-
1
-
-
0034789931
-
The organizing potential of sphingolipids in intracellular membrane transport
-
Holthuis, J.C., Pomorski, T., Raggers, R.J., Sprong, H. & Van Meer, G. The organizing potential of sphingolipids in intracellular membrane transport. Physiol. Rev. 81, 1689-1723 (2001).
-
(2001)
Physiol. Rev.
, vol.81
, pp. 1689-1723
-
-
Holthuis, J.C.1
Pomorski, T.2
Raggers, R.J.3
Sprong, H.4
Van Meer, G.5
-
3
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1- phosphate receptor agonists
-
Mandala, S. et al. Alteration of lymphocyte trafficking by sphingosine-1- phosphate receptor agonists. Science 296, 346-349 (2002).
-
(2002)
Science
, vol.296
, pp. 346-349
-
-
Mandala, S.1
-
4
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkmann, V. et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277, 21453-21457 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21453-21457
-
-
Brinkmann, V.1
-
5
-
-
34548329395
-
The metabolism and function of sphingolipids and glycosphingolipids
-
Lahiri, S. & Futerman, A. The metabolism and function of sphingolipids and glycosphingolipids. Cell. Mol. Life Sci. 64, 2270-2284 (2007).
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, pp. 2270-2284
-
-
Lahiri, S.1
Futerman, A.2
-
6
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
Hannun, Y.A. & Obeid, L.M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9, 139-150 (2008).
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
7
-
-
33845336495
-
Ceramides and other bioactive sphingolipid backbones in health and disease: Lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy
-
Zheng, W. et al. Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim. Biophys. Acta 1758, 1864-1884 (2006).
-
(2006)
Biochim. Biophys. Acta
, vol.1758
, pp. 1864-1884
-
-
Zheng, W.1
-
8
-
-
66349132796
-
Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities
-
Han, G. et al. Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities. Proc. Natl. Acad. Sci. USA 106, 8186-8191 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 8186-8191
-
-
Han, G.1
-
9
-
-
77649121162
-
Orm family proteins mediate sphingolipid homeostasis
-
Breslow, D.K. et al. Orm family proteins mediate sphingolipid homeostasis. Nature 463, 1048-1053 (2010).
-
(2010)
Nature
, vol.463
, pp. 1048-1053
-
-
Breslow, D.K.1
-
10
-
-
27844517355
-
Sphingosine 1-phosphate and ceramide 1-phosphate: Expanding roles in cell signaling
-
Chalfant, C.E. & Spiegel, S. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J. Cell Sci. 118, 4605-4612 (2005).
-
(2005)
J. Cell Sci.
, vol.118
, pp. 4605-4612
-
-
Chalfant, C.E.1
Spiegel, S.2
-
11
-
-
52449092057
-
Targeting SphK1 as a new strategy against cancer
-
Shida, D., Takabe, K., Kapitonov, D., Milstien, S. & Spiegel, S. Targeting SphK1 as a new strategy against cancer. Curr. Drug Targets 9, 662-673 (2008).
-
(2008)
Curr. Drug Targets
, vol.9
, pp. 662-673
-
-
Shida, D.1
Takabe, K.2
Kapitonov, D.3
Milstien, S.4
Spiegel, S.5
-
12
-
-
56949095716
-
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
-
Pyne, S., Lee, S.C., Long, J. & Pyne, N.J. Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. Cell. Signal. 21, 14-21 (2009).
-
(2009)
Cell. Signal.
, vol.21
, pp. 14-21
-
-
Pyne, S.1
Lee, S.C.2
Long, J.3
Pyne, N.J.4
-
13
-
-
33846811196
-
Regulation and functional roles of sphingosine kinases
-
Alemany, R., van Koppen, C.J., Danneberg, K., Ter Braak, M. & Meyer Zu Heringdorf, D. Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch. Pharmacol. 374, 413-428 (2007).
-
(2007)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.374
, pp. 413-428
-
-
Alemany, R.1
Van Koppen, C.J.2
Danneberg, K.3
Ter Braak, M.4
Meyer Zu Heringdorf, D.5
-
14
-
-
28544437478
-
Essential role for sphingosine kinases in neural and vascular development
-
Mizugishi, K. et al. Essential role for sphingosine kinases in neural and vascular development. Mol. Cell. Biol. 25, 11113-11121 (2005).
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 11113-11121
-
-
Mizugishi, K.1
-
15
-
-
60549113475
-
The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: Possible role in regulating cell division
-
Gillies, L. et al. The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. Cell. Signal. 21, 675-684 (2009).
-
(2009)
Cell. Signal.
, vol.21
, pp. 675-684
-
-
Gillies, L.1
-
16
-
-
73649108890
-
Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1
-
Jarman, K.E., Moretti, P.A., Zebol, J.R. & Pitson, S.M. Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. J. Biol. Chem. 285, 483-492 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 483-492
-
-
Jarman, K.E.1
Moretti, P.A.2
Zebol, J.R.3
Pitson, S.M.4
-
17
-
-
34948815697
-
Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice
-
Mizugishi, K. et al. Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J. Clin. Invest. 117, 2993-3006 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2993-3006
-
-
Mizugishi, K.1
-
18
-
-
69949113620
-
Regulation of histone acetylation in the nucleus by sphingosine-1- phosphate
-
Hait, N.C. et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325, 1254-1257 (2009).
-
(2009)
Science
, vol.325
, pp. 1254-1257
-
-
Hait, N.C.1
-
19
-
-
70249125866
-
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an antiinflammatory phenotype
-
Weigert, A. et al. Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an antiinflammatory phenotype. Int. J. Cancer 125, 2114-2121 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, pp. 2114-2121
-
-
Weigert, A.1
-
20
-
-
68149124148
-
Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis
-
Lai, W.Q. et al. Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis. J. Immunol. 183, 2097-2103 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 2097-2103
-
-
Lai, W.Q.1
-
21
-
-
70349682405
-
Hypoxic preconditioning-induced cerebral ischemic tolerance: Role of microvascular sphingosine kinase 2
-
Wacker, B.K., Park, T.S. & Gidday, J.M. Hypoxic preconditioning- induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2. Stroke 40, 3342-3348 (2009).
-
(2009)
Stroke
, vol.40
, pp. 3342-3348
-
-
Wacker, B.K.1
Park, T.S.2
Gidday, J.M.3
-
22
-
-
0141924852
-
Sphingosine kinase type 2 is a putative BH3-Only protein that induces apoptosis
-
Liu, H. et al. Sphingosine kinase type 2 is a putative BH3-Only protein that induces apoptosis. J. Biol. Chem. 278, 40330-40336 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40330-40336
-
-
Liu, H.1
-
23
-
-
77951745553
-
Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells
-
Weigert, A. et al. Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. Blood 115, 3531-3540 (2010).
-
(2010)
Blood
, vol.115
, pp. 3531-3540
-
-
Weigert, A.1
-
24
-
-
59649120559
-
A lipid binding domain in sphingosine kinase 2
-
Don, A.S. & Rosen, H. A lipid binding domain in sphingosine kinase 2. Biochem. Biophys. Res. Commun. 380, 87-92 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.380
, pp. 87-92
-
-
Don, A.S.1
Rosen, H.2
-
25
-
-
38449084602
-
Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate
-
Samy, E.T. et al. Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. J. Immunol. 179, 5644-5648 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 5644-5648
-
-
Samy, E.T.1
-
26
-
-
34247379074
-
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate
-
Pappu, R. et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316, 295-298 (2007).
-
(2007)
Science
, vol.316
, pp. 295-298
-
-
Pappu, R.1
-
27
-
-
17744367455
-
Integral membrane lipid phosphatases/phosphotransferases: Common structure and diverse functions
-
Sigal, Y.J., McDermott, M.I. & Morris, A.J. Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions. Biochem. J. 387, 281-293 (2005).
-
(2005)
Biochem. J.
, vol.387
, pp. 281-293
-
-
Sigal, Y.J.1
McDermott, M.I.2
Morris, A.J.3
-
28
-
-
66349139391
-
Lipid phosphate phosphatases and signaling
-
Brindley, D.N. & Pilquil, C. Lipid phosphate phosphatases and signaling. J. Lipid Res. 50 Suppl, S225-S230 (2009).
-
(2009)
J. Lipid Res.
, vol.50
, Issue.SUPPL.
-
-
Brindley, D.N.1
Pilquil, C.2
-
29
-
-
66049132933
-
Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney
-
Kirby, R.J. et al. Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney. Am. J. Physiol. Renal Physiol. 296, F634-F641 (2009).
-
(2009)
Am. J. Physiol. Renal Physiol.
, vol.296
-
-
Kirby, R.J.1
-
30
-
-
33745442062
-
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide
-
Giussani, P. et al. Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol. Cell. Biol. 26, 5055-5069 (2006).
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 5055-5069
-
-
Giussani, P.1
-
31
-
-
53549084071
-
Role of sphingosine-1-phosphate phosphohydrolase 1 in the regulation of resistance artery tone
-
Peter, B.F. et al. Role of sphingosine-1-phosphate phosphohydrolase 1 in the regulation of resistance artery tone. Circ. Res. 103, 315-324 (2008).
-
(2008)
Circ. Res.
, vol.103
, pp. 315-324
-
-
Peter, B.F.1
-
32
-
-
34250159500
-
FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3
-
Mechtcheriakova, D. et al. FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3. FEBS Lett. 581, 3063-3068 (2007).
-
(2007)
FEBS Lett.
, vol.581
, pp. 3063-3068
-
-
Mechtcheriakova, D.1
-
33
-
-
77953771709
-
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
-
Serra, M. & Saba, J.D. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv. Enzyme Regul. 50, 349-362 (2010).
-
(2010)
Adv. Enzyme Regul.
, vol.50
, pp. 349-362
-
-
Serra, M.1
Saba, J.D.2
-
34
-
-
33745218278
-
Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry
-
Zhan, X. & Desiderio, D.M. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. Anal. Biochem. 354, 279-289 (2006).
-
(2006)
Anal. Biochem.
, vol.354
, pp. 279-289
-
-
Zhan, X.1
Desiderio, D.M.2
-
35
-
-
50649095750
-
Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro
-
Mukhopadhyay, D., Howell, K.S., Riezman, H. & Capitani, G. Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro. J. Biol. Chem. 283, 20159-20169 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 20159-20169
-
-
Mukhopadhyay, D.1
Howell, K.S.2
Riezman, H.3
Capitani, G.4
-
36
-
-
58149474166
-
Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and nonlymphoid lesions
-
Vogel, P. et al. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and nonlymphoid lesions. PLoS ONE 4, e4112 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Vogel, P.1
-
37
-
-
66449084111
-
Subcellular origin of sphingosine-1-phosphate is essential for its toxic effect in lyase deficient neurons
-
Hagen, N. et al. Subcellular origin of sphingosine-1-phosphate is essential for its toxic effect in lyase deficient neurons. J. Biol. Chem. 284, 11346-11353 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 11346-11353
-
-
Hagen, N.1
-
38
-
-
77951213051
-
Sphingosine-1-phosphate lyase deficiency disrupts lipid homeostasis in liver
-
Bektas, M. et al. Sphingosine-1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J. Biol. Chem. 285, 10880-10889 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 10880-10889
-
-
Bektas, M.1
-
39
-
-
0037012907
-
Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila
-
Dobrosotskaya, I.Y., Seegmiller, A., Brown, M., Goldstein, J. & Rawson, R. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science 296, 879-883 (2002).
-
(2002)
Science
, vol.296
, pp. 879-883
-
-
Dobrosotskaya, I.Y.1
Seegmiller, A.2
Brown, M.3
Goldstein, J.4
Rawson, R.5
-
40
-
-
4344614649
-
Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
-
Stratford, S., Hoehn, K., Liu, F. & Summers, S. Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B. J. Biol. Chem. 279, 36608-36615 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36608-36615
-
-
Stratford, S.1
Hoehn, K.2
Liu, F.3
Summers, S.4
-
41
-
-
33847209549
-
Redirection of sphingolipid metabolism towards de novo synthesis of ethanolamine in Leishmania
-
Zhang, K. et al. Redirection of sphingolipid metabolism towards de novo synthesis of ethanolamine in Leishmania. EMBO J. 26, 1094-1104 (2007).
-
(2007)
EMBO J.
, vol.26
, pp. 1094-1104
-
-
Zhang, K.1
-
42
-
-
85029167252
-
-
(in press)
-
Bourquin, F., Riezman, H., Capitani, G. & Gerhard, M. Structure (in press).
-
Structure
-
-
Bourquin, F.1
Riezman, H.2
Capitani, G.3
Gerhard, M.4
-
43
-
-
51749090593
-
Sphingosine-1-phosphate regulation of mammalian development
-
Kono, M., Allende, M.L. & Proia, R.L. Sphingosine-1-phosphate regulation of mammalian development. Biochim. Biophys. Acta 1781, 435-441 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 435-441
-
-
Kono, M.1
Allende, M.L.2
Proia, R.L.3
-
44
-
-
49949116576
-
Biological roles of lysophospholipid receptors revealed by genetic null mice: An update
-
Choi, J.W., Lee, C.W. & Chun, J. Biological roles of lysophospholipid receptors revealed by genetic null mice: an update. Biochim. Biophys. Acta 1781, 531-539 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 531-539
-
-
Choi, J.W.1
Lee, C.W.2
Chun, J.3
-
45
-
-
66349136253
-
Lysophospholipid receptors in vertebrate development, physiology, and pathology
-
Skoura, A. & Hla, T. Lysophospholipid receptors in vertebrate development, physiology, and pathology. J. Lipid Res. 50 Suppl, S293-S298 (2009).
-
(2009)
J. Lipid Res.
, vol.50
, Issue.SUPPL.
-
-
Skoura, A.1
Hla, T.2
-
46
-
-
38949171328
-
A role for S1P signalling in axon guidance in the Xenopus visual system
-
Strochlic, L., Dwivedy, A., van Horck, F.P., Falk, J. & Holt, C.E. A role for S1P signalling in axon guidance in the Xenopus visual system. Development 135, 333-342 (2008).
-
(2008)
Development
, vol.135
, pp. 333-342
-
-
Strochlic, L.1
Dwivedy, A.2
Van Horck, F.P.3
Falk, J.4
Holt, C.E.5
-
47
-
-
77953225859
-
Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
-
doi:10.2353/ ajpath.2010.091234 (22 April)
-
Miron, V.E. et al. Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am. J. Pathol. doi:10.2353/ ajpath.2010.091234 (22 April 2010).
-
(2010)
Am. J. Pathol.
-
-
Miron, V.E.1
-
48
-
-
77951817430
-
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice
-
Olivera, A. et al. Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. J. Clin. Invest. 120, 1429-1440 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 1429-1440
-
-
Olivera, A.1
-
49
-
-
28444475519
-
Essential roles of sphingosine-1-phosphate and plateletderived growth factor in the maintenance of human embryonic stem cells
-
Pébay, A. et al. Essential roles of sphingosine-1-phosphate and plateletderived growth factor in the maintenance of human embryonic stem cells. Stem Cells 23, 1541-1548 (2005).
-
(2005)
Stem Cells
, vol.23
, pp. 1541-1548
-
-
Pébay, A.1
-
50
-
-
34250189127
-
Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription
-
Bai, A., Hu, H., Yeung, M. & Chen, J. Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription. J. Immunol. 178, 7632-7639 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 7632-7639
-
-
Bai, A.1
Hu, H.2
Yeung, M.3
Chen, J.4
-
51
-
-
70449732610
-
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
-
Jenne, C.N. et al. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J. Exp. Med. 206, 2469-2481 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2469-2481
-
-
Jenne, C.N.1
-
52
-
-
12544253058
-
Structural and functional characteristics of S1P receptors
-
Sanchez, T. & Hla, T. Structural and functional characteristics of S1P receptors. J. Cell. Biochem. 92, 913-922 (2004).
-
(2004)
J. Cell. Biochem.
, vol.92
, pp. 913-922
-
-
Sanchez, T.1
Hla, T.2
-
53
-
-
67650762826
-
Sphingosine 1-phosphate receptor signaling
-
Rosen, H., Gonzalez-Cabrera, P.J., Sanna, M.G. & Brown, S. Sphingosine 1-phosphate receptor signaling. Annu. Rev. Biochem. 78, 743-768 (2009).
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 743-768
-
-
Rosen, H.1
Gonzalez-Cabrera, P.J.2
Sanna, M.G.3
Brown, S.4
-
54
-
-
33750832270
-
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
-
Mitra, P. et al. Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc. Natl. Acad. Sci. USA 103, 16394-16399 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 16394-16399
-
-
Mitra, P.1
-
55
-
-
69249090929
-
Characterization of the ATPdependent sphingosine 1-phosphate transporter in rat erythrocytes
-
Kobayashi, N., Yamaguchi, A. & Nishi, T. Characterization of the ATPdependent sphingosine 1-phosphate transporter in rat erythrocytes. J. Biol. Chem. 284, 21192-21200 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21192-21200
-
-
Kobayashi, N.1
Yamaguchi, A.2
Nishi, T.3
-
56
-
-
0034644150
-
A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development
-
Kupperman, E., An, S., Osborne, N., Waldron, S. & Stainier, D.Y. A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development. Nature 406, 192-195 (2000).
-
(2000)
Nature
, vol.406
, pp. 192-195
-
-
Kupperman, E.1
An, S.2
Osborne, N.3
Waldron, S.4
Stainier, D.Y.5
-
57
-
-
58849083220
-
The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors
-
Kawahara, A. et al. The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science 323, 524-527 (2009).
-
(2009)
Science
, vol.323
, pp. 524-527
-
-
Kawahara, A.1
-
58
-
-
0035023142
-
Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster
-
Nakano, Y. et al. Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster. Mol. Cell. Biol. 21, 3775-3788 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3775-3788
-
-
Nakano, Y.1
-
59
-
-
54949085832
-
The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis
-
Hinkovska-Galcheva, V., VanWay, S.M., Shanley, T.P. & Kunkel, R.G. The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis. Curr. Opin. Investig. Drugs 9, 1192-1205 (2008).
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, pp. 1192-1205
-
-
Hinkovska-Galcheva, V.1
Vanway, S.M.2
Shanley, T.P.3
Kunkel, R.G.4
-
60
-
-
58149337334
-
Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells
-
Estrada, R. et al. Ligand-induced nuclear translocation of S1P(1) receptors mediates Cyr61 and CTGF transcription in endothelial cells. Histochem. Cell Biol. 131, 239-249 (2009).
-
(2009)
Histochem. Cell Biol.
, vol.131
, pp. 239-249
-
-
Estrada, R.1
-
61
-
-
33847328744
-
Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors
-
Liao, J.J. et al. Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. J. Biol. Chem. 282, 1964-1972 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 1964-1972
-
-
Liao, J.J.1
-
62
-
-
0032874879
-
De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs
-
Adachi-Yamada, T. et al. De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs. Mol. Cell. Biol. 19, 7276-7286 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 7276-7286
-
-
Adachi-Yamada, T.1
-
63
-
-
73949113416
-
Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction
-
Dasgupta, U. et al. Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction. Proc. Natl. Acad. Sci. USA 106, 20063-20068 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 20063-20068
-
-
Dasgupta, U.1
-
64
-
-
57749121687
-
The PDGF signaling pathway controls multiple steroid-producing lineages
-
Schmahl, J., Rizzolo, K. & Soriano, P. The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 22, 3255-3267 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 3255-3267
-
-
Schmahl, J.1
Rizzolo, K.2
Soriano, P.3
-
65
-
-
33750320417
-
The skeletal muscle satellite cell: The stem cell that came in from the cold
-
Zammit, P.S., Partridge, T.A. & Yablonka-Reuveni, Z. The skeletal muscle satellite cell: the stem cell that came in from the cold. J. Histochem. Cytochem. 54, 1177-1191 (2006).
-
(2006)
J. Histochem. Cytochem.
, vol.54
, pp. 1177-1191
-
-
Zammit, P.S.1
Partridge, T.A.2
Yablonka-Reuveni, Z.3
-
66
-
-
1642580757
-
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
-
Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355-360 (2004).
-
(2004)
Nature
, vol.427
, pp. 355-360
-
-
Matloubian, M.1
-
67
-
-
27744552046
-
Sphingosine kinase 2 is required for modulation of lympocyte traffic by FTY720
-
Kharel, Y. et al. Sphingosine kinase 2 is required for modulation of lympocyte traffic by FTY720 J Biol. Chem. 280, 36865-36872 (2005).
-
(2005)
J Biol. Chem.
, vol.280
, pp. 36865-36872
-
-
Kharel, Y.1
-
68
-
-
52949108813
-
The alliance of sphingosine-1-phosphate and its receptors in immunity
-
Rivera, J., Proia, R.L. & Olivera, A. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat. Rev. Immunol. 8, 753-763 (2008).
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 753-763
-
-
Rivera, J.1
Proia, R.L.2
Olivera, A.3
-
69
-
-
65249119361
-
Lipid mediators in health and disease: Enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation
-
Shimizu, T. Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 49, 123-150 (2009).
-
(2009)
Annu. Rev. Pharmacol. Toxicol.
, vol.49
, pp. 123-150
-
-
Shimizu, T.1
-
70
-
-
36248956701
-
Finding a way out: Lymphocyte egress from lymphoid organs
-
Schwab, S.R. & Cyster, J.G. Finding a way out: lymphocyte egress from lymphoid organs. Nat. Immunol. 8, 1295-1301 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1295-1301
-
-
Schwab, S.R.1
Cyster, J.G.2
-
71
-
-
77952961847
-
Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction
-
doi:10.1126/science.1188222 (22 April)
-
Zachariah, M.A. & Cyster, J.G. Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction. Science doi:10.1126/ science.1188222 (22 April 2010).
-
(2010)
Science
-
-
Zachariah, M.A.1
Cyster, J.G.2
-
72
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos, L. et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N. Engl. J. Med. 362, 387-401 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 387-401
-
-
Kappos, L.1
-
73
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen, J.A. et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N. Engl. J. Med. 362, 402-415 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
-
74
-
-
77952422757
-
Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex
-
Ratajczak, M.Z. et al. Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. Leukemia 24, 976-985(2010).
-
(2010)
Leukemia
, vol.24
, pp. 976-985
-
-
Ratajczak, M.Z.1
-
75
-
-
65549089187
-
Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25
-
Gossens, K. et al. Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25. J. Exp. Med. 206, 761-778 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 761-778
-
-
Gossens, K.1
-
76
-
-
70449700288
-
Discontinued postnatal thymocyte development in sphingosine 1-phosphatelyase- deficient mice
-
Weber, C. K.A., Münk, A., Bode, C., Van Veldhoven, P.P. & Gräler, M.H. Discontinued postnatal thymocyte development in sphingosine 1-phosphatelyase- deficient mice. J. Immunol. 183, 4292-4301 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 4292-4301
-
-
Weber, C.K.A.1
Münk, A.2
Bode, C.3
Van Veldhoven, P.P.4
Gräler, M.H.5
-
77
-
-
63649143900
-
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis
-
Ishii, M. et al. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature 458, 524-528 (2009).
-
(2009)
Nature
, vol.458
, pp. 524-528
-
-
Ishii, M.1
-
78
-
-
77949521813
-
A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow
-
Pereira, J.P., Xu, Y. & Cyster, J.G. A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. PLoS ONE 5, e9277 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Pereira, J.P.1
Xu, Y.2
Cyster, J.G.3
-
79
-
-
77952309720
-
S1P1 receptor directs the release of immature B cells from bone marrow into blood
-
doi: 10.1084/jem.20092210 (9 April)
-
Allende, M.L. et al. S1P1 receptor directs the release of immature B cells from bone marrow into blood. J. Exp. Med. doi: 10.1084/jem.20092210 (19 April 2010).
-
(2010)
J. Exp. Med.
-
-
Allende, M.L.1
-
80
-
-
70349333237
-
The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo
-
Wolf, A.M. et al. The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J. Immunol. 183, 3751-3760 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 3751-3760
-
-
Wolf, A.M.1
-
81
-
-
77949332336
-
Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation
-
Michaud, J., Im, D. & Hla, T. Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J. Immunol. 184, 1475-1483 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 1475-1483
-
-
Michaud, J.1
Im, D.2
Hla, T.3
-
82
-
-
34250809874
-
Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury
-
Means, C.K. et al. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 292, H2944-H2951 (2007).
-
(2007)
Am. J. Physiol. Heart Circ. Physiol.
, vol.292
-
-
Means, C.K.1
-
83
-
-
77449106966
-
Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats
-
Hasegawa, Y., Suzuki, H., Sozen, T., Rolland, W. & Zhang, J.H. Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats. Stroke 41, 368-374 (2010).
-
(2010)
Stroke
, vol.41
, pp. 368-374
-
-
Hasegawa, Y.1
Suzuki, H.2
Sozen, T.3
Rolland, W.4
Zhang, J.H.5
-
84
-
-
0033786639
-
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
-
Morita, Y. et al. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat. Med. 6, 1109-1114 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 1109-1114
-
-
Morita, Y.1
-
85
-
-
67449164535
-
Sphingosine-1-phosphate as a mediator of highdensity lipoprotein effects in cardiovascular protection
-
Sattler, K. & Levkau, B. Sphingosine-1-phosphate as a mediator of highdensity lipoprotein effects in cardiovascular protection. Cardiovasc. Res. 82, 201-211 (2009).
-
(2009)
Cardiovasc. Res.
, vol.82
, pp. 201-211
-
-
Sattler, K.1
Levkau, B.2
-
86
-
-
0034735916
-
An oncogenic role of sphingosine kinase
-
Xia, P. et al. An oncogenic role of sphingosine kinase. Curr. Biol. 10, 1527-1530 (2000).
-
(2000)
Curr. Biol.
, vol.10
, pp. 1527-1530
-
-
Xia, P.1
-
87
-
-
33644830810
-
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
-
Visentin, B. et al. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 9, 225-238 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 225-238
-
-
Visentin, B.1
-
88
-
-
33751225686
-
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer
-
Oskouian, B. et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer. Proc. Natl. Acad. Sci. USA 103, 17384-17389 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 17384-17389
-
-
Oskouian, B.1
-
89
-
-
73649096618
-
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation
-
Colié, S. et al. Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res. 69, 9346-9353 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 9346-9353
-
-
Colié, S.1
-
90
-
-
72249096210
-
Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation
-
Cattoretti, G. et al. Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. Cancer Res. 69, 8686-8692 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 8686-8692
-
-
Cattoretti, G.1
-
91
-
-
71849107705
-
Distinct receptormediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1)
-
Levi, M., Meijler, M.M., Gomez-Munoz, A. & Zor, T. Distinct receptormediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1). Mol. Cell. Endocrinol. 314, 248-255 (2010).
-
(2010)
Mol. Cell. Endocrinol.
, vol.314
, pp. 248-255
-
-
Levi, M.1
Meijler, M.M.2
Gomez-Munoz, A.3
Zor, T.4
-
92
-
-
30344439710
-
Substrate specificity of human ceramide kinase
-
Wijesinghe, D.S. et al. Substrate specificity of human ceramide kinase. J. Lipid Res. 46, 2706-2716 (2005).
-
(2005)
J. Lipid Res.
, vol.46
, pp. 2706-2716
-
-
Wijesinghe, D.S.1
-
93
-
-
58249129925
-
Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor
-
Granado, M.H. et al. Ceramide 1-phosphate (C1P) promotes cell migration Involvement of a specific C1P receptor. Cell. Signal. 21, 405-412 (2009).
-
(2009)
Cell. Signal.
, vol.21
, pp. 405-412
-
-
Granado, M.H.1
-
94
-
-
70449637583
-
Caged ceramide 1-phosphate analogues: Synthesis and properties
-
Lankalapalli, R.S., Ouro, A., Arana, L., Gomez-Munoz, A. & Bittman, R. Caged ceramide 1-phosphate analogues: synthesis and properties. J. Org. Chem. 74, 8844-8847 (2009).
-
(2009)
J. Org. Chem.
, vol.74
, pp. 8844-8847
-
-
Lankalapalli, R.S.1
Ouro, A.2
Arana, L.3
Gomez-Munoz, A.4
Bittman, R.5
-
95
-
-
67449147119
-
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
-
Vacaru, A.M. et al. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J. Cell Biol. 185, 1013-1027 (2009).
-
(2009)
J. Cell Biol.
, vol.185
, pp. 1013-1027
-
-
Vacaru, A.M.1
-
96
-
-
70350383478
-
Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase
-
Ternes, P., Brouwers, J.F., van den Dikkenberg, J. & Holthuis, J.C. Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase. J. Lipid Res. 50, 2270-2277 (2009).
-
(2009)
J. Lipid Res.
, vol.50
, pp. 2270-2277
-
-
Ternes, P.1
Brouwers, J.F.2
Van Den Dikkenberg, J.3
Holthuis, J.C.4
-
97
-
-
70949086543
-
Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1
-
Eichler, F.S. et al. Overexpression of the wild-type SPT1 subunit lowers desoxysphingolipid levels and rescues the phenotype of HSAN1. J. Neurosci. 29, 14646-14651 (2009).
-
(2009)
J. Neurosci.
, vol.29
, pp. 14646-14651
-
-
Eichler, F.S.1
-
98
-
-
2442571212
-
Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2-dimethylhydrazine-treated CF1 mice and ApcMin/+ mice
-
Symolon, H., Schmelz, E., Dillehay, D. & Merrill, A.J. Dietary soy sphingolipids suppress tumorigenesis and gene expression in 1,2- dimethylhydrazine-treated CF1 mice and ApcMin/+ mice. J. Nutr. 134, 1157-1161 (2004).
-
(2004)
J. Nutr.
, vol.134
, pp. 1157-1161
-
-
Symolon, H.1
Schmelz, E.2
Dillehay, D.3
Merrill, A.J.4
-
99
-
-
73649107657
-
Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis
-
Fyrst, H. et al. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer Res. 69, 9457-9464 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 9457-9464
-
-
Fyrst, H.1
-
100
-
-
52049122869
-
Two sphingolipid transfer proteins, CERT and FAPP2: Their roles in sphingolipid metabolism
-
Yamaji, T., Kumagai, K., Tomishige, N. & Hanada, K. Two sphingolipid transfer proteins, CERT and FAPP2: their roles in sphingolipid metabolism. IUBMB Life 60, 511-518 (2008).
-
(2008)
IUBMB Life
, vol.60
, pp. 511-518
-
-
Yamaji, T.1
Kumagai, K.2
Tomishige, N.3
Hanada, K.4
-
101
-
-
50049090026
-
Ceramidases: Regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
-
Mao, C. & Obeid, L.M. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim. Biophys. Acta 1781, 424-434 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 424-434
-
-
Mao, C.1
Obeid, L.M.2
|