Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

Nature

Volumn 400, Issue 6741, 1999, Pages 281-284

  Lin, Xinhua ^a   Perrimon, Norbert ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; GLYPICAN; HEPARAN SULFATE; MESSENGER RNA; PHOSPHATIDYLINOSITOL; PROTEOGLYCAN; SULFOTRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; DROSOPHILA; FEMALE; GENE ACTIVITY; GENE CONTROL; IN SITU HYBRIDIZATION; MUTATION; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ANIMALS; BODY PATTERNING; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; FRIZZLED RECEPTORS; GENES, INSECT; HEPARIN; INSECT PROTEINS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEOGLYCANS; PROTO-ONCOGENE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROTRANSMITTER; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SULFOTRANSFERASES; WING;

HEXAPODA; VERTEBRATA;

EID: 0033566126     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/22343     Document Type: Article

References (20)

1. Siegfried, E. & Perrimon, N. Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. BioEssays 16, 395-404 (1994).
2. David, G. Integral membrane heparan sulfate proteoglycans. FASEB J. 7, 1023-1030 (1993).
3. Reichsman, F., Smith, L. & Cumberledge, S. Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction. J. Cell Biol. 135, 819-827 (1996).
4. Cumberledge, S. & Reichsman, F. Glycosaminoglycans and WNTs: just a spoonful of sugar helps the signal go down. Trends Genet. 13, 421-423 (1997).
5. Perrimon, N., Lanjuin, A., Arnold, C. & Noll, E. Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogastsr. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Genetics 144, 168-1692 (1996).
6. Haecker, U., Lin, X. & Perrimon, N. The Drosophila sugarless gene modulates. Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis. Development 124, 3565-3573 (1997).
7. Neumann, C. J. & Cohen, S. M. Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development 124, 871-880 (1997).
8. Zecca, M., Basler, K. & Struhl, G. Direct and long-range action of a wingless morphogen gradient. Cell 87, 833-844 (1996).
9. Hashimoto, Y., Orellana, A., Gil, G. & Hirschberg, C. B. Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase. J. Biol. Chem. 267, 15744-15750 (1992).
10. Nakato, H., Futch, T. A. & Selleck, S. B. The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila. Development 121, 3687-3702 (1995).
11. Bhanot, P. et al. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382, 225-230 (1996).
12. Kennerdell, J. R. & Carthew, R. W. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95, 1017-1026 (1998).
13. Zhang, J. & Carthew, R. W. Interactions between Wingless and DFz2 during Drosophila wing development. Development 125, 3075-3085 (1998).
14. Cadigan, K. M., Fish, M. P., Rulifson, E. J. & Nusse, R. Wingless repression of Drosophila wing development. Development 125, 3075-3085 (1998).
15. Schlessinger, J., Lax, I. & Lemmon, M. Regulation of growth factor activation byproteoglycans: what is the role of the low affinity receptors? Cell 83, 357-360 (1995).
16. Jackson, S. M. et al. dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp. Development 124, 4113-4120 (1997).
17. Bullock, S. L., Fletcher, J. M., Beddington, R. S. & Wilson, V. A. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev. 12, 1894-1906 (1998).
18. Sen, J., Goltz, J. S., Stevens, L. & Stein, D. Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity. Cell 95, 471-481 (1998).
19. van de Wetering, M. et al. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88, 789-799 (1997).
20. Gustafson, K. & Boulianne, G. L. Distinct expression patterns detected within individual tissues by the GALA enhancer trap technique. Genome 39, 174-182 (1996).