CtBP, an unconventional transcriptional torepressor in development and oncogenesis

Molecular Cell

Volumn 9, Issue 2, 2002, Pages 213-224

  Chinnadurai, G ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HOMEODOMAIN PROTEIN; PROTEIN; PROTEIN P130;

AMINO TERMINAL SEQUENCE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL LINE; CELL PROLIFERATION; CHROMOSOME 21Q; DROSOPHILA; EXON; HUMAN; INTRON; INVERTEBRATE; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; VERTEBRATE; XENOPUS;

INVERTEBRATA; VERTEBRATA;

EID: 0036190459     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00443-4     Document Type: Review

References (87)

1. Hairy mediates dominant repression in the Drosophila embryo
2. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis
3. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
4. Long-range repression in the Drosophila embryo
5. Acetylation control of the retinoblastoma tumour-suppressor protein
6. Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation
7. Linking the Rb and polycomb pathways
8. FOG acts as a repressor of red blood cell development in Xenopus
9. A dynamic role for HDAC7 in MEF2-mediated muscle differentiation
10. Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability
11. The human T-cell transcription factor-4 gene: Structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines
12. The regulation of E2F by pRB-family proteins
13. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers
14. Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor δEF1
15. Molecular cloning and characterization of a novel retinoblastoma-binding protein
16. Evidence for a function of CtBP in epithelial gene regulation and anoikis
17. Sir-Ku-itous routes to make ends meet
18. Brinker requires two corepressors for maximal and versatile repression in Dpp signalling
19. Curbing the nuclear activities of β-catenin. Control over Wnt target gene expression
20. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation
21. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling
22. N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation
23. A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3
24. Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
25. dMi-2, a hunchback-interacting protein that functions in polycomb repression
26. dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein
27. Sin meets NuRD and other tails of repression
28. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
29. The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3
30. Hairy stripe 7 element mediates activation and repression in response to different domains and levels of Kruppel in the Drosophila embryo
31. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage
32. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
33. Rb interacts with histone deacetylase to repress transcription
34. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
35. The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo
36. Transcriptional coregulators in development
37. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF
38. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor
39. Structural determinants present in the C-terminal binding protein binding site of adenovirus early region 1A proteins
40. DNA tumor virus transforming proteins and the cell cycle
41. Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila
42. SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter
43. Role of the Rb/E2F pathway in cell growth control
44. CtBP-dependent activities of the short-range Giant repressor in the Drosophila embryo
45. dCtBP mediates transcriptional repression by Knirps, Kruppel and Snail in the Drosophila embryo
46. Interaction of short-range repressors with Drosophila CtBP in the embryo
47. Local action of long-range repressors in the Drosophila embryo
48. Corepressors and nuclear hormone receptor function
49. Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins
50. Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression
51. Wnt signaling and cancer
52. Drosophila CtBP: A Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression
53. ZEB represses transcription through interaction with the corepressor CtBP
54. Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors
55. E1A directly binds and regulates the P/CAF acetyltransferase
56. Binding of neuronal nitric oxide synthase to carboxy-terminal binding protein changes the localization of carboxy-terminal binding protein from the nucleus to the cytosol. A novel function for targeting by the PDZ domain of neuronal nitric oxide synthase
57. Genetic alterations in the human tcf-4 gene in japanese patients with sporadic gastrointestinal cancers with microsatellite instability
58. A Drosophila Polycomb group complex includes Zeste and dTAFII proteins
59. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation
60. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif
61. RIBEYE, a component of synaptic ribbons: A protein's journey through evolution provides insight into synaptic ribbon function
62. Induction of AP-2α expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1
63. C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins
64. The Sir2 protein family: A novel deacetylase for gene silencing and more
65. The CtBP binding domain in the adenovirus E1A protein controls CR1-dependent transactivation
66. Role of CtBP in transcriptional repression by the Drosophila giant protein
67. Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein
68. The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex
69. Functional knockout of the corepressor CtBP by the second exon of adenovirus E1a relieves repression of transcription
70. A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription
71. Physical and functional interactions between the corepressor CtBP and the Epstein-Barr virus nuclear antigen EBNA3C
72. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators
73. The CtBP family: Enigmatic and enzymatic transcriptional co-repressors
74. Human Kruppel-like factor 8: A CACCC-box binding protein that associates with CtBP and represses transcription
75. Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP
76. Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth
77. CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid
78. The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye
79. Characterization of a carboxy-terminal BRCA1 interacting protein
80. Effect of DNA damage on a BRCA1 complex
81. Interaction between the retinoblastoma protein and the oncoprotein MDM2
82. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression
83. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor
84. Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo
85. Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo
86. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
87. Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP