Effects of Diabetes and Insulin on the Expression of Galanin-Like Peptide in the Hypothalamus of the Rat

Diabetes

Volumn 53, Issue 5, 2004, Pages 1237-1242

  Fraley, Gregory S ^a   Scarlett, Jarrad M ^a   Shimada, Issei ^a   Teklemichael, Dawit N ^a   Acohido, Blake V ^a   Clifton, Donald K ^a   Steiner, Robert A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALANIN LIKE PEPTIDE; INSULIN; LEPTIN;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; HYPOTHALAMUS; INSULIN BLOOD LEVEL; INSULIN DEFICIENCY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; FASTING; GALANIN-LIKE PEPTIDE; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; INSULIN; LEPTIN; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; THIRD VENTRICLE; TIME FACTORS;

EID: 2342648840     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.5.1237     Document Type: Article

References (44)

1. Kyriaki G: Brain insulin: regulation, mechanisms of action and functions. Cell Mol Neurobiol 23:1-25, 2003
2. Woods SC, Schwartz MW, Baskin DG, Seeley RJ: Food intake and the regulation of body weight. Annu Rev Psychol 51:255-277, 2000
3. Woods SC, Lotter EC, McKay LD, Porte D Jr: Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282:503-505, 1979
4. Marks JL, Porte D Jr, Stahl WL, Baskin DG: Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 127:3234-3236, 1990
5. Werther GA, Hogg A, Oldfield BJ, McKinley MJ, Figdor R, Allen AM, Mendelsohn FA: Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology 121:1562-1570, 1987
6. Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L: Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5:566-572, 2002
7. Ohtaki T, Kumano S, Ishibashi Y, Ogi K, Matsui H, Harada M, Kitada C, Kurokawa T, Onda H, Fujino M: Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus. J Biol Chem 274:37041-37045, 1999
8. Takatsu Y, Matsumoto H, Ohtald T, Kumano S, Kitada C, Onda H, Nishimura O, Fujino M: Distribution of galanin-like peptide in the rat brain. Endocrinology 142:1626-1634, 2001
9. Larm JA, Gundlach AL: Galanin-like peptide (GALP) mRNA expression is restricted to arcuate nucleus of hypothalamus in adult male rat brain. Neuroendocrinology 72:67-71, 2000
10. Juréus A, Cunningham MJ, Li D, Johnson LL, Krasnow SM, Teklemichael DN, Clifton DK, Steiner RA: Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse. Endocrinology 142:5140-5144, 2001
11. Krasnow SM, Fraley GS, Schuh SM, Baumgartner JW, Clifton DK, Steiner RA: A role for galanin-like peptide (GALP) in the integration of feeding, body weight regulation and reproduction in the mouse. Endocrinology 144:813-822, 2003
12. Kumano S, Matsumoto H, Takatsu Y, Noguchi J, Kitada C, Ohtaki T: Changes in hypothalamic expression levels of galanin-like peptide in rat and mouse models support that it is a leptin-target peptide. Endocrinology 144:2634-2643, 2003
13. Juréus A, Cunningham MJ, McClain ME, Clifton DK, Steiner RA: Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat. Endocrinology 141:2703-2706, 2000
14. Chowen JA, Steiner RA, Clifton DK: Semiquantitative analysis of cellular somatostatin mRNA levels by in situ hybridization histochemistry. Methods Neurosci 5:137-158, 1991
15. Bergmeyer HU: Methods of Enzymatic Analysis. New York, Academic Press, 1974
16. Havel PJ, Hahn TM, Sindelar DK, Baskin DG, DaUman MF, Weigle DS, Schwartz MW: Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes 49:244-252, 2000
17. Foster LA, Ames NK, Emery RS: Food intake and serum insulin responses to intraventricular infusions of insulin and IGF-I. Physiol Behav 50:745-749, 1991
18. Schultz-Klarr S, Wright-Richey J, Dunbar JC: Plasma glucose, insulin and cardiovascular responses after intravenous intracersbroventricular injections of insulin, 2-deoxyglucose and glucose in rats. Diabetes Res Clin Pract 26:81-89, 1994
19. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP, et al.: Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130:3608-3616, 1992
20. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG: Central nervous system control of food intake. Nature 404:661-671, 2000
21. Air EL, Benoit SC, Clegg DJ, Seeley RJ, Woods SC: Insulin and leptin combine additively to reduce food intake and body weight in rats. Endocrinology 143:2449-2452, 2002
22. Hidaka S, Yoshimatsu H, Kondou S, Tsuruta Y, Oka K, Noguchi H, Okamoto K, Sakino H, Teshima Y, Okeda T, Sakata T: Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J 16:509-518, 2002
23. Kumar JS, Menon VP: Effect of diabetes on levels of lipid peroxides and glycolipids in rat brain. Metabolism 42:1435-1439, 1993
24. Rinaudo MT, Curto M, Bruno R: Effect of insulin on the pyruvate dehydrogenase complex in the rat brain. Ital J Biochem 34:229-237, 1985
25. Paschoalini MA, Migliorini RH: Participation of the CNS in the control of FFA mobilization during fasting in rabbits. Physiol Behav 47:461-465, 1990
26. Nagatani S, Guthikonda P, Thompson RC, Tsukamura H, Maeda KI, Foster DL: Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology 67:370-376, 1998
27. Daniel JA, Thomas MG, Hale CS, Simmons JM, Keisler DH: Effect of cerebroventricular infusion of insulin and (or) glucose on hypothalamic expression of leptin receptor and pituitary secretion of LH in diet-restricted ewes. Domest Anim Endocrinol 18:177-185, 2000
28. Henry BA, Goding JW, Tilbrook AJ, Dunshea FR, Clarke IJ: Intracerebroventricular infusion of leptin elevates the secretion of luteinising hormone without affecting food intake in long-term food-restricted sheep, but increases growth hormone irrespective of bodyweight. J Endocrinol 168:67-77, 2001
29. Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR: Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122-2125, 2000
30. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK: Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21:1375-1385, 1998
31. Muller C, Voirol MJ, Stefanoni N, Surmely JF, Jequier E, Gaillard RC, Tappy L: Effect of chronic intracerebroventricular infusion of insulin on brown adipose tissue activity in fed and fasted rats. Int J Obes Relat Metab Disord 21:562-566, 1997
32. Shen J, Balourdos G, O'Donnell L, Gundlach AL: Pubertal induction of galanin-like peptide (GALP) expression in the hypothalamus and testis: links with LHRH signaling (Abstract)? Neurosci 7:637, 2002
33. Matsumoto H, Noguchi J, Takatsu Y, Horikoshi Y, Kumano S, Ohtaki T, Kitada C, Itoh T, Onda H, Nishimura O, Fujino M: Stimulation effect of galanin-like peptide (GALP) on luteinizing hormone-releasing hormone-mediated luteinizing hormone (LH) secretion in male rats. Endocrinology 142:3693-3696, 2001
34. Lawrence CB, Baudoin FM, Luckman SM: Centrally administered galanin-like peptide modifies food intake in the rat: a comparison with galanin. J Neuroendocrinol 14:853-860, 2002
35. Gundlach AL: Galanin/GALP and galanin receptors: role in central control of feeding, body weight/obesity and reproduction? Eur J Pharmacol 440:255-268, 2002
36. Hansen KR, Krasnow SM, Nolan MA, Fraley GS, Baumgartner JW, Clifton DK, Steiner RA: Activation of the sympathetic nervous system by galanin-like peptide-a possible link between leptin and metabolism. Endocrinology 144:4709-4717, 2003
37. Niswender KD, Gallis B, Blevins JE, Corson MA, Schwartz MW, Baskin DG: Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem 51:275-283, 2003
38. Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG Jr, Seeley RJ, Schwartz MW: Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52:227-231, 2003
39. Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB: In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 141:2328-2339, 2000
40. Zhao AZ, Shinohara MM, Huang D, Shimizu M, Eldar-Finkelman H, Krebs EG, Beavo JA, Bomfeldt KE: Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem 275:11348-11354, 2000
41. White MF: The insulin signalling system and the IRS proteins. Diabetologia 40 (Suppl. 2):S2-S17, 1997
42. Zhao AZ, Bornfeldt KE, Beavo JA: Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest 102:869-873, 1998
43. Zhao AZ, Huan JN, Gupta S, Pal R, Sahu A: A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat Neurosci 5:727-728, 2002
44. Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG Jr, Schwartz MW: Intracellular signalling: key enzyme in leptin-induced anorexia. Nature 413:794-795, 2001