Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720

Japanese Journal of Cancer Research

Volumn 92, Issue 6, 2001, Pages 680-687

  Nagahara, Yukitoshi ^a,b   Matsuoka, Yumiko ^a,b   Saito, Kaoru ^a   Ikekita, Masahiko ^b   Higuchi, Shigesada ^c   Shinomiya, Takahisa ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c SHOWA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cell cycle arrest; FTY20; Lymphoma cells; Retinoblastoma protein

Indexed keywords

ENZYME INHIBITOR; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 2A INHIBITOR; PROTEIN BCL 2; REAGENT; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DEATH; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG POTENCY; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOCYTE; LYMPHOCYTE COUNT; LYMPHOMA CELL; MITOCHONDRION; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BROMODEOXYURIDINE; CELL CYCLE; CELL DIVISION; DNA FRAGMENTATION; DOWN-REGULATION; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JURKAT CELLS; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PRECIPITIN TESTS; PROPYLENE GLYCOLS; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; SPHINGOSINE; TIME FACTORS;

EID: 0034929391     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01148.x     Document Type: Article

References (39)

1. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
2. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
3. Differential regulation of E2F transactivation by cyclin/CDK2 complexes
4. Cyclin D1/CDK4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
5. Differential regulation of retinoblastoma protein function by specific CDK phosphorylation sites
6. The consensus motif for phosphorylation by cyclin D1-CDK4 is different from that for phosphorylation by cyclin A/E-CDK2
7. Cell cycle control and cancer
8. p27, a novel inhibitor of G1 cyclin-CDK protein kinase activity, is related to p21
9. Kipl, a cyclin-CDK inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
10. Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death
11. p53 is required for radiation-induced apoptosis in mouse thymocytes
12. Activation of cyclin A-dependent protein kinases during apoptosis
13. Induction of cyclin B and H1 kinase activity in apoptotic PC12 cells
14. Cyclin D1 is an essential mediator of apoptotic neuronal cell death
15. Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2
16. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
17. Kip1-induced apoptosis
18. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite
19. Potent immunosuppressants, 2-alkyl-2-aminopropane-1,3-diols
20. Induction of selective cell death targeting mature T-lymphocytes in rats by a novel immunosuppressant, FTY720
21. Evidence that FTY720 induces T cell apoptosis in vivo
22. An immunosuppressive agent, FTY720, increases intracellular concentration of calcium ion and induces apoptosis in HL-60
23. A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes
24. Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation
25. Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria
26. Labeling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation
27. Single-step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides: Detection of apoptosis and bromodeoxyuridine incorporation
28. WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells
29. Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis
30. Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases
31. Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines
32. Kip1 through the phosphatidylinositol 3-kinase/AKT pathway
33. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
34. s6k function is essential for G1 progression
35. Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts
36. Bcl-2 phosphorylation required for anti-apoptosis function
37. A functional role for mitochondrial protein kinase C alpha in Bc12 phosphorylation and suppression of apoptosis
38. Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation
39. The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2