MicroRNA roles in beta-catenin pathway

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Huang, Kai ^a,b,c   Zhang, Jun Xia ^a,b,d   Han, Lei ^a,b,c   You, Yong Ping ^d   Jiang, Tao ^e   Pu, Pei Yu ^a,b,c   Kang, Chun Sheng ^a,b,c  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b Tianjin Neurological Institute   (China)

^c BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^d THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^e CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; APC PROTEIN; AXIN; BETA CATENIN; CGP 049090; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; HISTONE DEACETYLASE; LYMPHOID ENHANCER FACTOR 1; MICRORNA; MICRORNA 122A; MICRORNA 15; MICRORNA 16; MICRORNA 200A; MICRORNA 203; MICRORNA 21; MICRORNA 375; MICRORNA 8; PKF 115 584; PKF 118 310; PROTEIN AKT1; PROTEIN C JUN; PROTEIN INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN WG; QUERCETIN; T CELL FACTOR PROTEIN; T CELL FACTOR PROTEIN 4; UNCLASSIFIED DRUG; UNINDEXED DRUG; WNT PROTEIN;

CARCINOGENESIS; CELL DIFFERENTIATION; CELL GROWTH; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; GENETICS; METABOLISM; NEOPLASM; PHYSIOLOGY;

ANIMALS; BETA CATENIN; HUMANS; MICRORNAS; MODELS, BIOLOGICAL; NEOPLASMS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 77956668326     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-252     Document Type: Review

References (100)

1. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006, 127:469-480. 10.1016/j.cell.2006.10.018, 17081971.
2. Waltzer L, Bienz M. Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. Nature 1998, 395:521-525. 10.1038/26785, 9774110.
3. Kemler R. Classical cadherins. Semin Cell Biol 1992, 3:149-155. 10.1016/S1043-4682(10)80011-X, 1623204.
4. Yost C, Torres M, Miller JR, Huang E, Kimelman D, Moon RT. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev 1996, 10:1443-1454. 10.1101/gad.10.12.1443, 8666229.
5. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002, 108:837-847. 10.1016/S0092-8674(02)00685-2, 11955436.
6. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 2003, 1653:1-24.
7. Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, Durand H, Perret C, Rubinfeld B, Margottin F, Benarous R, Polakis P. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol 1999, 9:207-210. 10.1016/S0960-9822(99)80091-8, 10074433.
8. Cadigan KM, Liu YI. Wnt signaling: complexity at the surface. J Cell Sci 2006, 119:395-402. 10.1242/jcs.02826, 16443747.
9. Malbon CC, Wang HY. Dishevelled: a mobile scaffold catalyzing development. Curr Top Dev Biol 2006, 72:153-166. 10.1016/S0070-2153(05)72002-0, 16564334.
10. Kimelman D, Xu W. beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene 2006, 25:7482-7491. 10.1038/sj.onc.1210055, 17143292.
11. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW. Identification of c-MYC as a target of the APC pathway. Science 1998, 281:1509-1512. 10.1126/science.281.5382.1509, 9727977.
12. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398:422-426. 10.1038/18884, 10201372.
13. Caspi M, Zilberberg A, Eldar-Finkelman H, Rosin-Arbesfeld R. Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner. Oncogene 2008, 27:3546-3555. 10.1038/sj.onc.1211026, 18223684.
14. Yang LH, Xu HT, Han Y, Li QC, Liu Y, Zhao Y, Yang ZQ, Dong QZ, Miao Y, Dai SD, Wang EH. Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells. Mol Cancer 2010, 9:25. 10.1186/1476-4598-9-25, 2827467, 20122174.
15. Ying Y, Tao Q. Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics 2009, 4:307-312. 10.4161/epi.4.5.9371, 19633433.
16. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW. APC mutations occur early during colorectal tumorigenesis. Nature 1992, 359:235-237. 10.1038/359235a0, 1528264.
17. Sareddy GR, Panigrahi M, Challa S, Mahadevan A, Babu PP. Activation of Wnt/beta-catenin/Tcf signaling pathway in human astrocytomas. Neurochem Int 2009, 55:307-317. 10.1016/j.neuint.2009.03.016, 19576519.
18. Pu P, Zhang Z, Kang C, Jiang R, Jia Z, Wang G, Jiang H. Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth. Cancer Gene Ther 2009, 16:351-361. 10.1038/cgt.2008.78, 18949017.
19. Hunter L, Cohen KB. Biomedical language processing: what's beyond PubMed?. Mol Cell 2006, 21:589-594. 10.1016/j.molcel.2006.02.012, 1702322, 16507357.
20. Jean C, Blanc A, Prade-Houdellier N, Ysebaert L, Hernandez-Pigeon H, Al Saati T, Haure MJ, Coluccia AM, Charveron M, Delabesse E, Laurent G. Epidermal growth factor receptor/beta-catenin/T-cell factor 4/matrix metalloproteinase 1: a new pathway for regulating keratinocyte invasiveness after UVA irradiation. Cancer Res 2009, 69:3291-3299. 10.1158/0008-5472.CAN-08-1909, 19336574.
21. Hoschuetzky H, Aberle H, Kemler R. Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 1994, 127:1375-1380. 10.1083/jcb.127.5.1375, 2120252, 7962096.
22. Roura S, Miravet S, Piedra J, Garcia de Herreros A, Dunach M. Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. J Biol Chem 1999, 274:36734-36740. 10.1074/jbc.274.51.36734, 10593980.
23. Lee CH, Hung HW, Hung PH, Shieh YS. Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Mol Cancer 2010, 9:64. 10.1186/1476-4598-9-64, 2850885, 20302655.
24. Zeng G, Apte U, Micsenyi A, Bell A, Monga SP. Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions. Exp Cell Res 2006, 312:3620-3630. 10.1016/j.yexcr.2006.08.003, 1820835, 16952352.
25. Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol 1998, 8:779-782. 10.1016/S0960-9822(98)70302-1, 9651683.
26. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789. 10.1038/378785a0, 8524413.
27. Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 2000, 60:3504-3513.
28. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 2007, 282:11221-11229. 10.1074/jbc.M611871200, 1850976, 17287208.
29. He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 2007, 39:189-198. 10.1038/ng1928, 17237784.
30. Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY. Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Proc Natl Acad Sci USA 2006, 103:16313-16318. 10.1073/pnas.0602557103, 1637579, 17060633.
31. Lee MH, Koria P, Qu J, Andreadis ST. JNK phosphorylates beta-catenin and regulates adherens junctions. Faseb J 2009, 23:3874-3883. 10.1096/fj.08-117804, 19667122.
32. Hu D, Fang W, Han A, Gallagher L, Davis RJ, Xiong B, Yang W. c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis 2008, 29:2317-2324. 10.1093/carcin/bgn239, 2639245, 18952597.
33. Wu X, Tu X, Joeng KS, Hilton MJ, Williams DA, Long F. Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell 2008, 133:340-353. 10.1016/j.cell.2008.01.052, 2390926, 18423204.
34. Nateri AS, Spencer-Dene B, Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 2005, 437:281-285. 10.1038/nature03914, 16007074.
35. Fang W, Han A, Bi X, Xiong B, Yang W. Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling. Int J Cancer 2010, 127:32-42.
36. Korpal M, Lee ES, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008, 283:14910-14914. 10.1074/jbc.C800074200, 18411277.
37. Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, Brabletz T. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 2008, 9:582-589. 10.1038/embor.2008.74, 2396950, 18483486.
38. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008, 10:593-601. 10.1038/ncb1722, 18376396.
39. Kong D, Li Y, Wang Z, Banerjee S, Ahmad A, Kim HR, Sarkar FH. miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells. Stem Cells 2009, 27:1712-1721. 10.1002/stem.101, 19544444.
40. Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008, 22:894-907. 10.1101/gad.1640608, 2279201, 18381893.
41. Tryndyak VP, Beland FA, Pogribny IP. E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int J Cancer 2010, 126:2575-83.
42. Saydam O, Shen Y, Wurdinger T, Senol O, Boke E, James MF, Tannous BA, Stemmer-Rachamimov AO, Yi M, Stephens RM, Fraefel C, Gusella JF, Krichevsky AM, Breakefield XO. Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol Cell Biol 2009, 29:5923-5940. 10.1128/MCB.00332-09, 2772747, 19703993.
43. Hashimi ST, Fulcher JA, Chang MH, Gov L, Wang S, Lee B. MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation. Blood 2009, 114:404-414. 10.1182/blood-2008-09-179150, 2927176, 19398721.
44. Chen Y, Liu W, Chao T, Zhang Y, Yan X, Gong Y, Qiang B, Yuan J, Sun M, Peng X. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. Cancer Lett 2008, 272:197-205. 10.1016/j.canlet.2008.06.034, 19013014.
45. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007, 133:647-658. 10.1053/j.gastro.2007.05.022, 17681183.
46. Yao Q, Xu H, Zhang QQ, Zhou H, Qu LH. MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells. Biochem Biophys Res Commun 2009, 388:539-542. 10.1016/j.bbrc.2009.08.044, 19682430.
47. Zhang Z, Li Z, Gao C, Chen P, Chen J, Liu W, Xiao S, Lu H. miR-21 plays a pivotal role in gastric cancer pathogenesis and progression. Lab Invest 2008, 88:1358-1366. 10.1038/labinvest.2008.94, 18794849.
48. Thatcher EJ, Paydar I, Anderson KK, Patton JG. Regulation of zebrafish fin regeneration by microRNAs. Proc Natl Acad Sci USA 2008, 105:18384-18389. 10.1073/pnas.0803713105, 2587605, 19015519.
49. Kennell JA, Gerin I, MacDougald OA, Cadigan KM. The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc Natl Acad Sci USA 2008, 105:15417-15422. 10.1073/pnas.0807763105, 2563117, 18824696.
50. Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A, Meijer GA, Agami R. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res 2008, 68:5795-5802. 10.1158/0008-5472.CAN-08-0951, 18632633.
51. Silver SJ, Hagen JW, Okamura K, Perrimon N, Lai EC. Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci USA 2007, 104:18151-18156. 10.1073/pnas.0706673104, 2084312, 17989227.
52. Arce L, Pate KT, Waterman ML. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. BMC Cancer 2009, 9:159. 10.1186/1471-2407-9-159, 2701438, 19460168.
53. Brannon M, Brown JD, Bates R, Kimelman D, Moon RT. XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development. Development 1999, 126:3159-3170.
54. Cavallo RA, Cox RT, Moline MM, Roose J, Polevoy GA, Clevers H, Peifer M, Bejsovec A. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature 1998, 395:604-608. 10.1038/26982, 9783586.
55. Yu X, Li P, Roeder RG, Wang Z. Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split. Mol Cell Biol 2001, 21:4614-4625. 10.1128/MCB.21.14.4614-4625.2001, 87125, 11416139.
56. Chen G, Fernandez J, Mische S, Courey AJ. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev 1999, 13:2218-2230. 10.1101/gad.13.17.2218, 316998, 10485845.
57. Daniels DL, Weis WI. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol 2005, 12:364-371. 10.1038/nsmb912, 15768032.
58. Belenkaya TY, Han C, Standley HJ, Lin X, Houston DW, Heasman J, Lin X. pygopus Encodes a nuclear protein essential for wingless/Wnt signaling. Development 2002, 129:4089-4101.
59. Kramps T, Peter O, Brunner E, Nellen D, Froesch B, Chatterjee S, Murone M, Zullig S, Basler K. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 2002, 109:47-60. 10.1016/S0092-8674(02)00679-7, 11955446.
60. Takemaru KI, Moon RT. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression. J Cell Biol 2000, 149:249-254. 10.1083/jcb.149.2.249, 2175158, 10769018.
61. Billin AN, Thirlwell H, Ayer DE. Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator. Mol Cell Biol 2000, 20:6882-6890. 10.1128/MCB.20.18.6882-6890.2000, 88764, 10958684.
62. Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, van Es JH, Clevers H, Hsieh J, Bassel-Duby R, Olson EN, Lu QR. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci 2009, 12:829-838. 10.1038/nn.2333, 2701973, 19503085.
63. Yamaguchi M, Tonou-Fujimori N, Komori A, Maeda R, Nojima Y, Li H, Okamoto H, Masai I. Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways. Development 2005, 132:3027-3043. 10.1242/dev.01881, 15944187.
64. Godman CA, Joshi R, Tierney BR, Greenspan E, Rasmussen TP, Wang HW, Shin DG, Rosenberg DW, Giardina C. HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. Cancer Biol Ther 2008, 7:1570-1580. 10.4161/cbt.7.10.6561, 2614677, 18769117.
65. Li Y, Zhang X, Polakiewicz RD, Yao TP, Comb MJ. HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem 2008, 283:12686-12690. 10.1074/jbc.C700185200, 18356165.
66. Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, Bodmer WF, Moyer MP, Riecken EO, Buhr HJ, Hanski C. Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci USA 1999, 96:1603-1608. 10.1073/pnas.96.4.1603, 15532, 9990071.
67. Toualbi K, Guller MC, Mauriz JL, Labalette C, Buendia MA, Mauviel A, Bernuau D. Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes. Oncogene 2007, 26:3492-3502. 10.1038/sj.onc.1210133, 17146436.
68. Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L. Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol 2008, 180:1087-1100. 10.1083/jcb.200710050, 2290839, 18347071.
69. Hwang SG, Yu SS, Lee SW, Chun JS. Wnt-3a regulates chondrocyte differentiation via c-Jun/AP-1 pathway. FEBS Lett 2005, 579:4837-4842. 10.1016/j.febslet.2005.07.067, 16099458.
70. Mahmoudi T, Li VS, Ng SS, Taouatas N, Vries RG, Mohammed S, Heck AJ, Clevers H. The kinase TNIK is an essential activator of Wnt target genes. Embo J 2009, 28:3329-3340. 10.1038/emboj.2009.285, 19816403.
71. Stemmer V, de Craene B, Berx G, Behrens J. Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene 2008, 27:5075-5080. 10.1038/onc.2008.140, 18469861.
72. Evans PM, Chen X, Zhang W, Liu C. KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. Mol Cell Biol 2010, 30:372-381. 10.1128/MCB.00063-09, 2798472, 19901072.
73. Hong CF, Chou YT, Lin YS, Wu CW. MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation. J Biol Chem 2009, 284:19613-19622. 10.1074/jbc.M109.005017, 2740587, 19443654.
74. Gao H, Le Y, Wu X, Silberstein LE, Giese RW, Zhu Z. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res 2010, 70:202-211. 10.1158/0008-5472.CAN-09-2668, 20028861.
75. Young CS, Kitamura M, Hardy S, Kitajewski J. Wnt-1 induces growth, cytosolic beta-catenin, and Tcf/Lef transcriptional activation in Rat-1 fibroblasts. Mol Cell Biol 1998, 18:2474-2485. 110627, 9566868.
76. Hatzis P, van der Flier LG, van Driel MA, Guryev V, Nielsen F, Denissov S, Nijman IJ, Koster J, Santo EE, Welboren W, Versteeg R, Cuppen E, van de Wetering M, Clevers H, Stunnenberg HG. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol 2008, 28:2732-2744. 10.1128/MCB.02175-07, 2293123, 18268006.
77. Dihlmann S, Kloor M, Fallsehr C, von Knebel Doeberitz M. Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells. Carcinogenesis 2005, 26:1503-1512. 10.1093/carcin/bgi120, 15888491.
78. Han A, Song Z, Tong C, Hu D, Bi X, Augenlicht LH, Yang W. Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol 2008, 583:26-31. 10.1016/j.ejphar.2007.12.034, 2350231, 18291362.
79. Behari J, Zeng G, Otruba W, Thompson MD, Muller P, Micsenyi A, Sekhon SS, Leoni L, Monga SP. R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells. J Hepatol 2007, 46:849-857. 10.1016/j.jhep.2006.11.017, 1924913, 17275129.
80. Rigas B, Kashfi K. Nitric-oxide-donating NSAIDs as agents for cancer prevention. Trends Mol Med 2004, 10:324-330. 10.1016/j.molmed.2004.05.004, 15242680.
81. Wang Z, Havasi A, Gall JM, Mao H, Schwartz JH, Borkan SC. Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax. J Am Soc Nephrol 2009, 20:1919-1928. 10.1681/ASN.2009030253, 2736777, 19696224.
82. Li B, Kuriyama S, Moreno M, Mayor R. The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction. Development 2009, 136:3267-3278. 10.1242/dev.036954, 2808295, 19736322.
83. Delmas V, Beermann F, Martinozzi S, Carreira S, Ackermann J, Kumasaka M, Denat L, Goodall J, Luciani F, Viros A, Demirkan N, Bastian BC, Goding CR, Larue L. Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev 2007, 21:2923-2935. 10.1101/gad.450107, 2049194, 18006687.
84. Savage J, Voronova A, Mehta V, Sendi-Mukasa F, Skerjanc IS. Canonical Wnt signaling regulates Foxc1/2 expression in P19 cells. Differentiation 2010, 79:31-40. 10.1016/j.diff.2009.08.008, 19782461.
85. Rena V, Angeletti S, Panzetta-Dutari G, Genti-Raimondi S. Activation of beta-catenin signalling increases StarD7 gene expression in JEG-3 cells. Placenta 2009, 30:876-883. 10.1016/j.placenta.2009.07.010, 19679347.
86. Hao J, Li TG, Qi X, Zhao DF, Zhao GQ. WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev Biol 2006, 290:81-91. 10.1016/j.ydbio.2005.11.011, 16330017.
87. Yan S, Zhou C, Zhang W, Zhang G, Zhao X, Yang S, Wang Y, Lu N, Zhu H, Xu N. beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett 2008, 271:85-97. 10.1016/j.canlet.2008.05.035, 18602747.
88. Kawada M, Seno H, Uenoyama Y, Sawabu T, Kanda N, Fukui H, Shimahara Y, Chiba T. Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer. Cancer Res 2006, 66:2913-2917. 10.1158/0008-5472.CAN-05-3460, 16540637.
89. Abramova MV, Zatulovskiy EA, Svetlikova SB, Kukushkin AN, Pospelov VA. e2f1 Gene is a new member of Wnt/beta-catenin/Tcf-regulated genes. Biochem Biophys Res Commun 2010, 391:142-146. 10.1016/j.bbrc.2009.11.020, 19900401.
90. Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Naar AM, Dyson NJ. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 2008, 455:552-556. 10.1038/nature07310, 18794899.
91. Xie W, Jin L, Mei Y, Wu M. E2F1 represses beta-catenin/TCF activity by direct upregulation of Siah1. J Cell Mol Med 2009, 13:1719-1727. 10.1111/j.1582-4934.2008.00423.x, 20187294.
92. Zhou F, Zhang L, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y. LEF-1 activates the transcription of E2F1. Biochem Biophys Res Commun 2008, 365:149-153. 10.1016/j.bbrc.2007.10.138, 17980157.
93. Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, Mamidi A, Morsut L, Soligo S, Tran U, Dupont S, Cordenonsi M, Wessely O, Piccolo S. MicroRNA control of Nodal signalling. Nature 2007, 449:183-188. 10.1038/nature06100, 17728715.
94. Wang X, Lam EK, Zhang J, Jin H, Sung JJ. MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers. Biochem Biophys Res Commun 2009, 387:376-380. 10.1016/j.bbrc.2009.07.034, 19607815.
95. Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, Rebouissou S, Zucman-Rossi J. MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 2008, 47:1955-1963. 10.1002/hep.22256, 18433021.
96. Park CH, Chang JY, Hahm ER, Park S, Kim HK, Yang CH. Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun 2005, 328:227-234. 10.1016/j.bbrc.2004.12.151, 15670774.
97. Shan BE, Wang MX, Li RQ. Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest 2009, 27:604-612. 10.1080/07357900802337191, 19440933.
98. Wei W, Chua MS, Grepper S, So S. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer 2010, 126:2426-2436.
99. Takemaru KI, Ohmitsu M, Li FQ. An oncogenic hub: beta-catenin as a molecular target for cancer therapeutics. Handb Exp Pharmacol 2008, 261-284. full_text, 18491056.
100. Dehnhardt CM, Venkatesan AM, Chen Z, Ayral-Kaloustian S, Dos Santos O, Delos Santos E, Curran K, Follettie MT, Diesl V, Lucas J, Geng Y, Dejoy SQ, Petersen R, Chaudhary I, Brooijmans N, Mansour TS, Arndt K, Chen L. Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition. J Med Chem 2010, 53:897-910. 10.1021/jm901370m, 20025292.