메뉴 건너뛰기




Volumn 12, Issue 5, 2010, Pages 545-552

Glucose stimulation of hypothalamic MCH neurons involves KATP channels, is modulated by ucp2, and regulates peripheral glucose homeostasis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; UNCOUPLING PROTEIN 2;

EID: 78049433920     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2010.09.013     Document Type: Article
Times cited : (161)

References (33)
  • 1
    • 0025162079 scopus 로고
    • Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels
    • M.L. Ashford, P.R. Boden, and J.M. Treherne Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels Pflugers Arch. 415 1990 479 483
    • (1990) Pflugers Arch. , vol.415 , pp. 479-483
    • Ashford, M.L.1    Boden, P.R.2    Treherne, J.M.3
  • 2
    • 33645893473 scopus 로고    scopus 로고
    • Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem
    • R.H. Balfour, A.M. Hansen, and S. Trapp Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem J. Physiol. 570 2006 469 484
    • (2006) J. Physiol. , vol.570 , pp. 469-484
    • Balfour, R.H.1    Hansen, A.M.2    Trapp, S.3
  • 3
    • 0026766094 scopus 로고
    • The melanin-concentrating hormone system of the rat brain: An immuno- and hybridization histochemical characterization
    • J.C. Bittencourt, F. Presse, C. Arias, C. Peto, J. Vaughan, J.L. Nahon, W. Vale, and P.E. Sawchenko The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization J. Comp. Neurol. 319 1992 218 245
    • (1992) J. Comp. Neurol. , vol.319 , pp. 218-245
    • Bittencourt, J.C.1    Presse, F.2    Arias, C.3    Peto, C.4    Vaughan, J.5    Nahon, J.L.6    Vale, W.7    Sawchenko, P.E.8
  • 4
    • 57449088632 scopus 로고    scopus 로고
    • Glucose-induced inhibition: How many ionic mechanisms?
    • D. Burdakov, and F. Lesage Glucose-induced inhibition: how many ionic mechanisms? Acta Physiol. (Oxf.) 195 2009 71 78
    • (2009) Acta Physiol. (Oxf.) , vol.195 , pp. 71-78
    • Burdakov, D.1    Lesage, F.2
  • 5
    • 14644396121 scopus 로고    scopus 로고
    • Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ
    • D. Burdakov, O. Gerasimenko, and A. Verkhratsky Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ J. Neurosci. 25 2005 2429 2433
    • (2005) J. Neurosci. , vol.25 , pp. 2429-2433
    • Burdakov, D.1    Gerasimenko, O.2    Verkhratsky, A.3
  • 11
    • 1442276966 scopus 로고    scopus 로고
    • Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons
    • L. Kang, V.H. Routh, E.V. Kuzhikandathil, L.D. Gaspers, and B.E. Levin Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons Diabetes 53 2004 549 559
    • (2004) Diabetes , vol.53 , pp. 549-559
    • Kang, L.1    Routh, V.H.2    Kuzhikandathil, E.V.3    Gaspers, L.D.4    Levin, B.E.5
  • 12
    • 0034677634 scopus 로고    scopus 로고
    • Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes
    • J.C. Koster, B.A. Marshall, N. Ensor, J.A. Corbett, and C.G. Nichols Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes Cell 100 2000 645 654
    • (2000) Cell , vol.100 , pp. 645-654
    • Koster, J.C.1    Marshall, B.A.2    Ensor, N.3    Corbett, J.A.4    Nichols, C.G.5
  • 18
    • 33845945261 scopus 로고    scopus 로고
    • Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide y requires changes in AMP-activated protein kinase activity
    • P.D. Mountjoy, S.J. Bailey, and G.A. Rutter Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity Diabetologia 50 2007 168 177
    • (2007) Diabetologia , vol.50 , pp. 168-177
    • Mountjoy, P.D.1    Bailey, S.J.2    Rutter, G.A.3
  • 19
    • 0034488835 scopus 로고    scopus 로고
    • Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision
    • A. Novak, C. Guo, W. Yang, A. Nagy, and C.G. Lobe Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision Genesis 28 2000 147 155
    • (2000) Genesis , vol.28 , pp. 147-155
    • Novak, A.1    Guo, C.2    Yang, W.3    Nagy, A.4    Lobe, C.G.5
  • 22
  • 23
    • 0019794835 scopus 로고
    • Glucoreceptors controlling feeding and blood glucose: Location in the hindbrain
    • R.C. Ritter, P.G. Slusser, and S. Stone Glucoreceptors controlling feeding and blood glucose: location in the hindbrain Science 213 1981 451 452
    • (1981) Science , vol.213 , pp. 451-452
    • Ritter, R.C.1    Slusser, P.G.2    Stone, S.3
  • 24
    • 45549098243 scopus 로고    scopus 로고
    • Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism
    • E. Rother, A.C. Konner, and J.C. Bruning Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism Am. J. Physiol. Endocrinol. Metab. 294 2008 E810 E816
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294
    • Rother, E.1    Konner, A.C.2    Bruning, J.C.3
  • 25
    • 0036065157 scopus 로고    scopus 로고
    • Glucose-sensing neurons: Are they physiologically relevant?
    • V.H. Routh Glucose-sensing neurons: are they physiologically relevant? Physiol. Behav. 76 2002 403 413
    • (2002) Physiol. Behav. , vol.76 , pp. 403-413
    • Routh, V.H.1
  • 26
    • 0029561629 scopus 로고
    • Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle
    • H. Sakura, C. Ammala, P.A. Smith, F.M. Gribble, and F.M. Ashcroft Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle FEBS Lett. 377 1995 338 344
    • (1995) FEBS Lett. , vol.377 , pp. 338-344
    • Sakura, H.1    Ammala, C.2    Smith, P.A.3    Gribble, F.M.4    Ashcroft, F.M.5
  • 28
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • M.W. Schwartz, and D. Porte Jr. Diabetes, obesity, and the brain Science 307 2005 375 379
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte Jr., D.2
  • 29
    • 2642641299 scopus 로고    scopus 로고
    • Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons
    • I.A. Silver, and M. Erecinska Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons J. Neurophysiol. 79 1998 1733 1745
    • (1998) J. Neurophysiol. , vol.79 , pp. 1733-1745
    • Silver, I.A.1    Erecinska, M.2
  • 30
    • 12144275681 scopus 로고    scopus 로고
    • Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus
    • Z. Song, and V.H. Routh Differential effects of glucose and lactate on glucosensing neurons in the ventromedial hypothalamic nucleus Diabetes 54 2005 15 22
    • (2005) Diabetes , vol.54 , pp. 15-22
    • Song, Z.1    Routh, V.H.2
  • 31
    • 2442538044 scopus 로고    scopus 로고
    • Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
    • A.N. van den Pol, C. Acuna-Goycolea, K.R. Clark, and P.K. Ghosh Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection Neuron 42 2004 635 652
    • (2004) Neuron , vol.42 , pp. 635-652
    • Van Den Pol, A.N.1    Acuna-Goycolea, C.2    Clark, K.R.3    Ghosh, P.K.4
  • 32
    • 0035875087 scopus 로고    scopus 로고
    • Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
    • C.Y. Zhang, G. Baffy, P. Perret, S. Krauss, O. Peroni, D. Grujic, T. Hagen, A.J. Vidal-Puig, O. Boss, and Y.B. Kim Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes Cell 105 2001 745 755
    • (2001) Cell , vol.105 , pp. 745-755
    • Zhang, C.Y.1    Baffy, G.2    Perret, P.3    Krauss, S.4    Peroni, O.5    Grujic, D.6    Hagen, T.7    Vidal-Puig, A.J.8    Boss, O.9    Kim, Y.B.10
  • 33
    • 33744548069 scopus 로고    scopus 로고
    • Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets
    • C.Y. Zhang, L.E. Parton, C.P. Ye, S. Krauss, R. Shen, C.T. Lin, J.A. Porco Jr., and B.B. Lowell Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets Cell Metab. 3 2006 417 427
    • (2006) Cell Metab. , vol.3 , pp. 417-427
    • Zhang, C.Y.1    Parton, L.E.2    Ye, C.P.3    Krauss, S.4    Shen, R.5    Lin, C.T.6    Porco Jr., J.A.7    Lowell, B.B.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.