Cytotoxic effects of novel phytosphingosine derivatives, including N,N-dimethylphytosphingosine and -monomethylphytosphingosine, in human leukemia cell line HL60

Leukemia and Lymphoma

Volumn 51, Issue 1, 2010, Pages 132-145

  Park, Sook Ryun ^a,b   Cho, Hyo Jin ^b   Moon, Kyung Jin ^b   Chun, Kyung Hee ^b   Kong, Sun Young ^b   Yoon, Sung Soo ^a   Lee, Jong Seok ^c   Park, Seonyang ^a  

^a Seoul National University   (South Korea)

^b National Cancer Center   (South Korea)

^c Seoul National University Bundang Hospital   (South Korea)

Author keywords

Apoptosis; Cytotoxicity; Daunorubicin; Leukemia; N,N dimethylphytosphingosine; N monomethylphytosphingosine

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DAUNORUBICIN; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; N MONOMETHYLPHYTOSPHINGOSINE; N,N DIMETHYLPHYTOSPHINGOSINE; PHYTOSPHINGOSINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DEPHOSPHORYLATION; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, LEUKEMIC; HL-60 CELLS; HUMANS; LEUKEMIA; SPHINGOSINE;

EID: 74949143796     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428190903383419     Document Type: Article

References (31)

1. Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004;4:604-616.
2. Kolesnick R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J Clin Invest 2002; 110:3-8.
3. Perry DK, Hannun YA. The role of ceramide in cell signaling. Biochim Biophys Acta 1998;1436:233-243.
4. Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol 2000;10:73-80.
5. Pettus BJ, Chalfant CE, Hannun YA. Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta 2002;1585:114-125.
6. Cuvillier O. Sphingosine in apoptosis signaling. Biochim Biophys Acta 2002;1585:153-162.
7. Cuvillier O, Pirianov G, Kleuser B, et al. Suppression of ceramide-mediated programmed cell death by sphingosine-1- phosphate. Nature 1996;381:800-803.
8. Spiegel S, Milstien S. Sphingosine-1-phosphate: signaling inside and out. FEBS Lett 2000;476:55-57.
9. Cuvillier O, Levade T. Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. Blood 2001;98:2828-2836.
10. Edsall LC, Cuvillier O, Twitty S, Spiegel S, Milstien S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J Neurochem 2001; 76:1573-1584.
11. Olivera A, Kohama T, Edsall L, et al. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol 1999;147:545-558.
12. Bonhoure E, Pchejetski D, Aouali N, et al. Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1. Leukemia 2006;20:95-102.
13. Park MT, Kang JA, Choi JA, et al. Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells. Clin Cancer Res 2003;9:878-885.
14. Park MT, Choi JA, KimMJ, et al. Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondriamediated cell death in phytosphingosine-treated human cancer cells. J Biol Chem 2003;278:50624-50634.
15. Sakakura C, Sweeney EA, Shirahama T, et al. Selectivity of sphingosine-induced apoptosis. Lack of activity of DLerythyro- dihydrosphingosine. Biochem Biophys Res Commun 1998;246:827-830.
16. Lunghi P, Tabilio A, Dall'Aglio PP, et al. Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts. Leukemia 2003;17:1783-1793.
17. Milella M, Kornblau SM, Estrov Z, et al. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 2001;108:851-859.
18. Mas VM, Hernandez H, Plo I, et al. Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin. Blood 2003;101:1543-1550.
19. Scudiero DA, Shoemaker RH, Paull KD, et al. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 1988;48:4827-4833.
20. Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
21. Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 1997;411:77-82.
22. Walczak H, Krammer PH. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp Cell Res 2000; 256:58-66.
23. Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008;9:47-59.
24. Nagahara Y, Shinomiya T, Kuroda S, Kaneko N, Nishio R, Ikekita M. Phytosphingosine induced mitochondria-involved apoptosis. Cancer Sci 2005;96:83-92.
25. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-1312.
26. Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 1997;91:627-637.
27. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998;94:491-501.
28. Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004;18:189-218.
29. Kim SC, Hahn JS, Min YH, Yoo NC, Ko YW, Lee WJ. Constitutive activation of extracellular signalregulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1. Blood 1999;93:3893-3899.
30. TowatariM, Iida H, TanimotoM, IwataH,HamaguchiM, Saito H. Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells. Leukemia 1997; 11:479-484.
31. Jaffrezou JP, Levade T, Bettaieb A, et al. Daunorubicininduced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J 1996;15:2417-2424.