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Volumn 7, Issue 7, 2009, Pages 1086-1098

Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID 1 RECEPTOR; CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; CERAMIDE SYNTHASE 3; CERAMIDE SYNTHASE 6; DIHYDROCERAMIDE DESATURASE; METHANANDAMIDE; SERINE PALMITOYLTRANSFERASE; SMALL INTERFERING RNA; SPHINGOSINE KINASE 1; SYNTHETASE; UNCLASSIFIED DRUG;

EID: 67651151234     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0361     Document Type: Article
Times cited : (49)

References (51)
  • 1
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active sphingolipids in cancer pathogenesis and treatment
    • Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004;4:604-16.
    • (2004) Nat Rev Cancer , vol.4 , pp. 604-616
    • Ogretmen, B.1    Hannun, Y.A.2
  • 2
    • 33748746334 scopus 로고    scopus 로고
    • When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis
    • Pewzner-Jung Y, Ben-Dor S, Futerman AH. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: insights into the regulation of ceramide synthesis. J Biol Chem 2006;281:25001-5.
    • (2006) J Biol Chem , vol.281 , pp. 25001-25005
    • Pewzner-Jung, Y.1    Ben-Dor, S.2    Futerman, A.H.3
  • 3
    • 33644836567 scopus 로고    scopus 로고
    • Importance of C16 ceramide accumulation during apoptosis in prostate cancer cells
    • Eto M, Bennouna J, Hunter OC, Lotze MT, Amoscato AA. Importance of C16 ceramide accumulation during apoptosis in prostate cancer cells. Int J Urol 2006; 13:148-56.
    • (2006) Int J Urol , vol.13 , pp. 148-156
    • Eto, M.1    Bennouna, J.2    Hunter, O.C.3    Lotze, M.T.4    Amoscato, A.A.5
  • 4
    • 0038352072 scopus 로고    scopus 로고
    • BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome
    • Kroesen BJ, Jacobs S, Pettus BJ, et al. BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem 2003;278:14723-31.
    • (2003) J Biol Chem , vol.278 , pp. 14723-14731
    • Kroesen, B.J.1    Jacobs, S.2    Pettus, B.J.3
  • 5
    • 0035957921 scopus 로고    scopus 로고
    • Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria
    • Kroesen BJ, Pettus B, Luberto C, et al. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem 2001;276:13606-14.
    • (2001) J Biol Chem , vol.276 , pp. 13606-13614
    • Kroesen, B.J.1    Pettus, B.2    Luberto, C.3
  • 6
    • 7244244035 scopus 로고    scopus 로고
    • Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas
    • Koybasi S, Senkal CE, Sundararaj K, et al. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 2004;279:44311-9.
    • (2004) J Biol Chem , vol.279 , pp. 44311-44319
    • Koybasi, S.1    Senkal, C.E.2    Sundararaj, K.3
  • 7
    • 33751198532 scopus 로고    scopus 로고
    • Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma
    • Gustafsson K, Christensson B, Sander B, Flygare J. Cannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphoma. Mol Pharmacol 2006;70:1612-20.
    • (2006) Mol Pharmacol , vol.70 , pp. 1612-1620
    • Gustafsson, K.1    Christensson, B.2    Sander, B.3    Flygare, J.4
  • 8
    • 33746138649 scopus 로고    scopus 로고
    • Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
    • Carracedo A, Gironella M, Lorente M, et al. Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 2006;66:6748-55.
    • (2006) Cancer Res , vol.66 , pp. 6748-6755
    • Carracedo, A.1    Gironella, M.2    Lorente, M.3
  • 9
    • 37349095918 scopus 로고    scopus 로고
    • Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: A new marker of cannabinoid antitumoral activity?
    • Blazquez C, Carracedo A, Salazar M, et al. Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? Neuropharmacology 2008;54:235-43.
    • (2008) Neuropharmacology , vol.54 , pp. 235-243
    • Blazquez, C.1    Carracedo, A.2    Salazar, M.3
  • 10
    • 33748747214 scopus 로고    scopus 로고
    • LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity
    • Mizutani Y, Kihara A, Igarashi Y. LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. Biochem J 2006;398:531-8.
    • (2006) Biochem J , vol.398 , pp. 531-538
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 11
    • 23944483995 scopus 로고    scopus 로고
    • Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
    • Mizutani Y, Kihara A, Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem J 2005;390:263-71.
    • (2005) Biochem J , vol.390 , pp. 263-271
    • Mizutani, Y.1    Kihara, A.2    Igarashi, Y.3
  • 12
    • 0014429876 scopus 로고
    • Biosynthesis of sphingolipid bases. II. Keto intermediates in synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri
    • Braun PE, Snell EE. Biosynthesis of sphingolipid bases. II. Keto intermediates in synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri. J Biol Chem 1968;243:3775-83.
    • (1968) J Biol Chem , vol.243 , pp. 3775-3783
    • Braun, P.E.1    Snell, E.E.2
  • 13
    • 0030660670 scopus 로고    scopus 로고
    • Conversion of dihydroceramide into ceramide: Involvement of a desaturase
    • Geeraert L, Mannaerts GP, van Veldhoven PP. Conversion of dihydroceramide into ceramide: involvement of a desaturase. Biochem J 1997;327:125-32.
    • (1997) Biochem J , vol.327 , pp. 125-132
    • Geeraert, L.1    Mannaerts, G.P.2    van Veldhoven, P.P.3
  • 15
    • 33846811196 scopus 로고    scopus 로고
    • Alemany R, van Koppen CJ, Danneberg K, Ter BraakM,Meyer Zu Heringdorf D. Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch Pharmacol 2007;374:413-28.
    • Alemany R, van Koppen CJ, Danneberg K, Ter BraakM,Meyer Zu Heringdorf D. Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch Pharmacol 2007;374:413-28.
  • 17
    • 0034614095 scopus 로고    scopus 로고
    • Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism
    • Maurer BJ, Melton L, Billups C, Cabot MC, Reynolds CP. Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism. J Natl Cancer Inst 2000;92:1897-909.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1897-1909
    • Maurer, B.J.1    Melton, L.2    Billups, C.3    Cabot, M.C.4    Reynolds, C.P.5
  • 18
    • 2442494074 scopus 로고    scopus 로고
    • Down-regulation of sphingosine kinase-1 by DNA damage: Dependence on proteases and p53
    • Taha TA, Osta W, Kozhaya L, et al. Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem 2004;279: 20546-54.
    • (2004) J Biol Chem , vol.279 , pp. 20546-20554
    • Taha, T.A.1    Osta, W.2    Kozhaya, L.3
  • 19
    • 12444323123 scopus 로고    scopus 로고
    • Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: Role of Bcl-2 expression
    • Bektas M, Jolly PS, Muller C, Eberle J, Spiegel S, Geilen CC. Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression. Oncogene 2005;24:178-87.
    • (2005) Oncogene , vol.24 , pp. 178-187
    • Bektas, M.1    Jolly, P.S.2    Muller, C.3    Eberle, J.4    Spiegel, S.5    Geilen, C.C.6
  • 20
    • 2142769665 scopus 로고    scopus 로고
    • Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells
    • Liu YY, Han TY, Yu JY, et al. Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells. J Lipid Res 2004;45:933-40.
    • (2004) J Lipid Res , vol.45 , pp. 933-940
    • Liu, Y.Y.1    Han, T.Y.2    Yu, J.Y.3
  • 21
    • 32144447613 scopus 로고    scopus 로고
    • Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells
    • Sun YL, Zhou GY, Li KN, et al. Suppression of glucosylceramide synthase by RNA interference reverses multidrug resistance in human breast cancer cells. Neoplasma 2006;53:1-8.
    • (2006) Neoplasma , vol.53 , pp. 1-8
    • Sun, Y.L.1    Zhou, G.Y.2    Li, K.N.3
  • 22
    • 0035399826 scopus 로고    scopus 로고
    • Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity
    • Olshefski RS, Ladisch S. Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity. Int J Cancer 2001;93:131-8.
    • (2001) Int J Cancer , vol.93 , pp. 131-138
    • Olshefski, R.S.1    Ladisch, S.2
  • 23
    • 33645462079 scopus 로고    scopus 로고
    • PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy
    • Dijkhuis AJ, Klappe K, Jacobs S, et al. PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy. Mol Cancer Ther 2006;5:593-601.
    • (2006) Mol Cancer Ther , vol.5 , pp. 593-601
    • Dijkhuis, A.J.1    Klappe, K.2    Jacobs, S.3
  • 24
    • 18144371163 scopus 로고    scopus 로고
    • Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
    • Gouaze V, Liu YY, Prickett CS, Yu JY, Giuliano AE, Cabot MC. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res 2005;65: 3861-7.
    • (2005) Cancer Res , vol.65 , pp. 3861-3867
    • Gouaze, V.1    Liu, Y.Y.2    Prickett, C.S.3    Yu, J.Y.4    Giuliano, A.E.5    Cabot, M.C.6
  • 25
    • 28844473489 scopus 로고    scopus 로고
    • Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
    • Flygare J, Gustafsson K, Kimby E, Christensson B, Sander B. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. FEBS Lett 2005;579:6885-9.
    • (2005) FEBS Lett , vol.579 , pp. 6885-6889
    • Flygare, J.1    Gustafsson, K.2    Kimby, E.3    Christensson, B.4    Sander, B.5
  • 26
    • 53449089095 scopus 로고    scopus 로고
    • Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: A nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group
    • Geisler CH, Kolstad A, Laurell A, et al. Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group. Blood 2008;112:2687-93.
    • (2008) Blood , vol.112 , pp. 2687-2693
    • Geisler, C.H.1    Kolstad, A.2    Laurell, A.3
  • 27
    • 0029075192 scopus 로고
    • Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin
    • Miyake Y, Kozutsumi Y, Nakamura S, Fujita T, Kawasaki T. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem Biophys Res Commun 1995;211:396-403.
    • (1995) Biochem Biophys Res Commun , vol.211 , pp. 396-403
    • Miyake, Y.1    Kozutsumi, Y.2    Nakamura, S.3    Fujita, T.4    Kawasaki, T.5
  • 28
    • 0346363142 scopus 로고    scopus 로고
    • Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase
    • Triola G, Fabrias G, Casas J, Llebaria A. Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase. J Org Chem 2003;68:9924-32.
    • (2003) J Org Chem , vol.68 , pp. 9924-9932
    • Triola, G.1    Fabrias, G.2    Casas, J.3    Llebaria, A.4
  • 29
    • 27744577642 scopus 로고    scopus 로고
    • Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1
    • Soriano JM, Gonzalez L, Catala AI. Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. Prog Lipid Res 2005;44: 345-56.
    • (2005) Prog Lipid Res , vol.44 , pp. 345-356
    • Soriano, J.M.1    Gonzalez, L.2    Catala, A.I.3
  • 30
    • 0034829843 scopus 로고    scopus 로고
    • Killing cancer cells by poly-drug elevation of ceramide levels: A hypothesis whose time has come?
    • Radin NS. Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come? Eur J Biochem 2001;268:193-204.
    • (2001) Eur J Biochem , vol.268 , pp. 193-204
    • Radin, N.S.1
  • 31
    • 4644333556 scopus 로고    scopus 로고
    • Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells
    • Norris-Cervetto E, Callaghan R, Platt FM, Dwek RA, Butters TD. Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells. J Biol Chem 2004;279:40412-8.
    • (2004) J Biol Chem , vol.279 , pp. 40412-40418
    • Norris-Cervetto, E.1    Callaghan, R.2    Platt, F.M.3    Dwek, R.A.4    Butters, T.D.5
  • 33
    • 33744913027 scopus 로고    scopus 로고
    • The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
    • Herrera B, Carracedo A, Diez-Zaera M, Gomez del Pulgar T, Guzman M, Velasco G. The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway. Exp Cell Res 2006;312: 2121-31.
    • (2006) Exp Cell Res , vol.312 , pp. 2121-2131
    • Herrera, B.1    Carracedo, A.2    Diez-Zaera, M.3    Gomez del Pulgar, T.4    Guzman, M.5    Velasco, G.6
  • 34
    • 17344380844 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
    • Galve-Roperh I, Sanchez C, Cortes ML, del Pulgar TG, Izquierdo M, Guzman M. Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 2000;6:313-9.
    • (2000) Nat Med , vol.6 , pp. 313-319
    • Galve-Roperh, I.1    Sanchez, C.2    Cortes, M.L.3    del Pulgar, T.G.4    Izquierdo, M.5    Guzman, M.6
  • 35
    • 0036534724 scopus 로고    scopus 로고
    • De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis
    • Gomez del Pulgar T, Velasco G, Sanchez C, Haro A, Guzman M. De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem J 2002;363:183-8.
    • (2002) Biochem J , vol.363 , pp. 183-188
    • Gomez del Pulgar, T.1    Velasco, G.2    Sanchez, C.3    Haro, A.4    Guzman, M.5
  • 36
    • 1542319001 scopus 로고    scopus 로고
    • Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry
    • Pettus BJ, Kroesen BJ, Szulc ZM, et al. Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. Rapid Commun Mass Spectrom 2004;18:577-83.
    • (2004) Rapid Commun Mass Spectrom , vol.18 , pp. 577-583
    • Pettus, B.J.1    Kroesen, B.J.2    Szulc, Z.M.3
  • 37
    • 3142754843 scopus 로고    scopus 로고
    • Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders
    • Pettus BJ, Baes M, Busman M, Hannun YA, Van Veldhoven PP. Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders. Rapid Commun Mass Spectrom 2004;18:1569-74.
    • (2004) Rapid Commun Mass Spectrom , vol.18 , pp. 1569-1574
    • Pettus, B.J.1    Baes, M.2    Busman, M.3    Hannun, Y.A.4    Van Veldhoven, P.P.5
  • 38
    • 0037680229 scopus 로고    scopus 로고
    • Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism
    • Hanada K. Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta 2003;1632:16-30.
    • (2003) Biochim Biophys Acta , vol.1632 , pp. 16-30
    • Hanada, K.1
  • 39
    • 45149116217 scopus 로고    scopus 로고
    • Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: A link to ceramide synthase-3
    • Rabionet M, van der Spoel AC, Chuang CC, et al. Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem 2008;283:13357-69.
    • (2008) J Biol Chem , vol.283 , pp. 13357-13369
    • Rabionet, M.1    van der Spoel, A.C.2    Chuang, C.C.3
  • 40
    • 47249137829 scopus 로고    scopus 로고
    • Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation
    • Gustafsson K, Wang X, Severa D, et al. Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation. Int J Cancer 2008;123:1025-33.
    • (2008) Int J Cancer , vol.123 , pp. 1025-1033
    • Gustafsson, K.1    Wang, X.2    Severa, D.3
  • 41
    • 40949083594 scopus 로고    scopus 로고
    • Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression
    • Blazquez C, Salazar M, Carracedo A, et al. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res 2008;68:1945-52.
    • (2008) Cancer Res , vol.68 , pp. 1945-1952
    • Blazquez, C.1    Salazar, M.2    Carracedo, A.3
  • 42
    • 34347221936 scopus 로고    scopus 로고
    • Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity
    • Dbaibo GS, Kfoury Y, Darwiche N, et al. Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity. Haematologica 2007;92:753-62.
    • (2007) Haematologica , vol.92 , pp. 753-762
    • Dbaibo, G.S.1    Kfoury, Y.2    Darwiche, N.3
  • 43
    • 0027527545 scopus 로고
    • Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide
    • Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA. Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem 1993;268:26226-32.
    • (1993) J Biol Chem , vol.268 , pp. 26226-26232
    • Bielawska, A.1    Crane, H.M.2    Liotta, D.3    Obeid, L.M.4    Hannun, Y.A.5
  • 44
    • 33745028656 scopus 로고    scopus 로고
    • Dihydroceramide hinders ceramide channel formation: Implications on apoptosis
    • Stiban J, Fistere D, Colombini M. Dihydroceramide hinders ceramide channel formation: implications on apoptosis. Apoptosis 2006;11:773-80.
    • (2006) Apoptosis , vol.11 , pp. 773-780
    • Stiban, J.1    Fistere, D.2    Colombini, M.3
  • 45
    • 3042821855 scopus 로고    scopus 로고
    • Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity
    • Tserng KY, Griffin RL. Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. Biochem J 2004;380:715-22.
    • (2004) Biochem J , vol.380 , pp. 715-722
    • Tserng, K.Y.1    Griffin, R.L.2
  • 46
    • 34447115107 scopus 로고    scopus 로고
    • Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells
    • Kraveka JM, Li L, Szulc ZM, et al. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem 2007; 282:16718-28.
    • (2007) J Biol Chem , vol.282 , pp. 16718-16728
    • Kraveka, J.M.1    Li, L.2    Szulc, Z.M.3
  • 47
    • 25844457390 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
    • Sarkar S, Maceyka M, Hait NC, et al. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett 2005;579:5313-7.
    • (2005) FEBS Lett , vol.579 , pp. 5313-5317
    • Sarkar, S.1    Maceyka, M.2    Hait, N.C.3
  • 48
    • 33645763253 scopus 로고    scopus 로고
    • The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
    • Carracedo A, Lorente M, Egia A, et al. The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell 2006;9:301-12.
    • (2006) Cancer Cell , vol.9 , pp. 301-312
    • Carracedo, A.1    Lorente, M.2    Egia, A.3
  • 50
    • 33746271951 scopus 로고    scopus 로고
    • Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry
    • Bielawski J, Szulc ZM, Hannun YA, Bielawska A. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods 2006;39:82-91.
    • (2006) Methods , vol.39 , pp. 82-91
    • Bielawski, J.1    Szulc, Z.M.2    Hannun, Y.A.3    Bielawska, A.4
  • 51
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-7.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2


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