-583.
-
(2011)
Cell Metab
, vol.13
, pp. 573-583
-
-
Chao, P.T.1
Yang, L.2
Aja, S.3
Moran, T.H.4
Bi, S.5
-
19
-
-
0033588184
-
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
-
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999). Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98, 437-451.
-
(1999)
Cell
, vol.98
, pp. 437-451
-
-
Chemelli, R.M.1
Willie, J.T.2
Sinton, C.M.3
Elmquist, J.K.4
Scammell, T.5
Lee, C.6
Richardson, J.A.7
Williams, S.C.8
Xiong, Y.9
Kisanuki, Y.10
-
20
-
-
13344259300
-
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
-
Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K. J., Breitbart, R. E., et al. (1996). Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84, 491-495.
-
(1996)
Cell
, vol.84
, pp. 491-495
-
-
Chen, H.1
Charlat, O.2
Tartaglia, L.A.3
Woolf, E.A.4
Weng, X.5
Ellis, S.J.6
Lakey, N.D.7
Culpepper, J.8
Moore, K.J.9
Breitbart, R.E.10
-
21
-
-
2542475178
-
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
-
Chen, H. Y., Trumbauer, M. E., Chen, A. S., Weingarth, D. T., Adams, J. R., Frazier, E. G., Shen, Z., Marsh, D. J., Feighner, S. D., Guan, X. M., et al. (2004). Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145, 2607-2612.
-
(2004)
Endocrinology
, vol.145
, pp. 2607-2612
-
-
Chen, H.Y.1
Trumbauer, M.E.2
Chen, A.S.3
Weingarth, D.T.4
Adams, J.R.5
Frazier, E.G.6
Shen, Z.7
Marsh, D.J.8
Feighner, S.D.9
Guan, X.M.10
-
22
-
-
38549142801
-
Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation
-
Cheng, H., Isoda, F., Belsham, D. D., and Mobbs, C. V. (2008). Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation. Endocrinology 149, 703-710.
-
(2008)
Endocrinology
, vol.149
, pp. 703-710
-
-
Cheng, H.1
Isoda, F.2
Belsham, D.D.3
Mobbs, C.V.4
-
23
-
-
20144389727
-
The role of insulin receptor substrate 2 in hypothalamic and beta cell function
-
Choudhury, A. I., Heffron, H., Smith, M. A., Al-Qassab, H., Xu, A. W., Selman, C., Simmgen, M., Clements, M., Claret, M., Maccoll, G., et al. (2005). The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest 115, 940-950.
-
(2005)
J Clin Invest
, vol.115
, pp. 940-950
-
-
Choudhury, A.I.1
Heffron, H.2
Smith, M.A.3
Al-Qassab, H.4
Xu, A.W.5
Selman, C.6
Simmgen, M.7
Clements, M.8
Claret, M.9
Maccoll, G.10
-
24
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J. M., et al. (1998). A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clément, K.1
Vaisse, C.2
Lahlou, N.3
Cabrol, S.4
Pelloux, V.5
Cassuto, D.6
Gourmelen, M.7
Dina, C.8
Chambaz, J.9
Lacorte, J.M.10
-
25
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
Cohen, P., Zhao, C., Cai, X., Montez, J. M., Rohani, S. C., Feinstein, P., Mombaerts, P., and Friedman, J. M. (2001). Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 108, 1113-1121.
-
(2001)
J Clin Invest
, vol.108
, pp. 1113-1121
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
Montez, J.M.4
Rohani, S.C.5
Feinstein, P.6
Mombaerts, P.7
Friedman, J.M.8
-
26
-
-
0015792424
-
Effects of parabiosis of obese with diabetes and normal mice
-
Coleman, D. L. (1973). Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9, 294-298.
-
(1973)
Diabetologia
, vol.9
, pp. 294-298
-
-
Coleman, D.L.1
-
27
-
-
0014608866
-
Effects of parabiosis of normal with genetically diabetic mice
-
Coleman, D. L., and Hummel, K. P. (1969). Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 217, 1298-1304.
-
(1969)
Am J Physiol
, vol.217
, pp. 1298-1304
-
-
Coleman, D.L.1
Hummel, K.P.2
-
28
-
-
17844389670
-
The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
-
Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C. Jr, et al. (2005). The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab 1, 63-72.
-
(2005)
Cell Metab
, vol.1
, pp. 63-72
-
-
Coppari, R.1
Ichinose, M.2
Lee, C.E.3
Pullen, A.E.4
Kenny, C.D.5
McGovern, R.A.6
Tang, V.7
Liu, S.M.8
Ludwig, T.9
Chua Jr., S.C.10
-
29
-
-
33748920365
-
The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis
-
Covey, S. D., Wideman, R. D., McDonald, C., Unniappan, S., Huynh, F., Asadi, A., Speck, M., Webber, T., Chua, S. C., and Kieffer, T. J. (2006). The pancreatic beta cell is a key site for mediating the effects of leptin on glucose homeostasis. Cell Metab 4, 291-302.
-
(2006)
Cell Metab
, vol.4
, pp. 291-302
-
-
Covey, S.D.1
Wideman, R.D.2
McDonald, C.3
Unniappan, S.4
Huynh, F.5
Asadi, A.6
Speck, M.7
Webber, T.8
Chua, S.C.9
Kieffer, T.J.10
-
30
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., and Low, M. J. (2001). Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480-484.
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdán, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
31
-
-
78650678254
-
Characterization of Kiss1 neurons using transgenic mouse models
-
Cravo, R. M., Margatho, L. O., Osborne-Lawrence, S., Donato, J. Jr, Atkin, S., Bookout, A. L., Rovinsky, S., Frazão, R., Lee, C. E., Gautron, L., et al. (2011). Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience 173, 37-56.
-
(2011)
Neuroscience
, vol.173
, pp. 37-56
-
-
Cravo, R.M.1
Margatho, L.O.2
Osborne-Lawrence, S.3
Donato Jr., J.4
Atkin, S.5
Bookout, A.L.6
Rovinsky, S.7
Frazão, R.8
Lee, C.E.9
Gautron, L.10
-
32
-
-
34547533091
-
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene
-
d'Anglemont de Tassigny, X., Fagg, L. A., Dixon, J. P., Day, K., Leitch, H. G., Hendrick, A. G., Zahn, D., Franceschini, I., Caraty, A., Carlton, M. B., et al. (2007). Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A 104, 10714-10719.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 10714-10719
-
-
D'Anglemont de tassigny, X.1
Fagg, L.A.2
Dixon, J.P.3
Day, K.4
Leitch, H.G.5
Hendrick, A.G.6
Zahn, D.7
Franceschini, I.8
Caraty, A.9
Carlton, M.B.10
-
33
-
-
31044451078
-
Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
-
de Luca, C., Kowalski, T. J., Zhang, Y., Elmquist, J. K., Lee, C., Kilimann, M. W., Ludwig, T., Liu, S. M., and Chua, S. C. Jr. (2005). Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 115, 3484-3493.
-
(2005)
J Clin Invest
, vol.115
, pp. 3484-3493
-
-
de Luca, C.1
Kowalski, T.J.2
Zhang, Y.3
Elmquist, J.K.4
Lee, C.5
Kilimann, M.W.6
Ludwig, T.7
Liu, S.M.8
Chua Jr., S.C.9
-
34
-
-
78650902662
-
Optogenetics
-
Deisseroth, K. (2011). Optogenetics. Nat Methods 8, 26-29.
-
(2011)
Nat Methods
, vol.8
, pp. 26-29
-
-
Deisseroth, K.1
-
35
-
-
79959421553
-
Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling
-
Denroche, H. C., Levi, J., Wideman, R. D., Sequeira, R. M., Huynh, F. K., Covey, S. D., and Kieffer, T. J. (2011). Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes 60, 1414-1423.
-
(2011)
Diabetes
, vol.60
, pp. 1414-1423
-
-
Denroche, H.C.1
Levi, J.2
Wideman, R.D.3
Sequeira, R.M.4
Huynh, F.K.5
Covey, S.D.6
Kieffer, T.J.7
-
36
-
-
30644473109
-
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
-
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006). Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49, 191-203.
-
(2006)
Neuron
, vol.49
, pp. 191-203
-
-
Dhillon, H.1
Zigman, J.M.2
Ye, C.3
Lee, C.E.4
McGovern, R.A.5
Tang, V.6
Kenny, C.D.7
Christiansen, L.M.8
White, R.D.9
Edelstein, E.A.10
-
37
-
-
79952006344
-
An optogenetic toolbox designed for primates
-
Diester, I., Kaufman, M. T., Mogri, M., Pashaie, R., Goo, W., Yizhar, O., Ramakrishnan, C., Deisseroth, K., and Shenoy, K. V. (2011). An optogenetic toolbox designed for primates. Nat Neurosci 14, 387-397.
-
(2011)
Nat Neurosci
, vol.14
, pp. 387-397
-
-
Diester, I.1
Kaufman, M.T.2
Mogri, M.3
Pashaie, R.4
Goo, W.5
Yizhar, O.6
Ramakrishnan, C.7
Deisseroth, K.8
Shenoy, K.V.9
-
38
-
-
53149092080
-
Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide
-
Dungan Lemko, H. M., Clifton, D. K., Steiner, R. A., and Fraley, G. S. (2008). Altered response to metabolic challenges in mice with genetically targeted deletions of galanin-like peptide. Am J Physiol Endocrinol Metab 295, E605-E612.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
-
-
Dungan Lemko, H.M.1
Clifton, D.K.2
Steiner, R.A.3
Fraley, G.S.4
-
39
-
-
0037474141
-
Mouse vesicular GABA transporter gene: genomic organization, transcriptional regulation and chromosomal localization
-
Ebihara, S., Obata, K., and Yanagawa, Y. (2003). Mouse vesicular GABA transporter gene: genomic organization, transcriptional regulation and chromosomal localization. Brain Res Mol Brain Res 110, 126-139.
-
(2003)
Brain Res Mol Brain Res
, vol.110
, pp. 126-139
-
-
Ebihara, S.1
Obata, K.2
Yanagawa, Y.3
-
40
-
-
0033180532
-
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
-
Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbaek, C., Flier, J. S., Saper, C. B., and Elmquist, J. K. (1999). Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23, 775-786.
-
(1999)
Neuron
, vol.23
, pp. 775-786
-
-
Elias, C.F.1
Aschkenasi, C.2
Lee, C.3
Kelly, J.4
Ahima, R.S.5
Bjorbaek, C.6
Flier, J.S.7
Saper, C.B.8
Elmquist, J.K.9
-
41
-
-
27744436291
-
Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
-
Elmquist, J. K., Coppari, R., Balthasar, N., Ichinose, M., and Lowell, B. B. (2005). Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 493, 63-71.
-
(2005)
J Comp Neurol
, vol.493
, pp. 63-71
-
-
Elmquist, J.K.1
Coppari, R.2
Balthasar, N.3
Ichinose, M.4
Lowell, B.B.5
-
42
-
-
80052156758
-
Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance
-
Enriori, P. J., Sinnayah, P., Simonds, S. E., Garcia Rudaz, C., and Cowley, M. A. (2011). Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci 31, 12189-12197.
-
(2011)
J Neurosci
, vol.31
, pp. 12189-12197
-
-
Enriori, P.J.1
Sinnayah, P.2
Simonds, S.E.3
Garcia Rudaz, C.4
Cowley, M.A.5
-
43
-
-
34548356529
-
Inducible gene inactivation in neurons of the adult mouse forebrain
-
Erdmann, G., Schütz, G., and Berger, S. (2007). Inducible gene inactivation in neurons of the adult mouse forebrain. BMC Neurosci 8, 63.
-
(2007)
BMC Neurosci
, vol.8
, pp. 63
-
-
Erdmann, G.1
Schütz, G.2
Berger, S.3
-
44
-
-
35549009434
-
Differential accessibility of circulating leptin to individual hypothalamic sites
-
Faouzi, M., Leshan, R., Björnholm, M., Hennessey, T., Jones, J., and Mönzberg, H. (2007). Differential accessibility of circulating leptin to individual hypothalamic sites. Endocrinology 148, 5414-5423.
-
(2007)
Endocrinology
, vol.148
, pp. 5414-5423
-
-
Faouzi, M.1
Leshan, R.2
Björnholm, M.3
Hennessey, T.4
Jones, J.5
Mönzberg, H.6
-
45
-
-
79959873914
-
The development and application of optogenetics
-
Fenno, L., Yizhar, O., and Deisseroth, K. (2011). The development and application of optogenetics. Annu Rev Neurosci 34, 389-412.
-
(2011)
Annu Rev Neurosci
, vol.34
, pp. 389-412
-
-
Fenno, L.1
Yizhar, O.2
Deisseroth, K.3
-
46
-
-
78650679270
-
Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization
-
Ferguson, S. M., Eskenazi, D., Ishikawa, M., Wanat, M. J., Phillips, P. E., Dong, Y., Roth, B. L., and Neumaier, J. F. (2011). Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nat Neurosci 14, 22-24.
-
(2011)
Nat Neurosci
, vol.14
, pp. 22-24
-
-
Ferguson, S.M.1
Eskenazi, D.2
Ishikawa, M.3
Wanat, M.J.4
Phillips, P.E.5
Dong, Y.6
Roth, B.L.7
Neumaier, J.F.8
-
47
-
-
0842324779
-
Obesity wars: molecular progress confronts an expanding epidemic
-
Flier, J. S. (2004). Obesity wars: molecular progress confronts an expanding epidemic. Cell 116, 337-350.
-
(2004)
Cell
, vol.116
, pp. 337-350
-
-
Flier, J.S.1
-
48
-
-
33645095699
-
AgRP in energy balance: Will the real AgRP please stand up?
-
Flier, J. S. (2006). AgRP in energy balance: Will the real AgRP please stand up? Cell Metab 3, 83-85.
-
(2006)
Cell Metab
, vol.3
, pp. 83-85
-
-
Flier, J.S.1
-
49
-
-
77957223178
-
Lasker lauds leptin
-
Flier, J. S., and Maratos-Flier, E. (2010). Lasker lauds leptin. Cell 143, 9-12.
-
(2010)
Cell
, vol.143
, pp. 9-12
-
-
Flier, J.S.1
Maratos-Flier, E.2
-
50
-
-
2342648840
-
Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat
-
Fraley, G. S., Scarlett, J. M., Shimada, I., Teklemichael, D. N., Acohido, B. V., Clifton, D. K., and Steiner, R. A. (2004). Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the rat. Diabetes 53, 1237-1242.
-
(2004)
Diabetes
, vol.53
, pp. 1237-1242
-
-
Fraley, G.S.1
Scarlett, J.M.2
Shimada, I.3
Teklemichael, D.N.4
Acohido, B.V.5
Clifton, D.K.6
Steiner, R.A.7
-
51
-
-
2942707811
-
Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites
-
Fremeau, R. T. Jr, Kam, K., Qureshi, T., Johnson, J., Copenhagen, D. R., Storm-Mathisen, J., Chaudhry, F. A., Nicoll, R. A., and Edwards, R. H. (2004). Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science 304, 1815-1819.
-
(2004)
Science
, vol.304
, pp. 1815-1819
-
-
Fremeau Jr., R.T.1
Kam, K.2
Qureshi, T.3
Johnson, J.4
Copenhagen, D.R.5
Storm-Mathisen, J.6
Chaudhry, F.A.7
Nicoll, R.A.8
Edwards, R.H.9
-
52
-
-
78049271280
-
Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
-
Fujikawa, T., Chuang, J. C., Sakata, I., Ramadori, G., and Coppari, R. (2010). Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci U S A 107, 17391-17396.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 17391-17396
-
-
Fujikawa, T.1
Chuang, J.C.2
Sakata, I.3
Ramadori, G.4
Coppari, R.5
-
53
-
-
0036550073
-
Getting around lethality with inducible Cre-mediated excision
-
Garcia, E. L., and Mills, A. A. (2002). Getting around lethality with inducible Cre-mediated excision. Semin Cell Dev Biol 13, 151-158.
-
(2002)
Semin Cell Dev Biol
, vol.13
, pp. 151-158
-
-
Garcia, E.L.1
Mills, A.A.2
-
54
-
-
1242317632
-
The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids
-
Gasnier, B. (2004). The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids. Pflugers Arch 447, 756-759.
-
(2004)
Pflugers Arch
, vol.447
, pp. 756-759
-
-
Gasnier, B.1
-
55
-
-
33847658304
-
Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases
-
Gavériaux-Ruff, C., and Kieffer, B. L. (2007). Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases. Pharmacol Ther 113, 619-634.
-
(2007)
Pharmacol Ther
, vol.113
, pp. 619-634
-
-
Gavériaux-Ruff, C.1
Kieffer, B.L.2
-
56
-
-
79951638003
-
Leptin activates a novel CNS mechanism for insulinindependent normalization of severe diabetic hyperglycemia
-
German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J. Jr, Schwartz, M. W., and Morton, G. J. (2011). Leptin activates a novel CNS mechanism for insulinindependent normalization of severe diabetic hyperglycemia. Endocrinology 152, 394-404.
-
(2011)
Endocrinology
, vol.152
, pp. 394-404
-
-
German, J.P.1
Thaler, J.P.2
Wisse, B.E.3
Oh-I, S.4
Sarruf, D.A.5
Matsen, M.E.6
Fischer, J.D.7
Taborsky Jr., G.J.8
Schwartz, M.W.9
Morton, G.J.10
-
57
-
-
78651063747
-
Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin
-
Ghamari-Langroudi, M., Srisai, D., and Cone, R. D. (2011). Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin. Proc Natl Acad Sci U S A 108, 355-360.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 355-360
-
-
Ghamari-Langroudi, M.1
Srisai, D.2
Cone, R.D.3
-
58
-
-
72449209171
-
PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling
-
Hawke, Z., Ivanov, T. R., Bechtold, D. A., Dhillon, H., Lowell, B. B., and Luckman, S. M. (2009). PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling. J Neurosci 29, 14828-14835.
-
(2009)
J Neurosci
, vol.29
, pp. 14828-14835
-
-
Hawke, Z.1
Ivanov, T.R.2
Bechtold, D.A.3
Dhillon, H.4
Lowell, B.B.5
Luckman, S.M.6
-
59
-
-
45549104270
-
Hypothalamic pathways linking energy balance and reproduction
-
Hill, J. W., Elmquist, J. K., and Elias, C. F. (2008). Hypothalamic pathways linking energy balance and reproduction. Am J Physiol Endocrinol Metab 294, E827-E832.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
, pp. 827-832
-
-
Hill, J.W.1
Elmquist, J.K.2
Elias, C.F.3
-
60
-
-
7444269656
-
CART in feeding and obesity
-
Hunter, R. G., Philpot, K., Vicentic, A., Dominguez, G., Hubert, G. W., and Kuhar, M. J. (2004). CART in feeding and obesity. Trends Endocrinol Metab 15, 454-459.
-
(2004)
Trends Endocrinol Metab
, vol.15
, pp. 454-459
-
-
Hunter, R.G.1
Philpot, K.2
Vicentic, A.3
Dominguez, G.4
Hubert, G.W.5
Kuhar, M.J.6
-
61
-
-
66049133685
-
Leptin-dependent control of glucose balance and locomotor activity by POMC neurons
-
Huo, L., Gamber, K., Greeley, S., Silva, J., Huntoon, N., Leng, X. H., and Bjørbaek, C. (2009). Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab 9, 537-547.
-
(2009)
Cell Metab
, vol.9
, pp. 537-547
-
-
Huo, L.1
Gamber, K.2
Greeley, S.3
Silva, J.4
Huntoon, N.5
Leng, X.H.6
Bjørbaek, C.7
-
62
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997). Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141.
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
-
63
-
-
0034455629
-
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat
-
Juréus, A., Cunningham, M. J., McClain, M. E., Clifton, D. K., and Steiner, R. A. (2000). Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat. Endocrinology 141, 2703-2706.
-
(2000)
Endocrinology
, vol.141
, pp. 2703-2706
-
-
Juréus, A.1
Cunningham, M.J.2
McClain, M.E.3
Clifton, D.K.4
Steiner, R.A.5
-
64
-
-
0033038418
-
Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
-
Kalra, S. P., Dube, M. G., Pu, S., Xu, B., Horvath, T. L., and Kalra, P. S. (1999). Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20, 68-100.
-
(1999)
Endocr Rev
, vol.20
, pp. 68-100
-
-
Kalra, S.P.1
Dube, M.G.2
Pu, S.3
Xu, B.4
Horvath, T.L.5
Kalra, P.S.6
-
65
-
-
4344595580
-
NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy
-
Kalra, S. P., and Kalra, P. S. (2004). NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38, 201-211.
-
(2004)
Neuropeptides
, vol.38
, pp. 201-211
-
-
Kalra, S.P.1
Kalra, P.S.2
-
66
-
-
77955491310
-
Neuroendocrine control of energy homeostasis: update on new insights
-
Kalra, S. P., and Kalra, P. S. (2010). Neuroendocrine control of energy homeostasis: update on new insights. Prog Brain Res 181, 17-33.
-
(2010)
Prog Brain Res
, vol.181
, pp. 17-33
-
-
Kalra, S.P.1
Kalra, P.S.2
-
67
-
-
0023890753
-
PVN-hindbrain pathway involved in the hypothalamic hyperphagia-obesity syndrome
-
Kirchgessner, A. L., and Sclafani, A. (1988). PVN-hindbrain pathway involved in the hypothalamic hyperphagia-obesity syndrome. Physiol Behav 42, 517-528.
-
(1988)
Physiol Behav
, vol.42
, pp. 517-528
-
-
Kirchgessner, A.L.1
Sclafani, A.2
-
68
-
-
78049433920
-
Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis
-
Kong, D., Vong, L., Parton, L. E., Ye, C., Tong, Q., Hu, X., Choi, B., Brüning, J. C., and Lowell, B. B. (2010). Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab 12, 545-552.
-
(2010)
Cell Metab
, vol.12
, pp. 545-552
-
-
Kong, D.1
Vong, L.2
Parton, L.E.3
Ye, C.4
Tong, Q.5
Hu, X.6
Choi, B.7
Brüning, J.C.8
Lowell, B.B.9
-
69
-
-
34249651956
-
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
-
Könner, A. C., Janoschek, R., Plum, L., Jordan, S. D., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G. S., et al. (2007). Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 5, 438-449.
-
(2007)
Cell Metab
, vol.5
, pp. 438-449
-
-
Könner, A.C.1
Janoschek, R.2
Plum, L.3
Jordan, S.D.4
Rother, E.5
Ma, X.6
Xu, C.7
Enriori, P.8
Hampel, B.9
Barsh, G.S.10
-
70
-
-
79953307878
-
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
-
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., and Lowell, B. B. (2011). Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest 121, 1424-1428.
-
(2011)
J Clin Invest
, vol.121
, pp. 1424-1428
-
-
Krashes, M.J.1
Koda, S.2
Ye, C.3
Rogan, S.C.4
Adams, A.C.5
Cusher, D.S.6
Maratos-Flier, E.7
Roth, B.L.8
Lowell, B.B.9
-
71
-
-
0032492893
-
Hypothalamic CART is a new anorectic peptide regulated by leptin
-
Kristensen, P., Judge, M. E., Thim, L., Ribel, U., Christjansen, K. N., Wulff, B. S., Clausen, J. T., Jensen, P. B., Madsen, O. D., Vrang, N., et al. (1998). Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393, 72-76.
-
(1998)
Nature
, vol.393
, pp. 72-76
-
-
Kristensen, P.1
Judge, M.E.2
Thim, L.3
Ribel, U.4
Christjansen, K.N.5
Wulff, B.S.6
Clausen, J.T.7
Jensen, P.B.8
Madsen, O.D.9
Vrang, N.10
-
72
-
-
79551569614
-
Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats
-
Kruger, A. J., Yang, C., Lipson, K. L., Pino, S. C., Leif, J. H., Hogan, C. M., Whalen, B. J., Guberski, D. L., Lee, Y., Unger, R. H., et al. (2011). Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Autoimmunity 44, 137-148.
-
(2011)
Autoimmunity
, vol.44
, pp. 137-148
-
-
Kruger, A.J.1
Yang, C.2
Lipson, K.L.3
Pino, S.C.4
Leif, J.H.5
Hogan, C.M.6
Whalen, B.J.7
Guberski, D.L.8
Lee, Y.9
Unger, R.H.10
-
73
-
-
46349095132
-
Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
-
Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., and Zinn, A. R. (2008). Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol Endocrinol 22, 1723-1734.
-
(2008)
Mol Endocrinol
, vol.22
, pp. 1723-1734
-
-
Kublaoui, B.M.1
Gemelli, T.2
Tolson, K.P.3
Wang, Y.4
Zinn, A.R.5
-
74
-
-
9644260562
-
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus
-
Kubota, N., Terauchi, Y., Tobe, K., Yano, W., Suzuki, R., Ueki, K., Takamoto, I., Satoh, H., Maki, T., Kubota, T., et al. (2004). Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 114, 917-927.
-
(2004)
J Clin Invest
, vol.114
, pp. 917-927
-
-
Kubota, N.1
Terauchi, Y.2
Tobe, K.3
Yano, W.4
Suzuki, R.5
Ueki, K.6
Takamoto, I.7
Satoh, H.8
Maki, T.9
Kubota, T.10
-
75
-
-
23244458439
-
Regulation of blood glucose by hypothalamic pyruvate metabolism
-
Lam, T. K., Gutierrez-Juarez, R., Pocai, A., and Rossetti, L. (2005a). Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309, 943-947.
-
(2005)
Science
, vol.309
, pp. 943-947
-
-
Lam, T.K.1
Gutierrez-Juarez, R.2
Pocai, A.3
Rossetti, L.4
-
76
-
-
17844379953
-
Hypothalamic sensing of fatty acids
-
Lam, T. K., Schwartz, G. J., and Rossetti, L. (2005b). Hypothalamic sensing of fatty acids. Nat Neurosci 8, 579-584.
-
(2005)
Nat Neurosci
, vol.8
, pp. 579-584
-
-
Lam, T.K.1
Schwartz, G.J.2
Rossetti, L.3
-
77
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee, G. H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., and Friedman, J. M. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635.
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
Carroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
Friedman, J.M.7
-
78
-
-
79960425949
-
Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus
-
Leinninger, G. M. (2011). Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus. Physiol Behav 104, 572-581.
-
(2011)
Physiol Behav
, vol.104
, pp. 572-581
-
-
Leinninger, G.M.1
-
79
-
-
67849092898
-
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding
-
Leinninger, G. M., Jo, Y. H., Leshan, R. L., Louis, G. W., Yang, H., Barrera, J. G., Wilson, H., Opland, D. M., Faouzi, M. A., Gong, Y., et al. (2009). Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab 10, 89-98.
-
(2009)
Cell Metab
, vol.10
, pp. 89-98
-
-
Leinninger, G.M.1
Jo, Y.H.2
Leshan, R.L.3
Louis, G.W.4
Yang, H.5
Barrera, J.G.6
Wilson, H.7
Opland, D.M.8
Faouzi, M.A.9
Gong, Y.10
-
80
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
-
Lin, X., Taguchi, A., Park, S., Kushner, J. A., Li, F., Li, Y., and White, M. F. (2004). Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 114, 908-916.
-
(2004)
J Clin Invest
, vol.114
, pp. 908-916
-
-
Lin, X.1
Taguchi, A.2
Park, S.3
Kushner, J.A.4
Li, F.5
Li, Y.6
White, M.F.7
-
81
-
-
80052466069
-
CART peptide stimulation of G protein-mediated signaling in differentiated PC12 Cells: Identification of PACAP 6-38 as a CART receptor antagonist
-
[Epub ahead of print]. Aug 19, 2011
-
Lin, Y., Hall, R. A., and Kuhar, M. J. (2011). CART peptide stimulation of G protein-mediated signaling in differentiated PC12 Cells: Identification of PACAP 6-38 as a CART receptor antagonist. Neuropeptides. [Epub ahead of print]. Aug 19, 2011.
-
(2011)
Neuropeptides
-
-
Lin, Y.1
Hall, R.A.2
Kuhar, M.J.3
-
82
-
-
0022853586
-
Behavioral and endocrinological effects of single injections of monosodium glutamate in the mouse
-
Lorden, J. F., and Caudle, A. (1986). Behavioral and endocrinological effects of single injections of monosodium glutamate in the mouse. Neurobehav Toxicol Teratol 8, 509-519.
-
(1986)
Neurobehav Toxicol Teratol
, vol.8
, pp. 509-519
-
-
Lorden, J.F.1
Caudle, A.2
-
83
-
-
79956308808
-
Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis
-
Louis, G. W., Greenwald-Yarnell, M., Phillips, R., Coolen, L. M., Lehman, M. N., and Myers, M. G. Jr. (2011). Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology 152, 2302-2310.
-
(2011)
Endocrinology
, vol.152
, pp. 2302-2310
-
-
Louis, G.W.1
Greenwald-Yarnell, M.2
Phillips, R.3
Coolen, L.M.4
Lehman, M.N.5
Myers Jr., M.G.6
-
84
-
-
27344431720
-
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
-
Luquet, S., Perez, F. A., Hnasko, T. S., and Palmiter, R. D. (2005). NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310, 683-685.
-
(2005)
Science
, vol.310
, pp. 683-685
-
-
Luquet, S.1
Perez, F.A.2
Hnasko, T.S.3
Palmiter, R.D.4
-
85
-
-
79959879208
-
Central insulin and leptinmediated autonomic control of glucose homeostasis
-
Marino, J. S., Xu, Y., and Hill, J. W. (2011). Central insulin and leptinmediated autonomic control of glucose homeostasis. Trends Endocrinol Metab 22, 275-285.
-
(2011)
Trends Endocrinol Metab
, vol.22
, pp. 275-285
-
-
Marino, J.S.1
Xu, Y.2
Hill, J.W.3
-
86
-
-
0030734546
-
Identification and characterization of the vesicular GABA transporter
-
McIntire, S. L., Reimer, R. J., Schuske, K., Edwards, R. H., and Jorgensen, E. M. (1997). Identification and characterization of the vesicular GABA transporter. Nature 389, 870-876.
-
(1997)
Nature
, vol.389
, pp. 870-876
-
-
McIntire, S.L.1
Reimer, R.J.2
Schuske, K.3
Edwards, R.H.4
Jorgensen, E.M.5
-
87
-
-
0021956581
-
Distribution of the pro-opiomelanocortin derived peptides, adrenocorticotrope hormone, alpha-melanocyte-stimulating hormone and beta-endorphin (ACTH, alpha-MSH, beta-END) in the rat hypothalamus
-
Mezey, E., Kiss, J. Z., Mueller, G. P., Eskay, R., O'Donohue, T. L., and Palkovits, M. (1985). Distribution of the pro-opiomelanocortin derived peptides, adrenocorticotrope hormone, alpha-melanocyte-stimulating hormone and beta-endorphin (ACTH, alpha-MSH, beta-END) in the rat hypothalamus. Brain Res 328, 341-347.
-
(1985)
Brain Res
, vol.328
, pp. 341-347
-
-
Mezey, E.1
Kiss, J.Z.2
Mueller, G.P.3
Eskay, R.4
O'Donohue, T.L.5
Palkovits, M.6
-
88
-
-
79958702575
-
Nicotine decreases food intake through activation of POMC neurons
-
Mineur, Y. S., Abizaid, A., Rao, Y., Salas, R., DiLeone, R. J., Gündisch, D., Diano, S., De Biasi, M., Horvath, T. L., Gao, X. B., et al. (2011). Nicotine decreases food intake through activation of POMC neurons. Science 332, 1330-1332.
-
(2011)
Science
, vol.332
, pp. 1330-1332
-
-
Mineur, Y.S.1
Abizaid, A.2
Rao, Y.3
Salas, R.4
Dileone, R.J.5
Gündisch, D.6
Diano, S.7
de Biasi, M.8
Horvath, T.L.9
Gao, X.B.10
-
89
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997). Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
Wareham, N.J.6
Sewter, C.P.7
Digby, J.E.8
Mohammed, S.N.9
Hurst, J.A.10
-
90
-
-
72249092928
-
Recent advances in understanding leptin signaling and leptin resistance
-
Morris, D. L., and Rui, L. (2009). Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 297, E1247-E1259.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
, pp. 1247-1259
-
-
Morris, D.L.1
Rui, L.2
-
91
-
-
39149139689
-
Neurobiology of nutrition and obesity
-
Morrison, C. D., and Berthoud, H. R. (2007). Neurobiology of nutrition and obesity. Nutr Rev 65, 517-534.
-
(2007)
Nutr Rev
, vol.65
, pp. 517-534
-
-
Morrison, C.D.1
Berthoud, H.R.2
-
92
-
-
34548362074
-
Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
-
Morton, G. J. (2007). Hypothalamic leptin regulation of energy homeostasis and glucose metabolism. J Physiol 583, 437-443.
-
(2007)
J Physiol
, vol.583
, pp. 437-443
-
-
Morton, G.J.1
-
93
-
-
78049311283
-
Obesity and leptin resistance: distinguishing cause from effect
-
Myers, M. G. Jr, Leibel, R. L., Seeley, R. J., and Schwartz, M. W. (2010). Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab 21, 643-651.
-
(2010)
Trends Endocrinol Metab
, vol.21
, pp. 643-651
-
-
Myers Jr., M.G.1
Leibel, R.L.2
Seeley, R.J.3
Schwartz, M.W.4
-
94
-
-
58749086043
-
The geometry of leptin action in the brain: more complicated than a simple ARC
-
Myers, M. G. Jr, Münzberg, H., Leinninger, G. M., and Leshan, R. L. (2009). The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab 9, 117-123.
-
(2009)
Cell Metab
, vol.9
, pp. 117-123
-
-
Myers Jr., M.G.1
Münzberg, H.2
Leinninger, G.M.3
Leshan, R.L.4
-
95
-
-
0036267472
-
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
-
Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., and Rossetti, L. (2002a). Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5, 566-572.
-
(2002)
Nat Neurosci
, vol.5
, pp. 566-572
-
-
Obici, S.1
Feng, Z.2
Karkanias, G.3
Baskin, D.G.4
Rossetti, L.5
-
96
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici, S., Zhang, B. B., Karkanias, G., and Rossetti, L. (2002b). Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8, 1376-1382.
-
(2002)
Nat Med
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
97
-
-
0033601302
-
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus
-
Ohtaki, T., Kumano, S., Ishibashi, Y., Ogi, K., Matsui, H., Harada, M., Kitada, C., Kurokawa, T., Onda, H., and Fujino, M. (1999). Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J Biol Chem 274, 37041-37045.
-
(1999)
J Biol Chem
, vol.274
, pp. 37041-37045
-
-
Ohtaki, T.1
Kumano, S.2
Ishibashi, Y.3
Ogi, K.4
Matsui, H.5
Harada, M.6
Kitada, C.7
Kurokawa, T.8
Onda, H.9
Fujino, M.10
-
98
-
-
18244384200
-
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
-
Okamoto, H., Obici, S., Accili, D., and Rossetti, L. (2005). Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest 115, 1314-1322.
-
(2005)
J Clin Invest
, vol.115
, pp. 1314-1322
-
-
Okamoto, H.1
Obici, S.2
Accili, D.3
Rossetti, L.4
-
99
-
-
0030764741
-
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
-
Ollmann, M. M., Wilson, B. D., Yang, Y. K., Kerns, J. A., Chen, Y., Gantz, I., and Barsh, G. S. (1997). Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-138.
-
(1997)
Science
, vol.278
, pp. 135-138
-
-
Ollmann, M.M.1
Wilson, B.D.2
Yang, Y.K.3
Kerns, J.A.4
Chen, Y.5
Gantz, I.6
Barsh, G.S.7
-
100
-
-
77950547451
-
Pomcexpressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits
-
Padilla, S. L., Carmody, J. S., and Zeltser, L. M. (2010). Pomcexpressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat Med 16, 403-405.
-
(2010)
Nat Med
, vol.16
, pp. 403-405
-
-
Padilla, S.L.1
Carmody, J.S.2
Zeltser, L.M.3
-
101
-
-
34548604499
-
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
-
Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C. Y., Xu, C., Vianna, C. R., Balthasar, N., Lee, C. E., et al. (2007). Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449, 228-232.
-
(2007)
Nature
, vol.449
, pp. 228-232
-
-
Parton, L.E.1
Ye, C.P.2
Coppari, R.3
Enriori, P.J.4
Choi, B.5
Zhang, C.Y.6
Xu, C.7
Vianna, C.R.8
Balthasar, N.9
Lee, C.E.10
-
102
-
-
52049112608
-
Leptin: linking obesity, the metabolic syndrome, and cardiovascular disease
-
Patel, S. B., Reams, G. P., Spear, R. M., Freeman, R. H., and Villarreal, D. (2008). Leptin: linking obesity, the metabolic syndrome, and cardiovascular disease. Curr Hypertens Rep 10, 131-137.
-
(2008)
Curr Hypertens Rep
, vol.10
, pp. 131-137
-
-
Patel, S.B.1
Reams, G.P.2
Spear, R.M.3
Freeman, R.H.4
Villarreal, D.5
-
103
-
-
79951948090
-
Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells
-
Patterson, C. M., Leshan, R. L., Jones, J. C., and Myers, M. G. Jr. (2011). Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Res 1378, 18-28.
-
(2011)
Brain Res
, vol.1378
, pp. 18-28
-
-
Patterson, C.M.1
Leshan, R.L.2
Jones, J.C.3
Myers Jr., M.G.4
-
104
-
-
46249097105
-
Dysregulation of the mesolimbic dopamine system and reward in MCH-/-mice
-
Pissios, P., Frank, L., Kennedy, A. R., Porter, D. R., Marino, F. E., Liu, F. F., Pothos, E. N., and Maratos-Flier, E. (2008). Dysregulation of the mesolimbic dopamine system and reward in MCH-/-mice. Biol Psychiatry 64, 184-191.
-
(2008)
Biol Psychiatry
, vol.64
, pp. 184-191
-
-
Pissios, P.1
Frank, L.2
Kennedy, A.R.3
Porter, D.R.4
Marino, F.E.5
Liu, F.F.6
Pothos, E.N.7
Maratos-Flier, E.8
-
105
-
-
70350369729
-
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
-
Plum, L., Lin, H. V., Dutia, R., Tanaka, J., Aizawa, K. S., Matsumoto, M., Kim, A. J., Cawley, N. X., Paik, J. H., Loh, Y. P., et al. (2009). The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med 15, 1195-1201.
-
(2009)
Nat Med
, vol.15
, pp. 1195-1201
-
-
Plum, L.1
Lin, H.V.2
Dutia, R.3
Tanaka, J.4
Aizawa, K.S.5
Matsumoto, M.6
Kim, A.J.7
Cawley, N.X.8
Paik, J.H.9
Loh, Y.P.10
-
106
-
-
17844379717
-
Hypothalamic K(ATP) channels control hepatic glucose production
-
Pocai, A., Lam, T. K., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., and Rossetti, L. (2005). Hypothalamic K(ATP) channels control hepatic glucose production. Nature 434, 1026-1031.
-
(2005)
Nature
, vol.434
, pp. 1026-1031
-
-
Pocai, A.1
Lam, T.K.2
Gutierrez-Juarez, R.3
Obici, S.4
Schwartz, G.J.5
Bryan, J.6
Aguilar-Bryan, L.7
Rossetti, L.8
-
107
-
-
0036288345
-
Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice
-
Qian, S., Chen, H., Weingarth, D., Trumbauer, M. E., Novi, D. E., Guan, X., Yu, H., Shen, Z., Feng, Y., Frazier, E., et al. (2002). Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol 22, 5027-5035.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5027-5035
-
-
Qian, S.1
Chen, H.2
Weingarth, D.3
Trumbauer, M.E.4
Novi, D.E.5
Guan, X.6
Yu, H.7
Shen, Z.8
Feng, Y.9
Frazier, E.10
-
108
-
-
13344279395
-
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
-
Qu, D., Ludwig, D. S., Gammeltoft, S., Piper, M., Pelleymounter, M. A., Cullen, M. J., Mathes, W. F., Przypek, R., Kanarek, R., and Maratos-Flier, E. (1996). A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380, 243-247.
-
(1996)
Nature
, vol.380
, pp. 243-247
-
-
Qu, D.1
Ludwig, D.S.2
Gammeltoft, S.3
Piper, M.4
Pelleymounter, M.A.5
Cullen, M.J.6
Mathes, W.F.7
Przypek, R.8
Kanarek, R.9
Maratos-Flier, E.10
-
109
-
-
20244380014
-
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
-
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998). Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585.
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
Amemiya, A.2
Ishii, M.3
Matsuzaki, I.4
Chemelli, R.M.5
Tanaka, H.6
Williams, S.C.7
Richardson, J.A.8
Kozlowski, G.P.9
Wilson, S.10
-
110
-
-
74949088518
-
Endogenous ACTH, not only alpha-melanocyte-stimulating hormone, reduces food intake mediated by hypothalamic mechanisms
-
Schulz, C., Paulus, K., Lobmann, R., Dallman, M., and Lehnert, H. (2010). Endogenous ACTH, not only alpha-melanocyte-stimulating hormone, reduces food intake mediated by hypothalamic mechanisms. Am J Physiol Endocrinol Metab 298, E237-E244.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
, pp. 237-244
-
-
Schulz, C.1
Paulus, K.2
Lobmann, R.3
Dallman, M.4
Lehnert, H.5
-
111
-
-
0029739970
-
Identification of targets of leptin action in rat hypothalamus
-
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., and Baskin, D. G. (1996). Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98, 1101-1106.
-
(1996)
J Clin Invest
, vol.98
, pp. 1101-1106
-
-
Schwartz, M.W.1
Seeley, R.J.2
Campfield, L.A.3
Burn, P.4
Baskin, D.G.5
-
112
-
-
66149141484
-
Leptin targets in the mouse brain
-
Scott, M. M., Lachey, J. L., Sternson, S. M., Lee, C. E., Elias, C. F., Friedman, J. M., and Elmquist, J. K. (2009). Leptin targets in the mouse brain. J Comp Neurol 514, 518-532.
-
(2009)
J Comp Neurol
, vol.514
, pp. 518-532
-
-
Scott, M.M.1
Lachey, J.L.2
Sternson, S.M.3
Lee, C.E.4
Elias, C.F.5
Friedman, J.M.6
Elmquist, J.K.7
-
113
-
-
78650023056
-
Galanin-like peptide and the regulation of feeding behavior and energy metabolism
-
Shiba, K., Kageyama, H., Takenoya, F., and Shioda, S. (2010). Galanin-like peptide and the regulation of feeding behavior and energy metabolism. FEBS J 277, 5006-5013.
-
(2010)
FEBS J
, vol.277
, pp. 5006-5013
-
-
Shiba, K.1
Kageyama, H.2
Takenoya, F.3
Shioda, S.4
-
114
-
-
0032542294
-
Mice lacking melanin-concentrating hormone are hypophagic and lean
-
Shimada, M., Tritos, N. A., Lowell, B. B., Flier, J. S., and Maratos-Flier, E. (1998). Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396, 670-674.
-
(1998)
Nature
, vol.396
, pp. 670-674
-
-
Shimada, M.1
Tritos, N.A.2
Lowell, B.B.3
Flier, J.S.4
Maratos-Flier, E.5
-
115
-
-
78049445907
-
Brain expression of Cre recombinase driven by pancreas-specific promoters
-
Song, J., Xu, Y., Hu, X., Choi, B., and Tong, Q. (2010). Brain expression of Cre recombinase driven by pancreas-specific promoters. Genesis 48, 628-634.
-
(2010)
Genesis
, vol.48
, pp. 628-634
-
-
Song, J.1
Xu, Y.2
Hu, X.3
Choi, B.4
Tong, Q.5
-
116
-
-
12144275681
-
Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus
-
Song, Z., and Routh, V. H. (2005). Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 54, 15-22.
-
(2005)
Diabetes
, vol.54
, pp. 15-22
-
-
Song, Z.1
Routh, V.H.2
-
117
-
-
80955145282
-
Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT
-
2011 Jun 1. [Epub ahead of print]. doi: 10. 1002/dvg. 20773
-
Stubbusch, J., Majdazari, A., Schmidt, M., Schutz, G., Deller, T., and Rohrer, H. (2011). Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT. Genesis. 2011 Jun 1. [Epub ahead of print]. doi: 10. 1002/dvg. 20773.
-
(2011)
Genesis
-
-
Stubbusch, J.1
Majdazari, A.2
Schmidt, M.3
Schutz, G.4
Deller, T.5
Rohrer, H.6
-
118
-
-
2942556680
-
The synaptic vesicle cycle
-
Sudhof, T. C. (2004). The synaptic vesicle cycle. Annu Rev Neurosci 27, 509-547.
-
(2004)
Annu Rev Neurosci
, vol.27
, pp. 509-547
-
-
Sudhof, T.C.1
-
119
-
-
80052236883
-
The global obesity pandemic: shaped by global drivers and local environments
-
Swinburn, B. A., Sacks, G., Hall, K. D., McPherson, K., Finegood, D. T., Moodie, M. L., and Gortmaker, S. L. (2011). The global obesity pandemic: shaped by global drivers and local environments. Lancet 378, 804-814.
-
(2011)
Lancet
, vol.378
, pp. 804-814
-
-
Swinburn, B.A.1
Sacks, G.2
Hall, K.D.3
McPherson, K.4
Finegood, D.T.5
Moodie, M.L.6
Gortmaker, S.L.7
-
120
-
-
14244254196
-
Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons
-
Takahashi, K. A., and Cone, R. D. (2005). Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons. Endocrinology 146, 1043-1047.
-
(2005)
Endocrinology
, vol.146
, pp. 1043-1047
-
-
Takahashi, K.A.1
Cone, R.D.2
-
121
-
-
0041864128
-
Common endocrine control of body weight, reproduction, and bone mass
-
Takeda, S., Elefteriou, F., and Karsenty, G. (2003). Common endocrine control of body weight, reproduction, and bone mass. Annu Rev Nutr 23, 403-411.
-
(2003)
Annu Rev Nutr
, vol.23
, pp. 403-411
-
-
Takeda, S.1
Elefteriou, F.2
Karsenty, G.3
-
122
-
-
33747099576
-
The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions
-
Teitelbaum, P., and Epstein, A. N. (1962). The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions. Psychol Rev 69, 74-90.
-
(1962)
Psychol Rev
, vol.69
, pp. 74-90
-
-
Teitelbaum, P.1
Epstein, A.N.2
-
123
-
-
79551669211
-
Synaptotagmin 4: a new antiobesity target?
-
Tong, Q. (2011). Synaptotagmin 4: a new antiobesity target? Neuron 69, 401-403.
-
(2011)
Neuron
, vol.69
, pp. 401-403
-
-
Tong, Q.1
-
124
-
-
34247616021
-
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
-
Tong, Q., Ye, C., McCrimmon, R. J., Dhillon, H., Choi, B., Kramer, M. D., Yu, J., Yang, Z., Christiansen, L. M., Lee, C. E., et al. (2007). Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5, 383-393.
-
(2007)
Cell Metab
, vol.5
, pp. 383-393
-
-
Tong, Q.1
Ye, C.2
McCrimmon, R.J.3
Dhillon, H.4
Choi, B.5
Kramer, M.D.6
Yu, J.7
Yang, Z.8
Christiansen, L.M.9
Lee, C.E.10
-
125
-
-
50249120768
-
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
-
Tong, Q., Ye, C. P., Jones, J. E., Elmquist, J. K., and Lowell, B. B. (2008). Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 11, 998-1000.
-
(2008)
Nat Neurosci
, vol.11
, pp. 998-1000
-
-
Tong, Q.1
Ye, C.P.2
Jones, J.E.3
Elmquist, J.K.4
Lowell, B.B.5
-
126
-
-
0026783423
-
Ibotenic acid lesion of the hypothalamic paraventricular nucleus produces weight gain but modifies neither preference nor aversion for saccharin
-
Touzani, K., and Velley, L. (1992). Ibotenic acid lesion of the hypothalamic paraventricular nucleus produces weight gain but modifies neither preference nor aversion for saccharin. Physiol Behav 52, 673-678.
-
(1992)
Physiol Behav
, vol.52
, pp. 673-678
-
-
Touzani, K.1
Velley, L.2
-
127
-
-
37549055474
-
Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity
-
Unger, T. J., Calderon, G. A., Bradley, L. C., Sena-Esteves, M., and Rios, M. (2007). Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27, 14265-14274.
-
(2007)
J Neurosci
, vol.27
, pp. 14265-14274
-
-
Unger, T.J.1
Calderon, G.A.2
Bradley, L.C.3
Sena-Esteves, M.4
Rios, M.5
-
128
-
-
41549111593
-
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
-
van de Wall, E., Leshan, R., Xu, A. W., Balthasar, N., Coppari, R., Liu, S. M., Jo, Y. H., MacKenzie, R. G., Allison, D. B., Dun, N. J., et al. (2008). Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology 149, 1773-1785.
-
(2008)
Endocrinology
, vol.149
, pp. 1773-1785
-
-
van de Wall, E.1
Leshan, R.2
Xu, A.W.3
Balthasar, N.4
Coppari, R.5
Liu, S.M.6
Jo, Y.H.7
Mackenzie, R.G.8
Allison, D.B.9
Dun, N.J.10
-
129
-
-
0347993676
-
Weighing the role of hypothalamic feeding neurotransmitters
-
van den Pol, A. N. (2003). Weighing the role of hypothalamic feeding neurotransmitters. Neuron 40, 1059-1061.
-
(2003)
Neuron
, vol.40
, pp. 1059-1061
-
-
van den Pol, A.N.1
-
131
-
-
79960190012
-
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
-
Vong, L., Ye, C., Yang, Z., Choi, B., Chua, S. Jr, and Lowell, B. B. (2011). Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 71, 142-154.
-
(2011)
Neuron
, vol.71
, pp. 142-154
-
-
Vong, L.1
Ye, C.2
Yang, Z.3
Choi, B.4
Chua Jr., S.5
Lowell, B.B.6
-
132
-
-
77950373635
-
Leptin therapy in insulin-deficient type I diabetes
-
Wang, M. Y., Chen, L., Clark, G. O., Lee, Y., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B., et al. (2010). Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci U S A 107, 4813-4819.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 4813-4819
-
-
Wang, M.Y.1
Chen, L.2
Clark, G.O.3
Lee, Y.4
Stevens, R.D.5
Ilkayeva, O.R.6
Wenner, B.R.7
Bain, J.R.8
Charron, M.J.9
Newgard, C.B.10
-
133
-
-
80052245888
-
Health and economic burden of the projected obesity trends in the USA and the UK
-
Wang, Y. C., McPherson, K., Marsh, T., Gortmaker, S. L., and Brown, M. (2011). Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378, 815-825.
-
(2011)
Lancet
, vol.378
, pp. 815-825
-
-
Wang, Y.C.1
McPherson, K.2
Marsh, T.3
Gortmaker, S.L.4
Brown, M.5
-
134
-
-
20144386267
-
CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight
-
Wierup, N., Richards, W. G., Bannon, A. W., Kuhar, M. J., Ahrén, B., and Sundler, F. (2005). CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight. Regul Pept 129, 203-211.
-
(2005)
Regul Pept
, vol.129
, pp. 203-211
-
-
Wierup, N.1
Richards, W.G.2
Bannon, A.W.3
Kuhar, M.J.4
Ahrén, B.5
Sundler, F.6
-
135
-
-
77249146406
-
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
-
Williams, K. W., Margatho, L. O., Lee, C. E., Choi, M., Lee, S., Scott, M. M., Elias, C. F., and Elmquist, J. K. (2010). Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci 30, 2472-2479.
-
(2010)
J Neurosci
, vol.30
, pp. 2472-2479
-
-
Williams, K.W.1
Margatho, L.O.2
Lee, C.E.3
Choi, M.4
Lee, S.5
Scott, M.M.6
Elias, C.F.7
Elmquist, J.K.8
-
136
-
-
2342571477
-
An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size
-
Wojcik, S. M., Rhee, J. S., Herzog, E., Sigler, A., Jahn, R., Takamori, S., Brose, N., and Rosenmund, C. (2004). An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci U S A 101, 7158-7163.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 7158-7163
-
-
Wojcik, S.M.1
Rhee, J.S.2
Herzog, E.3
Sigler, A.4
Jahn, R.5
Takamori, S.6
Brose, N.7
Rosenmund, C.8
-
137
-
-
45549104844
-
Temporal and spatial regulation of CRE recombinase expression in gonadotrophin-releasing hormone neurones in the mouse
-
Wolfe, A., Divall, S., Singh, S. P., Nikrodhanond, A. A., Baria, A. T., Le, W. W., Hoffman, G. E., and Radovick, S. (2008). Temporal and spatial regulation of CRE recombinase expression in gonadotrophin-releasing hormone neurones in the mouse. J Neuroendocrinol 20, 909-916.
-
(2008)
J Neuroendocrinol
, vol.20
, pp. 909-916
-
-
Wolfe, A.1
Divall, S.2
Singh, S.P.3
Nikrodhanond, A.A.4
Baria, A.T.5
Le, W.W.6
Hoffman, G.E.7
Radovick, S.8
-
138
-
-
67549112681
-
Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation
-
Wu, Q., Boyle, M. P., and Palmiter, R. D. (2009). Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell 137, 1225-1234.
-
(2009)
Cell
, vol.137
, pp. 1225-1234
-
-
Wu, Q.1
Boyle, M.P.2
Palmiter, R.D.3
-
139
-
-
40649093320
-
Starvation after AgRP neuron ablation is independent of melanocortin signaling
-
Wu, Q., Howell, M. P., Cowley, M. A., and Palmiter, R. D. (2008). Starvation after AgRP neuron ablation is independent of melanocortin signaling. Proc Natl Acad Sci U S A 105, 2687-2692.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2687-2692
-
-
Wu, Q.1
Howell, M.P.2
Cowley, M.A.3
Palmiter, R.D.4
-
140
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
Xu, A. W., Kaelin, C. B., Takeda, K., Akira, S., Schwartz, M. W., and Barsh, G. S. (2005). PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 115, 951-958.
-
(2005)
J Clin Invest
, vol.115
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
141
-
-
0038392755
-
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
-
Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H., and Reichardt, L. F. (2003). Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6, 736-742.
-
(2003)
Nat Neurosci
, vol.6
, pp. 736-742
-
-
Xu, B.1
Goulding, E.H.2
Zang, K.3
Cepoi, D.4
Cone, R.D.5
Jones, K.R.6
Tecott, L.H.7
Reichardt, L.F.8
-
142
-
-
78650191226
-
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
-
Xu, Y., Berglund, E. D., Sohn, J. W., Holland, W. L., Chuang, J. C., Fukuda, M., Rossi, J., Williams, K. W., Jones, J. E., Zigman, J. M., et al. (2010). 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci 13, 1457-1459.
-
(2010)
Nat Neurosci
, vol.13
, pp. 1457-1459
-
-
Xu, Y.1
Berglund, E.D.2
Sohn, J.W.3
Holland, W.L.4
Chuang, J.C.5
Fukuda, M.6
Rossi, J.7
Williams, K.W.8
Jones, J.E.9
Zigman, J.M.10
-
143
-
-
0347993114
-
Mice lacking the thyrotropin-releasing hormone gene: what do they tell us?
-
Yamada, M., Satoh, T., and Mori, M. (2003). Mice lacking the thyrotropin-releasing hormone gene: what do they tell us? Thyroid 13, 1111-1121.
-
(2003)
Thyroid
, vol.13
, pp. 1111-1121
-
-
Yamada, M.1
Satoh, T.2
Mori, M.3
-
144
-
-
80052922112
-
Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
-
Yang, Y., Atasoy, D., Su, H. H., and Sternson, S. M. (2011). Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop. Cell 146, 992-1003.
-
(2011)
Cell
, vol.146
, pp. 992-1003
-
-
Yang, Y.1
Atasoy, D.2
Su, H.H.3
Sternson, S.M.4
-
145
-
-
0032863468
-
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
-
Yaswen, L., Diehl, N., Brennan, M. B., and Hochgeschwender, U. (1999). Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 5, 1066-1070.
-
(1999)
Nat Med
, vol.5
, pp. 1066-1070
-
-
Yaswen, L.1
Diehl, N.2
Brennan, M.B.3
Hochgeschwender, U.4
-
146
-
-
0031668219
-
A frameshift mutation in MC4R associated with dominantly inherited human obesity
-
Yeo, G. S., Farooqi, I. S., Aminian, S., Halsall, D. J., Stanhope, R. G., and O'Rahilly, S. (1998). A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20, 111-112.
-
(1998)
Nat Genet
, vol.20
, pp. 111-112
-
-
Yeo, G.S.1
Farooqi, I.S.2
Aminian, S.3
Halsall, D.J.4
Stanhope, R.G.5
O'Rahilly, S.6
-
147
-
-
52949140814
-
Making insulin-deficient type 1 diabetic rodents thrive without insulin
-
Yu, X., Park, B. H., Wang, M. Y., Wang, Z. V., and Unger, R. H. (2008). Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci U S A 105, 14070-14075.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 14070-14075
-
-
Yu, X.1
Park, B.H.2
Wang, M.Y.3
Wang, Z.V.4
Unger, R.H.5
-
148
-
-
79551665635
-
Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance
-
Zhang, G., Bai, H., Zhang, H., Dean, C., Wu, Q., Li, J., Guariglia, S., Meng, Q., and Cai, D. (2011a). Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron 69, 523-535.
-
(2011)
Neuron
, vol.69
, pp. 523-535
-
-
Zhang, G.1
Bai, H.2
Zhang, H.3
Dean, C.4
Wu, Q.5
Li, J.6
Guariglia, S.7
Meng, Q.8
Cai, D.9
-
149
-
-
79551512119
-
Leptinreceptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits
-
Zhang, Y., Kerman, I. A., Laque, A., Nguyen, P., Faouzi, M., Louis, G. W., Jones, J. C., Rhodes, C., and Münzberg, H. (2011b). Leptinreceptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci 31, 1873-1884.
-
(2011)
J Neurosci
, vol.31
, pp. 1873-1884
-
-
Zhang, Y.1
Kerman, I.A.2
Laque, A.3
Nguyen, P.4
Faouzi, M.5
Louis, G.W.6
Jones, J.C.7
Rhodes, C.8
Münzberg, H.9
-
150
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
|