Functional plasticity of macrophages: Reversible adaptation to changing microenvironments

Journal of Leukocyte Biology

Volumn 76, Issue 3, 2004, Pages 509-513

  Stout, Robert D ^a   Suttles, Jill ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Cytokines; Differentiation; Inflammation; Regulation

Indexed keywords

CELL RECEPTOR; CHEMOKINE; CYTOKINE; HORMONE; PATTERN RECOGNITION RECEPTOR; UNCLASSIFIED DRUG;

ADAPTATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL SUBPOPULATION; DENDRITIC CELL; ENVIRONMENTAL FACTOR; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; MICROENVIRONMENT; MONOCYTE; OSTEOCLAST; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CELL DIFFERENTIATION; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; HUMANS; IMMUNOLOGIC SURVEILLANCE; INFLAMMATION; MACROPHAGES; PHENOTYPE; RECEPTORS, CYTOKINE;

EID: 4344706372     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0504272     Document Type: Review

References (28)

1. Kennedy, D. W., Abkowitz, J. L. (1997) Kinetics of central nervous system microglial and macrophage engraftment: analysis using a transgenic bone marrow transplantation model. Blood 90, 986-993.
2. Laskin, D. L., Weinberger, B., Laskin, J. D. (2001) Functional heterogeneity in liver and lung macrophages. J. Leukoc. Biol. 70, 163-170.
3. Guillemin, G. J., Brew, B. J. (2004) Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J. Leukoc. Biol. 75, 388-397.
4. Stout, R. D., Suttles, J. (1995) T cell signaling of macrophage activation. Cell Contact-Dependent and Cytokine Signals, Austin, TX, R. G. Landes, Springer-Verlag.
5. Gordon, S., Fraser, I., Nath, D., Hughes, D., Clarke, S. (1992) Macrophages in tissues and in vitro. Curr. Opin. Immunol. 4, 25-32.
6. Slout, R. D., Suttles, J. (1997) T cell signaling of macrophage function in inflammatory disease. Front. Biosci. 2, d197-d206.
7. Gordon, S. (2003) Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23-35.
8. Schreiber, R. D. (1984) Identification of γ-interferon as a murine macrophage-activating factor for tumor cytotoxicity. Contemp. Top. Immunobiol. 13, 171-198.
9. Adams, D. O., Hamilton, T. A. (1992) Molecular basis of macrophage activation: diversity and its origins. In The Macrophage (C. E. Lewis, J. O. McGee, eds.), Oxford, UK, Oxford University Press, 75-114.
10. Stein, M., Keshav, S., Harris, N., Gordon, S. (1992) Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 176, 287-292.
11. Mosser, D. M. (2003) The many faces of macrophage activation. J. Leukoc. Biol. 73, 209-212.
12. Goerdt, S., Orfanos, C. E. (1999) Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 10, 137-142.
13. Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., Hill, A. M. (2000) M-1/M-2 macrophages and the Th1/Th2 paradigm. J. Immunol. 164, 6166-6173.
14. D'Andrea, A., Ma, X., Aste Amezaga, M., Paganin, C., Trinchieri, G. (1995) Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor α production. J. Exp. Med. 181, 537-546.
15. McKnight, A. J., Gordon, S. (1998) Membrane molecules as differentiation antigens of murine macrophages. Adv. Immunol. 68, 271-314.
16. Lang, R., Patel, D., Morris, J. J., Rutschman, R. L., Murray, P. J. (2002) Shaping gene expression in activated and resting primary macrophages by IL-10. J. Immunol. 169, 2253-2263.
17. Williams, L., Jarai, G., Smith, A., Finan, P. (2002) IL-10 expression profiling in human monocytes. J. Leukoc. Biol. 72, 800-809.
18. Wells, C. A., Ravasi, T., Faulkner, G. J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M., Wainwright, B. J., Hume, D. A. (2003) Genetic control of the innate immune response. BMC Immunol. 4, 5-23.
19. Tanaka, K. F., Kashima, H., Suzuki, H., Ono, K., Sawada, M. (2002) Existence of functional β1- and β2-adrenergic receptors on microglia. J. Neurosci. Res. 70, 232-237.
20. Hausser, G., Ludewig, B., Gelderblom, H. R., Tsunetsugu-Yokota, Y., Akagawa, K., Meyerhans, A. (1997) Monocyte-derived dendritic cells represent a transient stage of differentiation in the myeloid lineage. Immunobiology 197, 534-542.
21. Hanisch, U. K. (2002) Microglia as a source and target of cytokines. Glia 40, 140-155.
22. Liu, B., Hong, J. S. (2003) Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 304, 1-7.
23. Kempermann, G., Neumann, H. (2003) Neuroscience. Microglia: the enemy within? Science 302, 1689-1690.
24. Boyle, W. J., Simonet, W. S., Lacey, D. L. (2003) Osteoclast differentiation and activation. Nature 423, 337-342.
25. Fox, S. W., Fuller, K., Bayley, K. E., Lean, J. M., Chambers, T. J. (2000) TGF-β 1 and IFN-γ direct macrophage activation by TNF-α to osteoclastic or cytocidal phenotype. J. Immunol. 165, 4957-4963.
26. Bingle, L., Brown, N. J., Lewis, C. E. (2002) The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196, 254-265.
27. Doherty, T. M., Uzui, H., Fitzpatrick, L. A., Tripathi, P. V., Dunstan, C. R., Asotra, K., Rajavashisth, T. B. (2002) Rationale for the role of osteoclast-like cells in arterial calcification. FASEB J. 16, 577-582.
28. De Keyser, J., Zeinstra, E., Mostert, J., Wilczak, N. (2004) β 2-Adrenoceptor involvement in inflammatory demyelination and axonal degeneration in multiple sclerosis. Trends Pharmacol. Sci. 25, 67-71.