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Volumn 129, Issue 1-3, 2005, Pages 203-211

CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight

Author keywords

cells; CART; CART null mutant; Cocaine amphetamine regulated transcript; GLUT2; Islet function; Neuropeptides; Obesity; PDX 1; Type 2 diabetes

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE;

EID: 20144386267     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2005.02.016     Document Type: Article
Times cited : (103)

References (38)
  • 1
    • 0028947053 scopus 로고
    • PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine
    • J. Douglass, A.A. McKinzie, and P. Couceyro PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine J Neurosci 15 1995 2471 2481
    • (1995) J Neurosci , vol.15 , pp. 2471-2481
    • Douglass, J.1    McKinzie, A.A.2    Couceyro, P.3
  • 2
    • 0029737514 scopus 로고    scopus 로고
    • Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction
    • K.M. Gautvik, L. de Lecea, V.T. Gautvik, P.E. Danielson, P. Tranque, and A. Dopazo Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction Proc Natl Acad Sci USA 93 16 1996 8733 8738 Aug 6
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.16 , pp. 8733-8738
    • Gautvik, K.M.1    De Lecea, L.2    Gautvik, V.T.3    Danielson, P.E.4    Tranque, P.5    Dopazo, A.6
  • 3
    • 0030715274 scopus 로고    scopus 로고
    • Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland
    • E.O. Koylu, P.R. Couceyro, P.D. Lambert, N.C. Ling, E.B. DeSouza, and M.J. Kuhar Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland J Neuroendocrinol 9 1997 823 833
    • (1997) J Neuroendocrinol , vol.9 , pp. 823-833
    • Koylu, E.O.1    Couceyro, P.R.2    Lambert, P.D.3    Ling, N.C.4    Desouza, E.B.5    Kuhar, M.J.6
  • 4
    • 0032472826 scopus 로고    scopus 로고
    • Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain
    • E.O. Koylu, P.R. Couceyro, P.D. Lambert, and M.J. Kuhar Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain J Comp Neurol 391 1998 115 132
    • (1998) J Comp Neurol , vol.391 , pp. 115-132
    • Koylu, E.O.1    Couceyro, P.R.2    Lambert, P.D.3    Kuhar, M.J.4
  • 5
    • 0033198026 scopus 로고    scopus 로고
    • CART peptide analysis by western blotting
    • M.J. Kuhar, and L.L. Yoho CART peptide analysis by western blotting Synapse 33 1999 163 171
    • (1999) Synapse , vol.33 , pp. 163-171
    • Kuhar, M.J.1    Yoho, L.L.2
  • 6
    • 0038013621 scopus 로고    scopus 로고
    • Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3
    • A. Dey, X. Xhu, R. Carroll, C.W. Turck, J. Stein, and D.F. Steiner Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3 J Biol Chem 278 2003 15007 15014
    • (2003) J Biol Chem , vol.278 , pp. 15007-15014
    • Dey, A.1    Xhu, X.2    Carroll, R.3    Turck, C.W.4    Stein, J.5    Steiner, D.F.6
  • 7
    • 0033046967 scopus 로고    scopus 로고
    • Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat
    • L. Thim, P. Kristensen, P.F. Nielsen, B.S. Wulff, and J.T. Clausen Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat Proc Natl Acad Sci USA 96 1999 2722 2727
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2722-2727
    • Thim, L.1    Kristensen, P.2    Nielsen, P.F.3    Wulff, B.S.4    Clausen, J.T.5
  • 9
    • 0000178551 scopus 로고    scopus 로고
    • Arole for novel CART peptide fragment in the central control of food intake
    • P. Lambert, P. Couceyro, E. Koylu, N. Ling, E. DeSouza, and M. Kuhar Arole for novel CART peptide fragment in the central control of food intake Neuropeptides 31 6 1997 620 621 [Abs]
    • (1997) Neuropeptides , vol.31 , Issue.6 , pp. 620-621
    • Lambert, P.1    Couceyro, P.2    Koylu, E.3    Ling, N.4    Desouza, E.5    Kuhar, M.6
  • 12
    • 0033539614 scopus 로고    scopus 로고
    • Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: A putative mediator of cholecystokinin-induced satiety
    • C. Broberger, K. Holmberg, M.J. Kuhar, and T. Hökfelt Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: a putative mediator of cholecystokinin-induced satiety Proc Natl Acad Sci USA 96 1999 13506 13511
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13506-13511
    • Broberger, C.1    Holmberg, K.2    Kuhar, M.J.3    Hökfelt, T.4
  • 13
    • 0034711597 scopus 로고    scopus 로고
    • Differential expression of cocaine- and amphetamine-regulated transcript-immunoreactivity in the rat spinal preganglionic nuclei
    • S.L. Dun, D.A. Chianca Jr., N.J. Dun, J. Yang, and J.K. Chang Differential expression of cocaine- and amphetamine-regulated transcript-immunoreactivity in the rat spinal preganglionic nuclei Neurosci Lett 294 2000 143 146
    • (2000) Neurosci Lett , vol.294 , pp. 143-146
    • Dun, S.L.1    Chianca Jr., D.A.2    Dun, N.J.3    Yang, J.4    Chang, J.K.5
  • 14
    • 0034615849 scopus 로고    scopus 로고
    • Cocaine- and amphetamine-regulated transcript-immunoreactivity in the rat sympatho-adrenal axis
    • N.J. Dun, S.L. Dun, E.H. Kwok, J. Yang, and J. Chang Cocaine- and amphetamine-regulated transcript-immunoreactivity in the rat sympatho-adrenal axis Neurosci Lett 283 2000 97 100
    • (2000) Neurosci Lett , vol.283 , pp. 97-100
    • Dun, N.J.1    Dun, S.L.2    Kwok, E.H.3    Yang, J.4    Chang, J.5
  • 15
    • 0031878063 scopus 로고    scopus 로고
    • Cocaine-and amphetamine-regulated transcript (CART) peptide immunoreactivity in myenteric plexus neurons of the rat ileum and co-localization with choline acetyltransferase
    • P. Couceyro, M. Paquet, E. Koylu, M.J. Kuhar, and Y. Smith Cocaine-and amphetamine-regulated transcript (CART) peptide immunoreactivity in myenteric plexus neurons of the rat ileum and co-localization with choline acetyltransferase Synapse 30 1998 1 8
    • (1998) Synapse , vol.30 , pp. 1-8
    • Couceyro, P.1    Paquet, M.2    Koylu, E.3    Kuhar, M.J.4    Smith, Y.5
  • 16
    • 0142122992 scopus 로고    scopus 로고
    • Cocaine- and amphetamine-regulated transcript (CART): Distribution and function in rat gastro-intestinal tract
    • E. Ekblad, M. Kuhar, N. Wierup, and F. Sundler Cocaine- and amphetamine-regulated transcript (CART): distribution and function in rat gastro-intestinal tract Neurogastroenterol Motil 15 2003 1 13
    • (2003) Neurogastroenterol Motil , vol.15 , pp. 1-13
    • Ekblad, E.1    Kuhar, M.2    Wierup, N.3    Sundler, F.4
  • 17
    • 0030797958 scopus 로고    scopus 로고
    • Further studies on the anatomical distribution of CART by in situ hybridization
    • P.R. Couceyro, E.O. Koylu, and M.J. Kuhar Further studies on the anatomical distribution of CART by in situ hybridization J Chem Neuroanat 12 1997 229 241
    • (1997) J Chem Neuroanat , vol.12 , pp. 229-241
    • Couceyro, P.R.1    Koylu, E.O.2    Kuhar, M.J.3
  • 18
    • 0033043948 scopus 로고    scopus 로고
    • The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans
    • P.B. Jensen, P. Kristensen, J.T. Clausen, M.E. Judge, S. Hastrup, and L. Thim The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans FEBS Lett 447 2-3 1999 139 143 Mar 26
    • (1999) FEBS Lett , vol.447 , Issue.2-3 , pp. 139-143
    • Jensen, P.B.1    Kristensen, P.2    Clausen, J.T.3    Judge, M.E.4    Hastrup, S.5    Thim, L.6
  • 19
    • 0742287922 scopus 로고    scopus 로고
    • Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development
    • N. Wierup, M.J. Kuhar, B.O. Nilsson, H. Mulder, E. Ekblad, and F. Sundler Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development J Histochem Cytochem 52 2004 169
    • (2004) J Histochem Cytochem , vol.52 , pp. 169
    • Wierup, N.1    Kuhar, M.J.2    Nilsson, B.O.3    Mulder, H.4    Ekblad, E.5    Sundler, F.6
  • 20
    • 0742287489 scopus 로고    scopus 로고
    • β-cell expression of cocaine- and amphetamine-regulated transcript (CART) in rat type 2 diabetes models
    • N. Wierup, M.J. Kuhar, E. Ekblad, and F. Sundler β-cell expression of cocaine- and amphetamine-regulated transcript (CART) in rat type 2 diabetes models Diabetes Metab 29 2003 4S7 4S428 [Abs]
    • (2003) Diabetes Metab , vol.29
    • Wierup, N.1    Kuhar, M.J.2    Ekblad, E.3    Sundler, F.4
  • 21
    • 20144363121 scopus 로고    scopus 로고
    • CART regulates islet hormone secretion and is expressed in the b-cells of type 2 diabetic rats
    • N. Wierup, M. Björkqvist, M.J. Kuhar, H. Mulder, and F. Sundler CART regulates islet hormone secretion and is expressed in the b-cells of type 2 diabetic rats Diabetes 2005 [Under revision for publication]
    • (2005) Diabetes
    • Wierup, N.1    Björkqvist, M.2    Kuhar, M.J.3    Mulder, H.4    Sundler, F.5
  • 22
    • 20144374062 scopus 로고    scopus 로고
    • CART (cocaine and amphetamine regulated transcript); A new neurotransmitter in the porcine gastrointestinal tract
    • K. Tornoe, C. Örskov, J.T. Clausen, L. Thim, B.S. Wulff, and J.J. Holst CART (cocaine and amphetamine regulated transcript); a new neurotransmitter in the porcine gastrointestinal tract Gastroenterology 116 1999 G4743 [Abs]
    • (1999) Gastroenterology , vol.116 , pp. 4743
    • Tornoe, K.1    Örskov, C.2    Clausen, J.T.3    Thim, L.4    Wulff, B.S.5    Holst, J.J.6
  • 23
    • 0042626304 scopus 로고    scopus 로고
    • Effects of Ghrelin and other neuropeptides (CART, MCH, Orexin a and B, and GLP-1) on the release of insulin from isolated rat islets
    • M. Colombo, S. Gregersen, J. Xiao, and K. Hermansen Effects of Ghrelin and other neuropeptides (CART, MCH, Orexin A and B, and GLP-1) on the release of insulin from isolated rat islets Pancreas 27 2003 161 166
    • (2003) Pancreas , vol.27 , pp. 161-166
    • Colombo, M.1    Gregersen, S.2    Xiao, J.3    Hermansen, K.4
  • 24
    • 0035810764 scopus 로고    scopus 로고
    • Stimulation of rat pancreatic exocrine secretion by cocaine-and amphetamine-regulated transcript peptide
    • R.A. Cowles, B.J. Segura, and M.W. Mulholland Stimulation of rat pancreatic exocrine secretion by cocaine-and amphetamine-regulated transcript peptide Regul Pept 99 2001 61 68
    • (2001) Regul Pept , vol.99 , pp. 61-68
    • Cowles, R.A.1    Segura, B.J.2    Mulholland, M.W.3
  • 25
    • 0034806985 scopus 로고    scopus 로고
    • Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice
    • A. Asakawa, A. Inui, H. Yuzuriha, T. Nagata, T. Kaga, and N. Ueno Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice Horm Metab Res 33 9 2001 554 558 Sep
    • (2001) Horm Metab Res , vol.33 , Issue.9 , pp. 554-558
    • Asakawa, A.1    Inui, A.2    Yuzuriha, H.3    Nagata, T.4    Kaga, T.5    Ueno, N.6
  • 26
    • 0034465866 scopus 로고    scopus 로고
    • Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin- releasing factor system
    • T. Okumura, H. Yamada, W. Motomura, and Y. Kohgo Cocaine-amphetamine- regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system Endocrinology 141 2000 2854 2860
    • (2000) Endocrinology , vol.141 , pp. 2854-2860
    • Okumura, T.1    Yamada, H.2    Motomura, W.3    Kohgo, Y.4
  • 27
    • 0032486140 scopus 로고    scopus 로고
    • Utilization of microhomologous recombination in yeast to generate targeting constructs for mammalian genes
    • I. Khrebtukova, E.J. Michaud, C.M. Foster, K.L. Stark, D.J. Garfinkel, and R.P. Woychik Utilization of microhomologous recombination in yeast to generate targeting constructs for mammalian genes Mutat Res 401 1998 11 25
    • (1998) Mutat Res , vol.401 , pp. 11-25
    • Khrebtukova, I.1    Michaud, E.J.2    Foster, C.M.3    Stark, K.L.4    Garfinkel, D.J.5    Woychik, R.P.6
  • 28
    • 2442423329 scopus 로고    scopus 로고
    • Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology
    • L. Härndahl, N. Wierup, S. Enerbäck, H. Mulder, V.C. Manganiello, and F. Sundler Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology J Biol Chem 279 15 2004 15214 15222 Apr 9
    • (2004) J Biol Chem , vol.279 , Issue.15 , pp. 15214-15222
    • Härndahl, L.1    Wierup, N.2    Enerbäck, S.3    Mulder, H.4    Manganiello, V.C.5    Sundler, F.6
  • 29
    • 0031832016 scopus 로고    scopus 로고
    • PACAP stimulates insulin secretion but inhibits insulin sensitivity in mice
    • K. Filipsson, G. Pacini, A.J. Scheurink, and B. Ahren PACAP stimulates insulin secretion but inhibits insulin sensitivity in mice Am J Physiol 274 1998 E834 E842
    • (1998) Am J Physiol , vol.274
    • Filipsson, K.1    Pacini, G.2    Scheurink, A.J.3    Ahren, B.4
  • 30
    • 0002865087 scopus 로고
    • Islet innervation, with special reference to neuropeptides
    • E. Samols 1st ed. Raven Press New York
    • F. Sundler, and G. Böttcher Islet innervation, with special reference to neuropeptides E. Samols The Endocrine Pancreas 1st ed. 1991 Raven Press New York 29 52
    • (1991) The Endocrine Pancreas , pp. 29-52
    • Sundler, F.1    Böttcher, G.2
  • 31
    • 0034001450 scopus 로고    scopus 로고
    • Autonomic regulation of islet hormone secretion-implications for health and disease
    • B. Ahren Autonomic regulation of islet hormone secretion-implications for health and disease Diabetologia 43 2000 393 410
    • (2000) Diabetologia , vol.43 , pp. 393-410
    • Ahren, B.1
  • 32
    • 0034944773 scopus 로고    scopus 로고
    • The importance of first-phase insulin secretion: Implications for the therapy of type 2 diabetes mellitus
    • S. Del Prato, and A. Tiengo The importance of first-phase insulin secretion: implications for the therapy of type 2 diabetes mellitus Diabetes Metab Res Rev 17 2001 164 174
    • (2001) Diabetes Metab Res Rev , vol.17 , pp. 164-174
    • Del Prato, S.1    Tiengo, A.2
  • 33
    • 0026437459 scopus 로고
    • Molecular and cellular physiology of GLUT-2, a high-Km facilitated diffusion glucose transporter
    • B. Thorens Molecular and cellular physiology of GLUT-2, a high-Km facilitated diffusion glucose transporter Int Rev Cytol 137 1992 209 238
    • (1992) Int Rev Cytol , vol.137 , pp. 209-238
    • Thorens, B.1
  • 34
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • H. Ohlsson, K. Karlsson, and T. Edlund IPF1, a homeodomain-containing transactivator of the insulin gene Embo J 12 1993 4251 4259
    • (1993) Embo J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 35
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • J. Jonsson, L. Carlsson, T. Edlund, and H. Edlund Insulin-promoter-factor 1 is required for pancreas development in mice Nature 371 1994 606 609
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 36
    • 0030707689 scopus 로고    scopus 로고
    • Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
    • M.T. Guillam, E. Hummler, E. Schaerer, J.I. Yeh, M.J. Birnbaum, and F. Beermann Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 Nat Genet 17 3 1997 327 330 Nov
    • (1997) Nat Genet , vol.17 , Issue.3 , pp. 327-330
    • Guillam, M.T.1    Hummler, E.2    Schaerer, E.3    Yeh, J.I.4    Birnbaum, M.J.5    Beermann, F.6
  • 37
    • 0034802121 scopus 로고    scopus 로고
    • Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet
    • M.A. Asnicar, D.P. Smith, D.D. Yang, M.L. Heiman, N. Fox, and Y.F. Chen Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet Endocrinology 142 10 2001 4394 4400 Oct
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4394-4400
    • Asnicar, M.A.1    Smith, D.P.2    Yang, D.D.3    Heiman, M.L.4    Fox, N.5    Chen, Y.F.6
  • 38
    • 0035462630 scopus 로고    scopus 로고
    • Mutational screening of the CART gene in obese children: Identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family
    • E.M. del Giudice, N. Santoro, G. Cirillo, L. D'Urso, R. Di Toro, and L. Perrone Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family Diabetes 50 2001 2157 2160
    • (2001) Diabetes , vol.50 , pp. 2157-2160
    • Del Giudice, E.M.1    Santoro, N.2    Cirillo, G.3    D'Urso, L.4    Di Toro, R.5    Perrone, L.6


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