Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons

Endocrinology

Volumn 146, Issue 3, 2005, Pages 1043-1047

  Takahashi, Kanji A ^a,b   Cone, Roger D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; AGOUTI RELATED PROTEIN; IONOTROPIC RECEPTOR ANTAGONIST; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y;

ACTION POTENTIAL; ANIMAL TISSUE; APPETITE; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ELECTROPHYSIOLOGY; FEEDING; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; SPIKE; SYNAPSE; TRANSGENIC MOUSE; WILD TYPE;

ACTION POTENTIALS; ANIMALS; ARCUATE NUCLEUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FOOD DEPRIVATION; HYDROGEN-ION CONCENTRATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; NEURONS; NEUROPEPTIDE Y; PROTEINS; TIME FACTORS;

EID: 14244254196     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1397     Document Type: Article

References (30)

1. Pinto S, Rosebeny AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL 2004 Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304:110-115
2. Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, Shen Z, Marsh DJ, Feighner SD, Guan XM, Ye Z, Nargund RP, Smith RG, Van der Ploeg LH, Howard AD, MacNeil DJ, Qian S 2004 Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145:2607-2612
3. van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D 2004 Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 7:493-494
4. Barsh GS, Schwartz MW 2002 Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet 3:589-600
5. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671
6. Hagan MM, Rushing PA, Pritchard LM, Schwartz MW, Strack AM, Van Der Ploeg LH, Woods SC, Seeley RJ 2000 Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am J Physiol Regul Integr Comp Physiol 279:R47-R52
7. Hahn TM, Breininger JF, Baskin DG, Schwartz MW 1998 Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1:271-272
8. Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T 1998 The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA 95:15043-15048
9. Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, Luther M, Chen W, Woychik RP, Wilkison WO, Cone RD 1994 Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371:799-802
10. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168
11. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138
12. Sanacora G, Kershaw M, Finkelstein JA, White JD 1990 Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127:730-737
13. Chua Jr SC, Brown AW, Kim J, Hennessey KL, Leibel RL, Hirsch J 1991 Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation. Brain Res Mol Brain Res 11:291-299
14. Korner J, Savontaus E, Chua Jr SC, Leibel RL, Wardlaw SL 2001 Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. J Neuroendocrinol 13:959-966
15. Hokfelt T, Broberger C, Xu ZQ, Sergeyev V, Ubink R, Diez M 2000 Neuropeptides - an overview. Neuropharmacology 39:1337-1356
16. Namae M, Mori Y, Yasuda K, Kadowaki T, Kanazawa Y, Komeda K 1998 New method for genotyping the mouse Lep(ob) mutation, using a polymerase chain reaction assay. Lab Anim Sci 48:103-104
17. Horvat S, Bunger L 1999 Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for the mouse leptin receptor (Lepr(db)) mutation. Lab Anim 33:380-384
18. Takahashi KA, Smart JL, Liu H, Cone RD 2004 The anorexigenic fatty acid synthase inhibitor, C75, is a nonspecific neuronal activator. Endocrinology 145:184-193
19. Roberts WM, Almers W 1992 Patch voltage clamping with low-resistance seals: loose patch clamp. Methods Enzymol 207:155-176
20. Bouret SG, Draper SJ, Simerly RB 2004 Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304:108-110
21. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ, Trayhum P 1996 Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol 8:733-735
22. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP 1992 Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130:3608-3616
23. Van Heek M, Mullins DE, Wirth MA, Graziano MP, Fawzi AB, Compton DS, France CF, Hoos LM, Casale RL, Sybertz EJ, Strader CD, Davis Jr HR 1996 The relationship of tissue localization, distribution and turnover to feeding after intraperitoneal 1251-leptin administration to ob/ob and db/db mice. Horm Metab Res 28:653-658
24. Ahren B, Baldwin RM, Havel PJ 2000 Pharmacokinetics of human leptin in mice and rhesus monkeys. Int J Obes Relat Metab Disord 24:1579-1585
25. McNay EC, Sherwin RS 2004 From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurements. J Neurosci Methods 132:35-43
26. Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG, Jr. 2003 STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421:856-859
27. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK 1999 Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786
28. Shimizu-Albergine M, Ippolito DL, Beavo JA 2001 Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus. J Neurosci 21:1238-1246
29. Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, Mobbs CV 1999 Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology 140:4551-4557
30. Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH, Mobbs CV 2003 Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression. BMC Physiol 3:5