Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Mondal, Susmita ^a,d   Mandal, Chandan ^a   Sangwan, Rajender ^b   Chandra, Sarmila ^c   Mandal, Chitra ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^c Kothari Medical Centre   (India)

^d Current Address: Department of Microbiology   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; FUMONISIN B1; HERBACEOUS AGENT; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUTRAL SPHINGOMYELINASE 2; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WITHANOLIDE D; ANILINE DERIVATIVE; BENZYLIDENE DERIVATIVE; GW 4869; MAP2K3 PROTEIN, HUMAN; MAP2K4 PROTEIN, HUMAN; MAP2K6 PROTEIN, HUMAN; MAP2K7 PROTEIN, HUMAN; WITHANOLIDE;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIPOGENESIS; LYMPHOID CELL; NUCLEOTIDE SEQUENCE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; WITHANIA SOMNIFERA; DRUG ANTAGONISM; DRUG EFFECT; FLOW CYTOMETRY; GENETICS; LEUKEMIA; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; TUMOR CELL LINE; WESTERN BLOTTING;

WITHANIA SOMNIFERA;

ANILINE COMPOUNDS; APOPTOSIS; BENZYLIDENE COMPOUNDS; BLOTTING, WESTERN; CELL LINE, TUMOR; CERAMIDES; FLOW CYTOMETRY; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA; MAP KINASE KINASE 3; MAP KINASE KINASE 4; MAP KINASE KINASE 6; MAP KINASE KINASE 7; MICROSCOPY, ELECTRON, SCANNING; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR CELLS, CULTURED; WITHANOLIDES;

EID: 77956469863     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-239     Document Type: Article

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