Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11346-11353

  Hagen, Nadine ^a   Van Veldhoven, Paul P ^b   Proia, Richard L ^c   Park, Hyejung ^d   Merrill Jr , Alfred H ^d   Van Echten Deckert, Gerhild ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CEREBELLAR GRANULE CELLS; CULTURE MEDIUM; NEURONAL APOPTOSIS; NEUROTOXICITY; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATES; SUB-CELLULAR; TOXIC EFFECT; TWO SOURCES;

CELL CULTURE; CELL DEATH; TOXICITY;

NEURONS;

4 METHYLSPHINGOSINE PHOSPHATE; LYASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE DERIVATIVE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; UNCLASSIFIED DRUG; CASPASE; CERAMIDE; CYCLIN D1; CYCLIN E; DRUG DERIVATIVE; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL GRANULE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; ENZYME ACTIVITY; LIPID HYDROLYSIS; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; TOXIN ANALYSIS; ANIMAL; CELL MEMBRANE; CELL SURVIVAL; GENETICS; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS;

ANIMALS; APOPTOSIS; CASPASES; CELL MEMBRANE; CELL SURVIVAL; CERAMIDES; CYCLIN D1; CYCLIN E; LYSOPHOSPHOLIPIDS; MASS SPECTROMETRY; MICE; MICE, TRANSGENIC; NEURONS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SPHINGOSINE;

EID: 66449084111     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807336200     Document Type: Article

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