-
1
-
-
0025351642
-
Intracellular calcium release by sphingosine derivatives generated in cells
-
Ghosh, T.; Bian, J.; Gill, D., Intracellular calcium release by sphingosine derivatives generated in cells. Science, 1990, 248, 1653-1656.
-
(1990)
Science
, vol.248
, pp. 1653-1656
-
-
Ghosh, T.1
Bian, J.2
Gill, D.3
-
2
-
-
0026774525
-
Sphingosine 1- phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness
-
Sadahira, Y.; Ruan, F.; Hakomori, S.; Igarashi, Y., Sphingosine 1- phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. Proc. Natl. Acad. Sci. USA, 1992, 89, 9686-9690.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9686-9690
-
-
Sadahira, Y.1
Ruan, F.2
Hakomori, S.3
Igarashi, Y.4
-
3
-
-
0026049696
-
Sphingosine-1-Phosphate, a novel lipid, involved in cellular proliferation
-
Zhang, H.; Desai, N.; Olivera, A.; Seki, T.; Brooker, G.; Spiegel, S., Sphingosine-1-Phosphate, a novel lipid, involved in cellular proliferation. J. Cell Biol., 1991, 114 (1), 155-167.
-
(1991)
J. Cell Biol
, vol.114
, Issue.1
, pp. 155-167
-
-
Zhang, H.1
Desai, N.2
Olivera, A.3
Seki, T.4
Brooker, G.5
Spiegel, S.6
-
4
-
-
0027371722
-
Sphingosine 1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
-
Olivera, A.; Spiegel, S., Sphingosine 1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature, 1993, 365, 557-559.
-
(1993)
Nature
, vol.365
, pp. 557-559
-
-
Olivera, A.1
Spiegel, S.2
-
5
-
-
0024795059
-
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells
-
Okazaki, T.; Bell, R.; Hannun, Y., Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. J. Biol. Chem., 1989, 264 (32), 19076-19080.
-
(1989)
J. Biol. Chem
, vol.264
, Issue.32
, pp. 19076-19080
-
-
Okazaki, T.1
Bell, R.2
Hannun, Y.3
-
6
-
-
0027511687
-
Programmed cell death induced by ceramide
-
Obeid, L.; Linardic, C.; Karolak, L.; Hannun, Y., Programmed cell death induced by ceramide. Science, 1993, 259, 1769-1771.
-
(1993)
Science
, vol.259
, pp. 1769-1771
-
-
Obeid, L.1
Linardic, C.2
Karolak, L.3
Hannun, Y.4
-
7
-
-
0029948396
-
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
-
Cuvillier, O.; Pirianov, G.; Kleuser, B.; Vanek, P. G.; Coso, O. A.; Gutkind, S.; Spiegel, S., Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature, 1996, 381 (6585), 800-803.
-
(1996)
Nature
, vol.381
, Issue.6585
, pp. 800-803
-
-
Cuvillier, O.1
Pirianov, G.2
Kleuser, B.3
Vanek, P.G.4
Coso, O.A.5
Gutkind, S.6
Spiegel, S.7
-
8
-
-
0032579414
-
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas - and ceramide - mediated apoptosis in Jurkat T lymphocytes
-
Cuvillier, O.; Rosenthal, D. S.; Smulson, M. E.; Spiegel, S., Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide- mediated apoptosis in Jurkat T lymphocytes. J. Biol. Chem., 1998, 273 (5), 2910-2916.
-
(1998)
J. Biol. Chem
, vol.273
, Issue.5
, pp. 2910-2916
-
-
Cuvillier, O.1
Rosenthal, D.S.2
Smulson, M.E.3
Spiegel, S.4
-
9
-
-
77953790503
-
An update on sphingosine-1-phosphate and other sphingolipid mediators
-
Fyrst, H.; Saba, J., An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat. Chem. Biol., 2010, 6 (7), 489-497.
-
(2010)
Nat. Chem. Biol
, vol.6
, Issue.7
, pp. 489-497
-
-
Fyrst, H.1
Saba, J.2
-
10
-
-
69249090929
-
Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes
-
Kobayashi, N.; Yamaguchi, A.; Nishi, T., Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. J. Biol. Chem., 2009, 284 (32), 21192-21200.
-
(2009)
J. Biol. Chem
, vol.284
, Issue.32
, pp. 21192-21200
-
-
Kobayashi, N.1
Yamaguchi, A.2
Nishi, T.3
-
11
-
-
33750832270
-
Role of ABCC1 in export of sphingosine-1- phosphate from mast cells
-
Mitra, P.; Oskeritzian, C. A.; Payne, S. G.; Beaven, M. A.; Milstien, S.; Spiegel, S., Role of ABCC1 in export of sphingosine-1- phosphate from mast cells. Proc. Natl. Acad. Sci. USA, 2006, 103 (44), 16394-16399.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, Issue.44
, pp. 16394-16399
-
-
Mitra, P.1
Oskeritzian, C.A.2
Payne, S.G.3
Beaven, M.A.4
Milstien, S.5
Spiegel, S.6
-
12
-
-
58849083220
-
The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
-
Kawahara, A.; Nishi, T.; Hisano, Y.; Fukui, H.; Yamaguchi, A.; Mochizuki, N., The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science, 2009, 323, 524-527.
-
(2009)
Science
, vol.323
, pp. 524-527
-
-
Kawahara, A.1
Nishi, T.2
Hisano, Y.3
Fukui, H.4
Yamaguchi, A.5
Mochizuki, N.6
-
13
-
-
67649252344
-
Export and functions of sphingosine-1-phosphate
-
Kim, R. H.; Takabe, K.; Milstien, S.; Spiegel, S., Export and functions of sphingosine-1-phosphate. Biochim. Biophys. Acta, 2009.
-
(2009)
Biochim. Biophys. Acta
-
-
Kim, R.H.1
Takabe, K.2
Milstien, S.3
Spiegel, S.4
-
14
-
-
0034735916
-
An oncogenic role of sphingosine kinase
-
Xia, P.; Gamble, J. R.; Wang, L.; Pitson, S. M.; Moretti, P. A.; Wattenberg, B. W.; D'Andrea, R. J.; Vadas, M. A., An oncogenic role of sphingosine kinase. Curr. Biol., 2000, 10 (23), 1527-1530.
-
(2000)
Curr. Biol
, vol.10
, Issue.23
, pp. 1527-1530
-
-
Xia, P.1
Gamble, J.R.2
Wang, L.3
Pitson, S.M.4
Moretti, P.A.5
Wattenberg, B.W.6
D'Andrea, R.J.7
Vadas, M.A.8
-
15
-
-
0141507968
-
Discovery and evaluation of inhibitors of human sphingosine kinase
-
French, K.; Schrecengost, R.; Lee, B.; Zhuang, Y.; Smith, S.; Eberly, J.; Yun, J.; Smith, C., Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res., 2003, 63, 5962-5969.
-
(2003)
Cancer Res
, vol.63
, pp. 5962-5969
-
-
French, K.1
Schrecengost, R.2
Lee, B.3
Zhuang, Y.4
Smith, S.5
Eberly, J.6
Yun, J.7
Smith, C.8
-
16
-
-
78149426794
-
Sphingolipids and cancer: Ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
-
Ponnusamy, S.; Meyers-Needham, M.; Senkal, C. E.; Saddoughi, S. A.; Sentelle, D.; Selvam, S. P.; Salas, A.; Ogretmen, B., Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol., 2010, 6 (10), 1603-1624.
-
(2010)
Future Oncol
, vol.6
, Issue.10
, pp. 1603-1624
-
-
Ponnusamy, S.1
Meyers-Needham, M.2
Senkal, C.E.3
Saddoughi, S.A.4
Sentelle, D.5
Selvam, S.P.6
Salas, A.7
Ogretmen, B.8
-
17
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
Lavieu, G.; Scarlatti, F.; Sala, G.; Carpentier, S.; Levade, T.; Ghidoni, R.; Botti, J.; Codogno, P., Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J. Biol. Chem., 2006, 281, 8518-8527.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 8518-8527
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Carpentier, S.4
Levade, T.5
Ghidoni, R.6
Botti, J.7
Codogno, P.8
-
18
-
-
75149176725
-
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
-
Senkal, C. E.; Ponnusamy, S.; Bielawski, J.; Hannun, Y. A.; Ogretmen, B., Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J., 2010, 24 (1), 296-308.
-
(2010)
FASEB J
, vol.24
, Issue.1
, pp. 296-308
-
-
Senkal, C.E.1
Ponnusamy, S.2
Bielawski, J.3
Hannun, Y.A.4
Ogretmen, B.5
-
19
-
-
66449084111
-
Subcellular origin of sphingosine- 1-phosphate is essental for its toxic effect in lyase deficient neurons
-
Hagen, N.; Van Veldhoven, P. P.; Proia, R. L.; Park, H.; Merrill, A. H., Jr.; Van Echten-Deckert, G., Subcellular origin of sphingosine- 1-phosphate is essental for its toxic effect in lyase deficient neurons. J. Biol. Chem. 2009.
-
(2009)
J. Biol. Chem
-
-
Hagen, N.1
van Veldhoven, P.P.2
Proia, R.L.3
Park, H.4
Merrill Jr., A.H.5
Van Echten-Deckert, G.6
-
20
-
-
0036738085
-
Sphingosine-1-phosphate as a therapeutic agent
-
Spiegel, S.; Kolesnick, R., Sphingosine-1-phosphate as a therapeutic agent. Leukemia, 2002, 16, 1596-602.
-
(2002)
Leukemia
, vol.16
, pp. 1596-1602
-
-
Spiegel, S.1
Kolesnick, R.2
-
21
-
-
80054079185
-
Cancer treatment strategies targeting sphingolipid metabolism
-
Chalfant, C. E.; Del Poeta, M., Eds. Landes Bioscience: Austin, TX, in press
-
Oskouian, B.; Saba, J., Cancer treatment strategies targeting sphingolipid metabolism. In Sphingolipids as Signaling and Regulatory Molecules, Chalfant, C. E.; Del Poeta, M., Eds. Landes Bioscience: Austin, TX, 2009; p (in press).
-
(2009)
Sphingolipids As Signaling and Regulatory Molecules
-
-
Oskouian, B.1
Saba, J.2
-
22
-
-
52449092057
-
Targeting SphK1 as a new strategy against cancer
-
Shida, D.; Takabe, K.; Kapitonov, D.; Milstien, S.; Spiegel, S., Targeting SphK1 as a new strategy against cancer. Curr Drug Targets, 2008, 9 (8), 662-673.
-
(2008)
Curr Drug Targets
, vol.9
, Issue.8
, pp. 662-673
-
-
Shida, D.1
Takabe, K.2
Kapitonov, D.3
Milstien, S.4
Spiegel, S.5
-
23
-
-
77953966511
-
Sphingosine 1-phosphate and cancer
-
Pyne, N. J.; Pyne, S., Sphingosine 1-phosphate and cancer. Nat. Rev. Cancer, 2010, 10 (7), 489-503.
-
(2010)
Nat. Rev. Cancer
, vol.10
, Issue.7
, pp. 489-503
-
-
Pyne, N.J.1
Pyne, S.2
-
24
-
-
78650682926
-
Sphingolipids and expression regulation of genes in cancer
-
Patwardhan, G. A.; Liu, Y.-Y., Sphingolipids and expression regulation of genes in cancer. Prog. Lipid Res., 2011, 50 (1), 104-114.
-
(2011)
Prog. Lipid Res
, vol.50
, Issue.1
, pp. 104-114
-
-
Patwardhan, G.A.1
Liu, Y.-Y.2
-
25
-
-
78049518892
-
An overview of sphingolipid metabolism: From synthesis to breakdown
-
Gault, C. R.; Obeid, L. M.; Hannun, Y. A., An overview of sphingolipid metabolism: from synthesis to breakdown. Adv. Exp. Med. Biol., 2010, 688, 1-23.
-
(2010)
Adv. Exp. Med. Biol
, vol.688
, pp. 1-23
-
-
Gault, C.R.1
Obeid, L.M.2
Hannun, Y.A.3
-
26
-
-
79959610282
-
Functions of the multifaceted family of sphingosine kinases and some close relatives
-
Spiegel, S.; Milstien, S., Functions of the multifaceted family of sphingosine kinases and some close relatives. J. Biol. Chem. 2006.
-
(2006)
J. Biol. Chem
-
-
Spiegel, S.1
Milstien, S.2
-
27
-
-
73649108890
-
Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium - and integrin-binding protein 1
-
Jarman, K. E.; Moretti, P. A.; Zebol, J. R.; Pitson, S. M., Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. J. Biol. Chem., 2010, 285 (1), 483-492.
-
(2010)
J. Biol. Chem
, vol.285
, Issue.1
, pp. 483-492
-
-
Jarman, K.E.1
Moretti, P.A.2
Zebol, J.R.3
Pitson, S.M.4
-
28
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
-
Hait, N. C.; Allegood, J.; Maceyka, M.; Strub, G. M.; Harikumar, K. B.; Singh, S. K.; Luo, C.; Marmorstein, R.; Kordula, T.; Milstien, S.; Spiegel, S., Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science, 2009, 325 (5945), 1254-1257.
-
(2009)
Science
, vol.325
, Issue.5945
, pp. 1254-1257
-
-
Hait, N.C.1
Allegood, J.2
Maceyka, M.3
Strub, G.M.4
Harikumar, K.B.5
Singh, S.K.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
Spiegel, S.11
-
29
-
-
0141924852
-
Sphingosine kinase type 2 is a putative BH3-Only protein that induces apoptosis
-
Liu, H.; Toman, R. E.; Goparaju, S.; Maceyka, M.; Nava, V. E.; Sankala, H.; Payne, S. G.; Bektas, M.; Ishii, I.; Chun, J.; Milstien, S.; Spiegel, S., Sphingosine kinase type 2 is a putative BH3-Only protein that induces apoptosis. J. Biol. Chem., 2003, 278, 40330-40336.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 40330-40336
-
-
Liu, H.1
Toman, R.E.2
Goparaju, S.3
Maceyka, M.4
Nava, V.E.5
Sankala, H.6
Payne, S.G.7
Bektas, M.8
Ishii, I.9
Chun, J.10
Milstien, S.11
Spiegel, S.12
-
30
-
-
0035023404
-
Sphingosine-1-phosphate phosphatases
-
Mandala, S. M., Sphingosine-1-phosphate phosphatases. Prostaglandins Other Lipid Mediat., 2001, 64 (1-4), 143-156.
-
(2001)
Prostaglandins Other Lipid Mediat
, vol.64
, Issue.1-4
, pp. 143-156
-
-
Mandala, S.M.1
-
31
-
-
77953771709
-
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
-
Serra, M.; Saba, J. D., Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv. Enzyme Regul., 2010, 50 (1), 349-362.
-
(2010)
Adv. Enzyme Regul
, vol.50
, Issue.1
, pp. 349-362
-
-
Serra, M.1
Saba, J.D.2
-
32
-
-
73649096618
-
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation
-
Colie, S.; Van Veldhoven, P. P.; Kedjouar, B.; Bedia, C.; Albinet, V.; Sorli, S. C.; Garcia, V.; Djavaheri-Mergny, M.; Bauvy, C.; Codogno, P.; Levade, T.; Andrieu-Abadie, N., Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res., 2009, 69 (24), 9346-9353.
-
(2009)
Cancer Res
, vol.69
, Issue.24
, pp. 9346-9353
-
-
Colie, S.1
van Veldhoven, P.P.2
Kedjouar, B.3
Bedia, C.4
Albinet, V.5
Sorli, S.C.6
Garcia, V.7
Djavaheri-Mergny, M.8
Bauvy, C.9
Codogno, P.10
Levade, T.11
Andrieu-Abadie, N.12
-
33
-
-
2942666365
-
Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs
-
Min, J.; Stegner, A.; Alexander, H.; Alexander, S., Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. Eukaryotic Cell, 2004, 3.
-
(2004)
Eukaryotic Cell
, pp. 3
-
-
Min, J.1
Stegner, A.2
Alexander, H.3
Alexander, S.4
-
34
-
-
33751225686
-
Sphingosine-1- phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer
-
Oskouian, B.; Sooriyakumaran, P.; Borowsky, A.; Crans, A.; Dillard- Telm, L.; Tam, Y.; Bandhuvula, P.; Saba, J., Sphingosine-1- phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer. Proc. Natl. Acad. Sci. USA, 2006, 103, 17384-17389.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 17384-17389
-
-
Oskouian, B.1
Sooriyakumaran, P.2
Borowsky, A.3
Crans, A.4
Dillard-Telm, L.5
Tam, Y.6
Bandhuvula, P.7
Saba, J.8
-
35
-
-
0141445962
-
Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra - and extracellular sphingosine- 1-phosphate levels and cell viability
-
Johnson, K. R.; Johnson, K. Y.; Becker, K. P.; Bielawski, J.; Mao, C.; Obeid, L. M., Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine- 1-phosphate levels and cell viability. J. Biol. Chem., 2003, 278 (36), 34541-34547.
-
(2003)
J. Biol. Chem
, vol.278
, Issue.36
, pp. 34541-34547
-
-
Johnson, K.R.1
Johnson, K.Y.2
Becker, K.P.3
Bielawski, J.4
Mao, C.5
Obeid, L.M.6
-
36
-
-
0037119991
-
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
-
Le Stunff, H.; Galve-Roperh, I.; Peterson, C.; Milstien, S.; Spiegel, S., Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J. Cell Biol., 2002, 158 (6), 1039-1049.
-
(2002)
J. Cell Biol
, vol.158
, Issue.6
, pp. 1039-1049
-
-
Le Stunff, H.1
Galve-Roperh, I.2
Peterson, C.3
Milstien, S.4
Spiegel, S.5
-
37
-
-
0029014026
-
Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: Antagonism by cell-permeable ceramides
-
Gomez-Munoz, A.; Duffy, P.; Martin, A.; O'Brien, L.; Byun, H.; Bittman, R.; Brindley, D., Short-chain ceramide-1-phosphates are novel stimulators of DNA synthesis and cell division: antagonism by cell-permeable ceramides. Mol. Pharmacol., 1995, 47 (5), 833-839.
-
(1995)
Mol. Pharmacol
, vol.47
, Issue.5
, pp. 833-839
-
-
Gomez-Munoz, A.1
Duffy, P.2
Martin, A.3
O'Brien, L.4
Byun, H.5
Bittman, R.6
Brindley, D.7
-
38
-
-
52449119800
-
Ceramide kinase and the ceramide- 1-phosphate/cPLA2alpha interaction as a therapeutic target
-
Lamour, N. F.; Chalfant, C. E., Ceramide kinase and the ceramide- 1-phosphate/cPLA2alpha interaction as a therapeutic target. Curr. Drug Targets, 2008, 9 (8), 674-682.
-
(2008)
Curr. Drug Targets
, vol.9
, Issue.8
, pp. 674-682
-
-
Lamour, N.F.1
Chalfant, C.E.2
-
39
-
-
66349136253
-
Lysophospholipid receptors in vertebrate development, physiology, and pathology
-
Skoura, A.; Hla, T., Lysophospholipid receptors in vertebrate development, physiology, and pathology. J. Lipid Res., 2009, 50 Suppl, S293-S298.
-
(2009)
J. Lipid Res
, vol.50
, Issue.SUPPL.
, pp. 293-298
-
-
Skoura, A.1
Hla, T.2
-
40
-
-
21844457949
-
Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network
-
Rosen, H.; Goetzl, E. J., Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol., 2005, 5 (7), 560-570.
-
(2005)
Nat. Rev. Immunol
, vol.5
, Issue.7
, pp. 560-570
-
-
Rosen, H.1
Goetzl, E.J.2
-
41
-
-
0035793866
-
Role of the sphingosine- 1-phosphate receptor EDG-1 in PDGF-induced cell motility
-
Hobson, J. P.; Rosenfeldt, H. M.; Barak, L. S.; Olivera, A.; Poulton, S.; Caron, M. G.; Milstien, S.; Spiegel, S., Role of the sphingosine- 1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science, 2001, 291 (5509), 1800-1803.
-
(2001)
Science
, vol.291
, Issue.5509
, pp. 1800-1803
-
-
Hobson, J.P.1
Rosenfeldt, H.M.2
Barak, L.S.3
Olivera, A.4
Poulton, S.5
Caron, M.G.6
Milstien, S.7
Spiegel, S.8
-
42
-
-
0028981358
-
Ceramide activates the stress-activated protein kinases
-
Westwick, J. K.; Bielawska, A. E.; Dbaibo, G.; Hannun, Y. A.; Brenner, D. A., Ceramide activates the stress-activated protein kinases. J. Biol. Chem., 1995, 270 (39), 22689-22692.
-
(1995)
J. Biol. Chem
, vol.270
, Issue.39
, pp. 22689-22692
-
-
Westwick, J.K.1
Bielawska, A.E.2
Dbaibo, G.3
Hannun, Y.A.4
Brenner, D.A.5
-
43
-
-
0035860393
-
Baxdependent apoptosis induced by ceramide in HL-60 cells
-
Kim, H. J.; Mun, J. Y.; Chun, Y. J.; Choi, K. H.; Kim, M. Y., Baxdependent apoptosis induced by ceramide in HL-60 cells. FEBS Lett., 2001, 505 (2), 264-268.
-
(2001)
FEBS Lett
, vol.505
, Issue.2
, pp. 264-268
-
-
Kim, H.J.1
Mun, J.Y.2
Chun, Y.J.3
Choi, K.H.4
Kim, M.Y.5
-
44
-
-
0035883083
-
Signaling pathways activated by daunorubicin
-
Laurent, G.; Jaffrezou, J. P., Signaling pathways activated by daunorubicin. Blood, 2001, 98 (4), 913-924.
-
(2001)
Blood
, vol.98
, Issue.4
, pp. 913-924
-
-
Laurent, G.1
Jaffrezou, J.P.2
-
45
-
-
0028287960
-
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
-
Haimovitz-Friedman, A.; Kan, C.; Ehleiter, D.; Persaud, R.; McLoughlin, M.; Fuks, Z.; Kolesnick, R., Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med., 1994, 180, 525-535.
-
(1994)
J. Exp. Med
, vol.180
, pp. 525-535
-
-
Haimovitz-Friedman, A.1
Kan, C.2
Ehleiter, D.3
Persaud, R.4
McLoughlin, M.5
Fuks, Z.6
Kolesnick, R.7
-
46
-
-
0027327212
-
Tumor necrosis factor- (TNF-) signal transduction through ceramide
-
Dbaibo, G.; Obeid, L.; Hannun, Y., Tumor necrosis factor- (TNF-) signal transduction through ceramide. J. Biol. Chem., 1993, 268 (24), 17762-17766.
-
(1993)
J. Biol. Chem
, vol.268
, Issue.24
, pp. 17762-17766
-
-
Dbaibo, G.1
Obeid, L.2
Hannun, Y.3
-
47
-
-
0028076002
-
The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction
-
Schütze, S.; Machleidt, T.; Krönke, M., The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction. J. Leukoc. Biol., 1994, 56, 533-541.
-
(1994)
J. Leukoc. Biol
, vol.56
, pp. 533-541
-
-
Schütze, S.1
Machleidt, T.2
Krönke, M.3
-
48
-
-
0033537839
-
Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3
-
Takeda, Y.; Tashima, M.; Takahashi, A.; Uchiyama, T.; Okazaki, T., Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. J. Biol. Chem., 1999, 274 (15), 10654-10660.
-
(1999)
J. Biol. Chem
, vol.274
, Issue.15
, pp. 10654-10660
-
-
Takeda, Y.1
Tashima, M.2
Takahashi, A.3
Uchiyama, T.4
Okazaki, T.5
-
49
-
-
0035968191
-
Ceramide enables fas to cap and kill
-
Cremesti, A.; Paris, F.; Grassme, H.; Holler, N.; Tschopp, J.; Fuks, Z.; Gulbins, E.; Kolesnick, R., Ceramide enables fas to cap and kill. J. Biol. Chem., 2001, 276 (26), 23954-23961.
-
(2001)
J. Biol. Chem
, vol.276
, Issue.26
, pp. 23954-23961
-
-
Cremesti, A.1
Paris, F.2
Grassme, H.3
Holler, N.4
Tschopp, J.5
Fuks, Z.6
Gulbins, E.7
Kolesnick, R.8
-
50
-
-
0030448021
-
Functions of ceramide in coordinating cellular responses to stress
-
Hannun, Y. A., Functions of ceramide in coordinating cellular responses to stress. Science,1996, 274 (5294), 1855-1859.
-
(1996)
Science
, vol.274
, Issue.5294
, pp. 1855-1859
-
-
Hannun, Y.A.1
-
51
-
-
0030694255
-
Apoptosis-associated signaling pathways are required for chemotherapy - mediated female germ cell destruction [see comments]
-
Perez, G. I.; Knudson, C. M.; Leykin, L.; Korsmeyer, S. J.; Tilly, J. L., Apoptosis-associated signaling pathways are required for chemotherapy- mediated female germ cell destruction [see comments]. Nat. Med., 1997, 3 (11), 1228-1232.
-
(1997)
Nat. Med
, vol.3
, Issue.11
, pp. 1228-1232
-
-
Perez, G.I.1
Knudson, C.M.2
Leykin, L.3
Korsmeyer, S.J.4
Tilly, J.L.5
-
52
-
-
0029148660
-
Ceramide synthase mediates daunorubicininduced apoptosis: An alternative mechanism for generating death signals
-
Bose, R.; Verheij, M.; Haimovitz-Friedman, A.; Scotto, K.; Fuks, Z.; Kolesnick, R., Ceramide synthase mediates daunorubicininduced apoptosis: an alternative mechanism for generating death signals. Cell, 1995, 82 (3), 405-414.
-
(1995)
Cell
, vol.82
, Issue.3
, pp. 405-414
-
-
Bose, R.1
Verheij, M.2
Haimovitz-Friedman, A.3
Scotto, K.4
Fuks, Z.5
Kolesnick, R.6
-
53
-
-
0037132541
-
Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures
-
Franzen, R.; Pfeilschifter, J.; Huwiler, A., Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures. FEBS Lett., 2002, 532 (3), 441-444.
-
(2002)
FEBS Lett
, vol.532
, Issue.3
, pp. 441-444
-
-
Franzen, R.1
Pfeilschifter, J.2
Huwiler, A.3
-
54
-
-
0141706529
-
Neutral ceramidase gene: Role in regulating ceramide-induced apoptosis
-
Choi, M. S.; Anderson, M. A.; Zhang, Z.; Zimonjic, D. B.; Popescu, N.; Mukherjee, A. B., Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. Gene, 2003, 315, 113-122.
-
(2003)
Gene
, vol.315
, pp. 113-122
-
-
Choi, M.S.1
Anderson, M.A.2
Zhang, Z.3
Zimonjic, D.B.4
Popescu, N.5
Mukherjee, A.B.6
-
55
-
-
77949541016
-
Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death
-
Lafont, E.; Milhas, D.; Carpentier, S.; Garcia, V.; Jin, Z. X.; Umehara, H.; Okazaki, T.; Schulze-Osthoff, K.; Levade, T.; Benoist, H.; Segui, B., Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. Cell Death Differ., 2010, 17 (4), 642-654.
-
(2010)
Cell Death Differ
, vol.17
, Issue.4
, pp. 642-654
-
-
Lafont, E.1
Milhas, D.2
Carpentier, S.3
Garcia, V.4
Jin, Z.X.5
Umehara, H.6
Okazaki, T.7
Schulze-Osthoff, K.8
Levade, T.9
Benoist, H.10
Segui, B.11
-
56
-
-
0029949938
-
PrICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
-
Smyth, M. J.; Perry, D. K.; Zhang, J.; Poirier, G. G.; Hannun, Y. A.; Obeid, L. M., prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem. J., 1996, 316 (Pt 1), 25-28.
-
(1996)
Biochem. J
, vol.316
, Issue.Pt 1
, pp. 25-28
-
-
Smyth, M.J.1
Perry, D.K.2
Zhang, J.3
Poirier, G.G.4
Hannun, Y.A.5
Obeid, L.M.6
-
57
-
-
0028122397
-
Role of ceramide-activated protein phosphatase in ceramidemediated signal transduction
-
Wolff, R.; Dobrowsky, R.; Bielawska, A.; Obeid, L.; Hannun, Y., Role of ceramide-activated protein phosphatase in ceramidemediated signal transduction. J. Biol. Chem., 1994, 269 (30), 19605-19609.
-
(1994)
J. Biol. Chem
, vol.269
, Issue.30
, pp. 19605-19609
-
-
Wolff, R.1
Dobrowsky, R.2
Bielawska, A.3
Obeid, L.4
Hannun, Y.5
-
58
-
-
0027202552
-
Ceramide activates a heterotrimeric protein phosphatase 2A
-
Dobrowsky, R.; Kamibayashi, C.; Mumby, M.; Hannun, Y., Ceramide activates a heterotrimeric protein phosphatase 2A. J. Biol. Chem., 1993, 268 (21), 15523-15530.
-
(1993)
J. Biol. Chem
, vol.268
, Issue.21
, pp. 15523-15530
-
-
Dobrowsky, R.1
Kamibayashi, C.2
Mumby, M.3
Hannun, Y.4
-
59
-
-
77956469863
-
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
-
Mondal, S.; Mandal, C.; Sangwan, R.; Chandra, S., Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol. Cancer, 2010, 9, 239.
-
(2010)
Mol. Cancer
, vol.9
, pp. 239
-
-
Mondal, S.1
Mandal, C.2
Sangwan, R.3
Chandra, S.4
-
60
-
-
0031439924
-
Coordinate regulation of stress - and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine
-
Jarvis, W. D.; Fornari, F. A., Jr.; Auer, K. L.; Freemerman, A. J.; Szabo, E.; Birrer, M. J.; Johnson, C. R.; Barbour, S. E.; Dent, P.; Grant, S., Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. Mol. Pharmacol., 1997, 52 (6), 935-947.
-
(1997)
Mol. Pharmacol
, vol.52
, Issue.6
, pp. 935-947
-
-
Jarvis, W.D.1
Fornari Jr., F.A.2
Auer, K.L.3
Freemerman, A.J.4
Szabo, E.5
Birrer, M.J.6
Johnson, C.R.7
Barbour, S.E.8
Dent, P.9
Grant, S.10
-
61
-
-
78549233741
-
Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia
-
Liu, X.; Ryland, L.; Yang, J.; Liao, A.; Aliaga, C.; Watts, R.; Tan, S. F.; Kaiser, J.; Shanmugavelandy, S. S.; Rogers, A.; Loughran, K.; Petersen, B.; Yuen, J.; Meng, F.; Baab, K. T.; Jarbadan, N. R.; Broeg, K.; Zhang, R.; Liao, J.; Sayers, T. J.; Kester, M.; Loughran, T. P., Jr., Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia. Blood, 2010, 116 (20), 4192-4201.
-
(2010)
Blood
, vol.116
, Issue.20
, pp. 4192-4201
-
-
Liu, X.1
Ryland, L.2
Yang, J.3
Liao, A.4
Aliaga, C.5
Watts, R.6
Tan, S.F.7
Kaiser, J.8
Shanmugavelandy, S.S.9
Rogers, A.10
Loughran, K.11
Petersen, B.12
Yuen, J.13
Meng, F.14
Baab, K.T.15
Jarbadan, N.R.16
Broeg, K.17
Zhang, R.18
Liao, J.19
Sayers, T.J.20
Kester, M.21
Loughran Jr., T.P.22
more..
-
62
-
-
35248872133
-
Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1
-
Wooten-Blanks, L. G.; Song, P.; Senkal, C. E.; Ogretmen, B., Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. FASEB J., 2007, 21 (12), 3386-3397.
-
(2007)
FASEB J
, vol.21
, Issue.12
, pp. 3386-3397
-
-
Wooten-Blanks, L.G.1
Song, P.2
Senkal, C.E.3
Ogretmen, B.4
-
63
-
-
27644468706
-
Tumor necrosis factoralpha inhibits hTERT gene expression in human myeloid normal and leukemic cells
-
Beyne-Rauzy, O.; Prade-Houdellier, N.; Demur, C.; Recher, C.; Ayel, J.; Laurent, G.; Mansat-De Mas, V., Tumor necrosis factoralpha inhibits hTERT gene expression in human myeloid normal and leukemic cells. Blood, 2005, 106 (9), 3200-3205.
-
(2005)
Blood
, vol.106
, Issue.9
, pp. 3200-3205
-
-
Beyne-Rauzy, O.1
Prade-Houdellier, N.2
Demur, C.3
Recher, C.4
Ayel, J.5
Laurent, G.6
Mansat-De, M.V.7
-
64
-
-
0030026922
-
2+ system in HL60 leukemia cells
-
2+ system in HL60 leukemia cells. FEBS, 1996, 379, 260-264.
-
(1996)
FEBS
, vol.379
, pp. 260-264
-
-
Okajima, F.1
Tomura, H.2
Sho, K.3
Nochi, H.4
Tamoto, K.5
Kondo, Y.6
-
65
-
-
0030023697
-
Activation of a high affinity Gi protein - coupled plasma membrane receptor by sphingosine-1- phosphate
-
Van Koppen, C.; Meyer, z. H. M.; Laser, K. T.; Zhang, C.; Jakobs, K. H.; Bunemann, M.; Pott, L., Activation of a high affinity Gi protein- coupled plasma membrane receptor by sphingosine-1- phosphate. J. Biol. Chem., 1996, 271 (4), 2082-2087.
-
(1996)
J. Biol. Chem
, vol.271
, Issue.4
, pp. 2082-2087
-
-
van Koppen, C.1
Meyerz, H.M.2
Laser, K.T.3
Zhang, C.4
Jakobs, K.H.5
Bunemann, M.6
Pott, L.7
-
66
-
-
0030592536
-
Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity
-
Buehrer, B.; Bardes, E.; Bell, R., Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity. Biochim. Biophys. Acta, 1996, 1303, 233-242.
-
(1996)
Biochim. Biophys. Acta
, vol.1303
, pp. 233-242
-
-
Buehrer, B.1
Bardes, E.2
Bell, R.3
-
67
-
-
0035525748
-
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria
-
Cuvillier, O.; Levade, T., Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood, 2001, 98, 2828-2836.
-
(2001)
Blood
, vol.98
, pp. 2828-2836
-
-
Cuvillier, O.1
Levade, T.2
-
68
-
-
0032056362
-
1Alpha, 25-dihydroxyvitamin D3 inhibits programmed cell death in HL60 cells by activation of sphingosine kinase
-
Kleuser, B.; Cuvillier, O.; Spiegel, S., 1Alpha, 25-dihydroxyvitamin D3 inhibits programmed cell death in HL60 cells by activation of sphingosine kinase. Cancer Res., 1998, 58, 1817-1824.
-
(1998)
Cancer Res
, vol.58
, pp. 1817-1824
-
-
Kleuser, B.1
Cuvillier, O.2
Spiegel, S.3
-
69
-
-
0032546933
-
Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells
-
Nakamura, H.; Oda, T.; Hamada, K.; Hirano, T.; Shimizu, N.; Utiyama, H., Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. J. Biol. Chem., 1998, 273 (25), 15345-15351.
-
(1998)
J. Biol. Chem
, vol.273
, Issue.25
, pp. 15345-15351
-
-
Nakamura, H.1
Oda, T.2
Hamada, K.3
Hirano, T.4
Shimizu, N.5
Utiyama, H.6
-
70
-
-
0032571139
-
Involvement of Mac-1-mediated adherence and sphingosine-1-phosphate in survival of phorbol ester-treated U937 cells
-
Hamada, K.; Nakamura, H.; Oda, T.; Hirano, T.; Shimizu, N.; Utiyama, H., Involvement of Mac-1-mediated adherence and sphingosine-1-phosphate in survival of phorbol ester-treated U937 cells. Biochem. Biophys. Res. Commun., 1998, 244, 745-750.
-
(1998)
Biochem. Biophys. Res. Commun
, vol.244
, pp. 745-750
-
-
Hamada, K.1
Nakamura, H.2
Oda, T.3
Hirano, T.4
Shimizu, N.5
Utiyama, H.6
-
71
-
-
0033548157
-
Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase
-
Alemany, R.; Meyer zu Heringdorf, D.; van Koppen, C.; Jakobs, K., Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. J. Biol. Chem., 1999, 274, 3994-3999.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 3994-3999
-
-
Alemany, R.1
Meyerzu, H.D.2
van Koppen, C.3
Jakobs, K.4
-
72
-
-
46149100507
-
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: Relevance as a marker for daunorubicin sensitivity of leukemia cells
-
Sobue, S.; Nemoto, S.; Murakami, M.; Ito, H.; Kimura, A.; Gao, S.; Furuhata, A.; Takagi, A.; Kojima, T.; Nakamura, M.; Ito, Y.; Suzuki, M.; Banno, Y.; Nozawa, Y.; Murate, T., Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells. Int. J. Hematol., 2008, 87 (3), 266-275.
-
(2008)
Int. J. Hematol
, vol.87
, Issue.3
, pp. 266-275
-
-
Sobue, S.1
Nemoto, S.2
Murakami, M.3
Ito, H.4
Kimura, A.5
Gao, S.6
Furuhata, A.7
Takagi, A.8
Kojima, T.9
Nakamura, M.10
Ito, Y.11
Suzuki, M.12
Banno, Y.13
Nozawa, Y.14
Murate, T.15
-
73
-
-
0032489574
-
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1
-
Lee, M. J.; Van Brocklyn, J. R.; Thangada, S.; Liu, C. H.; Hand, A. R.; Menzeleev, R.; Spiegel, S.; Hla, T., Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science, 1998, 279 (5356), 1552-1555.
-
(1998)
Science
, vol.279
, Issue.5356
, pp. 1552-1555
-
-
Lee, M.J.1
van Brocklyn, J.R.2
Thangada, S.3
Liu, C.H.4
Hand, A.R.5
Menzeleev, R.6
Spiegel, S.7
Hla, T.8
-
74
-
-
0032545224
-
Downregulation of mRNA expression of Edg-3, a putative sphingosine- 1-phosphate receptor coupled to Ca2+ signaling, during differentiation of HL-60 leukemia cells
-
Sato, K.; Murata, N.; Kon, J.; Tomura, H.; Nochi, H.; Tamoto, K.; Osada, M.; Ohta, H.; Tokumitsu, Y.; Ui, M.; Okajima, F., Downregulation of mRNA expression of Edg-3, a putative sphingosine- 1-phosphate receptor coupled to Ca2+ signaling, during differentiation of HL-60 leukemia cells. Biochem. Biophys. Res. Commun., 1998, 253, 253-256.
-
(1998)
Biochem. Biophys. Res. Commun
, vol.253
, pp. 253-256
-
-
Sato, K.1
Murata, N.2
Kon, J.3
Tomura, H.4
Nochi, H.5
Tamoto, K.6
Osada, M.7
Ohta, H.8
Tokumitsu, Y.9
Ui, M.10
Okajima, F.11
-
75
-
-
20444429404
-
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors
-
Jolly, P. S.; Bektas, M.; Watterson, K. R.; Sankala, H.; Payne, S. G.; Milstien, S.; Spiegel, S., Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood, 2005, 105 (12), 4736-4742.
-
(2005)
Blood
, vol.105
, Issue.12
, pp. 4736-4742
-
-
Jolly, P.S.1
Bektas, M.2
Watterson, K.R.3
Sankala, H.4
Payne, S.G.5
Milstien, S.6
Spiegel, S.7
-
76
-
-
0037069748
-
Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia
-
Kothapalli, R.; Kusmartseva, I.; Loughran, T. P., Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. Biochim. Biophys. Acta, 2002, 1579 (2-3), 117-123.
-
(2002)
Biochim. Biophys. Acta
, vol.1579
, Issue.2-3
, pp. 117-123
-
-
Kothapalli, R.1
Kusmartseva, I.2
Loughran, T.P.3
-
77
-
-
33645056193
-
Large granular lymphocyte leukemia
-
Sokol, L.; Loughran, T. P., Jr., Large granular lymphocyte leukemia. Oncologist, 2006, 11 (3), 263-273.
-
(2006)
Oncologist
, vol.11
, Issue.3
, pp. 263-273
-
-
Sokol, L.1
Loughran Jr., T.P.2
-
78
-
-
55849100058
-
Network model of survival signaling in large granular lymphocyte leukemia
-
Zhang, R.; Shah, M. V.; Yang, J.; Nyland, S. B.; Liu, X.; Yun, J. K.; Albert, R.; Loughran, T. P., Jr., Network model of survival signaling in large granular lymphocyte leukemia. Proc. Natl. Acad. Sci. USA, 2008, 105 (42), 16308-16313.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, Issue.42
, pp. 16308-16313
-
-
Zhang, R.1
Shah, M.V.2
Yang, J.3
Nyland, S.B.4
Liu, X.5
Yun, J.K.6
Albert, R.7
Loughran Jr., T.P.8
-
79
-
-
50949132631
-
Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes
-
Shah, M. V.; Zhang, R.; Irby, R.; Kothapalli, R.; Liu, X.; Arrington, T.; Frank, B.; Lee, N. H.; Loughran, T. P., Jr., Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes. Blood, 2008, 112 (3), 770-781.
-
(2008)
Blood
, vol.112
, Issue.3
, pp. 770-781
-
-
Shah, M.V.1
Zhang, R.2
Irby, R.3
Kothapalli, R.4
Liu, X.5
Arrington, T.6
Frank, B.7
Lee, N.H.8
Loughran Jr., T.P.9
-
80
-
-
23944509761
-
Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression
-
Le Scolan, E.; Pchejetski, D.; Banno, Y.; Denis, N.; Mayeux, P.; Vainchenker, W.; Levade, T.; Moreau-Gachelin, F., Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression. Blood, 2005, 106 (5), 1808-1816.
-
(2005)
Blood
, vol.106
, Issue.5
, pp. 1808-1816
-
-
Le Scolan, E.1
Pchejetski, D.2
Banno, Y.3
Denis, N.4
Mayeux, P.5
Vainchenker, W.6
Levade, T.7
Moreau-Gachelin, F.8
-
81
-
-
79953151232
-
Molecular and cellular bases of chronic myeloid leukemia
-
Chen, Y.; Peng, C.; Li, D.; Li, S., Molecular and cellular bases of chronic myeloid leukemia. Protein & Cell, 2010, 1 (2), 124-132.
-
(2010)
Protein & Cell
, vol.1
, Issue.2
, pp. 124-132
-
-
Chen, Y.1
Peng, C.2
Li, D.3
Li, S.4
-
82
-
-
34249737950
-
Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells
-
Baran, Y.; Salas, A.; Senkal, C. E.; Gunduz, U.; Bielawski, J.; Obeid, L. M.; Ogretmen, B., Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. J. Biol. Chem., 2007, 282 (15), 10922-10934.
-
(2007)
J. Biol. Chem
, vol.282
, Issue.15
, pp. 10922-10934
-
-
Baran, Y.1
Salas, A.2
Senkal, C.E.3
Gunduz, U.4
Bielawski, J.5
Obeid, L.M.6
Ogretmen, B.7
-
83
-
-
33644974376
-
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1
-
Bonhoure, E.; Pchejetski, D.; Aouali, N.; Morjani, H.; Levade, T.; Kohama, T.; Cuvillier, O., Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia, 2006, 20 (1), 95-102.
-
(2006)
Leukemia
, vol.20
, Issue.1
, pp. 95-102
-
-
Bonhoure, E.1
Pchejetski, D.2
Aouali, N.3
Morjani, H.4
Levade, T.5
Kohama, T.6
Cuvillier, O.7
-
84
-
-
79956274055
-
Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia (CML) cells
-
Accepted manuscript
-
Marfe, G.; Di Stefano, C.; Gambacurta, A.; Ottone, T.; Martini, V.; Abruzzese, E.; Mologni, L.; Sinibaldi-Salimei, P.; de Fabritis, P.; Gambacorti-Passerini, C.; Amadori, S.; Birge, R. B., Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia (CML) cells. Exp. Hematol. 2011, (Accepted manuscript)
-
(2011)
Exp. Hematol
-
-
Marfe, G.1
Di Stefano, C.2
Gambacurta, A.3
Ottone, T.4
Martini, V.5
Abruzzese, E.6
Mologni, L.7
Sinibaldi-Salimei, P.8
de Fabritis, P.9
Gambacorti-Passerini, C.10
Amadori, S.11
Birge, R.B.12
-
85
-
-
78649982367
-
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
-
Lee, H.; Deng, J.; Kujawski, M.; Yang, C.; Liu, Y.; Herrmann, A.; Kortylewski, M.; Horne, D.; Somlo, G.; Forman, S.; Jove, R.; Yu, H., STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat. Med., 2010, 16 (12), 1421-1428.
-
(2010)
Nat. Med
, vol.16
, Issue.12
, pp. 1421-1428
-
-
Lee, H.1
Deng, J.2
Kujawski, M.3
Yang, C.4
Liu, Y.5
Herrmann, A.6
Kortylewski, M.7
Horne, D.8
Somlo, G.9
Forman, S.10
Jove, R.11
Yu, H.12
-
86
-
-
27544476971
-
The role of IL-6 and STAT3 in inflammation and cancer
-
Hodge, D. R.; Hurt, E. M.; Farrar, W. L., The role of IL-6 and STAT3 in inflammation and cancer. Eur. J. Cancer, 2005, 41 (16), 2502-2512.
-
(2005)
Eur. J. Cancer
, vol.41
, Issue.16
, pp. 2502-2512
-
-
Hodge, D.R.1
Hurt, E.M.2
Farrar, W.L.3
-
87
-
-
70349323403
-
Targeting signal transducer and activator of transcription signaling pathway in leukemias
-
Benekli, M.; Baumann, H.; Wetzler, M., Targeting signal transducer and activator of transcription signaling pathway in leukemias. J. Clin. Oncol., 2009, 27 (26), 4422-4432.
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.26
, pp. 4422-4432
-
-
Benekli, M.1
Baumann, H.2
Wetzler, M.3
-
88
-
-
0032527809
-
Invasion of T-lymphoma cells: Cooperation between Rho family GTPases and lysophospholipid receptor signaling
-
Stam, J.; Michiels, F.; van der Kammen, R.; Moolenaar, W.; Collard, J., Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. EMBO J., 1998, 17, 4066-4074.
-
(1998)
EMBO J
, vol.17
, pp. 4066-4074
-
-
Stam, J.1
Michiels, F.2
van der Kammen, R.3
Moolenaar, W.4
Collard, J.5
-
89
-
-
0036597808
-
The Edg family G proteincoupled receptors for lysophospholipids: Their signaling properties and biological activities
-
Takuwa, Y.; Takuwa, N.; Sugimoto, N., The Edg family G proteincoupled receptors for lysophospholipids: their signaling properties and biological activities. J. Biochem., 2002, 131 (6), 767-771.
-
(2002)
J. Biochem
, vol.131
, Issue.6
, pp. 767-771
-
-
Takuwa, Y.1
Takuwa, N.2
Sugimoto, N.3
-
90
-
-
36348962321
-
RUNX genes in development and cancer: Regulation of viral gene expression and the discovery of RUNX family genes
-
Ito, Y., RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes. Adv. Cancer Res., 2008, 99, 33-76.
-
(2008)
Adv. Cancer Res
, vol.99
, pp. 33-76
-
-
Ito, Y.1
-
91
-
-
77955016925
-
Runx regulation of sphingolipid metabolism and survival signaling
-
Kilbey, A.; Terry, A.; Jenkins, A.; Borland, G.; Zhang, Q.; Wakelam, M. J.; Cameron, E. R.; Neil, J. C., Runx regulation of sphingolipid metabolism and survival signaling. Cancer Res., 2010, 70 (14), 5860-5869.
-
(2010)
Cancer Res
, vol.70
, Issue.14
, pp. 5860-5869
-
-
Kilbey, A.1
Terry, A.2
Jenkins, A.3
Borland, G.4
Zhang, Q.5
Wakelam, M.J.6
Cameron, E.R.7
Neil, J.C.8
-
92
-
-
54249151827
-
Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1- phosphate receptor 2
-
Li, M. H.; Sanchez, T.; Pappalardo, A.; Lynch, K. R.; Hla, T.; Ferrer, F., Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1- phosphate receptor 2. Mol. Cancer Res., 2008, 6 (10), 1649-1656.
-
(2008)
Mol. Cancer Res
, vol.6
, Issue.10
, pp. 1649-1656
-
-
Li, M.H.1
Sanchez, T.2
Pappalardo, A.3
Lynch, K.R.4
Hla, T.5
Ferrer, F.6
-
93
-
-
34848892421
-
Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina
-
Skoura, A.; Sanchez, T.; Claffey, K.; Mandala, S. M.; Proia, R. L.; Hla, T., Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J. Clin. Invest., 2007, 117 (9), 2506-2516.
-
(2007)
J. Clin. Invest
, vol.117
, Issue.9
, pp. 2506-2516
-
-
Skoura, A.1
Sanchez, T.2
Claffey, K.3
Mandala, S.M.4
Proia, R.L.5
Hla, T.6
-
94
-
-
72249096210
-
Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
-
Cattoretti, G.; Mandelbaum, J.; Lee, N.; Chaves, A. H.; Mahler, A. M.; Chadburn, A.; Dalla-Favera, R.; Pasqualucci, L.; MacLennan, A. J., Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res., 2009, 69 (22), 8686-8692.
-
(2009)
Cancer Res
, vol.69
, Issue.22
, pp. 8686-8692
-
-
Cattoretti, G.1
Mandelbaum, J.2
Lee, N.3
Chaves, A.H.4
Mahler, A.M.5
Chadburn, A.6
Dalla-Favera, R.7
Pasqualucci, L.8
Maclennan, A.J.9
-
95
-
-
76549090692
-
S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice
-
Du, W.; Takuwa, N.; Yoshioka, K.; Okamoto, Y.; Gonda, K.; Sugihara, K.; Fukamizu, A.; Asano, M.; Takuwa, Y., S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Cancer Res., 2010, 70 (2), 772-781.
-
(2010)
Cancer Res
, vol.70
, Issue.2
, pp. 772-781
-
-
Du, W.1
Takuwa, N.2
Yoshioka, K.3
Okamoto, Y.4
Gonda, K.5
Sugihara, K.6
Fukamizu, A.7
Asano, M.8
Takuwa, Y.9
-
96
-
-
67651151234
-
Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism
-
Gustafsson, K.; Sander, B.; Bielawski, J.; Hannun, Y. A.; Flygare, J., Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism. Mol. Cancer Res., 2009, 7 (7), 1086-1098.
-
(2009)
Mol. Cancer Res
, vol.7
, Issue.7
, pp. 1086-1098
-
-
Gustafsson, K.1
Sander, B.2
Bielawski, J.3
Hannun, Y.A.4
Flygare, J.5
-
97
-
-
77649275845
-
Expression of sphingosine- 1-phosphate receptor 1 in mantle cell lymphoma
-
Nishimura, H.; Akiyama, T.; Monobe, Y.; Matsubara, K.; Igarashi, Y.; Abe, M.; Sugihara, T.; Sadahira, Y., Expression of sphingosine- 1-phosphate receptor 1 in mantle cell lymphoma. Mod. Pathol., 2010, 23 (3), 439-449.
-
(2010)
Mod. Pathol
, vol.23
, Issue.3
, pp. 439-449
-
-
Nishimura, H.1
Akiyama, T.2
Monobe, Y.3
Matsubara, K.4
Igarashi, Y.5
Abe, M.6
Sugihara, T.7
Sadahira, Y.8
-
98
-
-
46749153415
-
Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions
-
Bayerl, M. G.; Bruggeman, R. D.; Conroy, E. J.; Hengst, J. A.; King, T. S.; Jimenez, M.; Claxton, D. F.; Yun, J. K., Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions. Leuk. Lymphoma, 2008, 49 (5), 948-954.
-
(2008)
Leuk. Lymphoma
, vol.49
, Issue.5
, pp. 948-954
-
-
Bayerl, M.G.1
Bruggeman, R.D.2
Conroy, E.J.3
Hengst, J.A.4
King, T.S.5
Jimenez, M.6
Claxton, D.F.7
Yun, J.K.8
-
99
-
-
69449087658
-
Tsc10p and FVT1: Topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals
-
Gupta, S. D.; Gable, K.; Han, G.; Borovitskaya, A.; Selby, L.; Dunn, T. M.; Harmon, J. M., Tsc10p and FVT1: topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals. J. Lipid Res., 2009, 50 (8), 1630-1640.
-
(2009)
J. Lipid Res
, vol.50
, Issue.8
, pp. 1630-1640
-
-
Gupta, S.D.1
Gable, K.2
Han, G.3
Borovitskaya, A.4
Selby, L.5
Dunn, T.M.6
Harmon, J.M.7
-
100
-
-
58049194284
-
Expression of the follicular lymphoma variant translocation 1 gene in diffuse large Bcell lymphoma correlates with subtype and clinical outcome
-
Czuchlewski, D. R.; Csernus, B.; Bubman, D.; Hyjek, E.; Martin, P.; Chadburn, A.; Knowles, D. M.; Cesarman, E., Expression of the follicular lymphoma variant translocation 1 gene in diffuse large Bcell lymphoma correlates with subtype and clinical outcome. Am. J. Clin. Pathol., 2008, 130 (6), 957-962.
-
(2008)
Am. J Clin. Pathol
, vol.130
, Issue.6
, pp. 957-962
-
-
Czuchlewski, D.R.1
Csernus, B.2
Bubman, D.3
Hyjek, E.4
Martin, P.5
Chadburn, A.6
Knowles, D.M.7
Cesarman, E.8
-
101
-
-
42749092078
-
Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis
-
Li, Q.-F.; Wu, C.-T.; Guo, Q.; Wang, H.; Wang, L.-S., Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis. Biochem. Biophys. Res. Comm., 2008, 371, 159-162.
-
(2008)
Biochem. Biophys. Res. Comm
, vol.371
, pp. 159-162
-
-
Li, Q.-F.1
Wu, C.-T.2
Guo, Q.3
Wang, H.4
Wang, L.-S.5
-
102
-
-
34547647448
-
Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis
-
Li, Q.-F.; Wu, C.-T.; Duan, H.-F.; Sun, H.-Y.; Wang, H.; Lu, Z.-Z.; Zhang, Q.-W.; Liu, H.-J.; Wang, L.-S., Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis. Br. J. Haematol., 2007, 138, 632-639.
-
(2007)
Br. J. Haematol
, vol.138
, pp. 632-639
-
-
Li, Q.-F.1
Wu, C.-T.2
Duan, H.-F.3
Sun, H.-Y.4
Wang, H.5
Lu, Z.-Z.6
Zhang, Q.-W.7
Liu, H.-J.8
Wang, L.-S.9
-
103
-
-
0028372227
-
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite
-
Fujita, T.; Inoue, K.; Yamamoto, S.; Ikumoto, T.; Sasaki, S.; Toyama, R.; Chiba, K.; Hoshino, Y. T O., Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J. Antibiot. (Tokyo)., 1994, 47, 208-215.
-
(1994)
J. Antibiot. (Tokyo)
, vol.47
, pp. 208-215
-
-
Fujita, T.1
Inoue, K.2
Yamamoto, S.3
Ikumoto, T.4
Sasaki, S.5
Toyama, R.6
Chiba, K.7
Hoshino, Y.T.O.8
-
104
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1- phosphate receptor agonists
-
Mandala, S.; Hajdu, R.; Bergstrom, J.; Quackenbush, E.; Xie, J.; Milligan, J.; Thornton, R.; Shei, G. J.; Card, D.; Keohane, C.; Rosenbach, M.; Hale, J.; Lynch, C. L.; Rupprecht, K.; Parsons, W.; Rosen, H., Alteration of lymphocyte trafficking by sphingosine-1- phosphate receptor agonists. Science, 2002, 296 (5566), 346-349.
-
(2002)
Science
, vol.296
, Issue.5566
, pp. 346-349
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
Thornton, R.7
Shei, G.J.8
Card, D.9
Keohane, C.10
Rosenbach, M.11
Hale, J.12
Lynch, C.L.13
Rupprecht, K.14
Parsons, W.15
Rosen, H.16
-
105
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann, V.; Davis, M. D.; Heise, C. E.; Albert, R.; Cottens, S.; Hof, R.; Bruns, C.; Prieschl, E.; Baumruker, T.; Hiestand, P.; Foster, C. A.; Zollinger, M.; Lynch, K. R., The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem., 2002, 277 (24), 21453-21457.
-
(2002)
J. Biol. Chem
, vol.277
, Issue.24
, pp. 21453-21457
-
-
Brinkmann, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
Bruns, C.7
Prieschl, E.8
Baumruker, T.9
Hiestand, P.10
Foster, C.A.11
Zollinger, M.12
Lynch, K.R.13
-
106
-
-
32644444604
-
Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720
-
Zemann, B.; Kinzel, B.; Muller, M.; Reuschel, R.; Mechtcheriakova, D.; Urtz, N.; Bornancin, F.; Baumruker, T.; Billich, A., Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720. Blood, 2006, 107 (4), 1454-1458.
-
(2006)
Blood
, vol.107
, Issue.4
, pp. 1454-1458
-
-
Zemann, B.1
Kinzel, B.2
Muller, M.3
Reuschel, R.4
Mechtcheriakova, D.5
Urtz, N.6
Bornancin, F.7
Baumruker, T.8
Billich, A.9
-
107
-
-
2442679391
-
The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G protein-coupled receptors
-
Graler, M. H.; Goetzl, E. J., The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G protein-coupled receptors. FASEB J., 2004, 18 (3), 551-553.
-
(2004)
FASEB J
, vol.18
, Issue.3
, pp. 551-553
-
-
Graler, M.H.1
Goetzl, E.J.2
-
108
-
-
34648832173
-
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome - positive acute lymphocytic leukemia
-
Neviani, P.; Santhanam, R.; Oaks, J. J.; Eiring, A. M.; Notari, M.; Blaser, B. W.; Liu, S.; Trotta, R.; Muthusamy, N.; Gambacorti- Passerini, C.; Druker, B. J.; Cortes, J.; Marcucci, G.; Chen, C. S.; Verrills, N. M.; Roy, D. C.; Caligiuri, M. A.; Bloomfield, C. D.; Byrd, J. C.; Perrotti, D., FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome- positive acute lymphocytic leukemia. J. Clin. Invest., 2007, 117 (9), 2408-2421.
-
(2007)
J. Clin. Invest
, vol.117
, Issue.9
, pp. 2408-2421
-
-
Neviani, P.1
Santhanam, R.2
Oaks, J.J.3
Eiring, A.M.4
Notari, M.5
Blaser, B.W.6
Liu, S.7
Trotta, R.8
Muthusamy, N.9
Gambacorti-Passerini, C.10
Druker, B.J.11
Cortes, J.12
Marcucci, G.13
Chen, C.S.14
Verrills, N.M.15
Roy, D.C.16
Caligiuri, M.A.17
Bloomfield, C.D.18
Byrd, J.C.19
Perrotti, D.20
more..
-
109
-
-
0036181066
-
Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells)
-
Fujino, M.; Li, X. K.; Kitazawa, Y.; Guo, L.; Kawasaki, M.; Funeshima, N.; Amano, T.; Suzuki, S., Distinct pathways of apoptosis triggered by FTY720, etoposide, and anti-Fas antibody in human T-lymphoma cell line (Jurkat cells). J. Pharmacol. Exp. Ther., 2002, 300 (3), 939-945.
-
(2002)
J. Pharmacol. Exp. Ther
, vol.300
, Issue.3
, pp. 939-945
-
-
Fujino, M.1
Li, X.K.2
Kitazawa, Y.3
Guo, L.4
Kawasaki, M.5
Funeshima, N.6
Amano, T.7
Suzuki, S.8
-
110
-
-
0034929391
-
Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720
-
Nagahara, Y.; Matsuoka, Y.; Saito, K.; Ikekita, M.; Higuchi, S.; Shinomiya, T., Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720. Jpn. J. Cancer Res., 2001, 92 (6), 680-687.
-
(2001)
Jpn. J. Cancer Res
, vol.92
, Issue.6
, pp. 680-687
-
-
Nagahara, Y.1
Matsuoka, Y.2
Saito, K.3
Ikekita, M.4
Higuchi, S.5
Shinomiya, T.6
-
111
-
-
23844515685
-
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance
-
Yasui, H.; Hideshima, T.; Raje, N.; Roccaro, A. M.; Shiraishi, N.; Kumar, S.; Hamasaki, M.; Ishitsuka, K.; Tai, Y. T.; Podar, K.; Catley, L.; Mitsiades, C. S.; Richardson, P. G.; Albert, R.; Brinkmann, V.; Chauhan, D.; Anderson, K. C., FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. Cancer Res., 2005, 65 (16), 7478-7484.
-
(2005)
Cancer Res
, vol.65
, Issue.16
, pp. 7478-7484
-
-
Yasui, H.1
Hideshima, T.2
Raje, N.3
Roccaro, A.M.4
Shiraishi, N.5
Kumar, S.6
Hamasaki, M.7
Ishitsuka, K.8
Tai, Y.T.9
Podar, K.10
Catley, L.11
Mitsiades, C.S.12
Richardson, P.G.13
Albert, R.14
Brinkmann, V.15
Chauhan, D.16
Anderson, K.C.17
-
112
-
-
77954376747
-
Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers
-
Roberts, K. G.; Smith, A. M.; McDougall, F.; Carpenter, H.; Horan, M.; Neviani, P.; Powell, J. A.; Thomas, D.; Guthridge, M. A.; Perrotti, D.; Sim, A. T.; Ashman, L. K.; Verrills, N. M., Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. Cancer Res., 2010, 70 (13), 5438-5447.
-
(2010)
Cancer Res
, vol.70
, Issue.13
, pp. 5438-5447
-
-
Roberts, K.G.1
Smith, A.M.2
McDougall, F.3
Carpenter, H.4
Horan, M.5
Neviani, P.6
Powell, J.A.7
Thomas, D.8
Guthridge, M.A.9
Perrotti, D.10
Sim, A.T.11
Ashman, L.K.12
Verrills, N.M.13
-
113
-
-
79954449794
-
PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect
-
Cristobal, I.; Garcia-Orti, L.; Cirauqui, C.; Alonso, M. M.; Calasanz, M. J.; Odero, M. D., PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Leukemia, 2011.
-
(2011)
Leukemia
-
-
Cristobal, I.1
Garcia-Orti, L.2
Cirauqui, C.3
Alonso, M.M.4
Calasanz, M.J.5
Odero, M.D.6
-
114
-
-
79951981180
-
Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration
-
Sabbadini, R. A., Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. Br. J. Pharmacol., 2011, 162 (6), 1225-1238.
-
(2011)
Br. J. Pharmacol
, vol.162
, Issue.6
, pp. 1225-1238
-
-
Sabbadini, R.A.1
-
115
-
-
0028900748
-
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation
-
Ohta, H.; Sweeney, E.; Masamune, A.; Yatomi, Y.; Hakomori, S.; Igarashi, Y., Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Cancer Res., 1995, 55 (3), 691-697.
-
(1995)
Cancer Res
, vol.55
, Issue.3
, pp. 691-697
-
-
Ohta, H.1
Sweeney, E.2
Masamune, A.3
Yatomi, Y.4
Hakomori, S.5
Igarashi, Y.6
-
116
-
-
61649099040
-
Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway
-
Coward, J.; Ambrosini, G.; Musi, E.; Truman, J. P.; Haimovitz- Friedman, A.; Allegood, J. C.; Wang, E.; Merrill, A. H., Jr.; Schwartz, G. K., Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway. Autophagy, 2009, 5 (2), 184-193.
-
(2009)
Autophagy
, vol.5
, Issue.2
, pp. 184-193
-
-
Coward, J.1
Ambrosini, G.2
Musi, E.3
Truman, J.P.4
Haimovitz-Friedman, A.5
Allegood, J.C.6
Wang, E.7
Merrill Jr., A.H.8
Schwartz, G.K.9
-
117
-
-
79954625512
-
A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors
-
Dickson, M. A.; Carvajal, R. D.; Merrill, A. H.; Gonen, M.; Cane, L. M.; Schwartz, G. K., A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. Clin. Cancer Res., 2011.
-
(2011)
Clin. Cancer Res
-
-
Dickson, M.A.1
Carvajal, R.D.2
Merrill, A.H.3
Gonen, M.4
Cane, L.M.5
Schwartz, G.K.6
-
118
-
-
0030905826
-
A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin
-
Schwartz, G. K.; Ward, D.; Saltz, L.; Casper, E. S.; Spiess, T.; Mullen, E.; Woodworth, J.; Venuti, R.; Zervos, P.; Storniolo, A. M.; Kelsen, D. P., A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin. Clin. Cancer Res., 1997, 3 (4), 537-543.
-
(1997)
Clin. Cancer Res
, vol.3
, Issue.4
, pp. 537-543
-
-
Schwartz, G.K.1
Ward, D.2
Saltz, L.3
Casper, E.S.4
Spiess, T.5
Mullen, E.6
Woodworth, J.7
Venuti, R.8
Zervos, P.9
Storniolo, A.M.10
Kelsen, D.P.11
-
119
-
-
51649122574
-
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia
-
Paugh, S. W.; Paugh, B. S.; Rahmani, M.; Kapitonov, D.; Almenara, J. A.; Kordula, T.; Milstien, S.; Adams, J. K.; Zipkin, R. E.; Grant, S.; Spiegel, S., A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood, 2008, 112 (4), 1382-1391.
-
(2008)
Blood
, vol.112
, Issue.4
, pp. 1382-1391
-
-
Paugh, S.W.1
Paugh, B.S.2
Rahmani, M.3
Kapitonov, D.4
Almenara, J.A.5
Kordula, T.6
Milstien, S.7
Adams, J.K.8
Zipkin, R.E.9
Grant, S.10
Spiegel, S.11
-
120
-
-
77951085269
-
A novel sphingosine kinase inhibitor induces autophagy in tumor cells
-
Beljanski, V.; Knaak, C.; Smith, C. D., A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J. Pharmacol. Exp. Ther., 2010, 333 (2), 454-464.
-
(2010)
J. Pharmacol. Exp. Ther
, vol.333
, Issue.2
, pp. 454-464
-
-
Beljanski, V.1
Knaak, C.2
Smith, C.D.3
-
121
-
-
0036494268
-
Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models
-
Azuma, H.; Takahara, S.; Ichimaru, N.; Wang, J. D.; Itoh, Y.; Otsuki, Y.; Morimoto, J.; Fukui, R.; Hoshiga, M.; Ishihara, T.; Nonomura, N.; Suzuki, S.; Okuyama, A.; Katsuoka, Y., Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res., 2002, 62 (5), 1410-1419.
-
(2002)
Cancer Res
, vol.62
, Issue.5
, pp. 1410-1419
-
-
Azuma, H.1
Takahara, S.2
Ichimaru, N.3
Wang, J.D.4
Itoh, Y.5
Otsuki, Y.6
Morimoto, J.7
Fukui, R.8
Hoshiga, M.9
Ishihara, T.10
Nonomura, N.11
Suzuki, S.12
Okuyama, A.13
Katsuoka, Y.14
-
122
-
-
0038286415
-
Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment
-
Azuma, H.; Takahara, S.; Horie, S.; Muto, S.; Otsuki, Y.; Katsuoka, Y., Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment. J. Urol. 2003, 169 (6), 2372-237.
-
(2003)
J. Urol
, vol.169
, Issue.6
, pp. 237-2372
-
-
Azuma, H.1
Takahara, S.2
Horie, S.3
Muto, S.4
Otsuki, Y.5
Katsuoka, Y.6
-
123
-
-
0030004270
-
Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
-
Sweeney, E. A.; Sakakura, C.; Shirahama, T.; Masamune, A.; Ohta, H.; Hakomori, S.; Igarashi, Y., Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Int. J. Cancer 1996, 66 (3), 358-366.
-
(1996)
Int. J. Cancer
, vol.66
, Issue.3
, pp. 358-366
-
-
Sweeney, E.A.1
Sakakura, C.2
Shirahama, T.3
Masamune, A.4
Ohta, H.5
Hakomori, S.6
Igarashi, Y.7
-
124
-
-
74949143796
-
Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60
-
Park, S. R.; Cho, H. J.; Moon, K. J.; Chun, K. H.; Kong, S. Y.; Yoon, S. S.; Lee, J. S.; Park, S., Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and N-monomethylphytosphingosine, in human leukemia cell line HL60. Leuk. Lymphoma, 2010, 51 (1), 132-145.
-
(2010)
Leuk. Lymphoma
, vol.51
, Issue.1
, pp. 132-145
-
-
Park, S.R.1
Cho, H.J.2
Moon, K.J.3
Chun, K.H.4
Kong, S.Y.5
Yoon, S.S.6
Lee, J.S.7
Park, S.8
-
125
-
-
73649107657
-
Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis
-
Fyrst, H.; Oskouian, B.; Bandhuvula, P.; Gong, Y.; Byun, H. S.; Bittman, R.; Lee, A. R.; Saba, J. D., Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer Res., 2009, 69 (24), 9457-9464.
-
(2009)
Cancer Res
, vol.69
, Issue.24
, pp. 9457-9464
-
-
Fyrst, H.1
Oskouian, B.2
Bandhuvula, P.3
Gong, Y.4
Byun, H.S.5
Bittman, R.6
Lee, A.R.7
Saba, J.D.8
-
126
-
-
33644830810
-
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
-
Visentin, B.; Vekich, J.; Sibbald, B.; Cavalli, A.; Moreno, K.; Matteo, R.; Garland, W.; Lu, Y.; Yu, S.; Hall, H.; Kundra, V.; Mills, G.; Sabbadini, R., Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell, 2006, 9, 225-238.
-
(2006)
Cancer Cell
, vol.9
, pp. 225-238
-
-
Visentin, B.1
Vekich, J.2
Sibbald, B.3
Cavalli, A.4
Moreno, K.5
Matteo, R.6
Garland, W.7
Lu, Y.8
Yu, S.9
Hall, H.10
Kundra, V.11
Mills, G.12
Sabbadini, R.13
-
127
-
-
34250732783
-
Role of acid ceramidase in resistance to FasL: Therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy
-
Elojeimy, S.; Liu, X.; McKillop, J. C.; El-Zawahry, A. M.; Holman, D. H.; Cheng, J. Y.; Meacham, W. D.; Mahdy, A. E.; Saad, A. F.; Turner, L. S.; Cheng, J.T A. D.; Dong, J. Y.; Bielawska, A.; Hannun, Y. A.; Norris, J. S., Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol. Ther., 2007, 15 (7), 1259-1263.
-
(2007)
Mol. Ther
, vol.15
, Issue.7
, pp. 1259-1263
-
-
Elojeimy, S.1
Liu, X.2
McKillop, J.C.3
El-Zawahry, A.M.4
Holman, D.H.5
Cheng, J.Y.6
Meacham, W.D.7
Mahdy, A.E.8
Saad, A.F.9
Turner, L.S.10
Cheng, J.T.A.D.11
Dong, J.Y.12
Bielawska, A.13
Hannun, Y.A.14
Norris, J.S.15
-
128
-
-
42549100356
-
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy
-
Saad, A. F.; Meacham, W. D.; Bai, A.; Anelli, V.; Elojeimy, S.; Mahdy, A. E.; Turner, L. S.; Cheng, J.; Bielawska, A.; Bielawski, J.; Keane, T. E.; Obeid, L. M.; Hannun, Y. A.; Norris, J. S.; Liu, X., The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol. Ther., 2007, 6 (9), 1455-1460.
-
(2007)
Cancer Biol. Ther
, vol.6
, Issue.9
, pp. 1455-1460
-
-
Saad, A.F.1
Meacham, W.D.2
Bai, A.3
Anelli, V.4
Elojeimy, S.5
Mahdy, A.E.6
Turner, L.S.7
Cheng, J.8
Bielawska, A.9
Bielawski, J.10
Keane, T.E.11
Obeid, L.M.12
Hannun, Y.A.13
Norris, J.S.14
Liu, X.15
-
129
-
-
38449123215
-
Acid ceramidase inhibition: A novel target for cancer therapy
-
Liu, X.; Elojeimy, S.; Turner, L. S.; Mahdy, A. E.; Zeidan, Y. H.; Bielawska, A.; Bielawski, J.; Dong, J. Y.; El-Zawahry, A. M.; Guo, G. W.; Hannun, Y. A.; Holman, D. H.; Rubinchik, S.; Szulc, Z.; Keane, T. E.; Tavassoli, M.; Norris, J. S., Acid ceramidase inhibition: a novel target for cancer therapy. Front. Biosci., 2008, 13, 2293-2298.
-
(2008)
Front. Biosci
, vol.13
, pp. 2293-2298
-
-
Liu, X.1
Elojeimy, S.2
Turner, L.S.3
Mahdy, A.E.4
Zeidan, Y.H.5
Bielawska, A.6
Bielawski, J.7
Dong, J.Y.8
El-Zawahry, A.M.9
Guo, G.W.10
Hannun, Y.A.11
Holman, D.H.12
Rubinchik, S.13
Szulc, Z.14
Keane, T.E.15
Tavassoli, M.16
Norris, J.S.17
-
130
-
-
61649091570
-
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer
-
Mahdy, A. E.; Cheng, J. C.; Li, J.; Elojeimy, S.; Meacham, W. D.; Turner, L. S.; Bai, A.; Gault, C. R.; McPherson, A. S.; Garcia, N.; Beckham, T. H.; Saad, A.; Bielawska, A.; Bielawski, J.; Hannun, Y. A.; Keane, T. E.; Taha, M. I.; Hammouda, H. M.; Norris, J. S.; Liu, X., Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol. Ther., 2009, 17 (3), 430-438.
-
(2009)
Mol. Ther
, vol.17
, Issue.3
, pp. 430-438
-
-
Mahdy, A.E.1
Cheng, J.C.2
Li, J.3
Elojeimy, S.4
Meacham, W.D.5
Turner, L.S.6
Bai, A.7
Gault, C.R.8
McPherson, A.S.9
Garcia, N.10
Beckham, T.H.11
Saad, A.12
Bielawska, A.13
Bielawski, J.14
Hannun, Y.A.15
Keane, T.E.16
Taha, M.I.17
Hammouda, H.M.18
Norris, J.S.19
Liu, X.20
more..
-
131
-
-
79251525201
-
Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells
-
Kim, Y. J.; Kim, E. A.; Sohn, U. D.; Yim, C. B.; Im, C., Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells. Korean J. Physiol. Pharmacol., 2010, 14 (6), 441-447.
-
(2010)
Korean J. Physiol. Pharmacol
, vol.14
, Issue.6
, pp. 441-447
-
-
Kim, Y.J.1
Kim, E.A.2
Sohn, U.D.3
Yim, C.B.4
Im, C.5
-
132
-
-
79958144606
-
Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide
-
Gouaze-Andersson, V.; Flowers, M.; Karimi, R.; Fabrias, G.; Delgado, A.; Casas, J.; Cabot, M. C., Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide. Prostate 2010.
-
(2010)
Prostate
-
-
Gouaze-Andersson, V.1
Flowers, M.2
Karimi, R.3
Fabrias, G.4
Delgado, A.5
Casas, J.6
Cabot, M.C.7
-
133
-
-
0028108788
-
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
-
Dobrowsky, R.; Werner, M.; Castellino, A.; Chao, M.; Hannun, Y., Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science, 1994, 265, 1596-1599.
-
(1994)
Science
, vol.265
, pp. 1596-1599
-
-
Dobrowsky, R.1
Werner, M.2
Castellino, A.3
Chao, M.4
Hannun, Y.5
-
134
-
-
0027076191
-
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine
-
Chao, R.; Kahn, W.; Hannun, Y., Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J. Biol. Chem., 1992, 267 (33), 23459-23462.
-
(1992)
J. Biol. Chem
, vol.267
, Issue.33
, pp. 23459-23462
-
-
Chao, R.1
Kahn, W.2
Hannun, Y.3
-
135
-
-
11144239577
-
N., gamma- Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis
-
Jiang, Q.; Wong, J.; Fyrst, H.; Saba, J. D.; Ames, B. N., gamma- Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc. Natl. Acad. Sci. USA, 2004, 101 (51), 17825-17830.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, Issue.51
, pp. 17825-17830
-
-
Jiang, Q.1
Wong, J.2
Fyrst, H.3
Saba, J.D.4
Ames, B.N.5
-
136
-
-
34447115107
-
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells
-
Kraveka, J.; Li, L.; Szulc, Z.; Bielawski, J.; Ogretmen, B.; Hannun, Y.; Obeid, L.; Bielawska, A., Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J. Biol. Chem., 2007, 282, 16718-16728.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 16718-16728
-
-
Kraveka, J.1
Li, L.2
Szulc, Z.3
Bielawski, J.4
Ogretmen, B.5
Hannun, Y.6
Obeid, L.7
Bielawska, A.8
-
137
-
-
79954419484
-
The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner
-
Kumar, A.; Byun, H. S.; Bittman, R.; Saba, J. D., The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell. Signal., 2011.
-
(2011)
Cell. Signal
-
-
Kumar, A.1
Byun, H.S.2
Bittman, R.3
Saba, J.D.4
-
138
-
-
79959958500
-
S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism
-
Kumar, A.; Oskouian, B.; Fyrst, H.; Zhang, M.; Paris, F.; Saba, J. D., S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Cell Death Dis., 2011, 2 (1), e119.
-
(2011)
Cell Death Dis
, vol.2
, Issue.1
-
-
Kumar, A.1
Oskouian, B.2
Fyrst, H.3
Zhang, M.4
Paris, F.5
Saba, J.D.6
-
139
-
-
53149129878
-
Progress in childhood cancer: 50 years of research collaboration, a report from the Children's Oncology Group
-
O'Leary, M.; Krailo, M.; Anderson, J. R.; Reaman, G. H., Progress in childhood cancer: 50 years of research collaboration, a report from the Children's Oncology Group. Semin. Oncol.,2008, 35 (5), 484-493.
-
(2008)
Semin. Oncol
, vol.35
, Issue.5
, pp. 484-493
-
-
O'Leary, M.1
Krailo, M.2
Anderson, J.R.3
Reaman, G.H.4
-
140
-
-
0036732415
-
Sphingosine-1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring
-
Paris, F.; Perez, G.; Fuks, Z.; Haimovitz-Friedman, A.; Nguyen, H.; Bose, M.; Ilagan, A.; Hunt, P.; Morgan, W.; Tilly, J.; Kolesnick, R., Sphingosine-1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat. Med., 2002, 8, 901-902.
-
(2002)
Nat. Med
, vol.8
, pp. 901-902
-
-
Paris, F.1
Perez, G.2
Fuks, Z.3
Haimovitz-Friedman, A.4
Nguyen, H.5
Bose, M.6
Ilagan, A.7
Hunt, P.8
Morgan, W.9
Tilly, J.10
Kolesnick, R.11
-
141
-
-
78649914463
-
Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis
-
Bonnaud, S.; Niaudet, C.; Legoux, F.; Corre, I.; Delpon, G.; Saulquin, X.; Fuks, Z.; Gaugler, M. H.; Kolesnick, R.; Paris, F., Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. Cancer Res., 2010, 70 (23), 9905-9915.
-
(2010)
Cancer Res
, vol.70
, Issue.23
, pp. 9905-9915
-
-
Bonnaud, S.1
Niaudet, C.2
Legoux, F.3
Corre, I.4
Delpon, G.5
Saulquin, X.6
Fuks, Z.7
Gaugler, M.H.8
Kolesnick, R.9
Paris, F.10
-
142
-
-
0041589527
-
Microvascular function regulates intestinal crypt response to radiation
-
Maj, J.; Paris, F.; Haimovitz-Friedman, A.; Venkatraman, E.; Kolesnick, R.; Fuks, Z., Microvascular function regulates intestinal crypt response to radiation. Cancer Res., 2003, 63 (15), 4338-4341.
-
(2003)
Cancer Res
, vol.63
, Issue.15
, pp. 4338-4341
-
-
Maj, J.1
Paris, F.2
Haimovitz-Friedman, A.3
Venkatraman, E.4
Kolesnick, R.5
Fuks, Z.6
-
143
-
-
76249095670
-
Regulation of ceramide synthase - mediated crypt epithelium apoptosis by DNA damage repair enzymes
-
Rotolo, J. A.; Mesicek, J.; Maj, J.; Truman, J. P.; Haimovitz- Friedman, A.; Kolesnick, R.; Fuks, Z., Regulation of ceramide synthase- mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res., 2010, 70 (3), 957-967.
-
(2010)
Cancer Res
, vol.70
, Issue.3
, pp. 957-967
-
-
Rotolo, J.A.1
Mesicek, J.2
Maj, J.3
Truman, J.P.4
Haimovitz-Friedman, A.5
Kolesnick, R.6
Fuks, Z.7
-
144
-
-
0037373487
-
Graft-versus-host disease can be separated from graft-versuslymphoma effects by control of lymphocyte trafficking with FTY720
-
Kim, Y. M.; Sachs, T.; Asavaroengchai, W.; Bronson, R.; Sykes, M., Graft-versus-host disease can be separated from graft-versuslymphoma effects by control of lymphocyte trafficking with FTY720. J. Clin. Invest., 2003, 111 (5), 659-669.
-
(2003)
J. Clin. Invest
, vol.111
, Issue.5
, pp. 659-669
-
-
Kim, Y.M.1
Sachs, T.2
Asavaroengchai, W.3
Bronson, R.4
Sykes, M.5
-
145
-
-
79955771110
-
S1P lyase (SPL): A novel therapeutic target for ischemia/ reperfusion injury of the heart
-
Bandhuvula, P.; Honbo, N.; Wang, G. Y.; Jin, Z. Q.; Fyrst, H.; Zhang, M.; Borowsky, A. D.; Dillard, L.; Karliner, J. S.; Saba, J. D., S1P lyase (SPL): a novel therapeutic target for ischemia/ reperfusion injury of the heart. Am. J. Physiol. Heart Circ. Physiol., 2011.
-
(2011)
Am. J. Physiol. Heart Circ. Physiol
-
-
Bandhuvula, P.1
Honbo, N.2
Wang, G.Y.3
Jin, Z.Q.4
Fyrst, H.5
Zhang, M.6
Borowsky, A.D.7
Dillard, L.8
Karliner, J.S.9
Saba, J.D.10
-
146
-
-
80051658461
-
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression
-
in prsee
-
Zhao, Y.; Gorshkova, I.; Berdyshev, E.; He, D.; Fu, P.; Ma, W.; Su, Y.; Usatyuk, P.; Pendyala, S.; Oskouian, B.; Saba, J.; Garcia, J.; Natarajan, V., Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am. J. Respir. Cell Mol. Biol., 2011.(in prsee)
-
(2011)
Am. J. Respir. Cell Mol. Biol
-
-
Zhao, Y.1
Gorshkova, I.2
Berdyshev, E.3
He, D.4
Fu, P.5
Ma, W.6
Su, Y.7
Usatyuk, P.8
Pendyala, S.9
Oskouian, B.10
Saba, J.11
Garcia, J.12
Natarajan, V.13
|