Human anti-inflammatory macrophages induce Foxp3+GITR +CD25+ regulatory T cells, which suppress via membrane-bound TGFβ-1

Journal of Immunology

Volumn 181, Issue 3, 2008, Pages 2220-2226

  Savage, Nigel D L ^a   De Boer, Tjitske ^a   Walburg, Kimberley V ^a   Joosten, Simone A ^a   Van Meijgaarden, Krista ^a   Geluk, Annemiek ^a   Ottenhoff, Tom H M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; MEMBRANE ANTIGEN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; ALLOANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; NERVE GROWTH FACTOR RECEPTOR; TNFRSF18 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CELL CONTACT; CELL DIFFERENTIATION; CELL FUNCTION; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE CONTROL; DISEASE EXACERBATION; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MICROENVIRONMENT; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; CELL COMMUNICATION; CELL CULTURE; CELL MEMBRANE; CELL PROLIFERATION; CYTOLOGY; IMMUNOLOGY; METABOLISM; PROTEIN BINDING;

CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MEMBRANE; CELL PROLIFERATION; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMATION; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; ISOANTIGENS; MACROPHAGES; PROTEIN BINDING; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1;

EID: 49649093608     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.3.2220     Document Type: Article

References (33)

1. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194: 629-644.
2. + regulatory T cell activity in both humans and mice. J. Immunol. 172: 834-842.
3. Huang, C. T., C. J. Workman, D. Flies, X. Pan, A. L. Marson, G. Zhou, E. L. Hipkiss, S. Ravi, J. Kowalski, H. I. Levitsky, et al. 2004. Role of LAG-3 in regulatory T cells. Immunity 21: 503-513.
4. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3: 135-142.
5. + regulatory T cells are derived by rapid turnover of memory populations in vivo. J. Clin. Invest. 116: 2423-2433.
6. Levings, M. K., R. Sangregorio, F. Galbiati, S. Squadrone, M. R. de Waal, and M. G. Roncarolo. 2001. IFN-α and IL-10 induce the differentiation of human type 1 T regulatory cells. J. Immunol. 166: 5530-5539.
7. Chai, J. G., I. Bartok, P. Chandler, S. Vendetti, A. Antoniou, J. Dyson, and R. Lechler. 1999. Anergic T cells act as suppressor cells in vitro and in vivo. Eur. J. Immunol. 29: 686-692.
8. Lombardi, G., S. Sidhu, R. Batchelor, and R. Lechler. 1994. Anergic T cells as suppressor cells in vitro. Science 264: 1587-1589.
9. Vendetti, S., J. G. Chai, J. Dyson, E. Simpson, G. Lombardi, and R. Lechler. 2000. Anergic T cells inhibit the antigen-presenting function of dendritic cells. J. Immunol. 165: 1175-1181.
10. Faria, A. M., and H. L. Weiner. 2006. Oral tolerance: therapeutic implications for autoimmune diseases. Clin. Dev. Immunol. 13: 143-157.
11. Jiang, S., R. I. Lechler, X. S. He, and J. F. Huang. 2006. Regulatory T cells and transplantation tolerance. Hum. Immunol. 67: 765-776.
12. Verreck, F. A., T. de Boer, D. M. Langenberg, M. A. Hoeve, M. Kramer, E. Vaisberg, R. Kastelein, A. Kolk, R. Waal-Malefyt, and T. H. Ottenhoff. 2004. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc. Natl. Acad. Sci. USA 101: 4560-4565.
13. Fleetwood, A. J., T. Lawrence, J. A. Hamilton, and A. D. Cook. 2007. Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J. Immunol. 178: 5245-5252.
14. Smythies, L. E., M. Sellers, R. H. Clements, M. Mosteller-Barnum, G. Meng, W. H. Benjamin, J. M. Orenstein, and P. D. Smith. 2005. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J. Clin. Invest. 115: 66-75.
15. Xu, W., N. Schlagwein, A. Roos, T. K. van den Berg, M. R. Daha, and C. van Kooten. 2007. Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages. Eur. J. Immunol. 37: 1594-1599.
16. Kzhyshkowska, J., G. Workman, M. Cardo-Vila, W. Arap, R. Pasqualini, A. Gratchev, L. Krusell, S. Goerdt, and E. H. Sage. 2006. Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC. J. Immunol. 176: 5825-5832.
17. Verreck, F. A., T. de Boer, D. M. Langenberg, L. van der Zanden, and T. H. Ottenhoff. 2006. Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-γ- and CD40L-mediated costimulation. J. Leukocyte Biol. 79: 285-293.
18. + regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proc. Natl. Acad. Sci. USA 104: 8029-8034.
19. Saharinen, J., M. Hyytiainen, J. Taipale, and J. Keski-Oja. 1999. Latent transforming growth factor-β binding proteins (LTBPs): structural extracellular matrix proteins for targeting TGF-β action. Cytokine Growth Factor Rev. 10: 99-117.
20. Esparza, E. M., and R. H. Arch. 2006. Signaling triggered by glucocorticoid-induced tumor necrosis factor receptor family-related gene: regulation at the interface between regulatory T cells and immune effector cells. Front. Biosci. 11: 1448-1465.
21. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
22. + regulatory T cells. Nat. Immunol. 4: 330-336.
23. Hoves, S., S. W. Krause, C. Schutz, D. Halbritter, J. Scholmerich, H. Herfarth, and M. Fleck. 2006. Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells. J. Immunol. 177: 2691-2698.
24. Jordan, W. J., P. A. Brookes, R. M. Szydlo, J. M. Goldman, R. I. Lechler, and M. A. Ritter. 2004. IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation. Blood 103: 717-724.
25. Hildebrandt, G. C., S. W. Choi, G. Mueller, K. M. Olkiewicz, B. B. Moore, and K. R. Cooke. 2007. The absence of donor-derived IL-13 exacerbates the severity of acute graft-versus-host disease following allogeneic bone marrow transplantation. Pediatr. Blood Cancer 50: 911-914.
26. 1. J. Exp. Med. 194: 809-821.
27. Ostroukhova, M., Z. Qi, T. B. Oriss, B. Dixon-McCarthy, P. Ray, and A. Ray. 2006. Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β. J. Clin. Invest. 116: 996-1004.
28. + regulatory T cell-mediated immunosuppression. Cytokine Growth Factor Rev. 14: 85-89.
29. + T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood 105: 2845-2851.
30. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3: 135-142.
31. +FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-β dependent but does not confer a regulatory phenotype. Blood 110: 2983-2990.
32. Faria, A. M., and H. L. Weiner. 2006. Oral tolerance and TGF-β-producing cells. Inflamm. Allergy Drug Targets 5: 179-190.
33. + T cells is facilitated by CTLA-4 signaling. J. Immunol. 177: 2331-2339.