-
1
-
-
67649980370
-
Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders
-
Bagdanoff J, Donoviel M, Nouraldeen A, Tarver J, Fu Q, Carlsen M, Jessop T, Zhang H, Hazelwood J, Nguyen H, Baugh S, Gardyan M, Terranova K, Barbosa J, Yan J, Bednarz M, Layek S, Courtney L, Taylor J, Digeorge-Foushee A, Gopinathan S, Bruce D, Smith T, Moran L, O'Neill E, Kramer J, Lai Z, Kimball S, Liu Q, Sun W, Yu S, Swaffield J, Wilson A, Main A, Carson K, Oravecz T, Augeri D. Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders. J Med Chem 52: 3941-3953, 2009.
-
(2009)
J Med Chem
, vol.52
, pp. 3941-3953
-
-
Bagdanoff, J.1
Donoviel, M.2
Nouraldeen, A.3
Tarver, J.4
Fu, Q.5
Carlsen, M.6
Jessop, T.7
Zhang, H.8
Hazelwood, J.9
Nguyen, H.10
Baugh, S.11
Gardyan, M.12
Terranova, K.13
Barbosa, J.14
Yan, J.15
Bednarz, M.16
Layek, S.17
Courtney, L.18
Taylor, J.19
Digeorge-Foushee, A.20
Gopinathan, S.21
Bruce, D.22
Smith, T.23
Moran, L.24
O'Neill, E.25
Kramer, J.26
Lai, Z.27
Kimball, S.28
Liu, Q.29
Sun, W.30
Yu, S.31
Swaffield, J.32
Wilson, A.33
Main, A.34
Carson, K.35
Oravecz, T.36
Augeri, D.37
more..
-
2
-
-
37249006747
-
A rapid fluorescent assay for sphingosine-1-phosphate lyase enzyme activity
-
Bandhuvula P, Fyrst H, Saba J. A rapid fluorescent assay for sphingosine-1-phosphate lyase enzyme activity. J Lipid Res 48: 2769-2778, 2007.
-
(2007)
J Lipid Res
, vol.48
, pp. 2769-2778
-
-
Bandhuvula, P.1
Fyrst, H.2
Saba, J.3
-
3
-
-
77951213051
-
Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver
-
Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL. Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J Biol Chem 285: 10880-10889, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 10880-10889
-
-
Bektas, M.1
Allende, M.L.2
Lee, B.G.3
Chen, W.4
Amar, M.J.5
Remaley, A.T.6
Saba, J.D.7
Proia, R.L.8
-
4
-
-
77953790503
-
An update on sphingosine-1-phosphate and other sphingolipid mediators
-
Fyrst H, Saba J. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol 6: 489-497, 2010.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 489-497
-
-
Fyrst, H.1
Saba, J.2
-
5
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate
-
Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325: 1254-1257, 2009.
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.C.1
Allegood, J.2
Maceyka, M.3
Strub, G.M.4
Harikumar, K.B.5
Singh, S.K.6
Luo, C.7
Marmorstein, R.8
Kordula, T.9
Milstien, S.10
Spiegel, S.11
-
6
-
-
67650263679
-
Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion
-
Hofmann U, Burkard N, Vogt C, Thoma A, Frantz S, Ertl G, Ritter O, Bonz A. Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion. Cardiovasc Res 83: 285-293, 2009.
-
(2009)
Cardiovasc Res
, vol.83
, pp. 285-293
-
-
Hofmann, U.1
Burkard, N.2
Vogt, C.3
Thoma, A.4
Frantz, S.5
Ertl, G.6
Ritter, O.7
Bonz, A.8
-
7
-
-
67449152428
-
Sphingosine-1-phosphate and modulation of vascular tone
-
Igarashi J, Michel T. Sphingosine-1-phosphate and modulation of vascular tone. Cardiovasc Res 82: 212-220, 2009.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 212-220
-
-
Igarashi, J.1
Michel, T.2
-
8
-
-
45849147642
-
Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation
-
Jin Z, Karliner J, Vessey D. Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation. Cardiovasc Res 79: 134-140, 2008.
-
(2008)
Cardiovasc Res
, vol.79
, pp. 134-140
-
-
Jin, Z.1
Karliner, J.2
Vessey, D.3
-
9
-
-
34548411384
-
A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/ reperfusion injury
-
Jin Z, Zhang J, Huang Y, Hoover H, Vessey D, Karliner J. A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/ reperfusion injury. Cardiovasc Res 76: 41-50, 2007.
-
(2007)
Cardiovasc Res
, vol.76
, pp. 41-50
-
-
Jin, Z.1
Zhang, J.2
Huang, Y.3
Hoover, H.4
Vessey, D.5
Karliner, J.6
-
10
-
-
0036083489
-
Cardioprotection mediated by sphingosine-1- phosphate and ganglioside GM-1 in wild-type and PKC-e knockout mouse hearts
-
Jin Z, Zhou H, Zhu P, Honbo N, Mochly-Rosen D, Messing R, Goetzl E, Karliner J, Gray M. Cardioprotection mediated by sphingosine-1- phosphate and ganglioside GM-1 in wild-type and PKC-e knockout mouse hearts. Am J Physiol Heart Circ Physiol 282: H1970-H1977, 2002.
-
(2002)
Am J Physiol Heart Circ Physiol
, vol.282
-
-
Jin, Z.1
Zhou, H.2
Zhu, P.3
Honbo, N.4
Mochly-Rosen, D.5
Messing, R.6
Goetzl, E.7
Karliner, J.8
Gray, M.9
-
11
-
-
4944246652
-
Sphingosine kinase activation mediates ischemic preconditioning in murine heart
-
Jin ZQ, Goetzl EJ, Karliner JS. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation 110: 1980-1989, 2004.
-
(2004)
Circulation
, vol.110
, pp. 1980-1989
-
-
Jin, Z.Q.1
Goetzl, E.J.2
Karliner, J.S.3
-
12
-
-
0034856123
-
The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes
-
Karliner JS, Honbo N, Summers K, Gray MO, Goetzl EJ. The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. J Mol Cell Cardiol 33: 1713-1717, 2001.
-
(2001)
J Mol Cell Cardiol
, vol.33
, pp. 1713-1717
-
-
Karliner, J.S.1
Honbo, N.2
Summers, K.3
Gray, M.O.4
Goetzl, E.J.5
-
13
-
-
35848933939
-
HDL and its sphingosine-1-phosphate content in cardioprotection
-
Keul P, Sattler K, Levkau B. HDL and its sphingosine-1-phosphate content in cardioprotection. Heart Fail Rev 12: 301-306, 2007.
-
(2007)
Heart Fail Rev
, vol.12
, pp. 301-306
-
-
Keul, P.1
Sattler, K.2
Levkau, B.3
-
14
-
-
69149089682
-
Lyase to live by: Sphingosine phosphate lyase as a therapeutic target
-
Kumar A, Saba JD. Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert Opin Ther Targets 13: 1013-1025, 2009.
-
(2009)
Expert Opin Ther Targets
, vol.13
, pp. 1013-1025
-
-
Kumar, A.1
Saba, J.D.2
-
15
-
-
9344262922
-
High-density lipoprotein stimulates myocardial perfusion in vivo
-
Levkau B, Hermann S, Theilmeier G, van der Giet M, Chun J, Schober O, Schäfers M. High-density lipoprotein stimulates myocardial perfusion in vivo. Circulation 110: 3355-3359, 2004.
-
(2004)
Circulation
, vol.110
, pp. 3355-3359
-
-
Levkau, B.1
Hermann, S.2
Theilmeier, G.3
van der Giet, M.4
Chun, J.5
Schober, O.6
Schäfers, M.7
-
16
-
-
34250809874
-
Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury
-
Means C, Xiao C, Li Z, Zhang T, Omens J, Ishii I, Chun J, Brown J. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 292: H2944-H2951, 2007.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
-
-
Means, C.1
Xiao, C.2
Li, Z.3
Zhang, T.4
Omens, J.5
Ishii, I.6
Chun, J.7
Brown, J.8
-
17
-
-
67449138784
-
Sphingosine 1-phosphate receptor signalling in the heart
-
Means CK, Brown JH. Sphingosine 1-phosphate receptor signalling in the heart. Cardiovasc Res 82: 193-200, 2009.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 193-200
-
-
Means, C.K.1
Brown, J.H.2
-
18
-
-
11144356028
-
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
-
Nofer JR, van der Giet M, Tölle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Gödecke A, Ishii I, Kleuser B, Schäfers M, Fobker M, Zidek W, Assmann G, Chun J, Levkau B. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest 113: 569-581, 2004.
-
(2004)
J Clin Invest
, vol.113
, pp. 569-581
-
-
Nofer, J.R.1
van der Giet, M.2
Tölle, M.3
Wolinska, I.4
von Wnuck Lipinski, K.5
Baba, H.A.6
Tietge, U.J.7
Gödecke, A.8
Ishii, I.9
Kleuser, B.10
Schäfers, M.11
Fobker, M.12
Zidek, W.13
Assmann, G.14
Chun, J.15
Levkau, B.16
-
19
-
-
77951644400
-
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
-
Olsen J, Vermeulen M, Santamaria A, Kumar C, Miller M, Jensen L, Gnad F, Cox J, Jensen S, Nigg E, Bruna S, Mann M. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3: ra3, 2010.
-
(2010)
Sci Signal
, vol.3
-
-
Olsen, J.1
Vermeulen, M.2
Santamaria, A.3
Kumar, C.4
Miller, M.5
Jensen, L.6
Gnad, F.7
Cox, J.8
Jensen, S.9
Nigg, E.10
Bruna, S.11
Mann, M.12
-
20
-
-
33751225686
-
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer
-
Oskouian B, Sooriyakumaran P, Borowsky A, Crans A, DIllard-Telm L, Tam Y, Bandhuvula P, Saba J. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer. Proc Natl Acad Sci USA 103: 17384-17389, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17384-17389
-
-
Oskouian, B.1
Sooriyakumaran, P.2
Borowsky, A.3
Crans, A.4
Dillard-Telm, L.5
Tam, Y.6
Bandhuvula, P.7
Saba, J.8
-
21
-
-
67449164535
-
Sphingosine-1-phosphate as a mediator of highdensity lipoprotein effects in cardiovascular protection
-
Sattler K, Levkau B. Sphingosine-1-phosphate as a mediator of highdensity lipoprotein effects in cardiovascular protection. Cardiovasc Res 82: 201-211, 2009.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 201-211
-
-
Sattler, K.1
Levkau, B.2
-
22
-
-
33845894956
-
PDGF signaling specificity is mediated through multiple immediate early genes
-
Schmahl J, Raymond CS, Soriano P. PDGF signaling specificity is mediated through multiple immediate early genes. Nat Genet 39: 52-60, 2007.
-
(2007)
Nat Genet
, vol.39
, pp. 52-60
-
-
Schmahl, J.1
Raymond, C.S.2
Soriano, P.3
-
23
-
-
24644469502
-
Lymphocyte sequestration through S1P lyase inhibition an disruption of S1P gradients
-
Schwab S, Pereira J, Matloubian M, Xu Y, Huang Y, Cyster J. Lymphocyte sequestration through S1P lyase inhibition an disruption of S1P gradients. Science 309: 1735-1739, 2005.
-
(2005)
Science
, vol.309
, pp. 1735-1739
-
-
Schwab, S.1
Pereira, J.2
Matloubian, M.3
Xu, Y.4
Huang, Y.5
Cyster, J.6
-
24
-
-
77953771709
-
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
-
Serra M, Saba JD. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul 50: 349-362, 2010.
-
(2010)
Adv Enzyme Regul
, vol.50
, pp. 349-362
-
-
Serra, M.1
Saba, J.D.2
-
25
-
-
77956862615
-
Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1- phosphate
-
Siow D, Anderson C, Berdyshev E, Skobeleva A, Pitson S, Wattenberg B. Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1- phosphate. J Lipid Res 51: 2546-2559, 2010.
-
(2010)
J Lipid Res
, vol.51
, pp. 2546-2559
-
-
Siow, D.1
Anderson, C.2
Berdyshev, E.3
Skobeleva, A.4
Pitson, S.5
Wattenberg, B.6
-
26
-
-
79551648970
-
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration
-
Strub GM, Paillard M, Liang J, Gomez L, Allegood JC, Hait NC, Maceyka M, Price MM, Chen Q, Simpson DC, Kordula T, Milstien S, Lesnefsky EJ, Spiegel S. Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J 25: 600-612, 2011.
-
(2011)
FASEB J
, vol.25
, pp. 600-612
-
-
Strub, G.M.1
Paillard, M.2
Liang, J.3
Gomez, L.4
Allegood, J.C.5
Hait, N.C.6
Maceyka, M.7
Price, M.M.8
Chen, Q.9
Simpson, D.C.10
Kordula, T.11
Milstien, S.12
Lesnefsky, E.J.13
Spiegel, S.14
-
27
-
-
0035970197
-
Analysis of sphingosine-1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography
-
Sullards MC, Merrill AHJ. Analysis of sphingosine-1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography. Sci STKE 67: 1-11, 2001.
-
(2001)
Sci STKE
, vol.67
, pp. 1-11
-
-
Sullards, M.C.1
Merrill, A.H.J.2
-
28
-
-
49949099544
-
Sphingosine-1- phosphate signaling and biological activities in the cardiovascular system
-
Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. Sphingosine-1- phosphate signaling and biological activities in the cardiovascular system. Biochim Biophys Acta 1781: 483-488, 2008.
-
(2008)
Biochim Biophys Acta
, vol.1781
, pp. 483-488
-
-
Takuwa, Y.1
Okamoto, Y.2
Yoshioka, K.3
Takuwa, N.4
-
29
-
-
77749273758
-
High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia/reoxygenation through lipoprotein-associated sphingosine-1-phosphate
-
Tao R, Hoover H, Honbo N, Kalinowski M, Alano C, Karliner J, Raffai R. High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia/reoxygenation through lipoprotein-associated sphingosine-1-phosphate. Am J Physiol Heart Circ Physiol 298: H1022-H1028, 2010.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
-
-
Tao, R.1
Hoover, H.2
Honbo, N.3
Kalinowski, M.4
Alano, C.5
Karliner, J.6
Raffai, R.7
-
30
-
-
68249121132
-
Cardiomyocyte S1P1 receptor-mediated ERK signaling and desensitization
-
Tao R, Hoover H, Zhang J, Honbo N, Alano C, Karliner J. Cardiomyocyte S1P1 receptor-mediated ERK signaling and desensitization. J Cardiovasc Pharmacol 53: 486-494, 2009.
-
(2009)
J Cardiovasc Pharmacol
, vol.53
, pp. 486-494
-
-
Tao, R.1
Hoover, H.2
Zhang, J.3
Honbo, N.4
Alano, C.5
Karliner, J.6
-
31
-
-
33847680435
-
A sphingosine kinase-1 mutation determines cell fate during hypoxia in adult mouse cardiomyocytes
-
Tao R, Zhang J, Vessey D, Honbo N, Karliner J. A sphingosine kinase-1 mutation determines cell fate during hypoxia in adult mouse cardiomyocytes. Cardiovasc Res 74: 56-63, 2007.
-
(2007)
Cardiovasc Res
, vol.74
, pp. 56-63
-
-
Tao, R.1
Zhang, J.2
Vessey, D.3
Honbo, N.4
Karliner, J.5
-
32
-
-
70349629000
-
Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning
-
Vessey D, Li L, Honbo N, Karliner J. Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning. Am J Physiol Heart Circ Physiol 297: H1429-H1435, 2009.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.297
-
-
Vessey, D.1
Li, L.2
Honbo, N.3
Karliner, J.4
-
33
-
-
33749673952
-
Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury
-
Vessey DA, Kelley M, Li L, Huang Y, Zhou HZ, Zhu BQ, Karliner JS. Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury. Med Sci Monit 12: BR318-BR324, 2006.
-
(2006)
Med Sci Monit
, vol.12
-
-
Vessey, D.A.1
Kelley, M.2
Li, L.3
Huang, Y.4
Zhou, H.Z.5
Zhu, B.Q.6
Karliner, J.S.7
-
34
-
-
58149474166
-
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions
-
Vogel P, Donoviel M, Read R, Hansen G, Hazlewood J, Anderson S, Sun W, Swaffield J, Oravecz T. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS ONE 4: e4112, 2009.
-
(2009)
PLoS ONE
, vol.4
-
-
Vogel, P.1
Donoviel, M.2
Read, R.3
Hansen, G.4
Hazlewood, J.5
Anderson, S.6
Sun, W.7
Swaffield, J.8
Oravecz, T.9
-
35
-
-
33745218278
-
Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry
-
Zhan X, Desiderio DM. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. Anal Biochem 354: 279-289, 2006.
-
(2006)
Anal Biochem
, vol.354
, pp. 279-289
-
-
Zhan, X.1
Desiderio, D.M.2
-
36
-
-
36148982619
-
Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia
-
Zhang J, Honbo N, Goetzl EJ, Chatterjee K, Karliner JS, Gray MO. Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia. Am J Physiol Heart Circ Physiol 293: H3150-H3158, 2007.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.293
-
-
Zhang, J.1
Honbo, N.2
Goetzl, E.J.3
Chatterjee, K.4
Karliner, J.S.5
Gray, M.O.6
-
37
-
-
0032567648
-
Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast
-
Zhou J, Saba J. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem Biophys Res Commun 242: 502-507, 1998.
-
(1998)
Biochem Biophys Res Commun
, vol.242
, pp. 502-507
-
-
Zhou, J.1
Saba, J.2
|