Wnt Signaling. Signaling at and Above the Receptor Level

Current Topics in Developmental Biology

Volumn 97, Issue , 2011, Pages 21-53

  Buechling, Tina ^a   Boutros, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Protein trafficking; Signal transduction; Wnt secretion; Wnt signaling

Indexed keywords

EID: 80755130066     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385975-4.00008-5     Document Type: Chapter

References (178)

1. Aberle H., Bauer A., Stappert J., Kispert A., Kemler R. beta-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 1997, 16(13):3797-3804.
2. Adamson M.C., Dennis C., Delaney S., Christiansen J., Monkley S., Kozak C.A., Wainwright B. Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics 1994, 24(1):9-13.
3. Adell T., Salo E., Boutros M., Bartscherer K. Smed-Evi/Wntless is required for beta-catenin-dependent and -independent processes during planarian regeneration. Development 2009, 136(6):905-910.
4. Amit S., Hatzubai A., Birman Y., Andersen J.S., Ben-Shushan E., Mann M., Ben-Neriah Y., Alkalay I. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: A molecular switch for the Wnt pathway. Genes Dev. 2002, 16(9):1066-1076.
5. Angers S., Moon R.T. Proximal events in Wnt signal transduction. Nat. Rev. Mol. Cell Biol. 2009, 10(7):468-477.
6. Angers S., Thorpe C.J., Biechele T.L., Goldenberg S.J., Zheng N., MacCoss M.J., Moon R.T. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat. Cell Biol. 2006, 8(4):348-357.
7. Axelrod J.D. Progress and challenges in understanding planar cell polarity signaling. Semin. Cell Dev. Biol. 2009, 20(8):964-971.
8. Banziger C., Soldini D., Schutt C., Zipperlen P., Hausmann G., Basler K. Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell 2006, 125(3):509-522.
9. Bartscherer K., Boutros M. Regulation of Wnt protein secretion and its role in gradient formation. EMBO Rep. 2008, 9(10):977-982.
10. Bartscherer K., Pelte N., Ingelfinger D., Boutros M. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 2006, 125(3):523-533.
11. Belenkaya T.Y., Han C., Standley H.J., Lin X., Houston D.W., Heasman J. pygopus Encodes a nuclear protein essential for wingless/Wnt signaling. Development 2002, 129(17):4089-4101.
12. Belenkaya T.Y., Wu Y., Tang X., Zhou B., Cheng L., Sharma Y.V., Yan D., Selva E.M., Lin X. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev. Cell 2008, 14(1):120-131.
13. Biddick R., Young E.T. Yeast mediator and its role in transcriptional regulation. C. R. Biol. 2005, 328(9):773-782.
14. Bjorklund S., Gustafsson C.M. The yeast Mediator complex and its regulation. Trends Biochem. Sci. 2005, 30(5):240-244.
15. Bolognesi R., Farzana L., Fischer T.D., Brown S.J. Multiple Wnt genes are required for segmentation in the short-germ embryo of Tribolium castaneum. Curr. Biol. 2008, 18(20):1624-1629.
16. Bonifacino J.S., Hurley J.H. Retromer. Curr. Opin. Cell Biol. 2008, 20(4):427-436.
17. Boutros M., Paricio N., Strutt D.I., Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 1998, 94(1):109-118.
18. Bovolenta P., Esteve P., Ruiz J.M., Cisneros E., Lopez-Rios J. Beyond Wnt inhibition: New functions of secreted Frizzled-related proteins in development and disease. J. Cell Sci. 2008, 121(Pt 6):737-746.
19. Buechling T., Bartscherer K., Ohkawara B., Chaudhary V., Spirohn K., Niehrs C., Boutros M. Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Curr. Biol. 2010, 20(14):1263-1268.
20. Cadigan K.M., Peifer M. Wnt signaling from development to disease: Insights from model systems. Cold Spring Harb. Perspect Biol. 2009, 1(2):a002881.
21. Caricasole A., Ferraro T., Rimland J.M., Terstappen G.C. Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine. Gene 2002, 288(1-2):147-157.
22. Carpenter A.C., Rao S., Wells J.M., Campbell K., Lang R.A. Generation of mice with a conditional null allele for Wntless. Genesis 2010, 48(9):554-558.
23. Carrera I., Janody F., Leeds N., Duveau F., Treisman J.E. Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proc. Natl. Acad. Sci. USA 2008, 105(18):6644-6649.
24. Charollais J., Van Der Goot F.G. Palmitoylation of membrane proteins (Review). Mol. Membr. Biol. 2009, 26(1):55-66.
25. Chen G., Fernandez J., Mische S., Courey A.J. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev. 1999, 13(17):2218-2230.
26. Chen W.S., Antic D., Matis M., Logan C.Y., Povelones M., Anderson G.A., Nusse R., Axelrod J.D. Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell 2008, 133(6):1093-1105.
27. Ching W., Hang H.C., Nusse R. Lipid-independent secretion of a Drosophila Wnt protein. J. Biol. Chem. 2008, 283(25):17092-17098.
28. Chinnadurai G. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell 2002, 9(2):213-224.
29. Collins B.M. The structure and function of the retromer protein complex. Traffic 2008, 9(11):1811-1822.
30. Conaway J.W., Florens L., Sato S., Tomomori-Sato C., Parmely T.J., Yao T., Swanson S.K., Banks C.A., Washburn M.P., Conaway R.C. The mammalian Mediator complex. FEBS Lett. 2005, 579(4):904-908.
31. Coombs G.S., Yu J., Canning C.A., Veltri C.A., Covey T.M., Cheong J.K., Utomo V., Banerjee N., Zhang Z.H., Jadulco R.C., Concepcion G.P., Bugni T.S., et al. WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. J. Cell Sci. 2010, 123(Pt 19):3357-3367.
32. Coudreuse D.Y., Roel G., Betist M.C., Destree O., Korswagen H.C. Wnt gradient formation requires retromer function in Wnt-producing cells. Science 2006, 312(5775):921-924.
33. Couso J.P., Martinez Arias A. Notch is required for wingless signaling in the epidermis of Drosophila. Cell 1994, 79(2):259-272.
34. Croce J.C., McClay D.R. Evolution of the Wnt pathways. Methods Mol. Biol. 2008, 469:3-18.
35. Cruciat C.M., Ohkawara B., Acebron S.P., Karaulanov E., Reinhard C., Ingelfinger D., Boutros M., Niehrs C. Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 2010, 327(5964):459-463.
36. Culi J., Mann R.S. Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell 2003, 112(3):343-354.
37. Davidson G., Wu W., Shen J., Bilic J., Fenger U., Stannek P., Glinka A., Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 2005, 438:867-872.
38. Davidson G., Niehrs C. Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol. 2010, 20(8):453-460.
39. Davidson G., Shen J., Huang Y.L., Su Y., Karaulanov E., Bartscherer K., Hassler C., Stannek P., Boutros M., Niehrs C. Cell cycle control of wnt receptor activation. Dev. Cell 2009, 17(6):788-799.
40. Dhoot G.K., Gustafsson M.K., Ai X., Sun W., Standiford D.M., Emerson C.P. Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase. Science 2001, 293(5535):1663-1666.
41. Dissanayake S.K., Wade M., Johnson C.E., O'Connell M.P., Leotlela P.D., French A.D., Shah K.V., Hewitt K.J., Rosenthal D.T., Indig F.E., Jiang Y., Nickoloff B.J., et al. The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J. Biol. Chem. 2007, 282(23):17259-17271.
42. Doubravska L., Krausova M., Gradl D., Vojtechova M., Tumova L., Lukas J., Valenta T., Pospichalova V., Fafilek B., Plachy J., Sebesta O., Korinek V. Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling. Cell. Signal. 2011, 23(5):837-848.
43. Du S.J., Purcell S.M., Christian J.L., McGrew L.L., Moon R.T. Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol. Cell. Biol. 1995, 15(5):2625-2634.
44. Egger-Adam D., Katanaev V.L. The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway. Dev. Dyn. 2009, 239(1):168-183.
45. Feiguin F., Hannus M., Mlodzik M., Eaton S. The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Dev. Cell 2001, 1(1):93-101.
46. Firestein R., Bass A.J., Kim S.Y., Dunn I.F., Silver S.J., Guney I., Freed E., Ligon A.H., Vena N., Ogino S., Chheda M.G., Tamayo P., et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 2008, 455(7212):547-551.
47. Franch-Marro X., Marchand O., Piddini E., Ricardo S., Alexandre C., Vincent J.P. Glypicans shunt the Wingless signal between local signalling and further transport. Development 2005, 132(4):659-666.
48. Franch-Marro X., Wendler F., Griffith J., Maurice M.M., Vincent J.P. In vivo role of lipid adducts on Wingless. J. Cell Sci. 2008, 121(Pt 10):1587-1592.
49. Franch-Marro X., Wendler F., Guidato S., Griffith J., Baena-Lopez A., Itasaki N., Maurice M.M., Vincent J.P. Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex. Nat. Cell Biol. 2008, 10(2):170-177.
50. Fu J., Jiang M., Mirando A.J., Yu H.M., Hsu W. Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc. Natl. Acad. Sci. USA 2009, 106(44):18598-18603.
51. Fu J., Ivy Yu H.M., Maruyama T., Mirando A.J., Hsu W. Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev. Dyn. 2011, 240(2):365-371.
52. Fuerer C., Habib S.J., Nusse R. A study on the interactions between heparan sulfate proteoglycans and Wnt proteins. Dev. Dyn. 2009, 239(1):184-190.
53. Gagliardi M., Piddini E., Vincent J.P. Endocytosis: A positive or a negative influence on Wnt signalling?. Traffic 2008, 9(1):1-9.
54. Gallet A., Staccini-Lavenant L., Therond P.P. Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis. Dev. Cell 2008, 14(5):712-725.
55. Galli L.M., Barnes T.L., Secrest S.S., Kadowaki T., Burrus L.W. Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube. Development 2007, 134(18):3339-3348.
56. Ganguly A., Jiang J., Ip Y.T. Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo. Development 2005, 132(15):3419-3429.
57. Gao C., Chen Y.G. Dishevelled: The hub of Wnt signaling. Cell. Signal. 2010, 22(5):717-727.
58. Gavin B.J., McMahon J.A., McMahon A.P. Expression of multiple novel Wnt1/int1related genes during fetal and adult mouse development. Genes Dev. 1990, 4(12(B)):2319-2332.
59. Goodman R.M., Thombre S., Firtina Z., Gray D., Betts D., Roebuck J., Spana E.P., Selva E.M. Sprinter: A novel transmembrane protein required for Wg secretion and signaling. Development 2006, 133(24):4901-4911.
60. Gordon M.D., Dionne M.S., Schneider D.S., Nusse R. WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature 2005, 437(7059):746-749.
61. Gorfinkiel N., Sierra J., Callejo A., Ibanez C., Guerrero I. The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog. Dev. Cell 2005, 8(2):241-253.
62. Griffin C.T., Curtis C.D., Davis R.B., Muthukumar V., Magnuson T. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc. Natl. Acad. Sci. USA 2011, 108(6):2282-2287.
63. Grigoryan T., Wend P., Klaus A., Birchmeier W. Deciphering the function of canonical Wnt signals in development and disease: Conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev. 2008, 22(17):2308-2341.
64. Gu B., Watanabe K., Dai X. Epithelial stem cells: An epigenetic and Wnt-centric perspective. J. Cell. Biochem. 2010, 110(6):1279-1287.
65. Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D., Collier S., Roote J. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Genes Dev. 1999, 13(17):2315-2327.
66. Hacker U., Lin X., Perrimon N. The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. Development 1997, 124(18):3565-3573.
67. Han C., Yan D., Belenkaya T.Y., Lin X. Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Development 2005, 132(4):667-679.
68. He X., Saint-Jeannet J.P., Wang Y., Nathans J., Dawid I., Varmus H. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 1997, 275(5306):1652-1654.
69. Heisenberg C.P., Tada M., Rauch G.J., Saude L., Concha M.L., Geisler R., Stemple D.L., Smith J.C., Wilson S.W. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature 2000, 405(6782):76-81.
70. Hermle T., Saltukoglu D., Grunewald J., Walz G., Simons M. Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit. Curr. Biol. 2010, 20(14):1269-1276.
71. Hikasa H., Sokol S.Y. Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2. J. Biol. Chem. 2011, 286(14):12093-12100.
72. Hoppler S., Kavanagh C.L. Wnt signalling: Variety at the core. J. Cell Sci. 2007, 120(Pt 3):385-393.
73. Huang K., Zhang J.X., Han L., You Y.P., Jiang T., Pu P.Y., Kang C.S. MicroRNA roles in beta-catenin pathway. Mol. Cancer 2010, 9:252.
74. Insel P.A., Head B.P., Ostrom R.S., Patel H.H., Swaney J.S., Tang C.M., Roth D.M. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Ann. NY. Acad. Sci. 2005, 1047:166-172.
75. James R.G., Biechele T.L., Conrad W.H., Camp N.D., Fass D.M., Major M.B., Sommer K., Yi X., Roberts B.S., Cleary M.A., Arthur W.T., MacCoss M., et al. Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Sci. Signal. 2009, 2(72):ra25.
76. Jin J., Kittanakom S., Wong V., Reyes B.A., Van Bockstaele E.J., Stagljar I., Berrettini W., Levenson R. Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: Potential implications for opioid dependence. BMC Neurosci. 2010, 11:33.
77. Jin J., Morse M., Frey C., Petko J., Levenson R. Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells. Dev. Dyn. 2010, 239(9):2426-2434.
78. Kadowaki T., Wilder E., Klingensmith J., Zachary K., Perrimon N. The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev. 1996, 10(24):3116-3128.
79. Kamimura K., Maeda N., Nakato H. In vivo manipulation of heparan sulfate structure and its effect on Drosophila development. Glycobiology 2010, 21(5):607-618.
80. Katanaev V.L., Ponzielli R., Semeriva M., Tomlinson A. Trimeric G protein-dependent frizzled signaling in Drosophila. Cell 2005, 120(1):111-122.
81. Katanaev V.L., Solis G.P., Hausmann G., Buestorf S., Katanayeva N., Schrock Y., Stuermer C.A., Basler K. Reggie-1/fl otillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. EMBO J. 2008, 27:509-521.
82. Kategaya L.S., Changkakoty B., Biechele T., Conrad W.H., Kaykas A., Dasgupta R., Moon R.T. Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS One 2009, 4(7):e6129.
83. Kennell J.A., Gerin I., MacDougald O.A., Cadigan K.M. The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc. Natl. Acad. Sci. USA 2008, 105(40):15417-15422.
84. Kikuchi A., Kishida S., Yamamoto H. Regulation of Wnt signaling by protein-protein interaction and post-translational modifications. Exp. Mol. Med. 2006, 38(1):1-10.
85. Kikuchi A., Yamamoto H., Sato A. Selective activation mechanisms of Wnt signaling pathways. Trends Cell Biol. 2009, 19(3):119-129.
86. Kilian B., Mansukoski H., Barbosa F.C., Ulrich F., Tada M., Heisenberg C.P. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech. Dev. 2003, 120(4):467-476.
87. Kim H., Cheong S.M., Ryu J., Jung H.J., Jho E.H., Han J.K. Xenopus Wntless and the retromer complex cooperate to regulate XWnt4 secretion. Mol. Cell. Biol. 2009, 29(8):2118-2128.
88. Klaus A., Birchmeier W. Wnt signalling and its impact on development and cancer. Nat. Rev. Cancer 2008, 8(5):387-398.
89. Kleinschmit A., Koyama T., Dejima K., Hayashi Y., Kamimura K., Nakato H. Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation. Dev. Biol. 2010, 345(2):204-214.
90. Kleinschmit A., Koyama T., Dejima K., Hayashi Y., Kamimura K., Nakato H. Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation. Dev. Biol. 2011, 345(2):204-214.
91. Kohn A.D., Moon R.T. Wnt and calcium signaling: beta-Catenin-independent pathways. Cell Calcium 2005, 38(3-4):439-446.
92. Komekado H., Yamamoto H., Chiba T., Kikuchi A. Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a. Genes Cells 2007, 12(4):521-534.
93. Korkut C., Ataman B., Ramachandran P., Ashley J., Barria R., Gherbesi N., Budnik V. Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. Cell 2009, 139(2):393-404.
94. Korpal M., Lee E.S., Hu G., Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J. Biol. Chem. 2008, 283(22):14910-14914.
95. Kramps T., Peter O., Brunner E., Nellen D., Froesch B., Chatterjee S., Murone M., Zullig S., Basler K. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 2002, 109(1):47-60.
96. Kuhl M., Sheldahl L.C., Park M., Miller J.R., Moon R.T. The Wnt/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape. Trends Genet. 2000, 16(7):279-283.
97. Kurayoshi M., Yamamoto H., Izumi S., Kikuchi A. Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem. J. 2007, 402(3):515-523.
98. Li Y., Bavarva J.H., Wang Z., Guo J., Qian C., Thibodeau S.N., Golemis E.A., Liu W. HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. Oncogene 2011, 30(23):2633-2643.
99. Li Z., Nie F., Wang S., Li L. From the Cover: Feature Article: Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc. Natl. Acad. Sci. USA 2011, 108(8):3116-3123.
100. Lin X., Perrimon N. Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling. Nature 1999, 400(6741):281-284.
101. Liu C., Li Y., Semenov M., Han C., Baeg G.H., Tan Y., Zhang Z., Lin X., He X. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002, 108(6):837-847.
102. Lorenowicz M.J., Korswagen H.C. Sailing with the Wnt: Charting the Wnt processing and secretion route. Exp. Cell Res. 2009, 315(16):2683-2689.
103. Lucero O.M., Dawson D.W., Moon R.T., Chien A.J. A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr. Oncol. Rep. 2010, 12(5):314-318.
104. Luo W., Peterson A., Garcia B.A., Coombs G., Kofahl B., Heinrich R., Shabanowitz J., Hunt D.F., Yost H.J., Virshup D.M. Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J. 2007, 26(6):1511-1521.
105. MacDonald B.T., Tamai K., He X. Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev. Cell 2009, 17(1):9-26.
106. Major M.B., Roberts B.S., Berndt J.D., Marine S., Anastas J., Chung N., Ferrer M., Yi X., Stoick-Cooper C.L., von Haller P.D., Kategaya L., Chien A., et al. New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci. Signal. 2008, 1(45):ra12.
107. Maloof J.N., Whangbo J., Harris J.M., Jongeward G.D., Kenyon C. A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. Development 1999, 126(1):37-49.
108. Mason J.O., Kitajewski J., Varmus H.E. Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. Mol. Biol. Cell 1992, 3(5):521-533.
109. Mosimann C., Hausmann G., Basler K. Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Cell 2006, 125(2):327-341.
110. Mosimann C., Hausmann G., Basler K. Beta-catenin hits chromatin: Regulation of Wnt target gene activation. Nat. Rev. Mol. Cell Biol. 2009, 10(4):276-286.
111. Nadanaka S., Ishida M., Ikegami M., Kitagawa H. Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate. J. Biol. Chem. 2008, 283(40):27333-27343.
112. Nadanaka S., Kinouchi H., Taniguchi-Morita K., Tamura J.I., Kitagawa H. Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a. J. Biol. Chem. 2010, 286:4199-4208.
113. Nagel R., le Sage C., Diosdado B., van der Waal M., Oude Vrielink J.A., Bolijn A., Meijer G.A., Agami R. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res. 2008, 68(14):5795-5802.
114. Neumann C., Cohen S. Morphogens and pattern formation. Bioessays 1997, 19(8):721-729.
115. Neumann S., Coudreuse D.Y., van der Westhuyzen D.R., Eckhardt E.R., Korswagen H.C., Schmitz G., Sprong H. Mammalian Wnt3a is released on lipoprotein particles. Traffic 2009, 10(3):334-343.
116. Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006, 25(57):7469-7481.
117. Niehrs C., Boutros M. Trafficking, acidification, and growth factor signaling. Sci. Signal. 2010, 3(134):pe26.
118. Niehrs C., Shen J. Regulation of Lrp6 phosphorylation. Cell. Mol. Life Sci. 2010, 67(15):2551-2562.
119. Nusse R. Wnt signaling and stem cell control. Cell Res. 2008, 18(5):523-527.
120. Nusse R., van Ooyen A., Cox D., Fung Y.K., Varmus H. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature 1984, 307(5947):131-136.
121. Nusslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287(5785):795-801.
122. Pan C.L., Baum P.D., Gu M., Jorgensen E.M., Clark S.G., Garriga G. C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless. Dev. Cell 2008, 14(1):132-139.
123. Panakova D., Sprong H., Marois E., Thiele C., Eaton S. Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 2005, 435(7038):58-65.
124. Parker D.S., Jemison J., Cadigan K.M. Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila. Development 2002, 129(11):2565-2576.
125. Parker D.S., Ni Y.Y., Chang J.L., Li J., Cadigan K.M. Wingless signaling induces widespread chromatin remodeling of target loci. Mol. Cell. Biol. 2008, 28(5):1815-1828.
126. Port F., Basler K. Wnt trafficking: New insights into Wnt maturation, secretion and spreading. Traffic 2010, 11(10):1265-1271.
127. Port F., Kuster M., Herr P., Furger E., Banziger C., Hausmann G., Basler K. Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat. Cell Biol. 2008, 10(2):178-185.
128. Prasad B.C., Clark S.G. Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans. Development 2006, 133(9):1757-1766.
129. Reyes A.R., Levenson R., Berrettini W., Van Bockstaele E.J. Ultrastructural relationship between the mu opioid receptor and its interacting protein, GPR177, in striatal neurons. Brain Res. 2010, 1358:71-80.
130. Roelink H., Nusse R. Expression of two members of the Wnt family during mouse development-restricted temporal and spatial patterns in the developing neural tube. Genes Dev. 1991, 5(3):381-388.
131. Roszko I., Sawada A., Solnica-Krezel L. Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Semin. Cell Dev. Biol. 2009, 20(8):986-997.
132. Saydam O., Shen Y., Wurdinger T., Senol O., Boke E., James M.F., Tannous B.A., Stemmer-Rachamimov A.O., Yi M., Stephens R.M., Fraefel C., Gusella J.F., et al. Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol. Cell. Biol. 2009, 29(21):5923-5940.
133. Seeling J.M., Miller J.R., Gil R., Moon R.T., White R., Virshup D.M. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 1999, 283(5410):2089-2091.
134. Segalen M., Bellaiche Y. Cell division orientation and planar cell polarity pathways. Semin. Cell Dev. Biol. 2009, 20(8):972-977.
135. Sharma R.P., Chopra V.L. Effect of the Wingless (wg1) mutation on wing and haltere development in Drosophila melanogaster. Dev. Biol. 1976, 48(2):461-465.
136. Shi A., Sun L., Banerjee R., Tobin M., Zhang Y., Grant B.D. Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8. EMBO J. 2009, 28(21):3290-3302.
137. Shimizu H., Julius M.A., Giarre M., Zheng Z., Brown A.M., Kitajewski J. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ. 1997, 8(12):1349-1358.
138. Sierra J., Yoshida T., Joazeiro C.A., Jones K.A. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev. 2006, 20(5):586-600.
139. Silhankova M., Port F., Harterink M., Basler K., Korswagen H.C. Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. EMBO J. 2010, 29(24):4094-4105.
140. Silver S.J., Hagen J.W., Okamura K., Perrimon N., Lai E.C. Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc. Natl. Acad. Sci. USA 2007, 104(46):18151-18156.
141. Simons M., Gault W.J., Gotthardt D., Rohatgi R., Klein T.J., Shao Y., Lee H.J., Wu A.L., Fang Y., Satlin L.M., Dow J.T., Chen J., et al. Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat. Cell Biol. 2009, 11(3):286-294.
142. Staal F.J., Luis T.C. Wnt signaling in hematopoiesis: Crucial factors for self-renewal, proliferation, and cell fate decisions. J. Cell. Biochem. 2010, 109(5):844-849.
143. Stadeli R., Hoffmans R., Basler K. Transcription under the control of nuclear Arm/beta-catenin. Curr. Biol. 2006, 16(10):R378-R385.
144. Strutt D.I. Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing. Mol. Cell 2001, 7(2):367-375.
145. Strutt H., Strutt D. Asymmetric localisation of planar polarity proteins: Mechanisms and consequences. Semin. Cell Dev. Biol. 2009, 20(8):957-963.
146. Takada R., Satomi Y., Kurata T., Ueno N., Norioka S., Kondoh H., Takao T., Takada S. Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion. Dev. Cell 2006, 11(6):791-801.
147. Tanaka K., Okabayashi K., Asashima M., Perrimon N., Kadowaki T. The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur. J. Biochem. 2000, 267(13):4300-4311.
148. Tanaka K., Kitagawa Y., Kadowaki T. Drosophila segment polarity gene product porcupine stimulates the posttranslational N-glycosylation of wingless in the endoplasmic reticulum. J. Biol. Chem. 2002, 277(15):12816-12823.
149. Tanaka S., Maeda Y., Tashima Y., Kinoshita T. Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. J. Biol. Chem. 2004, 279(14):14256-14263.
150. Tang W., Dodge M., Gundapaneni D., Michnoff C., Roth M., Lum L. A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proc. Natl. Acad. Sci. USA 2008, 105(28):9697-9702.
151. Thatcher E.J., Paydar I., Anderson K.K., Patton J.G. Regulation of zebrafish fin regeneration by microRNAs. Proc. Natl. Acad. Sci. USA 2008, 105(47):18384-18389.
152. Thompson B., Townsley F., Rosin-Arbesfeld R., Musisi H., Bienz M. A new nuclear component of the Wnt signalling pathway. Nat. Cell Biol. 2002, 4(5):367-373.
153. Usui T., Shima Y., Shimada Y., Hirano S., Burgess R.W., Schwarz T.L., Takeichi M., Uemura T. Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell 1999, 98(5):585-595.
154. van Amerongen R., Nusse R. Towards an integrated view of Wnt signaling in development. Development 2009, 136(19):3205-3214.
155. van Amerongen R., Mikels A., Nusse R. Alternative wnt signaling is initiated by distinct receptors. Sci. Signal. 2008, 1(35):re9.
156. van den Heuvel M., Harryman-Samos C., Klingensmith J., Perrimon N., Nusse R. Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J. 1993, 12(13):5293-5302.
157. van Ooyen A., Nusse R. Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact. Cell 1984, 39(1):233-240.
158. Wallingford J.B., Vogeli K.M., Harland R.M. Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway. Int. J. Dev. Biol. 2001, 45(1):225-227.
159. Wend P., Holland J.D., Ziebold U., Birchmeier W. Wnt signaling in stem and cancer stem cells. Semin. Cell Dev. Biol. 2010, 21(8):855-863.
160. Willert K., Logan C.Y., Arora A., Fish M., Nusse R. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. Development 1999, 126(18):4165-4173.
161. Willert K., Brown J.D., Danenberg E., Duncan A.W., Weissman I.L., Reya T., Yates J.R., Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003, 423(6938):448-452.
162. Wolff T., Rubin G.M. Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila. Development 1998, 125(6):1149-1159.
163. Wong G.T., Gavin B.J., McMahon A.P. Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 1994, 14(9):6278-6286.
164. Wu J., Mlodzik M. A quest for the mechanism regulating global planar cell polarity of tissues. Trends Cell Biol. 2009, 19(7):295-305.
165. Wu Y., Belenkaya T.Y., Lin X. Dual roles of Drosophila glypican Dally-like in Wingless/Wnt signaling and distribution. Methods Enzymol. 2010, 480:33-50.
166. Yamamoto A., Nagano T., Takehara S., Hibi M., Aizawa S. Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Cell 2005, 120(2):223-235.
167. Yan Q., Lennarz W.J. Oligosaccharyltransferase: A complex multisubunit enzyme of the endoplasmic reticulum. Biochem. Biophys. Res. Commun. 1999, 266(3):684-689.
168. Yan D., Lin X. Shaping morphogen gradients by proteoglycans. Cold Spring Harb. Perspect. Biol. 2009, 1(3):a002493.
169. Yan D., Wu Y., Feng Y., Lin S.C., Lin X. The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling. Dev. Cell 2009, 17(4):470-481.
170. Yanagawa S., Matsuda Y., Lee J.S., Matsubayashi H., Sese S., Kadowaki T., Ishimoto A. Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J. 2002, 21(7):1733-1742.
171. Yang P.T., Lorenowicz M.J., Silhankova M., Coudreuse D.Y., Betist M.C., Korswagen H.C. Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells. Dev. Cell 2008, 14(1):140-147.
172. You J., Belenkaya T., Lin X. Sulfated is a negative feedback regulator of wingless in Drosophila. Dev. Dyn. 2011, 240(3):640-648.
173. Yu H.M., Jin Y., Fu J., Hsu W. Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis. Dev. Dyn. 2010, 239(7):2102-2109.
174. Zecca M., Basler K., Struhl G. Direct and long-range action of a wingless morphogen gradient. Cell 1996, 87(5):833-844.
175. Zeng L., Fagotto F., Zhang T., Hsu W., Vasicek T.J., Perry W.L., Lee J.J., Tilghman S.M., Gumbiner B.M., Costantini F. The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 1997, 90(1):181-192.
176. Zeng X., Tamai K., Doble B., Li S., Huang H., Habas R., Okamura H., Woodgett J., He X. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 2005, 438:873-877.
177. Zhai L., Chaturvedi D., Cumberledge S. Drosophila wnt-1 undergoes a hydrophobic modification and is targeted to lipid rafts, a process that requires porcupine. J. Biol. Chem. 2004, 279(32):33220-33227.
178. Zoltewicz J.S., Ashique A.M., Choe Y., Lee G., Taylor S., Phamluong K., Solloway M., Peterson A.S. Wnt signaling is regulated by endoplasmic reticulum retention. PLoS One 2009, 4(7):e6191.